Mevacor

Peripheral Arterial Disease, Primary Hypercholesterolemia, Coronary Revascularization + 16 more
Treatment
20 Active Studies for Mevacor

What is Mevacor

LovastatinThe Generic name of this drug
Treatment SummaryLovastatin, also known under the brand name Mevacor, is a drug used to lower cholesterol and reduce the risk of cardiovascular disease. It belongs to a class of medications called statins, which work by blocking the production of cholesterol in the liver. Lovastatin and other statins are widely prescribed by doctors to help reduce the risk of heart attack, stroke, and other cardiovascular events. While all statins are effective, lovastatin is less potent than other statins like rosuvastatin and may cause fewer side effects. Clinical studies have shown that taking lovastatin can result in a 25-40%
Mevacoris the brand name
image of different drug pills on a surface
Mevacor Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Mevacor
Lovastatin
1987
285

Effectiveness

How Mevacor Affects PatientsLovastatin is a drug used to lower cholesterol levels in the blood by decreasing low-density lipoprotein (LDL) and total cholesterol while increasing high-density lipoprotein (HDL). High LDL, low HDL, and high triglyceride levels can increase the risk of atherosclerosis and cardiovascular disease. Studies have shown that taking lovastatin can reduce the risk of developing cardiovascular disease and all-cause mortality. Common side effects of lovastatin include muscle aches, which have been reported in 10-15% of people taking the drug. In rare cases, it can also cause liver dysfunction, which may manifest as
How Mevacor works in the bodyLovastatin works to reduce cholesterol levels by blocking an enzyme in the liver that helps make cholesterol. This reduces the amount of cholesterol in the body, and also inhibits the production of very low-density lipoprotein (VLDL). Taking lovastatin once a day, preferably in the evening, provides the best results. In addition to its cholesterol-lowering effects, lovastatin has been found to have other beneficial effects, such as improving endothelial function, stabilizing atherosclerotic plaques, reducing oxidative stress and inflammation, and inhibiting the thrombogenic response. It is also believed to

When to interrupt dosage

The recommended dose of Mevacor is contingent upon the specified condition, like Dyslipidemias, 1 year post-menarche and Cardiovascular Diseases. The dosage varies, in line with the approach of administration specified in the table below.
Condition
Dosage
Administration
Heart Attack
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral
Cholesterol, LDL
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral
Diet
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral
Coronary Heart Disease
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral
Apolipoprotein
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral
Hypercholesterolemia
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral
Dyslipidemias
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral
Low-Density Lipoproteins
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral
Cardiovascular Diseases
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral
Hypertriglyceridemia
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral
1 year post-menarche
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral
Coronary heart disease
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral
Angina, Unstable
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral
Coronary Artery Disease
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral
Low-Density Lipoproteins
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral
total cholesterol increased
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral
Peripheral Arterial Disease
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral
Primary Hypercholesterolemia
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral
Coronary Revascularization
20.0 mg, 40.0 mg, , 10.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, extended release; Tablet, multilayer, extended release, Tablet, extended release; Tablet, multilayer, extended release - Oral

Warnings

Mevacor Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Lovastatin may interact with Pulse Frequency
Liver Diseases
Do Not Combine
Breast Milk Production
Do Not Combine
Transaminases
Do Not Combine
Pulse Frequency
Do Not Combine
unexplained elevations of serum transaminases
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Mevacor.
Common Mevacor Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Lovastatin.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Lovastatin.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Lovastatin.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Lovastatin.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Lovastatin.
Mevacor Toxicity & Overdose RiskThe highest dose of lovastatin that has been found to be non-toxic is higher than 15 g/m2. Five people have taken up to 200 mg of lovastatin without any major side effects. In rare cases of overdose, no serious symptoms have been reported and all patients recovered without any long-term problems. Animal studies have found an increased risk of liver, lung, stomach, and thyroid tumors, as well as testicular atrophy, decreased sperm count, and decreased fertility in males. However, there is no evidence that lovastatin is mutagenic.
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Mevacor Novel Uses: Which Conditions Have a Clinical Trial Featuring Mevacor?

