CLINICAL TRIAL

Treatment for Aphasia

Recruiting · 18+ · All Sexes · Baltimore, MD

This study is evaluating whether multiple sessions of cerebellar tDCS can improve language function in people with aphasia.

See full description

About the trial for Aphasia

Eligible Conditions
Aphasia · Stroke

Treatment Groups

This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

Control Group 1
Semantic Feature Analysis (SFA)
BEHAVIORAL
+
Sham
DEVICE
Control Group 2
Semantic Feature Analysis (SFA)
BEHAVIORAL
+
Cathodal Cerebellar tDCS
DEVICE

Eligibility

This trial is for patients born any sex aged 18 and older. There are 6 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Age 18 or older
Premorbidly right handed
6 months post onset of stroke
View All
Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
Similar Trials

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Pre-treatment, 1 week, 1, 3, and 6 months post treatment
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Pre-treatment, 1 week, 1, 3, and 6 months post treatment.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Treatment will improve 7 secondary outcomes in patients with Aphasia. Measurement will happen over the course of Pre-treatment and at 1, 3 and 6 months post treatment.

Change in accuracy of naming untrained pictures (Philadelphia Naming Test)
PRE-TREATMENT AND AT 1, 3 AND 6 MONTHS POST TREATMENT
Behavioral measure of change in untrained naming. Scores ranges from 0 to 175 with higher scores meaning better naming ability.
Change in accuracy of naming trained pictures
PRE-TREATMENT AND AT 1, 3 AND 6 MONTHS POST TREATMENT
Behavioral measure of change in trained naming. Scores ranges from 0 to 50 with higher scores meaning better naming ability.
Change in Stroke and Aphasia Quality of Life (SAQOL) scale
PRE-TREATMENT, 1 WEEK, 1, 3, AND 6 MONTHS POST TREATMENT
It consists of 39 items which cover three domains: physical, communication, and psychosocial. Domain and overall mean scores range from 1 to 5, with higher scores indicative of better quality of life.
Change in the total content units produced during picture description.
PRE-TREATMENT, 1 WEEK, 1, 3, AND 6 MONTHS POST TREATMENT
Participants will describe the Cookie Theft Picture from the Boston Diagnostic Aphasia Examination. Analysis of descriptions of the Cookie Theft picture can provide useful and reliable information about connected speech. Content units captures the quantity of information conveyed. Content units are based on a standard scoring template of commonly identified concepts (nouns and verbs) in the left and right regions of the "Cookie Theft" picture. Participants either include or fail to include 30 concepts on the left side of the picture and 23 concepts on the right side of the picture.
Change in functional communication skills
PRE-TREATMENT, 1 WEEK, 1, 3, AND 6 MONTHS POST TREATMENT
Functional communication skills will be assessed using the Communication Activities of Daily Living, third edition (CADL-3). This test contains 50 items assessing communication activities in seven areas and participants receive a score of 0, 1, or 2 for each item. Higher scores reflect better communicative success.
Change in General Health Questionnaire-12 item (GHQ-12)
PRE-TREATMENT, 1 WEEK, 1, 3, AND 6 MONTHS POST TREATMENT
The General Health Questionnaire is a measure of psychological distress and it is 12 item scale. Scores range from 0 to 12; higher scores are indicative of higher distress.
See More

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can aphasia be cured?

Aphasia was a chronically unstable disorder of speech and language, in that many changes occurred within a relatively short period-in most cases, a few months. The treatment depended on the severity of speech disorder involved. The aphasics were not cured of their language disorder; rather, they were provided with language acquisition techniques that promoted the development of functionally meaningful language. Even if they were not cured of their language disruption, the treatment was associated with a significant improvement in their social interactions.

Anonymous Patient Answer

How many people get aphasia a year in the United States?

