475 Participants Needed

HS-20110 for Cancer

Recruiting at 2 trial locations
AG
HW
Overseen ByHongyan Wang
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new treatment called HS-20110 to assess its safety and tolerability in individuals with advanced solid tumors (cancer that has spread and formed solid lumps). Participants will receive HS-20110 to help researchers determine the optimal dose and identify any side effects. The trial seeks individuals diagnosed with advanced solid tumors who have at least one measurable tumor, excluding those in the brain. As a Phase 1 trial, the research focuses on understanding how the treatment works in people, offering participants the opportunity to be among the first to receive this new treatment.

Will I have to stop taking my current medications?

You may need to stop taking certain medications before joining the trial, especially if they are anti-tumor drugs, drugs affecting specific liver enzymes, or drugs that affect heart rhythm. The trial does not specify all medications, so it's best to discuss your current medications with the trial team.

Is there any evidence suggesting that HS-20110 is likely to be safe for humans?

Research shows that HS-20110 is still undergoing testing to determine its safety and tolerability, particularly in individuals with advanced solid tumors. This treatment is in the early testing phase, so researchers closely monitor participants to observe their responses. In Phase 1, the primary goal is to assess the treatment's safety for humans and identify any side effects.

Detailed safety information for HS-20110 remains limited because testing is ongoing. However, these early tests aim to identify potential risks and evaluate how well participants tolerate the treatment. Researchers closely monitor participants for any adverse reactions, which aids in understanding the treatment's safety.12345

Why do researchers think this study treatment might be promising?

Researchers are excited about HS-20110 because it targets cancer in a novel way. Unlike standard treatments like chemotherapy and radiation, which attack both healthy and cancerous cells, HS-20110 is designed to specifically target cancer cells, potentially reducing side effects. This targeted approach could lead to more effective treatment outcomes and a better quality of life for patients. Additionally, HS-20110 may open new avenues for treating types of cancer that are resistant to current therapies.

What evidence suggests that HS-20110 might be an effective treatment for cancer?

Research has shown that HS-20110, the investigational treatment in this trial, has produced promising results in early tests for treating solid tumors, such as colorectal cancer. In initial studies, participants demonstrated noticeable improvements in tumor response. This treatment targets cancer cells to inhibit their growth and spread. Early findings suggest this method might help manage advanced solid tumors, but further information is needed to confirm these results.12346

Are You a Good Fit for This Trial?

This trial is for individuals with advanced solid tumors, including uterine tumors. Participants must have at least one measurable lesion that can be tracked for changes. They should have a confirmed diagnosis through pathology but cannot join if they have brain lesions or conditions not disclosed here.

Inclusion Criteria

I have at least one measurable tumor outside of my brain.
My advanced cancer has been confirmed by lab tests.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Dose Escalation

Participants receive escalating doses of HS-20110 to evaluate safety and tolerability

8-12 weeks

Dose Expansion

Participants receive the determined safe dose of HS-20110 to further evaluate efficacy

12-16 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • HS-20110
Trial Overview The study is testing HS-20110 in two phases: Phase Ia focuses on finding the right dose (dose escalation), and Phase Ib observes the effects of this dose in more people (dose expansion). It's an early-stage trial to assess safety and how well participants tolerate the drug.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Group I: HS-20110 (Phase Ia:Dose escalation )Experimental Treatment1 Intervention
Group II: HS-20110 (Phase 1b Dose expansion)Experimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Hansoh BioMedical R&D Company

Lead Sponsor

Trials
29
Recruited
10,700+

Citations

A Study of HS-20110 in Participants With Advanced Solid ...A Phase I Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of HS-20110 in Participants With Advanced Solid Tumors.
HS-20110 for Cancer · Recruiting Participants for Phase ...This trial is for individuals with advanced solid tumors, including uterine tumors. Participants must have at least one measurable lesion that can be tracked ...
HS-20110 - Drug Targets, Indications, PatentsEliza Sun, executive director at Hansoh, noted that HS-20110 has shown "promising" early clinical activity in solid tumours including colorectal ...
A Study of HS-20110 in Participants With Advanced Solid ...This is an open-label, multicenter study to evaluate the safety and tolerability of HS-20110 in participants with advanced solid malignant tumors.
ESMO 2025Anti-tumor activity in osteosarcoma: HS-20093 administered at 12 mg/kg Q3W showed a trend towards better survival benefit compared to 8 mg/kg in ...
Hansoh Pharma Presents the phase 2 study findings of HS ...Heavily pretreated PROC patients:At data cut-off, 33 patients with high-grade serous ovarian cancer were enrolled and received at least one dose of HS-20089, ...
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