Metoprolol Succinate

Atrial Fibrillation, Thyroid Crisis, Migraine + 9 more

Treatment

4 FDA approvals

20 Active Studies for Metoprolol Succinate

What is Metoprolol Succinate

Metoprolol

The Generic name of this drug

Treatment Summary

Metoprolol is a medication used to treat high blood pressure and heart conditions. It comes in two forms, immediate release and extended release, and is one of the most commonly prescribed beta-blockers. Metoprolol was first developed in 1969 and was approved by the FDA in 1978. It is widely prescribed in the United States, Netherlands, and New Zealand.

Lopressor

is the brand name

image of different drug pills on a surface

Metoprolol Succinate Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Lopressor

Metoprolol

1978

983

Approved as Treatment by the FDA

Metoprolol, also known as Lopressor, is approved by the FDA for 4 uses including Hypertensive disease and Hypertension .

Hypertensive disease

Used to treat High Blood Pressure (Hypertension) in combination with Hydrochlorothiazide

Hypertension

Used to treat nonresponsive to antihypertensive monotherapy in combination with Hydrochlorothiazide

Hemodynamically Stable

Heart Attack

Effectiveness

How Metoprolol Succinate Affects Patients

When taken as prescribed, metoprolol can reduce heart rate and lower the amount of work the heart needs to do. It can also help treat arrhythmias by slowing down the speed of electrical signals between the heart’s chambers. In several clinical trials, taking metoprolol after a heart attack has been found to reduce the risk of sudden cardiac death and myocardial infarction (heart attack) by 17%.

How Metoprolol Succinate works in the body

Metoprolol is a drug that reduces the activity of certain receptors in the heart. This decreases the amount of work the heart does and helps it to beat slower and weaker. Metoprolol does not affect other parts of the body or have any direct stimulating effects.

When to interrupt dosage

The advised dosage of Metoprolol Succinate is contingent upon the diagnosed condition, including Hemodynamically Stable, Thyroid Crisis and Atrial Fibrillation. The measure of dosage fluctuates according to the technique of delivery (e.g. Tablet, coated or Tablet - Oral) featured in the table beneath.

Condition

Dosage

Administration

Chest Pain

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Heart Attack

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Hypertensive disease

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Hypertension

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Migraine Disorders

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Atrial Fibrillation

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Thyroid Crisis

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Migraine

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Hypesthesia

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Hypesthesia

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Hemodynamically Stable

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Tachycardia, Supraventricular

, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg

Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, coated

Warnings

Metoprolol Succinate has seven contraindications, and it must not be utilized in association with the situations in the following table.

Metoprolol Succinate Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Metoprolol may interact with Pulse Frequency

Heart Block

Do Not Combine

Shock, Cardiogenic

Do Not Combine

Heart Decompensation

Do Not Combine

Pulse Frequency

Do Not Combine

severe bradycardia

Do Not Combine

Sick Sinus Syndrome

Do Not Combine

There are 20 known major drug interactions with Metoprolol Succinate.

Common Metoprolol Succinate Drug Interactions

Drug Name

Risk Level

Description

4-Bromo-2,5-dimethoxyphenethylamine

Major

The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Metoprolol.

Abediterol

Major

The therapeutic efficacy of Abediterol can be decreased when used in combination with Metoprolol.

Adrafinil

Major

The therapeutic efficacy of Adrafinil can be decreased when used in combination with Metoprolol.

Agrostis gigantea pollen

Major

The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Metoprolol.

Agrostis stolonifera pollen

Major

The risk of a hypersensitivity reaction to Agrostis stolonifera pollen is increased when it is combined with Metoprolol.

Metoprolol Succinate Toxicity & Overdose Risk

The lethal dose of metoprolol in rats is between 3090 and 4670mg/kg. Overdosing on metoprolol can cause slow heart rate, low blood pressure, wheezing, and heart failure. If someone overdoses on metoprolol, it is recommended to perform gastric lavage and treat any symptoms that arise. Metoprolol has not been found to cause cancer, mutations, or fertility problems, although long-term use of high dosages has been linked to benign lung tumors.

image of a doctor in a lab doing drug, clinical research

Metoprolol Succinate Novel Uses: Which Conditions Have a Clinical Trial Featuring Metoprolol Succinate?

319 active clinical trials are currently evaluating the use of Metoprolol Succinate in providing Hypesthesia relief, managing Thyroid Crisis and treating Hypertensive diseases.

