Lufyllin

Bronchial Spasm, Cheyne-Stokes Respiration, Obstructive Sleep Apnea (OSA) + 4 more
Treatment
9 Active Studies for Lufyllin

What is Lufyllin

DyphyllineThe Generic name of this drug
Treatment SummaryDyphylline is a type of medication used to help open up the airways in the lungs and widen the blood vessels. It is commonly prescribed for treating asthma, shortness of breath, and bronchitis.
Lufyllin -GGis the brand name
image of different drug pills on a surface
Lufyllin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lufyllin -GG
Dyphylline
1968
2

Effectiveness

How Lufyllin Affects PatientsDyphylline is a drug used to help people with asthma and bronchitis breathe better. It belongs to a class of drugs called xanthines, and works by opening up the airways in the lungs. It can also help to widen the blood vessels in the body, as well as relax other muscles.
How Lufyllin works in the bodyDyphylline relaxes the airways in your lungs by blocking an enzyme called phosphodiesterase. This increases cyclic AMP, which relaxes the muscles that control your breathing. Dyphylline also blocks adenosine receptors, which further helps to keep your airways open.

When to interrupt dosage

The advised dosage of Lufyllin is contingent upon the deduced state, including Respiratory Tract Infections, Bronchospasm and Obstructive Sleep Apnea (OSA). The measure of dosage fluctuates as indicated by the technique of delivery (e.g. Solution or Oral) provided in the table below.
Condition
Dosage
Administration
Obstructive Sleep Apnea (OSA)
200.0 mg, , 100.0 mg/mL, 500.0 mg, 100.0 mg, 400.0 mg, 10.0 mg/mL, 500.0 mg/mL
Oral, , Tablet, Tablet - Oral, Syrup, Syrup - Oral, Intramuscular; Intravenous, Elixir, Solution - Oral, Liquid, Elixir - Oral, Solution, Liquid - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Liquid - Oral
Asthma
200.0 mg, , 100.0 mg/mL, 500.0 mg, 100.0 mg, 400.0 mg, 10.0 mg/mL, 500.0 mg/mL
Oral, , Tablet, Tablet - Oral, Syrup, Syrup - Oral, Intramuscular; Intravenous, Elixir, Solution - Oral, Liquid, Elixir - Oral, Solution, Liquid - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Liquid - Oral
Bronchial Spasm
200.0 mg, , 100.0 mg/mL, 500.0 mg, 100.0 mg, 400.0 mg, 10.0 mg/mL, 500.0 mg/mL
Oral, , Tablet, Tablet - Oral, Syrup, Syrup - Oral, Intramuscular; Intravenous, Elixir, Solution - Oral, Liquid, Elixir - Oral, Solution, Liquid - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Liquid - Oral
Emphysema
200.0 mg, , 100.0 mg/mL, 500.0 mg, 100.0 mg, 400.0 mg, 10.0 mg/mL, 500.0 mg/mL
Oral, , Tablet, Tablet - Oral, Syrup, Syrup - Oral, Intramuscular; Intravenous, Elixir, Solution - Oral, Liquid, Elixir - Oral, Solution, Liquid - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Liquid - Oral
Cheyne-Stokes Respiration
200.0 mg, , 100.0 mg/mL, 500.0 mg, 100.0 mg, 400.0 mg, 10.0 mg/mL, 500.0 mg/mL
Oral, , Tablet, Tablet - Oral, Syrup, Syrup - Oral, Intramuscular; Intravenous, Elixir, Solution - Oral, Liquid, Elixir - Oral, Solution, Liquid - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Liquid - Oral
Bronchitis, Chronic
200.0 mg, , 100.0 mg/mL, 500.0 mg, 100.0 mg, 400.0 mg, 10.0 mg/mL, 500.0 mg/mL
Oral, , Tablet, Tablet - Oral, Syrup, Syrup - Oral, Intramuscular; Intravenous, Elixir, Solution - Oral, Liquid, Elixir - Oral, Solution, Liquid - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Liquid - Oral
Respiratory Tract Infections
200.0 mg, , 100.0 mg/mL, 500.0 mg, 100.0 mg, 400.0 mg, 10.0 mg/mL, 500.0 mg/mL
Oral, , Tablet, Tablet - Oral, Syrup, Syrup - Oral, Intramuscular; Intravenous, Elixir, Solution - Oral, Liquid, Elixir - Oral, Solution, Liquid - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Liquid - Oral

Warnings

Lufyllin has three contraindications, so it should not be used while encountering any of the conditions enumerated in the table below.Lufyllin Contraindications
Condition
Risk Level
Notes
Heart Attack
Do Not Combine
Peptic Ulcer
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Dyphylline may interact with Pulse Frequency
There are 20 known major drug interactions with Lufyllin.
Common Lufyllin Drug Interactions
Drug Name
Risk Level
Description
Riociguat
Major
Dyphylline may increase the hypotensive activities of Riociguat.
Abacavir
Minor
Dyphylline may decrease the excretion rate of Abacavir which could result in a higher serum level.
Aclidinium
Minor
Dyphylline may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Dyphylline may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Dyphylline may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Lufyllin Toxicity & Overdose RiskThe toxic dose of the drug in mice, when taken orally, has been found to be 1954mg/kg.

Lufyllin Novel Uses: Which Conditions Have a Clinical Trial Featuring Lufyllin?

97 active trials are being conducted to assess the efficacy of Lufyllin in providing relief for Bronchial Asthma, Chronic Bronchitis and Obstructive Sleep Apnea (OSA).
Condition
Clinical Trials
Trial Phases
Respiratory Tract Infections
1 Actively Recruiting
Not Applicable
Obstructive Sleep Apnea (OSA)
3 Actively Recruiting
Not Applicable
Asthma
1 Actively Recruiting
Phase 4
Bronchitis, Chronic
0 Actively Recruiting
Cheyne-Stokes Respiration
0 Actively Recruiting
Emphysema
4 Actively Recruiting
Phase 2, Not Applicable
Bronchial Spasm
0 Actively Recruiting

Lufyllin Reviews: What are patients saying about Lufyllin?

5Patient Review
2/5/2008
Lufyllin for Bronchitis
I've only been taking this medication for two days, and I can already tell a significant improvement in my wheezing.

Patient Q&A Section about lufyllin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does dyphylline do?

"Dyphylline is a medication used to improve airflow to the lungs in adults and children 6 years and older who have bronchial asthma, chronic bronchitis, or emphysema."

Answered by AI

What is ipratropium bromide?

"Ipratropium bromide, and other drugs with a similar effect, are used to treat the symptoms of chronic obstructive pulmonary disease and asthma by opening up the medium and large airways in the lungs."

Answered by AI

Is theophylline and aminophylline the same?

"Aminophylline is a bronchodilator that is used to treat bronchospasm due to asthma, emphysema, and chronic bronchitis."

Answered by AI

Can I take guaifenesin with metoprolol?

"If you take metoprolol and pseudoephedrine together, your blood pressure may increase. Contact your doctor if your condition changes. If your doctor prescribes these medications together, you may need a dose adjustment or need to have your blood pressure checked more often."

Answered by AI

Clinical Trials for Lufyllin

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