Metipranolol

Open Angle Glaucoma, Ocular Hypertension

Treatment

4 FDA approvals

18 Active Studies for Metipranolol

What is Metipranolol

Metipranolol

The Generic name of this drug

Treatment Summary

Propranolol is a drug used to treat irregular heartbeats, high blood pressure, and glaucoma. It works by blocking the action of beta-1 and beta-2 receptors in the body.

OptiPranolol

is the brand name

Metipranolol Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

OptiPranolol

Metipranolol

1989

4

Approved as Treatment by the FDA

Metipranolol, otherwise known as OptiPranolol, is approved by the FDA for 4 uses like Ocular Hypertension and Open Angle Glaucoma (OAG) .

Ocular Hypertension

Helps manage Ocular Hypertension

Open Angle Glaucoma (OAG)

Helps manage Open Angle Glaucoma (OAG)

Open Angle Glaucoma

Helps manage Open Angle Glaucoma (OAG)

Ocular Hypertension

Helps manage Ocular Hypertension

Effectiveness

How Metipranolol Affects Patients

Metipranolol is a drug used to treat high pressure in the eye (ocular hypertension or open-angle glaucoma). It does not have any impact on the heart, nerves or muscle tissue, and instead works to reduce pressure in the eye. This drug does not lead to a narrowing of the pupil or any issues with vision, unlike some other drugs used for treating glaucoma.

How Metipranolol works in the body

Metipranolol works by attaching to the beta1 and beta2 adrenergic receptors. It has no effect on stimulating the body, but does have a slight effect on stabilizing the cell membrane and decreasing activity in the heart. Its primary effect is to reduce the amount of fluid in the eye, and there is some evidence that it also helps it flow out.

When to interrupt dosage

The suggested dosage of Metipranolol is contingent upon the diagnosed condition. The sum of dosage is contingent upon the mode of administration outlined in the table beneath.

Condition

Dosage

Administration

Open Angle Glaucoma

3.0 mg/mL,

, Solution / drops, Solution / drops - Ophthalmic, Ophthalmic

Ocular Hypertension

3.0 mg/mL,

, Solution / drops, Solution / drops - Ophthalmic, Ophthalmic

Warnings

Metipranolol has six contraindications; thus, it should not be mixed with any of the circumstances specified in the following table.

Metipranolol Contraindications

Condition

Risk Level

Notes

Heart Failure

Do Not Combine

Atrioventricular Block

Do Not Combine

Asthma

Do Not Combine

symptomatic sinus bradycardia

Do Not Combine

Shock, Cardiogenic

Do Not Combine

Asthma

Do Not Combine

There are 20 known major drug interactions with Metipranolol.

Common Metipranolol Drug Interactions

Drug Name

Risk Level

Description

Aliskiren

Minor

Metipranolol may increase the hypotensive activities of Aliskiren.

Ambrisentan

Minor

Metipranolol may increase the hypotensive activities of Ambrisentan.

Angiotensin 1-7

Minor

Metipranolol may increase the hypotensive activities of Angiotensin 1-7.

Azilsartan medoxomil

Minor

Metipranolol may increase the hypotensive activities of Azilsartan medoxomil.

BQ-123

Minor

Metipranolol may increase the hypotensive activities of BQ-123.

Metipranolol Novel Uses: Which Conditions Have a Clinical Trial Featuring Metipranolol?

34 clinical trials are presently underway to assess the utility of Metipranolol for therapeutic management of Open Angle Glaucoma.

Condition

Clinical Trials

Trial Phases

Ocular Hypertension

10 Actively Recruiting

Phase 3, Phase 1, Phase 2, Not Applicable, Phase 4

Open Angle Glaucoma

10 Actively Recruiting

Phase 3, Not Applicable, Phase 4

Patient Q&A Section about metipranolol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is metipranolol a beta blocker?

"These drugs therefore can produce a wide range of potential adverse effects, as well as being ineffective in some patients.

Glaucoma is a condition that can be treated with a variety of different pharmacological options. However, some drugs, like the beta blockers Timolol, Carteolol, Metipranolol, and Levobunolol, work by blocking both beta 1 and beta 2 receptors, and thus can produce a range of potential adverse effects. Additionally, these drugs may not be effective in all patients."

Answered by AI

What is metipranolol used for?

"Metipranolol is a beta blocker that is used to treat increased pressure in the eye that is caused by open-angle glaucoma or ocular hypertension. It can be used alone or with other medicines."

Answered by AI

How does metipranolol help glaucoma?

"Ophthalmic metipranolol is used to treat glaucoma, a condition in which increased pressure in the eye can lead to gradual loss of vision. Metipranolol belongs to a group of medications called beta-blockers. These drugs work by reducing pressure in the eye."

Answered by AI

How to use eye drops?

"To use eye drops correctly, tilt your head back and look up. With one hand, pull your lower eyelid down and away from your eyeball — this makes a “pocket” for the drops. With the other hand, hold the eye drop bottle upside down with the tip just above the pocket. Squeeze the prescribed number of eye drops into the pocket."

Answered by AI

Clinical Trials for Metipranolol

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We made a collection of clinical trials featuring Metipranolol, we think they might fit your search criteria.
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Image of Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham in Birmingham, United States.

AI-Based Screening for Glaucoma

18+
All Sexes
Birmingham, AL

The goal of this clinical trial is to learn if implementation of an eye screening program at Federally Qualified Health Center (FQHC) clinics provides results that participants may have glaucoma, and/or other eye conditions (diabetic retinopathy, cataract, visual acuity impairment). The glaucoma screening will incorporate use of an artificial intelligence (AI)-assisted screening tool. This project is called AI-RONA. The main questions it aims to answer are: * How does this eye screening program compare to the rate of glaucoma and other eye conditions detected at other FQHC clinics where the screening program has not been implemented? * Do particpants who screen positive for these conditions adhere to the physician's recommendation for a follow-up examination by an optometrist or ophthalmologist? * Are referral rates for a follow-up comprehensive eye exam by an optometrist or ophthalmologist similar to those implemented by an ophthalmologist using telemedicine (that is, using the results of the screening to make a diagnosis remotely)? * What is the cost-effectiveness of the AI-assisted screening program in diagnosing glaucoma as compared to a physician-guided program? * Are participants completing the screening satisfied with it? * Are physicians at the FQHC clinics administering the screening satisfied with it? Participants will: * Undergo an ocular screening whose goal is to detect glaucoma, diabetic retinopathy, cataract, and/or impairment in visual acuity. If the screening indicates that participants may have these conditions, participants will be referred for a comprehensive eye examination by an optometrist or ophthalmologist. * Following the screening, participants and physicians will complete a survey on their satisfaction with the program.

Recruiting
Has No Placebo

Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham

Cynthia Owsley, PhD

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