Patients with aphasia accounted for 6,100 hospital discharges in the year 2001 in the United States. There were 2,800 people with a stroke, 6,200 with a traumatic brain injury, and 4,200 with a congenital disability or developmental delay. There are 2-3 times as many people with aphasia hospitalized as inpatients (9,700 vs. 2,700), 2-3 times more hospitalized (6,800 vs. 2,200), and 1.4 times more hospitalized per 100,000 population (27.7 vs. 9.2) than patients with stroke, traumatic brain injury, or congenital disabilities or developmental delay.

Anonymous Patient Answer

What are common treatments for aphasia?

This article presents treatments for different types of aphasia. Treatments for aphasia include speech therapy, psychosocial interventions, and complementary and alternative medicine. These treatments have been shown to improve the quality of life for individuals with aphasia. It is important, however, that the individualized treatment plan be carefully assessed and reviewed by a specialist on an as needed basis.

Anonymous Patient Answer

What causes aphasia?

The causes of aphasia are multiple and complex. They do not necessarily follow one specific path, even if they all occur at the same time. The most prevalent pathological process underlying fluent aphasia is a left temporal lobe process or disruption, with involvement of both the anterior and posterior language-bearing hemispheres, especially at or around the temporal poles, or in the posterior superior temporal cortex. Wernicke's area may be involved at times but does not always cause fluent aphasia.

Anonymous Patient Answer

What are the signs of aphasia?

Aphasia presents with abnormalities in language production, comprehension, and single word comprehension. The language output can include paraphasias and other pragmatic difficulties. Aphasics typically have difficulty understanding others and may have trouble following and understanding instructions given by other people, or difficulty responding to questions or verbal commands. They may have problems in speaking from a long distance, repeating a message, or reading the telephone book. Patients may also have problems with reading and writing, and difficulty understanding and saying goodbye.

Anonymous Patient Answer

What is aphasia?

Aphasia was frequently described in the literature. This is the first analysis of the frequency of aphasia in patients with dementia with Lewy bodies (DLB). Aphasia occurred in 26 patients and occurred in a variety of ways in each. Data from a recent study confirmed that the majority of patients with DLB can be classified using the aphasia diagnosis.

Anonymous Patient Answer

What are the common side effects of treatment?

In a recent study, findings highlights the common adverse effects of (chemo)radiotherapy in our outpatient radiation oncology department. The [pain] and [swelling] were the most common painful effects; [nausea, emesis, and headache] were common [acute] adverse effects, [and there was no statistically significant difference from patients who had received [chemoradiotherapy instead of stereotactic body radiotherapy].

Anonymous Patient Answer

Have there been other clinical trials involving treatment?

Patients with dysphagia should be offered clinical trials in order to improve survival. However, patients with dysphagia should be treated before offering clinical trials because there is a large risk of worsening dysphagia under chemotherapy. Patients should also understand the importance of treatment compliance because a small reduction in survival could possibly have a negative impact on their quality of life and their ability to function.

Anonymous Patient Answer

Does treatment improve quality of life for those with aphasia?

Treatment can improve the QoL of patients with aphasia, but many patients with aphasia are not receiving treatment. There is an urgent need for timely treatment to improve life satisfaction and QoL for aphasic patients.

Anonymous Patient Answer

Is treatment safe for people?

It is important that treatments for people with dysphagia are safe and well tolerated. In order to inform treatment, swallowing clinicians and researchers should understand the specific considerations related to this condition. Clinical trials on aspiration and dysphagia often result in people being recruited who are at high risk of having aspiration or aspiration pneumonia. Such people are at high risk of developing aspiration and pneumonia associated with dysphagia and can be prevented if they are identified at the right time and managed appropriately.

Anonymous Patient Answer

What is treatment?

Aphasia patients are treated according to their individual deficits and functional status in order to facilitate the reoccupation of activities of their daily life and work.

Anonymous Patient Answer

How does treatment work?

Recent findings of this study may serve as a model for the design of future trials. The most obvious conclusion to be drawn is that treatment is very efficient; but also very important is that the effect is not as large in the short term as has been reported in clinical trials of the past.

Anonymous Patient Answer
See if you qualify for this trial
Get access to this novel treatment for Aphasia by sharing your contact details with the study coordinator.