Tiotropium for Asthma
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a treatment called tiotropium, a bronchodilator, to evaluate its effectiveness for people with asthma when exposed to allergens like dust or pollen. Participants will receive either the tiotropium treatment or a placebo (a substance with no active medicine) to compare their effects. The goal is to measure how tiotropium affects breathing after allergen exposure. This trial may suit adults with asthma who have been allergy-tested for common triggers and have not experienced a recent asthma flare-up or respiratory infection. As a Phase 4 trial, this research aims to understand how the already FDA-approved and effective tiotropium benefits more patients.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but if you are using budesonide/formoterol as needed, you should not have used it within 3 weeks before the allergen challenge.
What is the safety track record for this treatment?
Research has shown that tiotropium is generally safe for people with asthma. One study found a lower chance of unwanted side effects with tiotropium than without it. Another report indicated that tiotropium was well-tolerated when used daily alongside other asthma treatments, such as inhaled steroids. Some common side effects included worsening asthma and reduced airflow from the lungs, but these were not very common. Overall, tiotropium is considered safe when used as directed.12345
Why are researchers enthusiastic about this study treatment?
Tiotropium is unique because it offers a new approach for treating asthma by targeting the muscarinic receptors in the airways, which can help relax and open up the air passages. While most asthma treatments, like inhaled corticosteroids and beta-agonists, focus on reducing inflammation or stimulating the lungs to open up, tiotropium works differently by blocking the receptors that tighten the airways. This alternative mechanism of action is what excites researchers, as it has the potential to improve asthma control for patients who do not respond well to standard therapies.
What is the effectiveness track record for tiotropium in treating asthma?
Research has shown that tiotropium can greatly improve lung function in people with asthma. Studies indicate it helps maintain better breathing throughout the day and can lead to improved asthma control. In this trial, participants will receive either tiotropium or a placebo. Tiotropium has improved lung function, even for those whose asthma wasn't managed well by standard treatments. This medication works well for people of different ages and with varying levels of asthma severity. Experts agree on its effectiveness, making it a reliable option for managing asthma.46789
Are You a Good Fit for This Trial?
This trial is for individuals with asthma. Participants should be able to perform lung function tests and must not have had a respiratory infection or asthma exacerbation within the last four weeks. They cannot take part if they are currently smokers, have other significant health issues, or are using certain medications that might interfere with the study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a single dose of tiotropium or placebo 30 minutes prior to allergen challenge
Follow-up
Participants are monitored for early asthmatic response and inflammatory response post-allergen challenge
What Are the Treatments Tested in This Trial?
Interventions
- Tiotropium
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Saskatchewan
Lead Sponsor