Magnesium Infusion for Trauma Pain Management
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. However, if you regularly use opioids or are receiving continuous opioid infusions, you may not be eligible to participate.
What data supports the effectiveness of the drug Magnesium Sulfate for trauma pain management?
Is magnesium sulfate safe for use in humans?
Magnesium sulfate is generally considered safe when used at recommended doses, but it can cause side effects like low blood pressure, muscle weakness, and high magnesium levels in the blood. It is important to monitor for these effects, especially in settings like anesthesia and obstetrics where it is commonly used.26789
How does the drug magnesium sulfate differ from other treatments for trauma pain management?
Magnesium sulfate is unique because it can be administered as an infusion to reduce the need for other pain medications after surgery, potentially leading to fewer side effects and complications. It works by affecting the body's response to pain and reducing the need for additional painkillers.123410
What is the purpose of this trial?
Magnesium is a naturally occurring mineral that is important for your body and brain. Magnesium sulfate (study drug) is a medication containing magnesium that is commonly used to improve low blood levels of magnesium. Magnesium sulfate has also proven to be successful in managing pain before and after surgery. However, this drug has primarily been used for pain control in patients undergoing surgery. Patients in the ICU with injuries also need good pain control. Using magnesium may assist in decreasing narcotic (pain reliever) requirements and provide another non-narcotic drug for pain control.The purpose of this study is to test the effectiveness of continuous, intravenous (into or within a vein using a needle) administration of magnesium sulfate for pain control in trauma patients admitted to the adult Intensive Care Unit. This will be compared to intravenous normal saline (salt solution).
Eligibility Criteria
This trial is for adult trauma patients (18-99 years old) in the ICU who can consent to participate and are on a hospital-approved pain management plan. It's not for those with severe head injuries, heart failure, renal failure, alcohol withdrawal, expected anesthesia within 24-48 hours post-admission, unable to report pain, pregnant women, prisoners or regular opioid users.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a continuous intravenous infusion of magnesium sulfate or placebo for pain control
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Magnesium Sulfate
- Normal saline placebo
Magnesium Sulfate is already approved in United States, European Union, Canada for the following indications:
- Seizure prevention in pre-eclampsia
- Asthma exacerbation treatment
- Constipation treatment
- Pre-eclampsia and eclampsia treatment
- Hypomagnesemia treatment
- Seizure prevention in pre-eclampsia
- Asthma exacerbation treatment
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Davis
Lead Sponsor