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What is Metoprolol Succinate
MetoprololThe Generic name of this drug
Treatment SummaryMetoprolol is a medication used to treat high blood pressure and heart conditions. It comes in two forms, immediate release and extended release, and is one of the most commonly prescribed beta-blockers. Metoprolol was first developed in 1969 and was approved by the FDA in 1978. It is widely prescribed in the United States, Netherlands, and New Zealand.
Lopressoris the brand name
Metoprolol Succinate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lopressor
Metoprolol
1978
983
Approved as Treatment by the FDA
Metoprolol, also known as Lopressor, is approved by the FDA for 4 uses including Hemodynamically Stable and nonresponsive to antihypertensive monotherapy .Hemodynamically Stable
nonresponsive to antihypertensive monotherapy
Used to treat nonresponsive to antihypertensive monotherapy in combination with Hydrochlorothiazide
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Hydrochlorothiazide
Heart Attack
Effectiveness
How Metoprolol Succinate Affects PatientsWhen taken as prescribed, metoprolol can reduce heart rate and lower the amount of work the heart needs to do. It can also help treat arrhythmias by slowing down the speed of electrical signals between the heart’s chambers. In several clinical trials, taking metoprolol after a heart attack has been found to reduce the risk of sudden cardiac death and myocardial infarction (heart attack) by 17%.
How Metoprolol Succinate works in the bodyMetoprolol is a drug that reduces the activity of certain receptors in the heart. This decreases the amount of work the heart does and helps it to beat slower and weaker. Metoprolol does not affect other parts of the body or have any direct stimulating effects.
When to interrupt dosage
The advised dosage of Metoprolol Succinate is contingent upon the diagnosed condition, including Hemodynamically Stable, Thyroid Crisis and Atrial Fibrillation. The measure of dosage fluctuates according to the technique of delivery (e.g. Tablet, coated or Tablet - Oral) featured in the table beneath.Condition
Dosage
Administration
Hemodynamically Stable
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Supraventricular Tachycardia (SVT)
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Chest Pain
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Atrial Fibrillation
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Thyroid Crisis
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Migraine
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Hypesthesia
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
prophylaxis of migraine headaches
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Hypesthesia
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Heart Attack
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
nonresponsive to antihypertensive monotherapy
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Metoprolol Succinate has seven contraindications, and it must not be utilized in association with the situations in the following table.Metoprolol Succinate ContraindicationsCondition
Risk Level
Notes
Heart Block
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Heart Decompensation
Do Not Combine
Pulse Frequency
Do Not Combine
severe bradycardia
Do Not Combine
Sick Sinus Syndrome
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Metoprolol may interact with Pulse Frequency
Common Metoprolol Succinate Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Metoprolol.
Abediterol
Major
The therapeutic efficacy of Abediterol can be decreased when used in combination with Metoprolol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Metoprolol.
Agrostis gigantea pollen
Major
The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Metoprolol.
Agrostis stolonifera pollen
Major
The risk of a hypersensitivity reaction to Agrostis stolonifera pollen is increased when it is combined with Metoprolol.
Metoprolol Succinate Toxicity & Overdose RiskThe lethal dose of metoprolol in rats is between 3090 and 4670mg/kg. Overdosing on metoprolol can cause slow heart rate, low blood pressure, wheezing, and heart failure. If someone overdoses on metoprolol, it is recommended to perform gastric lavage and treat any symptoms that arise. Metoprolol has not been found to cause cancer, mutations, or fertility problems, although long-term use of high dosages has been linked to benign lung tumors.
Metoprolol Succinate Novel Uses: Which Conditions Have a Clinical Trial Featuring Metoprolol Succinate?
319 active clinical trials are currently evaluating the use of Metoprolol Succinate in providing Hypesthesia relief, managing Thyroid Crisis and treating Hypertensive diseases.Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
146 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Migraine
52 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
prophylaxis of migraine headaches
0 Actively Recruiting
Supraventricular Tachycardia (SVT)
1 Actively Recruiting
Not Applicable
Hypesthesia
8 Actively Recruiting
Not Applicable, Phase 1
nonresponsive to antihypertensive monotherapy
0 Actively Recruiting
Thyroid Crisis
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Hypesthesia
4 Actively Recruiting
Not Applicable
Heart Attack
53 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Chest Pain
6 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4
Hemodynamically Stable
0 Actively Recruiting
Metoprolol Succinate Reviews: What are patients saying about Metoprolol Succinate?
