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What is Kayexalate
TolevamerThe Generic name of this drug
Treatment SummarySodium polystyrene sulfonate is a drug used to lower dangerously high levels of potassium in the blood. It can be taken by mouth or given as an enema, and it works by binding potassium in the intestines. It is also used as a topical microbicide and spermicide to prevent the spread of infections such as HIV.
Kayexalateis the brand name
Kayexalate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Kayexalate
Tolevamer
1958
34
Effectiveness
How Kayexalate Affects PatientsPolystyrene sulfonate helps to balance the amount of sodium and potassium in the body. It is used to treat high levels of potassium, which is also known as hyperkalemia. Polystyrene sulfonate can be taken orally (25 grams with 20% sorbitol) or rectally (50 grams with 20% sorbitol).
How Kayexalate works in the bodyPolystyrene sulfonate is a medication that binds to excess potassium in the intestines and prevents it from being absorbed into the bloodstream. This way, it reduces the amount of potassium in the body, and is then flushed out of the system through the feces.
When to interrupt dosage
The amount of Kayexalate is contingent upon the diagnosed condition. The dosage likewise relies upon the method of delivery featured in the table beneath.Condition
Dosage
Administration
Hyperkalemia
0.0041 meq/mg, , 1.0 mg/mg, 100.0 %, 1500.0 mg/mL, 250.0 mg/mL, 0.0943 mg/mg, 0.999 mg/mg
, Oral; Rectal, Powder, for suspension, Powder, for suspension - Oral; Rectal, Powder, Oral, Powder - Oral, Powder - Oral; Rectal, Powder, for suspension - Oral, Suspension, Suspension - Oral; Rectal, Powder, for solution, Powder, for solution - Oral; Rectal, Suspension - Oral, Rectal, Suspension - Rectal
Warnings
There are 20 known major drug interactions with Kayexalate.Common Kayexalate Drug Interactions
Drug Name
Risk Level
Description
Technetium Tc-99m oxidronate
Major
Tolevamer may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.
Acetyldigitoxin
Moderate
The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Acetyldigitoxin.
Acetyldigoxin
Moderate
The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Acetyldigoxin.
Almasilate
Moderate
The risk or severity of adverse effects can be increased when Tolevamer is combined with Almasilate.
Aloglutamol
Moderate
The risk or severity of adverse effects can be increased when Tolevamer is combined with Aloglutamol.
Kayexalate Toxicity & Overdose RiskSigns of an overdose on this medication may include confusion, moodiness, difficulty concentrating, muscle weakness, or difficulty breathing.
Kayexalate Novel Uses: Which Conditions Have a Clinical Trial Featuring Kayexalate?
Currently, there are 7 active studies examining the potential of Kayexalate to manage Hyperkalemia.Condition
Clinical Trials
Trial Phases
Hyperkalemia
8 Actively Recruiting
Phase 3, Phase 4, Not Applicable, Phase 2, Phase 1
Kayexalate Reviews: What are patients saying about Kayexalate?
5Patient Review
9/16/2011 This treatment saved my life and I experienced no negative side effects.
5Patient Review
5/23/2008 This medication has been a lifesaver for me. It's helped to regulate my potassium levels and I couldn't be more grateful.
3.7Patient Review
5/6/2012 I was just prescribed this for high potassium in my blood. It tastes terrible, but if it does the job then I'm all for it.
2.7Patient Review
7/16/2009 I just took this today and the taste is vile. I'm also really worried about potential side effects after reading about them.
2Patient Review
7/20/2011 I don't love taking this, but it's tolerable.
1.7Patient Review
8/27/2013 I experienced nausea and an increase in mucus production while taking this medication.
Patient Q&A Section about kayexalate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How does KAYEXALATE lower potassium?
"Kayexalate is a drug that is used to treat hyperkalemia by exchanging sodium for potassium in the colon and excreting potassium from the body. This drug has been used to treat hyperkalemia for decades and is still a standard part of treatment for this condition."
Answered by AI
Does KAYEXALATE make you poop?
"Such trials would also assess patient-centric outcomes since hyperkalemia is often well-tolerated in chronic renal dysfunction while the side effects of Kayexalate plus sorbitol (diarrhea) are quite unpleasant."
Answered by AI
What is KAYEXALATE used for?
"This medication is designed to lower potassium levels in the blood. High potassium levels can sometimes lead to heart rhythm problems. Sodium polystyrene sulfonate helps the body remove excess potassium."
Answered by AI
When do you give KAYEXALATE?
"Administer KAYEXALATE at least 3 hours before or 3 hours after other oral medications. Patients with gastroparesis may require a 6 hour separation. Monitor clinical response and/or blood levels where possible."
Answered by AI