Lanoxin

Ventricular Arrhythmia, Congestive Heart Failure, Chronic Atrial Fibrillation + 2 more
Treatment
20 Active Studies for Lanoxin

What is Lanoxin

DigoxinThe Generic name of this drug
Treatment SummaryDigoxin is a medication used to treat irregular heartbeats and symptoms of heart failure. It was first approved by the FDA in 1954 and comes from the foxglove plant, which was studied by an English physician and botanist in the 1780s. It has a long history of use, with records of its use dating back to the 1250s. Digoxin is a type of cardiac glycoside and is one of the oldest cardiovascular medications used today.
Digoxinis the brand name
image of different drug pills on a surface
Lanoxin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Digoxin
Digoxin
1975
190

Effectiveness

How Lanoxin Affects PatientsDigoxin is a medicine that helps strengthen the force of your heartbeat and slows down the heart rate, which can be particularly helpful for people with atrial fibrillation, a condition where the heartbeat is fast and irregular. Digoxin has been shown to improve exercise capacity and reduce hospitalization for heart failure and emergency medical visits related to heart failure. It is important to note that digoxin has a narrow range in which it is safe and effective, and taking too much can be dangerous, as it can cause ventricular fibrillation which can lead to cardiac arrest and be fatal. People with sinus node disease or AV block are at an
How Lanoxin works in the bodyDigoxin helps improve the function of the heart. It does this by blocking the functioning of a protein called the sodium pump. This pump normally helps regulate the entry and exit of sodium, potassium, and calcium in and out of cells. Blocking the sodium pump boosts the amount of calcium and sodium inside cells, leading to an increase in the strength of heart contractions. Digoxin also stimulates the parasympathetic nervous system, slowing down the heart rate and reducing levels of norepinephrine.

When to interrupt dosage

The prescribed dosage of Lanoxin hinges upon the identified medical condition, for example Chronic Atrial Fibrillation, mild, moderate Heart Failure and Congestive Heart Failure. The amount of dosage is contingent upon the method of delivery (e.g. Oral or Liquid - Oral) as outlined in the table below.
Condition
Dosage
Administration
Ventricular Arrhythmia
0.125 mg, , 0.25 mg, 0.25 mg/mL, 0.05 mg/mL, 0.1875 mg, 0.0025 mg, 0.00125 mg, 0.0625 mg, 0.1 mg/mL, 0.2 mg, 0.1 mg, 0.5 mg/mL
, Oral, Tablet, Tablet - Oral, Injection, solution, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Solution - Oral, Solution, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Injection, Injection - Intramuscular; Intravenous, Capsule - Oral, Capsule, Capsule, liquid filled, Capsule, liquid filled - Oral
Heart failure
0.125 mg, , 0.25 mg, 0.25 mg/mL, 0.05 mg/mL, 0.1875 mg, 0.0025 mg, 0.00125 mg, 0.0625 mg, 0.1 mg/mL, 0.2 mg, 0.1 mg, 0.5 mg/mL
, Oral, Tablet, Tablet - Oral, Injection, solution, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Solution - Oral, Solution, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Injection, Injection - Intramuscular; Intravenous, Capsule - Oral, Capsule, Capsule, liquid filled, Capsule, liquid filled - Oral
Chronic Atrial Fibrillation
0.125 mg, , 0.25 mg, 0.25 mg/mL, 0.05 mg/mL, 0.1875 mg, 0.0025 mg, 0.00125 mg, 0.0625 mg, 0.1 mg/mL, 0.2 mg, 0.1 mg, 0.5 mg/mL
, Oral, Tablet, Tablet - Oral, Injection, solution, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Solution - Oral, Solution, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Injection, Injection - Intramuscular; Intravenous, Capsule - Oral, Capsule, Capsule, liquid filled, Capsule, liquid filled - Oral
Congestive Heart Failure
0.125 mg, , 0.25 mg, 0.25 mg/mL, 0.05 mg/mL, 0.1875 mg, 0.0025 mg, 0.00125 mg, 0.0625 mg, 0.1 mg/mL, 0.2 mg, 0.1 mg, 0.5 mg/mL
, Oral, Tablet, Tablet - Oral, Injection, solution, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Solution - Oral, Solution, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Injection, Injection - Intramuscular; Intravenous, Capsule - Oral, Capsule, Capsule, liquid filled, Capsule, liquid filled - Oral
Myocardial contractility
0.125 mg, , 0.25 mg, 0.25 mg/mL, 0.05 mg/mL, 0.1875 mg, 0.0025 mg, 0.00125 mg, 0.0625 mg, 0.1 mg/mL, 0.2 mg, 0.1 mg, 0.5 mg/mL
, Oral, Tablet, Tablet - Oral, Injection, solution, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Solution - Oral, Solution, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Injection, Injection - Intramuscular; Intravenous, Capsule - Oral, Capsule, Capsule, liquid filled, Capsule, liquid filled - Oral

Warnings

Lanoxin has three contraindications and it should not be employed concurrently with the conditions given in the following table.Lanoxin Contraindications
Condition
Risk Level
Notes
Ventricular Fibrillation
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Digoxin may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Digoxin may interact with Pulse Frequency
There are 20 known major drug interactions with Lanoxin.
Common Lanoxin Drug Interactions
Drug Name
Risk Level
Description
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Digoxin is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Digoxin is combined with Mobocertinib.
Revefenacin
Major
Digoxin may decrease the excretion rate of Revefenacin which could result in a higher serum level.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Digoxin is combined with Ziprasidone.
Abexinostat
Minor
The risk or severity of QTc prolongation can be increased when Digoxin is combined with Abexinostat.
Lanoxin Toxicity & Overdose RiskThe lowest toxic dose of digoxin for women is 100 micrograms per kilogram and 75 micrograms per kilogram for men. The lethal dose in rats is 28270 micrograms per kilogram. Consuming too much digoxin can cause nausea, vomiting, changes in vision, and irregular heartbeat. Older people, those with lower body weight, and those with reduced kidney function or electrolyte imbalances are more likely to experience digoxin toxicity.
image of a doctor in a lab doing drug, clinical research

Lanoxin Novel Uses: Which Conditions Have a Clinical Trial Featuring Lanoxin?