Condition

Clinical Trials

Trial Phases

Atrial Fibrillation

94 Actively Recruiting

Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1

Chest Pain

2 Actively Recruiting

Not Applicable, Phase 2, Phase 3

Heart Attack

23 Actively Recruiting

Not Applicable, Phase 1, Phase 4, Phase 2, Early Phase 1, Phase 3

Thyroid Crisis

0 Actively Recruiting

Hypesthesia

8 Actively Recruiting

Not Applicable, Phase 1

Hemodynamically Stable

0 Actively Recruiting

Tachycardia, Supraventricular

0 Actively Recruiting

Migraine

51 Actively Recruiting

Phase 4, Not Applicable, Phase 1, Phase 3, Phase 2, Early Phase 1

Hypesthesia

2 Actively Recruiting

Not Applicable

Hypertension

0 Actively Recruiting

Hypertensive disease

27 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Migraine Disorders

1 Actively Recruiting

Phase 3

Metoprolol Succinate Reviews: What are patients saying about Metoprolol Succinate?

5

Patient Review

11/10/2022

Metoprolol Succinate for Diastolic Heart Failure

At first, I was really scared to use the metoprolol succinate er 25 mg that my heart doctor prescribed for my diastolic dysfunction. But I slowly started taking it until I could take the whole pill. And now, while I still have occasional angina, this pill has saved me. So far so good!

2.3

Patient Review

4/2/2022

Metoprolol Succinate for Diastolic Heart Failure

I had covid twice in the past two years and started getting PVCs (premature ventricular contractions) as well as PACs (premature atrial contractions), along with high blood pressure. I was prescribed 25 mg of this drug once daily, and it completely eliminated my PVCs over a 3-month period. However, I am now experiencing bad side effects from the medicine, such as hair loss, weight gain, laziness, depression, anxiety, and higher blood pressure! I am slowly tapering off due to these horrible side effects.

2.3

Patient Review

3/16/2022

Metoprolol Succinate for High Blood Pressure

I was prescribed this medication two months ago to replace carvedilol. After taking it, I started to develop extra heartbeats from prednisone. When I told my cardiologist, she was doubtful that it could be the metoprolol. However, after reading these reviews, I believe that the metoprolol may be the cause of my symptoms which include: joint and upper back pain, fatigue and nausea. I am going to go to half dose and see if there is any improvement.

2.3

Patient Review

3/19/2022

Metoprolol Succinate for High Blood Pressure

My blood pressure is great, but I've been feeling really terrible side effects. For example, my neck has been tightening up and my heartbeat feels way off. I'm also super depressed and tired. I quit my job and stopped answering my phone. I don't want to go out in public because I feel socially awkward and anxious.

2.3

Patient Review

7/30/2022

Metoprolol Succinate for High Blood Pressure

Did not work for me at all. I saw a very slight reduction in blood pressure that only lasted five hours. Also caused some nasty headaches and made my fingers and ankles swell up. There are so many documented side effects, it's scary. I have no idea how this medication is on the market.

2.3

Patient Review

4/13/2022

Metoprolol Succinate for Prevention of Recurrent Atrial Fibrillation

I did not find this drug helpful for my palpitations. If anything, it made them worse. I also felt dizzy and lightheaded most of the time I was taking it. Shortness of breath was another issue I had while on this medication. After only two weeks, I decided to stop taking it. Thankfully, I immediately started feeling better.

2

Patient Review

4/22/2022

Metoprolol Succinate for High Blood Pressure

I was taking atenolol for over 30 years with little problems except weight gain, but as I aged it didn't work for me much anymore so my dr. switched me to metoporol succ. After taking it my bp went to numbers off the richter scale 260 over 110. Stopped taking it immediately and bp slowly came down after taking diltiazem. My brother takes it with no problem. Now back on smaller dose of atenolol and diltiazem and may wean off atenolol slower to see if I can do without.

1.7

Patient Review

6/9/2022

Metoprolol Succinate for High Blood Pressure

In the past 50 days of taking this medication, I have not seen any lower in my blood pressure. In fact, I haven't gotten any side effects at all. My blood pressure is still very high. My doctor says it will work, but when is the question. I have advised my doctor but has not done anything as yet. Time to find a real doctor.

1.3

Patient Review

7/19/2022

Metoprolol Succinate for High Blood Pressure

After taking metoprolol for a few months to manage my high blood pressure, I started having PVCs (premature ventricular contractions). My cardiologist did some tests and found that 13% of my heartbeats were PVCs. They upped the dosage on my medication, but then my hair started falling out, so they took me off it and put me on Carvidilol instead. Now my hair is growing back and my PVCs are down to 1.8%.

1

Patient Review

10/4/2022

Metoprolol Succinate for High Blood Pressure

I started taking this medicine 2 weeks ago at the minimum dosage of 12.5mg a day. I have never experienced such horrible side effects from any medication, and today my doctor and I decided to wean me off of it. It's unreal that the FDA approved this drug.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about metoprolol succinate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are side effects of metoprolol succinate ER?