5Patient Review
11/10/2022 At first, I was really scared to use the metoprolol succinate er 25 mg that my heart doctor prescribed for my diastolic dysfunction. But I slowly started taking it until I could take the whole pill. And now, while I still have occasional angina, this pill has saved me. So far so good!
2.3Patient Review
4/2/2022 I had covid twice in the past two years and started getting PVCs (premature ventricular contractions) as well as PACs (premature atrial contractions), along with high blood pressure. I was prescribed 25 mg of this drug once daily, and it completely eliminated my PVCs over a 3-month period. However, I am now experiencing bad side effects from the medicine, such as hair loss, weight gain, laziness, depression, anxiety, and higher blood pressure! I am slowly tapering off due to these horrible side effects.
2.3Patient Review
3/16/2022 I was prescribed this medication two months ago to replace carvedilol. After taking it, I started to develop extra heartbeats from prednisone. When I told my cardiologist, she was doubtful that it could be the metoprolol. However, after reading these reviews, I believe that the metoprolol may be the cause of my symptoms which include: joint and upper back pain, fatigue and nausea. I am going to go to half dose and see if there is any improvement.
2.3Patient Review
3/19/2022 My blood pressure is great, but I've been feeling really terrible side effects. For example, my neck has been tightening up and my heartbeat feels way off. I'm also super depressed and tired. I quit my job and stopped answering my phone. I don't want to go out in public because I feel socially awkward and anxious.
2.3Patient Review
7/30/2022 Did not work for me at all. I saw a very slight reduction in blood pressure that only lasted five hours. Also caused some nasty headaches and made my fingers and ankles swell up. There are so many documented side effects, it's scary. I have no idea how this medication is on the market.
2.3Patient Review
4/13/2022 I did not find this drug helpful for my palpitations. If anything, it made them worse. I also felt dizzy and lightheaded most of the time I was taking it. Shortness of breath was another issue I had while on this medication. After only two weeks, I decided to stop taking it. Thankfully, I immediately started feeling better.
2Patient Review
4/22/2022 I was taking atenolol for over 30 years with little problems except weight gain, but as I aged it didn't work for me much anymore so my dr. switched me to metoporol succ. After taking it my bp went to numbers off the richter scale 260 over 110. Stopped taking it immediately and bp slowly came down after taking diltiazem. My brother takes it with no problem. Now back on smaller dose of atenolol and diltiazem and may wean off atenolol slower to see if I can do without.
1.7Patient Review
6/9/2022 In the past 50 days of taking this medication, I have not seen any lower in my blood pressure. In fact, I haven't gotten any side effects at all. My blood pressure is still very high. My doctor says it will work, but when is the question. I have advised my doctor but has not done anything as yet. Time to find a real doctor.
1.3Patient Review
7/19/2022 After taking metoprolol for a few months to manage my high blood pressure, I started having PVCs (premature ventricular contractions). My cardiologist did some tests and found that 13% of my heartbeats were PVCs. They upped the dosage on my medication, but then my hair started falling out, so they took me off it and put me on Carvidilol instead. Now my hair is growing back and my PVCs are down to 1.8%.
1Patient Review
10/4/2022 I started taking this medicine 2 weeks ago at the minimum dosage of 12.5mg a day. I have never experienced such horrible side effects from any medication, and today my doctor and I decided to wean me off of it. It's unreal that the FDA approved this drug.
Patient Q&A Section about metoprolol succinate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are side effects of metoprolol succinate ER?
"dizziness, feeling tired, depression, confusion, memory problems, nightmares, trouble sleeping, diarrhea, mild itching, or rash."
Answered by AI
What are the most common side effects of metoprolol?
"If you have a headache, make sure to rest and drink plenty of fluids. If metoprolol makes you feel dizzy or weak, stop what you're doing and sit or lie down until you feel better. Cold hands or feet, feeling sick (nausea), and stomach pain are also side effects of metoprolol."
Answered by AI
What time of day should I take metoprolol er succinate?
"Metoprolol tartrate is usually taken twice each day, so it should be taken in the morning and at night. Metoprolol succinate is only taken once each day, so you can take it either in the morning or at night. Be sure to take each drug at about the same time or times each day."
Answered by AI
What is the best time to take metoprolol?
"Your doctor may tell you to take your first dose of metoprolol at night because it could make you feel dizzy. If you don't feel dizzy after the first dose, take it in the morning. Try to space out doses evenly throughout the day if you're taking metoprolol more than once a day."
Answered by AI