Metabolic Tests for Pediatric Non-alcoholic Fatty Liver Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial involves taking blood and liver tissue samples from children with NAFLD to understand the disease better. It focuses on this group because they are at higher risk of rapid disease progression. Researchers aim to find specific changes in the liver and blood that can help diagnose and understand NAFLD in children.
Will I have to stop taking my current medications?
You can continue taking medications for asthma, allergies, anxiety, depression, attention deficit disorder, menstrual cycle, hypothyroidism, gastric reflux, hypertension, and sleep. However, if you're on medications that affect weight loss or are experimental for metabolic or liver conditions, you may not be eligible to participate.
How does this treatment for pediatric non-alcoholic fatty liver disease differ from others?
Who Is on the Research Team?
Kevin Short, PhD
Principal Investigator
University of Oklahoma
Are You a Good Fit for This Trial?
This trial is for children and young adults aged 10 to 20.9 years with obesity or normal weight, including those diagnosed with NAFLD confirmed by liver biopsy. It's open to all genders and ethnicities. Those with chronic illnesses affecting metabolism, acute conditions, on certain medications, pregnant individuals, or substance abusers cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Testing
Participants undergo metabolic and descriptive tests, including blood analyses and liver biopsy for the NAFLD group
Follow-up
Participants are monitored for safety and effectiveness after testing
What Are the Treatments Tested in This Trial?
Interventions
- Cardiometabolic testing
- De novo lipogenesis test
- Gluconeogenesis test
- Oral sugar tolerance test
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Oklahoma
Lead Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator
National Institutes of Health (NIH)
Collaborator