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Beta Blocker

Atenolol for Osteoporosis Prevention (APO Trial)

Phase 2
Recruiting
Led By Sundeep Khosla, MD
Research Sponsored by Sundeep Khosla, M.D.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Aged 50-75 years
Postmenopausal women (FSH ≥ 16 IU/L) (no menses for at least one year)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 24 months
Awards & highlights

APO Trial Summary

This trial will evaluate whether atenolol prevents bone loss in postmenopausal women.

Who is the study for?
This trial is for postmenopausal women aged 50-75 who are healthy and can consent to participate. They must not have severe chronic diseases, recent use of certain heart or bone medications, a history of osteoporotic fractures, or very low blood pressure/heart rate.Check my eligibility
What is being tested?
The APO trial is testing if atenolol, a common beta blocker medication, can prevent bone loss in the lower back and hip among postmenopausal women. Participants will either receive atenolol or a placebo (a pill with no active drug).See study design
What are the potential side effects?
Atenolol may cause side effects such as tiredness, cold hands and feet, sleep disturbances, slow heartbeat. Since it's given to healthy subjects here for prevention of osteoporosis rather than heart issues, other specific risks should be discussed.

APO Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 50 and 75 years old.
Select...
I am a postmenopausal woman.

APO Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 24 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 24 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
: Percent change in femur neck bone mineral density (BMD)
Secondary outcome measures
: Percent changes in lumbar spine and total hip BMD
Additional

APO Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: AtenololExperimental Treatment1 Intervention
Study subjects will take Atenolol 50 mg daily over 2 years
Group II: PlaceboPlacebo Group1 Intervention
Study subjects will take a placebo daily over 2 years

Find a Location

Who is running the clinical trial?

Sundeep Khosla, M.D.Lead Sponsor
1 Previous Clinical Trials
120 Total Patients Enrolled
Columbia UniversityOTHER
1,426 Previous Clinical Trials
2,473,388 Total Patients Enrolled
MaineHealthOTHER
71 Previous Clinical Trials
48,887 Total Patients Enrolled

Media Library

Atenolol (Beta Blocker) Clinical Trial Eligibility Overview. Trial Name: NCT04905277 — Phase 2
Healthy Subjects Research Study Groups: Atenolol, Placebo
Healthy Subjects Clinical Trial 2023: Atenolol Highlights & Side Effects. Trial Name: NCT04905277 — Phase 2
Atenolol (Beta Blocker) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04905277 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the scientific research community's consensus on Atenolol 50 MG?

"There are presently seven clinical trials investigating Atenolol 50 MG, with two of them being in Phase 3. The majority of the trials for Atenolol 50 MG are based in Scarborough, Maine, but there are115 locations running studies for Atenolol 50 MG in total."

Answered by AI

Atenolol 50 MG is commonly used to manage which medical condition?

"Atenolol 50 MG is the go-to medication for treating tachycardia and ventricular. However, it can also help patients that suffer from angina pectoris, coronary artery atherosclerosis, and bradycardia."

Answered by AI

Does this experiment require participants to be over 25 years old?

"The age range that this clinical trial is accepting patients is between 50-75 years old."

Answered by AI

Are enrollees still being accepted for this experiment?

"The listing for this clinical trial on clinicaltrials.gov confirms that it is still recruiting participants. The trial was first posted on 7/27/2021 and was last updated on 8/15/2022."

Answered by AI

Could I take part in this scientific research?

"Investigators are looking for 420 individuals aged 50-75 who currently have healthy subjects (hs). The following inclusion criteria must also be met: Aged 50-75 years."

Answered by AI

How many participants are being allowed into this clinical trial?

"That is correct. If you visit clinicaltrials.gov, you will see that this trial was initially posted on July 27th, 2021 and updated as recently as August 15th, 2022. The study requires 420 individuals from 3 different locations."

Answered by AI

Has Atenolol 50 MG received FDA approval?

"Atenolol 50 MG ranks a 3 on our Power scale because it is a Phase 3 medication. This signifies that, while there is data supporting its efficacy, there are also multiple rounds of data supporting its safety."

Answered by AI

Who else is applying?

What state do they live in?
Pennsylvania
Massachusetts
New York
How old are they?
65+
18 - 65
What site did they apply to?
Mayo Clinic
Columbia University Irving Medical Center
MaineHealth
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria

Why did patients apply to this trial?

I would like to know what need treatments they are evaluating for Osteoporosis.
PatientReceived 2+ prior treatments

How responsive is this trial?

Most responsive sites:
  1. Columbia University Irving Medical Center: < 48 hours
Average response time
  • < 2 Days
Typically responds via
Email
Phone Call
~166 spots leftby Dec 2025