Lanoxin

Ventricular Arrhythmia, Congestive Heart Failure, Atrial Fibrillation + 2 more
Treatment
20 Active Studies for Lanoxin

What is Lanoxin

DigoxinThe Generic name of this drug
Treatment SummaryDigoxin is a medication used to treat irregular heartbeats and symptoms of heart failure. It was first approved by the FDA in 1954 and comes from the foxglove plant, which was studied by an English physician and botanist in the 1780s. It has a long history of use, with records of its use dating back to the 1250s. Digoxin is a type of cardiac glycoside and is one of the oldest cardiovascular medications used today.
Digoxinis the brand name
image of different drug pills on a surface
Lanoxin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Digoxin
Digoxin
1975
190

Effectiveness

How Lanoxin Affects PatientsDigoxin is a medicine that helps strengthen the force of your heartbeat and slows down the heart rate, which can be particularly helpful for people with atrial fibrillation, a condition where the heartbeat is fast and irregular. Digoxin has been shown to improve exercise capacity and reduce hospitalization for heart failure and emergency medical visits related to heart failure. It is important to note that digoxin has a narrow range in which it is safe and effective, and taking too much can be dangerous, as it can cause ventricular fibrillation which can lead to cardiac arrest and be fatal. People with sinus node disease or AV block are at an
How Lanoxin works in the bodyDigoxin helps improve the function of the heart. It does this by blocking the functioning of a protein called the sodium pump. This pump normally helps regulate the entry and exit of sodium, potassium, and calcium in and out of cells. Blocking the sodium pump boosts the amount of calcium and sodium inside cells, leading to an increase in the strength of heart contractions. Digoxin also stimulates the parasympathetic nervous system, slowing down the heart rate and reducing levels of norepinephrine.

When to interrupt dosage

The prescribed dosage of Lanoxin hinges upon the identified medical condition, for example Chronic Atrial Fibrillation, mild, moderate Heart Failure and Congestive Heart Failure. The amount of dosage is contingent upon the method of delivery (e.g. Oral or Liquid - Oral) as outlined in the table below.
Condition
Dosage
Administration
Heart failure
0.125 mg, , 0.25 mg, 0.25 mg/mL, 0.05 mg/mL, 0.1875 mg, 0.0025 mg, 0.00125 mg, 0.0625 mg, 0.1 mg/mL, 0.2 mg, 0.1 mg, 0.5 mg/mL
, Oral, Tablet, Tablet - Oral, Injection, solution, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Solution - Oral, Solution, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Injection, Injection - Intramuscular; Intravenous, Capsule - Oral, Capsule, Capsule, liquid filled, Capsule, liquid filled - Oral
Congestive Heart Failure
0.125 mg, , 0.25 mg, 0.25 mg/mL, 0.05 mg/mL, 0.1875 mg, 0.0025 mg, 0.00125 mg, 0.0625 mg, 0.1 mg/mL, 0.2 mg, 0.1 mg, 0.5 mg/mL
, Oral, Tablet, Tablet - Oral, Injection, solution, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Solution - Oral, Solution, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Injection, Injection - Intramuscular; Intravenous, Capsule - Oral, Capsule, Capsule, liquid filled, Capsule, liquid filled - Oral
Atrial Fibrillation
0.125 mg, , 0.25 mg, 0.25 mg/mL, 0.05 mg/mL, 0.1875 mg, 0.0025 mg, 0.00125 mg, 0.0625 mg, 0.1 mg/mL, 0.2 mg, 0.1 mg, 0.5 mg/mL
, Oral, Tablet, Tablet - Oral, Injection, solution, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Solution - Oral, Solution, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Injection, Injection - Intramuscular; Intravenous, Capsule - Oral, Capsule, Capsule, liquid filled, Capsule, liquid filled - Oral
Myocardial contractility
0.125 mg, , 0.25 mg, 0.25 mg/mL, 0.05 mg/mL, 0.1875 mg, 0.0025 mg, 0.00125 mg, 0.0625 mg, 0.1 mg/mL, 0.2 mg, 0.1 mg, 0.5 mg/mL
, Oral, Tablet, Tablet - Oral, Injection, solution, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Solution - Oral, Solution, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Injection, Injection - Intramuscular; Intravenous, Capsule - Oral, Capsule, Capsule, liquid filled, Capsule, liquid filled - Oral
Ventricular Arrhythmia
0.125 mg, , 0.25 mg, 0.25 mg/mL, 0.05 mg/mL, 0.1875 mg, 0.0025 mg, 0.00125 mg, 0.0625 mg, 0.1 mg/mL, 0.2 mg, 0.1 mg, 0.5 mg/mL
, Oral, Tablet, Tablet - Oral, Injection, solution, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Solution - Oral, Solution, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Injection, Injection - Intramuscular; Intravenous, Capsule - Oral, Capsule, Capsule, liquid filled, Capsule, liquid filled - Oral

