Sleep Restriction for High Blood Pressure
Trial Summary
Will I have to stop taking my current medications?
Yes, you will need to stop taking any regular prescription medications other than contraceptives to participate in this trial.
What data supports the effectiveness of the treatment Sleep Restriction for High Blood Pressure?
Research suggests that sleep restriction can raise blood pressure, which might not be beneficial for treating high blood pressure. However, extending sleep duration has been shown to reduce blood pressure in individuals with prehypertension or stage 1 hypertension, indicating that improving sleep quality and duration could be effective in managing high blood pressure.12345
Is sleep restriction generally safe for humans?
How does the treatment of sleep restriction differ from other treatments for high blood pressure?
Sleep restriction is unique because it involves intentionally reducing sleep duration, which can raise blood pressure and heart rate, unlike traditional treatments that typically focus on medication or lifestyle changes to lower blood pressure. This approach is based on the idea that altering sleep patterns can impact cardiovascular function, although more research is needed to confirm its effectiveness.12457
What is the purpose of this trial?
The purpose of this study is to research the effects of partial sleep deprivation (sleep restriction) in a group of individuals whose parents have high blood pressure compared to a group of individuals whose parents have normal blood pressure.
Research Team
Naima Covassin, Ph.D
Principal Investigator
Mayo Clinic
Eligibility Criteria
This trial is for healthy adults aged 18-35, nonsmokers with normal sleep patterns and no significant medical or psychiatric diseases. Participants must have both biological parents' hypertension history from specific records and not be on any drugs, including high caffeine or alcohol intake. Pregnant women, those with abnormal blood pressure or glucose levels, extreme physical activity habits, or poor kidney function are excluded.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline
Participants undergo a 3-day/2-night baseline assessment to establish initial conditions
Experimental
Participants undergo a 5-day/5-night experimental phase with either sleep restriction or normal sleep
Recovery
Participants undergo a 2-day/2-night recovery phase following the experimental phase
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Normal sleep
- Partial sleep deprivation (sleep restriction)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator