What is Invega
PaliperidoneThe Generic name of this drug
Treatment SummaryPaliperidone is a drug used to treat schizophrenia. It works by blocking signals from dopamine, serotonin, and other neurotransmitters in the brain. Paliperidone was approved by the FDA in 2006 and is available in tablet form or as an injection given once a month or every three months.
Invegais the brand name
Invega Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Invega
Paliperidone
2006
81
Effectiveness
How Invega Affects PatientsPaliperidone is an antipsychotic medication developed by Janssen Pharmaceutica. It is made from the same active ingredient as the older antipsychotic risperidone. How it works is still not clear, but it is thought to work in a similar way to risperidone.
How Invega works in the bodyPaliperidone is the active part of a drug used to treat schizophrenia. We don't know exactly how it works, but research suggests that it blocks the effects of dopamine and serotonin on the brain. Blocking these chemicals helps to reduce the symptoms of schizophrenia.
When to interrupt dosage
The proposed dosage of Invega is contingent upon the determined condition, like Therapeutic procedure, Schizophrenia and Mood stabilizing agents. The amount of dosage is subject to the technique of delivery listed in the table beneath.Condition
Dosage
Administration
Schizoaffective Disorder
1170.0 mg/mL, 546.0 mg/mL, 156.0 mg/mL, 9.0 mg, , 1.5 mg, 250.0 mg/mL, 150.0 mg/mL, 100.0 mg/mL, 263.0 mg/mL, 1750.0 mg/mL, 750.0 mg/mL, 819.0 mg/mL, 780.0 mg/mL, 525.0 mg/mL, 350.0 mg/mL, 410.0 mg/mL, 1000.0 mg, 700.0 mg, 2730.0 mg/mL, 700.0 mg/mL, 1000.0 mg/mL, 6.0 mg, 100.0 mg, 75.0 mg, 50.0 mg, 150.0 mg, 25.0 mg, 12.0 mg, 1560.0 mg/mL, 500.0 mg/mL, 3.0 mg, 525.0 mg, 175.0 mg, 263.0 mg, 234.0 mg/mL, 390.0 mg/mL, 1092.0 mg/mL, 350.0 mg, 1.5 mg/mg
, Intramuscular, Injection, suspension, extended release - Intramuscular, Injection - Intramuscular, Injection, Injection, suspension, extended release, Suspension, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, extended release, Oral, Suspension, extended release - Intramuscular, Tablet, film coated, extended release
Antidepressive Agents
1170.0 mg/mL, 546.0 mg/mL, 156.0 mg/mL, 9.0 mg, , 1.5 mg, 250.0 mg/mL, 150.0 mg/mL, 100.0 mg/mL, 263.0 mg/mL, 1750.0 mg/mL, 750.0 mg/mL, 819.0 mg/mL, 780.0 mg/mL, 525.0 mg/mL, 350.0 mg/mL, 410.0 mg/mL, 1000.0 mg, 700.0 mg, 2730.0 mg/mL, 700.0 mg/mL, 1000.0 mg/mL, 6.0 mg, 100.0 mg, 75.0 mg, 50.0 mg, 150.0 mg, 25.0 mg, 12.0 mg, 1560.0 mg/mL, 500.0 mg/mL, 3.0 mg, 525.0 mg, 175.0 mg, 263.0 mg, 234.0 mg/mL, 390.0 mg/mL, 1092.0 mg/mL, 350.0 mg, 1.5 mg/mg
, Intramuscular, Injection, suspension, extended release - Intramuscular, Injection - Intramuscular, Injection, Injection, suspension, extended release, Suspension, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, extended release, Oral, Suspension, extended release - Intramuscular, Tablet, film coated, extended release
Therapeutic procedure
1170.0 mg/mL, 546.0 mg/mL, 156.0 mg/mL, 9.0 mg, , 1.5 mg, 250.0 mg/mL, 150.0 mg/mL, 100.0 mg/mL, 263.0 mg/mL, 1750.0 mg/mL, 750.0 mg/mL, 819.0 mg/mL, 780.0 mg/mL, 525.0 mg/mL, 350.0 mg/mL, 410.0 mg/mL, 1000.0 mg, 700.0 mg, 2730.0 mg/mL, 700.0 mg/mL, 1000.0 mg/mL, 6.0 mg, 100.0 mg, 75.0 mg, 50.0 mg, 150.0 mg, 25.0 mg, 12.0 mg, 1560.0 mg/mL, 500.0 mg/mL, 3.0 mg, 525.0 mg, 175.0 mg, 263.0 mg, 234.0 mg/mL, 390.0 mg/mL, 1092.0 mg/mL, 350.0 mg, 1.5 mg/mg
, Intramuscular, Injection, suspension, extended release - Intramuscular, Injection - Intramuscular, Injection, Injection, suspension, extended release, Suspension, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, extended release, Oral, Suspension, extended release - Intramuscular, Tablet, film coated, extended release