134 active trials are presently being conducted to assess the potential of Mevacor to address Coronary Artery Atherosclerosis, Heart Attack and Coronary Heart Disease.
Condition
Clinical Trials
Trial Phases
Peripheral Arterial Disease
38 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Phase 1, Early Phase 1, Phase 4
Apolipoprotein
0 Actively Recruiting
Hypercholesterolemia
2 Actively Recruiting
Phase 1, Phase 3
Hypertriglyceridemia
0 Actively Recruiting
Coronary Artery Disease
1 Actively Recruiting
Not Applicable
Angina, Unstable
2 Actively Recruiting
Not Applicable
Coronary Revascularization
1 Actively Recruiting
Phase 4
Coronary Heart Disease
8 Actively Recruiting
Not Applicable, Early Phase 1
Cholesterol, LDL
0 Actively Recruiting
Diet
5 Actively Recruiting
Not Applicable, Phase 1
Low-Density Lipoproteins
0 Actively Recruiting
Heart Attack
26 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Phase 2, Early Phase 1, Phase 3
Coronary heart disease
0 Actively Recruiting
Primary Hypercholesterolemia
10 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Dyslipidemias
1 Actively Recruiting
Phase 2
1 year post-menarche
0 Actively Recruiting
total cholesterol increased
0 Actively Recruiting
Low-Density Lipoproteins
0 Actively Recruiting
Cardiovascular Diseases
0 Actively Recruiting

Mevacor Reviews: What are patients saying about Mevacor?

5Patient Review
12/17/2011
Mevacor for Combined High Blood Cholesterol and Triglyceride Level
I've been taking Mevacor for 20 years now, and it's really worked well for me. I had a heart attack when I was younger and my cholesterol levels were through the roof, but since then they've been manageable. The only downside is that the VA can't seem to get their hands on it anymore, and the other statins have some pretty severe side effects.
5Patient Review
8/19/2008
Mevacor for High Cholesterol
Unfortunately, this treatment caused some severe problems for me after just a few months. Namely, constipation and fatigue.
4.7Patient Review
3/25/2009
Mevacor for High Cholesterol
I experienced some muscle weakness and pain, as well as fatigue and decreased energy levels.
4Patient Review
7/11/2009
Mevacor for Changes Involving Fatty Deposits in the Blood Vessels
This treatment is really effective for leg cramps.
3.7Patient Review
1/25/2008
Mevacor for High Cholesterol
View All Reviews
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Patient Q&A Section about mevacor

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of Mevacor?

"You may experience some or all of the following side effects: headache, muscle pain/tenderness/weakness, joint pain, back pain, stomach pain, gas, bloating, stomach upset."

Answered by AI

What is the brand name for Mevacor?

"Lovastatin is available under the brand names Mevacor and Altoprev."

Answered by AI

What is the most serious side effect of lovastatin?

"This is a serious, potentially fatal condition that causes muscle pain, tenderness, and weakness along with kidney problems.

Lovastatin may cause serious muscle problems, including myopathy and rhabdomyolysis. Myopathy is a condition characterized by muscle pain, tenderness, or weakness. Rhabdomyolysis is a potentially fatal condition that causes muscle pain, tenderness, and weakness along with kidney problems."

Answered by AI

What is Mevacor prescribed for?

"Lovastatin is a drug that helps to lower bad cholesterol levels and raise good cholesterol levels when taken alongside a proper diet. It is a type of drug known as a statin, which works by reducing the amount of cholesterol produced by the liver."

Answered by AI

Clinical Trials for Mevacor

Have you considered Mevacor clinical trials? We made a collection of clinical trials featuring Mevacor, we think they might fit your search criteria.
Have you considered Mevacor clinical trials? We made a collection of clinical trials featuring Mevacor, we think they might fit your search criteria.
Have you considered Mevacor clinical trials? We made a collection of clinical trials featuring Mevacor, we think they might fit your search criteria.
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