Warnings

Lanoxin has three contraindications and it should not be employed concurrently with the conditions given in the following table.Lanoxin Contraindications
Condition
Risk Level
Notes
Ventricular Fibrillation
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Digoxin may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Digoxin may interact with Pulse Frequency
There are 20 known major drug interactions with Lanoxin.
Common Lanoxin Drug Interactions
Drug Name
Risk Level
Description
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Digoxin is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Digoxin is combined with Mobocertinib.
Revefenacin
Major
Digoxin may decrease the excretion rate of Revefenacin which could result in a higher serum level.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Digoxin is combined with Ziprasidone.
Abexinostat
Minor
The risk or severity of QTc prolongation can be increased when Digoxin is combined with Abexinostat.
Lanoxin Toxicity & Overdose RiskThe lowest toxic dose of digoxin for women is 100 micrograms per kilogram and 75 micrograms per kilogram for men. The lethal dose in rats is 28270 micrograms per kilogram. Consuming too much digoxin can cause nausea, vomiting, changes in vision, and irregular heartbeat. Older people, those with lower body weight, and those with reduced kidney function or electrolyte imbalances are more likely to experience digoxin toxicity.
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Lanoxin Novel Uses: Which Conditions Have a Clinical Trial Featuring Lanoxin?

At present, 308 active clinical trials are evaluating the effectiveness of Lanoxin in managing Cardiac Arrhythmia, Enhancing Myocardial Contractility and Treating Congestive Heart Failure.
Condition
Clinical Trials
Trial Phases
Congestive Heart Failure
173 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Myocardial contractility
0 Actively Recruiting
Atrial Fibrillation
1 Actively Recruiting
Not Applicable
Heart failure
0 Actively Recruiting
Ventricular Arrhythmia
5 Actively Recruiting
Not Applicable, Phase 3, Phase 4

Lanoxin Reviews: What are patients saying about Lanoxin?

5Patient Review
6/22/2008
Lanoxin for Chronic Heart Failure
This medication has helped me lose weight by curbing my appetite.
5Patient Review
5/30/2008
Lanoxin for Ventricular Rate Control in Atrial Fibrillation
4.7Patient Review
2/24/2009
Lanoxin for Ventricular Rate Control in Atrial Fibrillation
This new treatment is really effective. I'm glad I tried it.
4.3Patient Review
12/18/2008
Lanoxin for Chronic Heart Failure
Unfortunately, I experienced some nausea and vision problems while taking this medication. Additionally, my appetite decreased significantly.
4Patient Review
10/7/2021
Lanoxin for Ventricular Rate Control in Atrial Fibrillation
I've been taking this medication for Atrial fibrilation and it's helped a lot. I still have episodes, but they're less frequent now. The only downside is that it's caused some slight blurred vision when reading.
View All Reviews
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Patient Q&A Section about lanoxin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Lanoxin a beta blocker?

"Some brand names for drugs that contain digoxin are Lanoxin and Lanoxin Pediatric. Metoprolol, on the other hand, belongs to a different drug class and its brand names are Lopressor and Toprol XL."

Answered by AI

What is the side effect of Lanoxin?

"The following effects may occur: nausea, vomiting, headache, dizziness, loss of appetite, and diarrhea. If you experience any of these effects, tell your doctor or pharmacist."

Answered by AI

What is the use of Lanoxin?

"Lanoxin tablets contain digoxin, a substance that affects the heart muscle. The medication is used to treat heart failure by increasing the left ventricular ejection fraction, and to control the ventricular response rate in people with arrhythmias such as atrial fibrillation."

Answered by AI

What type of drug is Lanoxin?

"Lanoxin Tablets is a prescription medicine used to treat the symptoms of Atrial fibrillation and Heart failure. It may be used alone or with other medications. Lanoxin Tablets belongs to a class of drugs called Antidysrhythmics and Inotropic Agents."

Answered by AI

Clinical Trials for Lanoxin

Have you considered Lanoxin clinical trials? We made a collection of clinical trials featuring Lanoxin, we think they might fit your search criteria.
Have you considered Lanoxin clinical trials? We made a collection of clinical trials featuring Lanoxin, we think they might fit your search criteria.
Have you considered Lanoxin clinical trials? We made a collection of clinical trials featuring Lanoxin, we think they might fit your search criteria.
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