Blood Pressure Monitoring for Atrial Fibrillation

(OMRON-AF Trial)

Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of California, San Francisco
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The goal of this clinical trial is to learn if screening for atrial fibrillation (AFib), a common irregular heart rhythm, through daily home blood pressure monitoring will decrease the time to atrial fibrillation diagnosis in older adults with hypertension. The main question it aims to answer is:

\-- Does introducing screening for AFib using a blood pressure monitor with AFib detection technology decrease time to AFib diagnosis in patients with high blood pressure, compared to usual care using a conventional home blood pressure monitor with no AFib detection?

Participants will participate in two phases of the study: (1) clinical trial and (2) the registry.

During the 6-month clinical trial period, participants will be asked to:

* Take blood pressure measurements twice daily

* Answer short weekly mobile app-based surveys

* If assigned, complete continuous heart monitoring for 2 weeks and complete 1 blood test

During the 12-month registry period, participants will be asked to:

* Take blood pressure measurements twice daily

* Answer monthly mobile app-based surveys

Researchers will compare standard blood pressure measurements and AFib screening blood pressure measurements to see if there is a difference in the time to AFib diagnosis and other cardiovascular events.

Participants will participate in two phases of the study: (1) trial and (2) the registry.

During the 6-month trial period, participants will be asked to:

* Take daily blood pressure measurements

* Answer short weekly mobile app-based surveys

* If assigned, complete continuous heart monitoring for 2 weeks and complete 1 blood test

During the 12-month registry period, participants will be asked to:

* Take daily blood pressure measurements

* Answer monthly mobile app-based surveys

Who Is on the Research Team?

GM

Gregory M Marcus, MD, MAS

Principal Investigator

University of California, San Francisco

Are You a Good Fit for This Trial?

This trial is for people aged 70 or older who have high blood pressure, a BMI of at least 30, and a moderate-to-high risk of stroke (CHA2DS2-VASc score of 3 or more).

Inclusion Criteria

I am 60 or older with high blood pressure and meet at least one extra risk factor.

Exclusion Criteria

I have been diagnosed with an irregular heart rhythm like AFib or atrial flutter.
Inability to wear the patch ECG monitor or apply the monitor by herself/himself or with the help of a caregiver
History of skin allergies to adhesive patches
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Clinical Trial

Participants take daily blood pressure measurements and answer weekly surveys. If assigned, they complete continuous heart monitoring for 2 weeks and a blood test.

6 months
Weekly virtual surveys, potential in-person visits for ECG and blood test

Registry

Participants continue daily blood pressure measurements and answer monthly surveys to assess cardiovascular events and AFib occurrence.

12 months
Monthly virtual surveys

Follow-up

Participants are monitored for safety and effectiveness after the registry phase.

6 months

What Are the Treatments Tested in This Trial?

Interventions

  • Blood Pressure Monitor With AFib Detection
  • Blood Pressure Monitor Without AFib Detection

Trial Overview

The study compares two types of home blood pressure monitors: one with atrial fibrillation (AFib) detection technology and one without. It aims to see if AFib screening helps diagnose irregular heart rhythms faster in older adults with high blood pressure.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Group I: Standard Blood Pressure Monitoring (No AFib Detection)Experimental Treatment1 Intervention
Group II: Intervention Blood Pressure Monitoring (AFib Detection)Experimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of California, San Francisco

Lead Sponsor

Trials
2,636
Recruited
19,080,000+

Omron Healthcare Co., Ltd.

Industry Sponsor

Trials
14
Recruited
27,500+