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What is Invokana
CanagliflozinThe Generic name of this drug
Treatment SummaryCanagliflozin, also known as Invokana, is a medication used to treat type 2 diabetes. It works by restricting the body’s ability to absorb glucose from the blood. Canagliflozin was initially approved by the FDA in 2013, and then again in 2018 as a way to reduce the risk of cardiovascular events in people with type 2 diabetes. It is the first oral antidiabetic drug to be approved for this purpose, as cardiovascular disease is the most common cause of death among patients with type 2 diabetes.
Invokanais the brand name
Invokana Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Invokana
Canagliflozin
2013
17
Effectiveness
How Invokana Affects PatientsCanagliflozin helps control blood sugar levels by increasing how much glucose is released from the body in urine, and decreasing how much glucose is absorbed by the kidneys. This drug helps improve overall glycemic control, which is important for preventing cardiovascular problems in people with type 2 diabetes. Research has shown that controlling blood sugar levels over time can help avoid serious cardiovascular events such as heart attack and stroke.
How Invokana works in the bodyCanagliflozin blocks a protein called the sodium-glucose co-transporter2 which is found in the kidneys. This protein typically helps the body reabsorb glucose from the urine. By blocking this protein, canagliflozin prevents the body from reabsorbing the glucose, allowing it to be excreted in the urine instead.
When to interrupt dosage
The prescribed dose of Invokana is contingent upon the diagnosed malady, such as Diet, Heart Disease and Physical Activity. The amount of dosage also depends on the delivery technique featured in the table beneath.Condition
Dosage
Administration
Major Adverse Cardiac Events
100.0 mg, , 300.0 mg, 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Cardiovascular Mortality
100.0 mg, , 300.0 mg, 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Hospitalizations
100.0 mg, , 300.0 mg, 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Diabetic Nephropathy
100.0 mg, , 300.0 mg, 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Type 2 Diabetes
100.0 mg, , 300.0 mg, 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Diet
100.0 mg, , 300.0 mg, 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Diplopia
100.0 mg, , 300.0 mg, 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Congestive Heart Failure
100.0 mg, , 300.0 mg, 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Physical Activity
100.0 mg, , 300.0 mg, 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Heart Disease
100.0 mg, , 300.0 mg, 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Albuminuria
100.0 mg, , 300.0 mg, 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Kidney Failure
100.0 mg, , 300.0 mg, 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Warnings
Invokana has seven counter indications. It should not be employed in conjunction with the conditions noted in the below table.Invokana ContraindicationsCondition
Risk Level
Notes
patients with an eGFR less than 45 mL/min/1.73 m2
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
Kidney Failure
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
Renal Dialysis
Do Not Combine
Type 1 Diabetes
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Canagliflozin may interact with Pulse Frequency
Common Invokana Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Canagliflozin.
Axitinib
Major
The serum concentration of Axitinib can be increased when it is combined with Canagliflozin.
Bendamustine
Major
The serum concentration of Bendamustine can be increased when it is combined with Canagliflozin.
Binimetinib
Major
The serum concentration of Binimetinib can be increased when it is combined with Canagliflozin.
Bortezomib
Major
The serum concentration of Bortezomib can be increased when it is combined with Canagliflozin.
Invokana Toxicity & Overdose RiskIf someone takes too much canagliflozin, they should contact the Poison Control Center. Treatment may involve removing the drug from the stomach and providing additional support. Canagliflozin can be removed from the blood by hemodialysis. Pregnant or nursing women should not take this drug as it may have adverse effects on the fetus or baby. Studies have not found canagliflozin to be mutagenic in humans, but it did increase tumor incidence in mice.
Invokana Novel Uses: Which Conditions Have a Clinical Trial Featuring Invokana?
608 active clinical trials are assessing the potential of Invokana to mitigate Diet-related Type 2 Diabetes and reduce Major Adverse Cardiac Events.Condition
Clinical Trials
Trial Phases
Diplopia
0 Actively Recruiting
Cardiovascular Mortality
0 Actively Recruiting
Kidney Failure
54 Actively Recruiting
Phase 3, Phase 1, Phase 2, Phase 4, Not Applicable
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Congestive Heart Failure
312 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Major Adverse Cardiac Events
0 Actively Recruiting
Albuminuria
4 Actively Recruiting
Phase 3, Phase 4, Phase 2
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
Diet
5 Actively Recruiting
Not Applicable
Hospitalizations
2 Actively Recruiting
Not Applicable
Heart Disease
32 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 4, Phase 1, Early Phase 1
Physical Activity
39 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Invokana Reviews: What are patients saying about Invokana?