At present, 308 active clinical trials are evaluating the effectiveness of Lanoxin in managing Cardiac Arrhythmia, Enhancing Myocardial Contractility and Treating Congestive Heart Failure.
Condition
Clinical Trials
Trial Phases
Congestive Heart Failure
317 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Myocardial contractility
0 Actively Recruiting
Chronic Atrial Fibrillation
2 Actively Recruiting
Not Applicable
Ventricular Arrhythmia
2 Actively Recruiting
Not Applicable
Heart failure
0 Actively Recruiting

Lanoxin Reviews: What are patients saying about Lanoxin?

5Patient Review
6/22/2008
Lanoxin for Chronic Heart Failure
This medication has helped me lose weight by curbing my appetite.
5Patient Review
5/30/2008
Lanoxin for Ventricular Rate Control in Atrial Fibrillation
4.7Patient Review
2/24/2009
Lanoxin for Ventricular Rate Control in Atrial Fibrillation
This new treatment is really effective. I'm glad I tried it.
4.3Patient Review
12/18/2008
Lanoxin for Chronic Heart Failure
Unfortunately, I experienced some nausea and vision problems while taking this medication. Additionally, my appetite decreased significantly.
4Patient Review
10/7/2021
Lanoxin for Ventricular Rate Control in Atrial Fibrillation
I've been taking this medication for Atrial fibrilation and it's helped a lot. I still have episodes, but they're less frequent now. The only downside is that it's caused some slight blurred vision when reading.
4Patient Review
1/15/2009
Lanoxin for Ventricular Rate Control in Atrial Fibrillation
Finally, I can walk more than 100 feet without having to stop and rest.
4Patient Review
10/12/2009
Lanoxin for A Type of Fast Heartbeat - Paroxysmal Atrial Tachycardia
I've been taking .025 Lanoxin for over 10 years to manage my chronic atrial fibrillation. I still have short episodes occasionally, but they're not very often anymore.
3.7Patient Review
11/16/2010
Lanoxin for A Type of Fast Heartbeat - Paroxysmal Atrial Tachycardia
I'm not entirely sure about this medication yet. I've had some heart palpitations while taking it, even though I'm also on Toprol. It's helped somewhat with my fast heart rate, but not as much as I'd hoped.
3.3Patient Review
12/16/2014
Lanoxin for Having a Rapid Heart Action - Supraventricular Tachycardia
This medication was successful in controlling my atrial fibrillation (A-fib) for the last two years. However, I finally had an ablation which was successful in eliminating both the A-fib and the need for this medication.
3.3Patient Review
12/9/2007
Lanoxin for Chronic Heart Failure
2.3Patient Review
11/17/2008
Lanoxin for A Type of Fast Heartbeat - Paroxysmal Atrial Tachycardia
I still can't believe this is a real thing that people are using.
1.3Patient Review
4/27/2010
Lanoxin for Having a Rapid Heart Action - Supraventricular Tachycardia
This treatment caused me to lose my appetite, feel nauseous, and experience weakness and muscle pain in my legs.
1Patient Review
11/14/2009
Lanoxin for Chronic Heart Failure
I had terrible allergic reactions to this drug, which led to some serious mood swings and depression. I hope there's an alternative out there that can help people without these sorts of side effects.
1Patient Review
1/17/2009
Lanoxin for Having a Rapid Heart Action - Supraventricular Tachycardia
This medication has been incredibly helpful in managing my day-to-day life.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about lanoxin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Lanoxin a beta blocker?

"Some brand names for drugs that contain digoxin are Lanoxin and Lanoxin Pediatric. Metoprolol, on the other hand, belongs to a different drug class and its brand names are Lopressor and Toprol XL."

Answered by AI

What is the side effect of Lanoxin?

"The following effects may occur: nausea, vomiting, headache, dizziness, loss of appetite, and diarrhea. If you experience any of these effects, tell your doctor or pharmacist."

Answered by AI

What is the use of Lanoxin?

"Lanoxin tablets contain digoxin, a substance that affects the heart muscle. The medication is used to treat heart failure by increasing the left ventricular ejection fraction, and to control the ventricular response rate in people with arrhythmias such as atrial fibrillation."

Answered by AI

What type of drug is Lanoxin?

"Lanoxin Tablets is a prescription medicine used to treat the symptoms of Atrial fibrillation and Heart failure. It may be used alone or with other medications. Lanoxin Tablets belongs to a class of drugs called Antidysrhythmics and Inotropic Agents."

Answered by AI

Clinical Trials for Lanoxin

Have you considered Lanoxin clinical trials? We made a collection of clinical trials featuring Lanoxin, we think they might fit your search criteria.
Have you considered Lanoxin clinical trials? We made a collection of clinical trials featuring Lanoxin, we think they might fit your search criteria.
Have you considered Lanoxin clinical trials? We made a collection of clinical trials featuring Lanoxin, we think they might fit your search criteria.