Therapeutic procedure
1170.0 mg/mL, 546.0 mg/mL, 156.0 mg/mL, 9.0 mg, , 1.5 mg, 250.0 mg/mL, 150.0 mg/mL, 100.0 mg/mL, 263.0 mg/mL, 1750.0 mg/mL, 750.0 mg/mL, 819.0 mg/mL, 780.0 mg/mL, 525.0 mg/mL, 350.0 mg/mL, 410.0 mg/mL, 1000.0 mg, 700.0 mg, 2730.0 mg/mL, 700.0 mg/mL, 1000.0 mg/mL, 6.0 mg, 100.0 mg, 75.0 mg, 50.0 mg, 150.0 mg, 25.0 mg, 12.0 mg, 1560.0 mg/mL, 500.0 mg/mL, 3.0 mg, 525.0 mg, 175.0 mg, 263.0 mg, 234.0 mg/mL, 390.0 mg/mL, 1092.0 mg/mL, 350.0 mg, 1.5 mg/mg
, Intramuscular, Injection, suspension, extended release - Intramuscular, Injection - Intramuscular, Injection, Injection, suspension, extended release, Suspension, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, extended release, Oral, Suspension, extended release - Intramuscular, Tablet, film coated, extended release
Schizophrenia
1170.0 mg/mL, 546.0 mg/mL, 156.0 mg/mL, 9.0 mg, , 1.5 mg, 250.0 mg/mL, 150.0 mg/mL, 100.0 mg/mL, 263.0 mg/mL, 1750.0 mg/mL, 750.0 mg/mL, 819.0 mg/mL, 780.0 mg/mL, 525.0 mg/mL, 350.0 mg/mL, 410.0 mg/mL, 1000.0 mg, 700.0 mg, 2730.0 mg/mL, 700.0 mg/mL, 1000.0 mg/mL, 6.0 mg, 100.0 mg, 75.0 mg, 50.0 mg, 150.0 mg, 25.0 mg, 12.0 mg, 1560.0 mg/mL, 500.0 mg/mL, 3.0 mg, 525.0 mg, 175.0 mg, 263.0 mg, 234.0 mg/mL, 390.0 mg/mL, 1092.0 mg/mL, 350.0 mg, 1.5 mg/mg
, Intramuscular, Injection, suspension, extended release - Intramuscular, Injection - Intramuscular, Injection, Injection, suspension, extended release, Suspension, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, extended release, Oral, Suspension, extended release - Intramuscular, Tablet, film coated, extended release
Mood stabilizing agents
1170.0 mg/mL, 546.0 mg/mL, 156.0 mg/mL, 9.0 mg, , 1.5 mg, 250.0 mg/mL, 150.0 mg/mL, 100.0 mg/mL, 263.0 mg/mL, 1750.0 mg/mL, 750.0 mg/mL, 819.0 mg/mL, 780.0 mg/mL, 525.0 mg/mL, 350.0 mg/mL, 410.0 mg/mL, 1000.0 mg, 700.0 mg, 2730.0 mg/mL, 700.0 mg/mL, 1000.0 mg/mL, 6.0 mg, 100.0 mg, 75.0 mg, 50.0 mg, 150.0 mg, 25.0 mg, 12.0 mg, 1560.0 mg/mL, 500.0 mg/mL, 3.0 mg, 525.0 mg, 175.0 mg, 263.0 mg, 234.0 mg/mL, 390.0 mg/mL, 1092.0 mg/mL, 350.0 mg, 1.5 mg/mg
, Intramuscular, Injection, suspension, extended release - Intramuscular, Injection - Intramuscular, Injection, Injection, suspension, extended release, Suspension, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, extended release, Oral, Suspension, extended release - Intramuscular, Tablet, film coated, extended release
Warnings
There are 20 known major drug interactions with Invega.Common Invega Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Paliperidone.
Acepromazine
Major
Paliperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Alfuzosin
Major
Paliperidone may increase the hypotensive activities of Alfuzosin.
Amisulpride
Major
Paliperidone may increase the antipsychotic activities of Amisulpride.
Aripiprazole lauroxil
Major
Paliperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole lauroxil.
Invega Toxicity & Overdose RiskOverdosing on this drug may lead to confusion, seizures, or spasms of the head and neck, which could increase the risk of inhaling vomit if emesis is induced.
Invega Novel Uses: Which Conditions Have a Clinical Trial Featuring Invega?
221 active clinical trials are currently in progress to evaluate the potential of Invega for Schizoaffective Disorder, Schizophrenia and Mood stabilizing agent therapy.Condition
Clinical Trials
Trial Phases
Schizoaffective Disorder
60 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Phase 1, Phase 3, Early Phase 1
Schizophrenia
183 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Mood stabilizing agents
0 Actively Recruiting
Antidepressive Agents
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Invega Reviews: What are patients saying about Invega?