"dizziness, feeling tired, depression, confusion, memory problems, nightmares, trouble sleeping, diarrhea, mild itching, or rash."

Answered by AI

What are the most common side effects of metoprolol?

"If you have a headache, make sure to rest and drink plenty of fluids. If metoprolol makes you feel dizzy or weak, stop what you're doing and sit or lie down until you feel better. Cold hands or feet, feeling sick (nausea), and stomach pain are also side effects of metoprolol."

Answered by AI

What time of day should I take metoprolol er succinate?

"Metoprolol tartrate is usually taken twice each day, so it should be taken in the morning and at night. Metoprolol succinate is only taken once each day, so you can take it either in the morning or at night. Be sure to take each drug at about the same time or times each day."

Answered by AI

What is the best time to take metoprolol?

"Your doctor may tell you to take your first dose of metoprolol at night because it could make you feel dizzy. If you don't feel dizzy after the first dose, take it in the morning. Try to space out doses evenly throughout the day if you're taking metoprolol more than once a day."

Answered by AI

Clinical Trials for Metoprolol Succinate

Image of Miles Square Health Center Chicago in Chicago, United States.

Food is Medicine for High Blood Pressure and Obesity

Any Age
All Sexes
Chicago, IL

The goal of this clinical trial is to treat both hypertension and obesity in adults using a food is medicine framework. Participants will be randomized 1:1 to FIM+DASH or usual-care control. The 24-week trial includes a 12-week FIM+DASH intervention followed by a 12-week maintenance period and leverages existing partnerships with community-based organizations for home food delivery and culinary skill-skill building. The main questions it aims to answer are: (1) What is the effect of FIM+DASH vs. usual care control on blood pressure? (2) What is the effect of FIM+DASH vs. usual care control on DASH diet adherence (diet quality), body weight, and waist circumference? (3) How to identify factors associated with the sustainability and scalability of FIM+DASH in real-world settings?

Phase 2
Waitlist Available

Miles Square Health Center Chicago (+3 Sites)

Image of Northwestern University in Chicago, United States.

Exercise Program for Atrial Fibrillation and Heart Failure

60 - 99
All Sexes
Chicago, IL

Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) are very common conditions that often occur together and result in worsening symptoms and reduced quality of life (QoL). Limitations being able to participate in activities of daily living is a primary complaint for AF-HFpEF patients, yet effective strategies to address this issue remain limited. While exercise interventions targeting aerobic training (AT) are recommended for patients with AF and HFpEF, unique challenges exist in this patient population who tend to be older. Specifically, many older patients with AF and HFpEF have muscle weakness, sarcopenia and frailty, that can make aerobic-focused exercise difficult and less tolerable. This study proposes that starting with progressive resistance training (PRT) before aerobic exercise may overcome these issues by improving muscle strength, making AT more manageable, and leading to better health outcomes. The goal of this study is to assess whether a sequential exercise program, named 'PREACTIVE' improves how people feel, decrease the amount of symptoms, and their ability to participate in exercise and activities. This study will specifically test a sequenced exercise approach of resistance training followed by aerobic exercise to improve symptoms, and quality of life in AF-HFpEF.

Waitlist Available
Has No Placebo

Northwestern University

Deepika Laddu, PhD

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App-based Breathing Program for Migraine

18+
All Sexes
Phoenix, AZ

Migraine is one of the most common neurological disorders, characterized by recurrent headaches, sensitivity to light and movement, nausea, and autonomic dysregulation. Although mind-body interventions like biofeedback have shown their efficacy, they remain underutilized due to barriers such as transportation, time constraints, lack of awareness, stigma, and cost. A targeted approach to enhancing HRV is HRV biofeedback (HRVB), a technique using visual or auditory feedback to help people regulate HRV through slow-paced breathing and positive emotional regulation to promote ANS balance and emotional resilience. Investigators will conduct a remotely delivered pilot RCT of an 8-week, 10 min/day, novel app-based HRVB intervention compared to a sham control intervention (matching intervention time and attention with no biofeedback component) in adult with chronic migraine. Investigators hypothesize data collected from the study will: a) support the feasibility and acceptability of the remotely delivered app-based HRVB intervention among adults with chronic migraine, and b) provide insights into refining the intervention by examining patterns of change in migraine and psychological outcomes from pre- to post-intervention.

Waitlist Available
Online Trial

Arizona State University

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Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL

This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.

Waitlist Available
Has No Placebo

U Health (+1 Sites)

Ziad Zoghby, M.D., M.B.A.

Biobeat Technologies Ltd.

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