44 Participants Needed

Sleep Restriction for High Blood Pressure

SM
Overseen BySabah Munir
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

Yes, you will need to stop taking any regular prescription medications other than contraceptives to participate in this trial.

What data supports the effectiveness of the treatment Sleep Restriction for High Blood Pressure?

Research suggests that sleep restriction can raise blood pressure, which might not be beneficial for treating high blood pressure. However, extending sleep duration has been shown to reduce blood pressure in individuals with prehypertension or stage 1 hypertension, indicating that improving sleep quality and duration could be effective in managing high blood pressure.12345

Is sleep restriction generally safe for humans?

Research indicates that sleep restriction can raise blood pressure and heart rate, which may not return to normal even after recovery sleep. This suggests potential cardiovascular risks, especially for those with or at risk for high blood pressure.12456

How does the treatment of sleep restriction differ from other treatments for high blood pressure?

Sleep restriction is unique because it involves intentionally reducing sleep duration, which can raise blood pressure and heart rate, unlike traditional treatments that typically focus on medication or lifestyle changes to lower blood pressure. This approach is based on the idea that altering sleep patterns can impact cardiovascular function, although more research is needed to confirm its effectiveness.12457

What is the purpose of this trial?

The purpose of this study is to research the effects of partial sleep deprivation (sleep restriction) in a group of individuals whose parents have high blood pressure compared to a group of individuals whose parents have normal blood pressure.

Research Team

NC

Naima Covassin, Ph.D

Principal Investigator

Mayo Clinic

Eligibility Criteria

This trial is for healthy adults aged 18-35, nonsmokers with normal sleep patterns and no significant medical or psychiatric diseases. Participants must have both biological parents' hypertension history from specific records and not be on any drugs, including high caffeine or alcohol intake. Pregnant women, those with abnormal blood pressure or glucose levels, extreme physical activity habits, or poor kidney function are excluded.

Inclusion Criteria

I am a healthy adult between 18 and 35 years old.
Nonsmoker
I understand and can follow the study's procedures.
See 5 more

Exclusion Criteria

Pregnant or lactating
I don't know if my biological parents had high blood pressure or I am adopted.
Use of tobacco, vaping, marijuana products or other drugs
See 21 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline

Participants undergo a 3-day/2-night baseline assessment to establish initial conditions

3 days
Inpatient visit

Experimental

Participants undergo a 5-day/5-night experimental phase with either sleep restriction or normal sleep

5 days
Inpatient visit

Recovery

Participants undergo a 2-day/2-night recovery phase following the experimental phase

2 days
Inpatient visit

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

  • Normal sleep
  • Partial sleep deprivation (sleep restriction)
Trial Overview The study examines the impact of partial sleep deprivation on individuals with a family history of high blood pressure versus those without such a history. It involves comparing the effects of reduced sleep to normal sleep in these two groups.
Participant Groups
2Treatment groups
Experimental Treatment
Group I: Study Sequence BAExperimental Treatment2 Interventions
Normal sleep condition in the first period and sleep restriction condition in the second period. Each period will consist of a 10-day inpatient visit comprising a 3-day/2-night baseline, followed by a 5-day/5-night experimental phase, and a 2-day/2-night recovery phase.
Group II: Study Sequence ABExperimental Treatment2 Interventions
Sleep restriction condition in the first period and normal sleep condition in the second period. Each period will consist of a 10-day inpatient visit comprising a 3-day/2-night baseline, followed by a 5-day/5-night experimental phase, and a 2-day/2-night recovery phase.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials
3,427
Recruited
3,221,000+

National Heart, Lung, and Blood Institute (NHLBI)

Collaborator

Trials
3,987
Recruited
47,860,000+

Findings from Research

Adequate quality sleep is linked to lower blood pressure and may help prevent and treat hypertension, as shown by various studies including experimental, epidemiological, and interventional research.
Short sleep duration is associated with higher blood pressure, particularly in middle-aged adults and women, suggesting that improving sleep quality and duration could be an effective strategy for managing hypertension.
A review of evidence for the link between sleep duration and hypertension.Gangwisch, JE.[2022]
In a study involving 237 women, sleep restriction (reducing sleep by 1.5 hours per night for 6 weeks) was found to significantly increase systolic blood pressure and mean arterial pressure, indicating a potential cardiovascular risk associated with less sleep.
The study also revealed that psychological distress did not mediate the relationship between sleep restriction and blood pressure changes, suggesting that the effects of sleep on cardiovascular health may operate through mechanisms unrelated to stress.
Mild sleep restriction increases 24-hour ambulatory blood pressure in premenopausal women with no indication of mediation by psychological effects.St-Onge, MP., Campbell, A., Aggarwal, B., et al.[2021]
In a study comparing 62 subjects with resistant hypertension (RH) to 49 with controlled hypertension (CH) and 40 normotensive individuals, those with RH had significantly shorter sleep durations, averaging 33.8 minutes less than CH and 37.2 minutes less than normotensive subjects.
The findings indicate that reduced total and REM sleep times, along with lower sleep efficiency in RH patients, may contribute to the severity of hypertension, independent of obstructive sleep apnea (OSA).
Independent association of drug-resistant hypertension to reduced sleep duration and efficiency.Friedman, O., Bradley, TD., Ruttanaumpawan, P., et al.[2022]

References

A review of evidence for the link between sleep duration and hypertension. [2022]
Mild sleep restriction increases 24-hour ambulatory blood pressure in premenopausal women with no indication of mediation by psychological effects. [2021]
Independent association of drug-resistant hypertension to reduced sleep duration and efficiency. [2022]
Association of usual sleep duration with hypertension: the Sleep Heart Health Study. [2022]
Recovery Sleep After Sleep Restriction Is Insufficient to Return Elevated Daytime Heart Rate and Systolic Blood Pressure to Baseline Levels. [2023]
Gender-specific associations of short sleep duration with prevalent and incident hypertension: the Whitehall II Study. [2022]
Sleep Restriction Effects on BP: Systematic Review & Meta-analysis of RCTs. [2021]
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