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tDCS + Speech Therapy for Aphasia
N/A
Recruiting
Led By Sara Pillay, PhD
Research Sponsored by Medical College of Wisconsin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Patients must be adults and have English-language fluency
Patients with a language deficit from focal neurologic damage (e.g. stroke, tumor)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 time points: pre-assessment, 10 weeks post-therapy cycle a and 10 weeks post-therapy cycle b
Awards & highlights
Study Summary
This trial will test whether adding electrical stimulation to speech therapy can help people with post-stroke aphasia recover language skills.
Who is the study for?
This trial is for adults who have language difficulties due to brain damage like a stroke. They must speak English fluently and be able to undergo an MRI scan. People with advanced neurodegenerative diseases, severe psychiatric conditions, uncorrectable hearing or vision issues, developmental disabilities, or contraindications to MRI are not eligible.Check my eligibility
What is being tested?
The study tests if mild electrical stimulation (tDCS) combined with speech therapy can help improve language in people who've had a stroke causing aphasia. There are two types of tDCS being tested alongside two kinds of speech therapies focused on different aspects of language.See study design
What are the potential side effects?
Possible side effects from tDCS may include slight skin irritation under the electrodes, tingling sensations during treatment, fatigue, headache or nausea. However, these tend to be mild and temporary.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am an adult who speaks and understands English fluently.
Select...
I have language difficulties due to a stroke or brain tumor.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 3 time points: pre-assessment, 10 weeks post-therapy cycle a and 10 weeks post-therapy cycle b
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 time points: pre-assessment, 10 weeks post-therapy cycle a and 10 weeks post-therapy cycle b
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
change from baseline language performance on Picture Naming and Reading Tasks
Secondary outcome measures
fMRI
Other outcome measures
Performance on functional outcome measures assessed through the language battery
Trial Design
4Treatment groups
Experimental Treatment
Active Control
Group I: Targeted tDCS with Semantic-Focused Speech TherapyExperimental Treatment2 Interventions
Participants will receive semantic-focused speech therapy with targeted anodal-tDCS for 10 therapy sessions.
Group II: Targeted tDCS with Phonologic-Focused Speech TherapyExperimental Treatment2 Interventions
Participants will receive phonologic-focused speech therapy with targeted anodal-tDCS for 10 therapy sessions before.
Group III: Active Control tDCS with Phonologic-Focused Speech TherapyActive Control2 Interventions
Participants will receive phonologic-focused speech therapy with active control tDCS for 10 therapy sessions.
Group IV: Active Control tDCS with Semantic-Focused Speech TherapyActive Control2 Interventions
Participants will receive semantic-focused speech therapy with active control tDCS for 10 therapy sessions.
Find a Location
Who is running the clinical trial?
Medical College of WisconsinLead Sponsor
609 Previous Clinical Trials
1,162,579 Total Patients Enrolled
6 Trials studying Aphasia
529 Patients Enrolled for Aphasia
Sara Pillay, PhDPrincipal Investigator - Medical College of Wisconsin
Medical College of Wisconsin
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You have a serious mental illness like schizophrenia, bipolar disorder, or severe depression.You are able to have an MRI scan.I have an advanced stage of a brain condition like Alzheimer's, epilepsy, Parkinson's, or ALS.I do not have uncorrectable hearing, vision problems, or learning disabilities.I am an adult who speaks and understands English fluently.I have language difficulties due to a stroke or brain tumor.You cannot have an MRI if you are claustrophobic, have certain implanted devices, have metal in your body that can't be in an MRI, are extremely overweight, pregnant, unable to lie flat, or unable to see or hear during the test.
Research Study Groups:
This trial has the following groups:- Group 1: Targeted tDCS with Phonologic-Focused Speech Therapy
- Group 2: Active Control tDCS with Phonologic-Focused Speech Therapy
- Group 3: Active Control tDCS with Semantic-Focused Speech Therapy
- Group 4: Targeted tDCS with Semantic-Focused Speech Therapy
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
How many individuals have been recruited for participation in this research project?
"Yes, the details on clinicaltrials.gov confirm that this medical endeavour is currently recruiting patients. The initial listing was published on December 1st 2019 with a most recent update occurring April 11th 2022. To date, 4 participants are needed at one site for enrolment."
Answered by AI
What criteria must a volunteer fulfill to be eligible for this trial?
"This trial is currently searching for 4 persons aged from 18 to 85 who have suffered a stroke. Notably, applicants must fulfil the following criteria: those with language impairment resulting from neurological damage (e.g., strokes or tumours)."
Answered by AI
Does this study accept geriatric individuals as participants?
"This medical trial is searching for patients between the ages 18 and 85. Younger participants will be included in 42 other studies, while those over 65 can join 1,063 different trials."
Answered by AI
Is the enrollment phase of this experiment currently underway?
"The clinicaltrial.gov platform indicates that this medical trial is actively enrolling patients. The study was initially posted on December 1st 2019 and the information was most recently updated on April 11th 2022."
Answered by AI
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