CLINICAL TRIAL

Short Firm for Peripheral Nervous System Diseases

Recruiting · 18+ · All Sexes · Iowa City, IA

This study is evaluating whether different heel heights and stiffness's in ankle foot orthoses will improve the way individuals walk.

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About the trial for Peripheral Nervous System Diseases

Eligible Conditions
Musculoskeletal Injuries · Musculoskeletal Diseases · Nervous System Diseases · Peripheral Nervous System Diseases

Treatment Groups

This trial involves 24 different treatments. Short Firm is the primary treatment being studied. Participants will be divided into 24 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Experimental Group 1
Short Soft
DEVICE
+
Tall Soft
DEVICE
+
Tall Firm
DEVICE
+
Short Firm
DEVICE
Experimental Group 2
Short Soft
DEVICE
+
Tall Soft
DEVICE
+
Tall Firm
DEVICE
+
Short Firm
DEVICE
Experimental Group 3
Short Soft
DEVICE
+
Tall Soft
DEVICE
+
Tall Firm
DEVICE
+
Short Firm
DEVICE
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Eligibility

This trial is for patients born any sex aged 18 and older. There are 9 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
This individual can walk 50 feet without using an assistive device. show original
, all research participants were approached in person All research participants who could read and write in English and give written consent were approached in person. show original
categories AFOs are devices that fit into traditional footwear categories show original
GROUP 1 Patient Inclusion criteria
Ages: 18-70
Daily AFO use to address unilateral, below knee functional deficits that result from limb injury or musculoskeletal disease (e.g. fracture, muscle and/or nerve injury, ankle arthritis)
orthosis They have been using their orthosis for more than two weeks. show original
for a sustained period of time The ability to walk at a slow to moderate pace for a sustained period of time is something that is beneficial for everyone show original
GROUP 1 Patient
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Baseline
Screening: ~3 weeks
Treatment: Varies
Reporting: Baseline
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Baseline.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Short Firm will improve 6 primary outcomes and 4 secondary outcomes in patients with Peripheral Nervous System Diseases. Measurement will happen over the course of Baseline.

Center of pressure velocity magnitude
BASELINE
Magnitude of peak center of pressure velocity (m/s) during gait.
BASELINE
Modified Socket Comfort Score (Comfort and Smoothness)
BASELINE
Comfort scores range from 0 = most uncomfortable to 10 = most comfortable, and from 0 = least smooth to 10 = most smooth.
BASELINE
Activities-Specific Balance Confidence (ABC)
BASELINE
The ABC provides a standardized evaluation of balance confidence across a range of common daily tasks.
BASELINE
Peak Ankle Moment
BASELINE
Peak ankle moment (Nm/kg) during gait.
BASELINE
Ankle Range of Motion
BASELINE
Ankle range of motion (degrees) during gait.
BASELINE
Center of pressure velocity timing
BASELINE
Timing of peak center of pressure velocity (percent stance) during gait.
BASELINE
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Who is running the study

Principal Investigator
J. W.
Prof. Jason Wilken, Associate Professor
University of Iowa

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the signs of peripheral nervous system diseases?

These may be seen in early childhood, particularly peripheral neuropathy. The signs were similar to those that define autonomic-digestive manifestations but could also include symptoms of fatigue and unexplained weight loss.

Anonymous Patient Answer

Can peripheral nervous system diseases be cured?

This is an issue of public health because of the high number of patients with peripheral nervous system diseases in industrialized countries. However the treatments in question are a low investment strategy in relation to the benefits from the treatments.

Anonymous Patient Answer

How many people get peripheral nervous system diseases a year in the United States?

More than 80 different disorders of the peripheral nervous system are disabling, chronic diseases that affect most Americans. All of the peripheral nervous system diseases have been increasing in frequency between the years 1950 and 1999. Peripheral nervous system diseases can cause significant morbidity and can result in significant medical costs.

Anonymous Patient Answer

What is peripheral nervous system diseases?

Peripheral nervous system conditions comprise a wide range of disorders in which symptoms and signs relate to problems with peripheral nerves or nerves with the somatosensory section of the brain, including the spinal cord. Many conditions involve problems in ways that the words'mononeurosis' or 'polyneurosis' fail to articulate. These conditions may be more accurately described as multiple neuritis syndromes, a concept consistent with the'multiple fibre system' theory of the peripheral nerves.

Anonymous Patient Answer

What causes peripheral nervous system diseases?

I will describe the main reasons why peripheral nervous system diseases have been increasing during the last 30 years. The incidence of many peripheral nervous system diseases has been on the rise for several years, even though many of them may not be considered to be as yet prevalent when compared to cancers. In many instances, this is simply attributable to better detection. Other factors leading to the development of some peripheral nervous system diseases may be the more common increased life expectancy and better public health, the greater use of modern diagnostic aids, and the emergence of a more aggressive treatment regimen or the introduction of new treatment modalities.

Anonymous Patient Answer

What are common treatments for peripheral nervous system diseases?

The most common treatment for PNS diseases are medications, particularly antiepileptic drugs prescribed as a first-line option, which can be used either as monotherapy (monotherapy is also commonly used in the treatment of PNS disorders, such as Guillain-Barré syndrome) or as adjuvant therapy. Other commonly used treatments include anticonvulsants, corticosteroids, corticostriatoplastics, neuromodulators, and neuromuscular stimulants. The most commonly used non-pharmacological treatment is conservative treatment, such as exercise, massage, and relaxation.

Anonymous Patient Answer

Does peripheral nervous system diseases run in families?

PNS diseases are likely underdiagnosed. In a recent study, findings provides evidence of strong familial aggregation of diseases in the families of patients with PNS diseases. Identifying the genetic and environmental factors involved in the inheritance of these disorders will help uncover the risk factors.

Anonymous Patient Answer

How does short firm work?

In a recent study, findings suggest that a more consistent application of FFTs might positively influence the functioning of spinal cord. The impact of these effects on the balance of internal and external influence should be evaluated in a larger control sample.

Anonymous Patient Answer

What is the primary cause of peripheral nervous system diseases?

Recent findings provides the first evidence that peripheral nervous system diseases are a result of the development of autoimmune neuropathies. Autoanitibodies should now serve as a diagnostic marker for these diseases.

Anonymous Patient Answer

What does short firm usually treat?

Findings from a recent study concludes that most of the patients with short firm in our study were satisfied with the treatment and had no recurrence. It is the first study that summarizes the treatment options for short or firm perineum in the past 10-years in Chinese and foreign populations.

Anonymous Patient Answer

Does short firm improve quality of life for those with peripheral nervous system diseases?

This randomized, placebo-controlled trial found short firm treatment to be significantly better than no treatment and usual care in improving quality of life of persons with peripheral nervous system diseases, including decreased pain and improved sleep and physical function.

Anonymous Patient Answer

Has short firm proven to be more effective than a placebo?

The study is an evaluation in an unselected population of 2,000 patients who are given one treatment or placebo for 16 weeks based on severity of pain. In the short study, it has demonstrated that a short firm protocol is more effective than a placebo for people undergoing lumbar radiculopathy.

Anonymous Patient Answer
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