Norepinephrine Bitartrate

Hypovolemic Shock, Sudden Cardiac Arrest, Hypotension + 1 more

Treatment

10 Active Studies for Norepinephrine Bitartrate

Treatment for

Hypovolemic Shock

What is Norepinephrine Bitartrate

NorepinephrineThe Generic name of this drug

Treatment SummaryNorepinephrine is a hormone and neurotransmitter made by the adrenal medulla. It is released in response to stress and works as a stimulant to the body. Norepinephrine is used to stimulate the nervous system and is found in some plants. Medically, it is used as a medication to mimic the effects of the sympathetic nervous system.

Levophedis the brand name

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Norepinephrine Bitartrate Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Levophed

Norepinephrine

1982

Effectiveness

How Norepinephrine Bitartrate Affects PatientsNoradrenaline causes blood vessels to constrict by interacting with two types of receptors in the body (alpha-1 and alpha-2 adrenergic receptors). This drug typically increases blood pressure by blocking these two receptors and making it harder for the blood vessels to expand.

How Norepinephrine Bitartrate works in the bodyNorepinephrine affects the body in two ways. It tightens the blood vessels by stimulating alpha-adrenergic receptors and it increases the strength of heart contractions by stimulating beta-adrenergic receptors. It also widens coronary arteries.

When to interrupt dosage

The recommended dose of Norepinephrine Bitartrate is contingent upon the established condition, for example Hypotension, Hypovolemic Shock and Hypotension. The amount of dosage is contingent upon the method of administration (e.g. Intravenous or Injection, solution) as can be found in the following table.

Condition

Dosage

Administration

Hypotension

, 1.0 mg/mL, 0.016 mg/mL, 0.064 mg/mL, 0.032 mg/mL, 0.04 mg/mL, 0.08 mg/mL

, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous

Hypovolemic Shock

, 1.0 mg/mL, 0.016 mg/mL, 0.064 mg/mL, 0.032 mg/mL, 0.04 mg/mL, 0.08 mg/mL

Sudden Cardiac Arrest

, 1.0 mg/mL, 0.016 mg/mL, 0.064 mg/mL, 0.032 mg/mL, 0.04 mg/mL, 0.08 mg/mL

Hypotension

, 1.0 mg/mL, 0.016 mg/mL, 0.064 mg/mL, 0.032 mg/mL, 0.04 mg/mL, 0.08 mg/mL

Warnings

Norepinephrine Bitartrate Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Hypoxia

Do Not Combine

mesenteric or peripheral vascular thrombosis

Do Not Combine

Pulse Frequency

Do Not Combine

Hypotension

Do Not Combine

Hypercarbia

Do Not Combine

There are 20 known major drug interactions with Norepinephrine Bitartrate.

Common Norepinephrine Bitartrate Drug Interactions

Drug Name

Risk Level

Description

2,5-Dimethoxy-4-ethylamphetamine

Major

The therapeutic efficacy of 2,5-Dimethoxy-4-ethylamphetamine can be increased when used in combination with Norepinephrine.

2,5-Dimethoxy-4-ethylthioamphetamine

Major

The therapeutic efficacy of 2,5-Dimethoxy-4-ethylthioamphetamine can be increased when used in combination with Norepinephrine.

4-Bromo-2,5-dimethoxyamphetamine

Major

The therapeutic efficacy of 4-Bromo-2,5-dimethoxyamphetamine can be increased when used in combination with Norepinephrine.

Acebutolol

Major

The therapeutic efficacy of Acebutolol can be increased when used in combination with Norepinephrine.

Amphetamine

Major

The therapeutic efficacy of Amphetamine can be increased when used in combination with Norepinephrine.

Norepinephrine Bitartrate Toxicity & Overdose RiskTaking too much of this drug, or taking it in combination with other medications that affect blood pressure, can lead to reduced blood flow to the limbs and even limb death.

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Norepinephrine Bitartrate Novel Uses: Which Conditions Have a Clinical Trial Featuring Norepinephrine Bitartrate?

34 active clinical trials are presently assessing the potential of Norepinephrine Bitartrate to reduce the severity of Heart attack, Hypotension and Hypovolemic Shock.

Condition

Clinical Trials

Trial Phases

Hypovolemic Shock

10 Actively Recruiting

Phase 4, Phase 3, Not Applicable, Phase 2

Hypotension

0 Actively Recruiting

Sudden Cardiac Arrest

1 Actively Recruiting

Not Applicable

Hypotension

0 Actively Recruiting

Norepinephrine Bitartrate Reviews: What are patients saying about Norepinephrine Bitartrate?

1.3Patient Review

11/25/2008

Norepinephrine Bitartrate for Severely Low Blood Pressure

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Patient Q&A Section about norepinephrine bitartrate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Which condition is an indication for the use of norepinephrine bitartrate?

"Norepinephrine is indicated to raise blood pressure in adult patients with severe, acute hypotension."

Answered by AI

What happens if you take norepinephrine?

"The most common side effects of norepinephrine are a slow heart rate, high blood pressure, and irregular heartbeats."

Answered by AI

Is norepinephrine the same as norepinephrine bitartrate?

"The drug Norepinephrine Bitartrate is a salt of norepinephrine, which is a synthetic version of the natural chemical phenylethylamine. Norepinephrine Bitartrate affects the body in the same way as the body's natural norepinephrine, by acting on the alpha- and beta-adrenergic receptors."

Answered by AI

What is norepinephrine bitartrate used for?

"Levophed is a vasoconstrictor, similar to adrenaline, used to treat low blood pressure that can be life-threatening. Levophed is often used during or after CPR."

Answered by AI

Clinical Trials for Norepinephrine Bitartrate

Have you considered Norepinephrine Bitartrate clinical trials? We made a collection of clinical trials featuring Norepinephrine Bitartrate, we think they might fit your search criteria.

Explore trials for Norepinephrine Bitartrate

Have you considered Norepinephrine Bitartrate clinical trials? We made a collection of clinical trials featuring Norepinephrine Bitartrate, we think they might fit your search criteria.