5Patient Review
5/9/2019 Though it effectively treats mania, I hope to stop taking this medication soon because of the side effects that come with it.
5Patient Review
4/14/2020 This medication has been effective in keeping my voices at bay. I found coupons for it online that made it much more affordable.
5Patient Review
8/11/2022 I receive a monthly injection of Invega for bipolar disorder with psychosis, and it has been excellent for me! I can think more clearly and feel more positive about myself. As for the weight gain, I find myself hungry every couple hours, but I eat healthy and drink a lot of water. Great medication that has changed my life.
4Patient Review
8/7/2015 The weight gain is really the only downside to this medication; other than that, it's quite good.
4Patient Review
1/18/2022 Invegga successfully cured my delusions and psychotic behavior. However, I have noted several side effects including lack of motivation, excessive sleeping, increased appetite, and weight gain. Additionally, I experience anxiety and dizziness frequently.
3.7Patient Review
4/20/2017 Invega did a great job of stopping my delusional thoughts and psychosis. However, I gained 80 pounds in just six months from the shot. I know this for sure because I stopped taking the pill before and lost 40 pounds--so it's definitely the Invega that caused the weight gain. Hopefully I can try something else soon that will be more effective.
3Patient Review
3/25/2018 I've been on this medication for a week now, and I'm not sure how much longer I'll continue taking it. I came off of Risperdal because I gained 40lbs in two months, and while Invaga 3mg hasn't caused me to gain as much weight, I am starting to feel suffocated when I sleep.
3Patient Review
9/23/2021 I would say that this drug is effective more often than not. It's helped me for seven years now.
2.3Patient Review
9/12/2016 I would not want this drug anywhere near me. I'm pretty sure it destroyed my ability to orgasm and caused severe anxiety with uncontrolled movements, etc. Only when I stopped taking the drug and it had a chance to exit my system did the anxiety subside! I feel like my brain has been re-wired, having zero interest in sex, or possibly even being able to reach climax impossible. Yes, it did help with hallucinations, but NOT WORTH IT IN MY BOOK!
1Patient Review
9/22/2022 My brother was given this shot and ended up in the ICU. He now has to learn how to walk again. This drug is incredibly dangerous and needs to be recalled immediately.
1Patient Review
1/27/2021 Invega is NOT effective, and made me feel incredibly lazy. I would advise against taking this drug, based on my experience.
1Patient Review
10/29/2019 Invega caused me to gain 65lbs, and I now have high cholesterol, extremely high triglycerides, high liver enzymes, high blood pressure, high Prolactin, and prediabetes. In 2 1/2 years I was never told about my blood work nor was I refered to my primary care physician until I was at "very high risk of a stroke or heart attack at any moment".
1Patient Review
5/30/2021 I absolutely hated this drug. It made me feel terrible and I crashed my truck while on it. Northern Human Services in Conway, NH forced me to take it and I would strongly recommend against it.
1Patient Review
6/19/2022 This shot is the worst. It gave me depression and anxiety, and I exchanged one illness for another. I had voices before, but now I have full-blown depression and anxiety. I'm glad I'm getting off this medication because it is terrible.
Patient Q&A Section about invega
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does INVEGA do to the brain?
"Invega is designed to correct the imbalance of certain neurotransmitters in the brain, specifically dopamine and serotonin. Its chemical structure is similar to Risperdal's, but it often produces fewer extrapyramidal side effects (tremor, stiffness, etc.)."
Answered by AI
How does INVEGA make you feel?
"Avoid becoming overheated or dehydrated in hot weather or during exercise.
If you are taking INVEGA®, you may feel dizzy, sleepy, or less alert. Be careful when driving or operating machinery until you know how this medicine will affect you. You may be more sensitive to heat while taking this medication. Avoid overheating or becoming dehydrated in hot weather or during exercise."
Answered by AI
What is the drug INVEGA used for?
"Paliperidone is a medication that works in the brain by restoring the balance of dopamine and serotonin. This improves thinking, mood, and behavior in people with schizophrenia and schizoaffective disorder."
Answered by AI
What does INVEGA do to a normal person?
"Invega is a medication that helps restore the balance of certain neurotransmitters in the brain. Invega specifically affects dopamine and serotonin. It is similar to Risperdal in how it works, but often has fewer side effects."
Answered by AI
What are the side effects of taking INVEGA?
"The following side effects may occur: drowsiness, dizziness, lightheadedness, drooling, stomach/abdominal pain, weight gain, or tiredness. If you experience any of these side effects, talk to your doctor. Dizziness and lightheadedness can make you more likely to fall. To avoid falling, get up slowly when you stand up from a sitting or lying position."
Answered by AI