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What is Norepinephrine Bitartrate
NorepinephrineThe Generic name of this drug
Treatment SummaryNorepinephrine is a hormone and neurotransmitter made by the adrenal medulla. It is released in response to stress and works as a stimulant to the body. Norepinephrine is used to stimulate the nervous system and is found in some plants. Medically, it is used as a medication to mimic the effects of the sympathetic nervous system.
Levophedis the brand name
Norepinephrine Bitartrate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Levophed
Norepinephrine
1982
31
Effectiveness
How Norepinephrine Bitartrate Affects PatientsNoradrenaline causes blood vessels to constrict by interacting with two types of receptors in the body (alpha-1 and alpha-2 adrenergic receptors). This drug typically increases blood pressure by blocking these two receptors and making it harder for the blood vessels to expand.
How Norepinephrine Bitartrate works in the bodyNorepinephrine affects the body in two ways. It tightens the blood vessels by stimulating alpha-adrenergic receptors and it increases the strength of heart contractions by stimulating beta-adrenergic receptors. It also widens coronary arteries.
When to interrupt dosage
The recommended dose of Norepinephrine Bitartrate is contingent upon the established condition, for example Hypotension, Hypovolemic Shock and Hypotension. The amount of dosage is contingent upon the method of administration (e.g. Intravenous or Injection, solution) as can be found in the following table.Condition
Dosage
Administration
Hypovolemic Shock
, 1.0 mg/mL, 0.016 mg/mL, 0.064 mg/mL, 0.032 mg/mL, 0.04 mg/mL, 0.08 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Hypotension
, 1.0 mg/mL, 0.016 mg/mL, 0.064 mg/mL, 0.032 mg/mL, 0.04 mg/mL, 0.08 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Hypotension
, 1.0 mg/mL, 0.016 mg/mL, 0.064 mg/mL, 0.032 mg/mL, 0.04 mg/mL, 0.08 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Sudden Cardiac Arrest
, 1.0 mg/mL, 0.016 mg/mL, 0.064 mg/mL, 0.032 mg/mL, 0.04 mg/mL, 0.08 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Warnings
Norepinephrine Bitartrate ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Hypoxia
Do Not Combine
mesenteric or peripheral vascular thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
Hypotension
Do Not Combine
Hypercarbia
Do Not Combine
Common Norepinephrine Bitartrate Drug Interactions
Drug Name
Risk Level
Description
2,5-Dimethoxy-4-ethylamphetamine
Major
The therapeutic efficacy of 2,5-Dimethoxy-4-ethylamphetamine can be increased when used in combination with Norepinephrine.
2,5-Dimethoxy-4-ethylthioamphetamine
Major
The therapeutic efficacy of 2,5-Dimethoxy-4-ethylthioamphetamine can be increased when used in combination with Norepinephrine.
4-Bromo-2,5-dimethoxyamphetamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyamphetamine can be increased when used in combination with Norepinephrine.
Acebutolol
Major
The therapeutic efficacy of Acebutolol can be increased when used in combination with Norepinephrine.
Amphetamine
Major
The therapeutic efficacy of Amphetamine can be increased when used in combination with Norepinephrine.
Norepinephrine Bitartrate Toxicity & Overdose RiskTaking too much of this drug, or taking it in combination with other medications that affect blood pressure, can lead to reduced blood flow to the limbs and even limb death.
Norepinephrine Bitartrate Novel Uses: Which Conditions Have a Clinical Trial Featuring Norepinephrine Bitartrate?
34 active clinical trials are presently assessing the potential of Norepinephrine Bitartrate to reduce the severity of Heart attack, Hypotension and Hypovolemic Shock.Condition
Clinical Trials
Trial Phases
Hypotension
0 Actively Recruiting
Sudden Cardiac Arrest
10 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1
Hypovolemic Shock
29 Actively Recruiting
Phase 3, Phase 4, Not Applicable, Phase 2
Hypotension
0 Actively Recruiting
Norepinephrine Bitartrate Reviews: What are patients saying about Norepinephrine Bitartrate?
1.3Patient Review
11/25/2008Patient Q&A Section about norepinephrine bitartrate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Which condition is an indication for the use of norepinephrine bitartrate?
"Norepinephrine is indicated to raise blood pressure in adult patients with severe, acute hypotension."
Answered by AI
What happens if you take norepinephrine?
"The most common side effects of norepinephrine are a slow heart rate, high blood pressure, and irregular heartbeats."
Answered by AI
Is norepinephrine the same as norepinephrine bitartrate?
"The drug Norepinephrine Bitartrate is a salt of norepinephrine, which is a synthetic version of the natural chemical phenylethylamine. Norepinephrine Bitartrate affects the body in the same way as the body's natural norepinephrine, by acting on the alpha- and beta-adrenergic receptors."
Answered by AI
What is norepinephrine bitartrate used for?
"Levophed is a vasoconstrictor, similar to adrenaline, used to treat low blood pressure that can be life-threatening. Levophed is often used during or after CPR."
Answered by AI