5Patient Review
5/7/2017 Invokana has been a great help in managing my blood sugar levels. I've only been taking it for two months, but I can already tell a difference.
5Patient Review
9/4/2016 I lost weight and felt great all-around. The only downside was that I developed thrush and a UTI, which required additional medication. People definitely noticed the difference in my appearance.
5Patient Review
11/18/2016 This medication has been working well for me for the past six months. My A1C levels have dropped from 7.1 to 6.2, and while I haven't seen a significant weight loss, I'm hopeful that with continued diet changes I'll be able to get off the meds eventually.
5Patient Review
11/25/2016 I started with an a1c of 10 and my sugar was at 250. The first two days were tough as my sugar dropped, but I talked to my doctor and he explained that it was completely normal because my body was used to high sugar levels. Two weeks later, I'm feeling great with no side effects. My headaches are gone, I feel good, and my blood sugar averages 150 or less. I'm on a low carb eating plan and looking forward to seeing what my blood sugar will be in another 2 weeks!
5Patient Review
10/25/2017 100 mg of this medication really helped improve my A1C. I was also pleased to find that there were no negative side effects. Just be sure to drink plenty of water while taking it!
5Patient Review
8/17/2016 This treatment has been working great for me. I started taking it in December, and since then I've lost 30 pounds. My eating and drinking habits are now back to normal.
4.3Patient Review
9/7/2016 I initially experienced more UTI's, but that decreased over time. I'm also really happy with the weight loss and decrease in my A1C score. The only downside is having to get up to use the restroom more often; however, I am drinking more water so that may be part of the reason why. All things considered, I would say this medication has been working well for me with minimal side effects.
4.3Patient Review
6/29/2018 I started taking 200 mg of Invokana a day and it helped me lose 10lbs and bring my A1C down from 9 to 8. Then after about 2 years, it stopped working and I was put on 300mg. Another year later, my A1C is going back up and I had to add Trulicity once a week. I had no side effects with Invokana but you have to drink a lot of water with Invokana cause thatâ??s how you get rid of the sugar. Hopefully no side effects from the Trulicity.
4Patient Review
11/21/2017 I followed my doctor's orders and started taking 100mg with Lantus. I'm now up to 300mg without Lantus and have seen my A1C go from 7.8 to 6.3 in just four months! The only downside is that I've lost weight; I went from 154lbs to 144lbs, but I still look healthy overall.
3.7Patient Review
7/13/2016 While my blood sugar levels have improved, I am now constantly dealing with yeast and bladder infections, as well as nausea.
3.7Patient Review
11/21/2016 Originally, this lowered my A1C from 9.0 to 5.7; however, after about a year of use, I started having severe urinary tract infections with bloody urine. In addition, yeast infections also became more frequent. As a result, I'm currently trying another medication because the side effects are becoming too severe. Additionally, there was mild weight loss while taking this medication; however, given the other issues I experienced, it's not worth it in my opinion.
2.3Patient Review
2/11/2018 I had an acute pancreatitis episode, which is rare but has been found to be a potential side effect.
1Patient Review
8/25/2016 I experienced nearly three-fourths of the possible side effects while taking this medication. I also take Atenolol, and this just caused a lot of problems that I had never before experienced. So, I stopped taking it.
1Patient Review
9/12/2021 I am 64 and my first dose caused me to have periods again and severe pain in my right side. this scares me.
1Patient Review
9/1/2016 On the fourth day of taking this medication, I was woken up by shortness of breath. My heart rate was also elevated and anxiety set in very quickly so I went to the ER. They found that my potassium levels had dropped dangerously low as a result of Invokana. I received two shots of potassium and felt much better afterwards. However, I stopped taking Invokana and saw my doctor on Monday. We agreed that it would be best if I stopped taking the medication.
Patient Q&A Section about invokana
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Invokana used for?
"Invokana is a prescription medication used to lower blood sugar in adults with type 2 diabetes. It can also be used to reduce the risk of major cardiovascular events, such as heart attack, stroke, or death, in adults with type 2 diabetes who have known cardiovascular disease."
Answered by AI
Is Invokana the same as metformin?
"No, Invokana is not the same medicine as metformin. Invokana lower blood glucose levels by working in a different way than metformin."
Answered by AI
Why was Invokana taken off the market?
"We are updating our information to let you know that the FDA has confirmed that there is an increased risk of leg and foot amputations with the diabetes medicine canagliflozin."
Answered by AI
What are the side effects of Invokana?
"Dehydration can cause a number of serious problems, including low blood pressure, infections, and even amputations. It can also lead to low blood sugar and an increased risk of broken bones. In severe cases, it can even damage the kidneys."
Answered by AI