Actigall

obese experiencing rapid weight loss, Cholelithiasis, Liver Cirrhosis, Biliary

Treatment

3 FDA approvals

5 Active Studies for Actigall

Treatment for

obese experiencing rapid weight loss

What is Actigall

Ursodeoxycholic acidThe Generic name of this drug

Treatment SummaryUrsodeoxycholic acid is a medication used to treat gallstones. It works by changing the composition of bile in the body, which can help break down gallstones and prevent them from forming. Ursodeoxycholic acid is known as a cholagogue and choleretic, meaning it helps stimulate the production of bile and its secretion into the intestines.

Actigallis the brand name

Actigall Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Actigall

Ursodeoxycholic acid

1987

100

Approved as Treatment by the FDA

Ursodeoxycholic acid, otherwise known as Actigall, is approved by the FDA for 3 uses which include gallstone formation and obese experiencing rapid weight loss .

gallstone formation

obese experiencing rapid weight loss

Cholelithiasis

Effectiveness

How Actigall Affects PatientsUrsodiol is a drug made by bacteria in the intestine. It is a type of bile acid which helps to process fat in food. Ursodiol also controls cholesterol levels by stopping it from being absorbed as quickly, and can break down clumps of cholesterol. It is commonly used to treat gallstones without surgery.

How Actigall works in the bodyUrsodeoxycholic acid helps reduce elevated liver enzyme levels by helping bile flow more easily through the liver and protecting the liver cells. We don't know exactly how it works, but it's thought that the drug binds to cholesterol in bile, reducing the amount of cholesterol in bile. This means that cholesterol-based gallstones dissolve more easily.

When to interrupt dosage

The measure of Actigall is contingent upon the diagnosed condition, such as Primary Biliary Cholangitis, Cholelithiasis and overweight people with accelerated weight loss. The dosage fluctuates in accordance with the technique of delivery featured in the table beneath.

Condition

Dosage

Administration

obese experiencing rapid weight loss

, 300.0 mg, 250.0 mg, 500.0 mg, 0.0002 mg/mg, 10.0 mg, 200.0 mg, 400.0 mg

, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Dental, Paste, Paste - Dental

Cholelithiasis

, 300.0 mg, 250.0 mg, 500.0 mg, 0.0002 mg/mg, 10.0 mg, 200.0 mg, 400.0 mg

, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Dental, Paste, Paste - Dental

Liver Cirrhosis, Biliary

, 300.0 mg, 250.0 mg, 500.0 mg, 0.0002 mg/mg, 10.0 mg, 200.0 mg, 400.0 mg

, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Dental, Paste, Paste - Dental

Warnings

Actigall has nine contraindications, thus its utilization should be avoided for those with any of the conditions in the following table.Actigall Contraindications

Condition

Risk Level

Notes

Cholangitis

Do Not Combine

Pancreatitis

Do Not Combine

Biliary Fistula

Do Not Combine

Calcinosis

Do Not Combine

Bile duct structure

Do Not Combine

Urinary Bladder Calculi

Do Not Combine

Urinary Bladder Calculi

Do Not Combine

Cholecystitis

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Ursodeoxycholic Acid may interact with Pulse Frequency

There are 20 known major drug interactions with Actigall.

Common Actigall Drug Interactions

Drug Name

Risk Level

Description

Capmatinib

Major

The serum concentration of Capmatinib can be decreased when it is combined with Ursodeoxycholic acid.

Rimegepant

Major

The metabolism of Rimegepant can be increased when combined with Ursodeoxycholic acid.

Astemizole

Moderate

Ursodeoxycholic acid may decrease the excretion rate of Astemizole which could result in a higher serum level.

Atazanavir

Moderate

Ursodeoxycholic acid may decrease the excretion rate of Atazanavir which could result in a higher serum level.

Atenolol

Moderate

Ursodeoxycholic acid may decrease the excretion rate of Atenolol which could result in a higher serum level.

Actigall Toxicity & Overdose RiskUrsodeoxycholic acid overdoses have not been reported. Tests have shown that doses of 16-20 mg/kg/day can be tolerated for several months without any adverse effects. Animal tests have indicated that the lethal dose of ursodeoxycholic acid in rats is over 5000 mg/kg and over 7500 mg/kg in mice. If someone has a severe overdose, diarrhea is likely to occur, which should be treated as needed.

image of a doctor in a lab doing drug, clinical research

Actigall Novel Uses: Which Conditions Have a Clinical Trial Featuring Actigall?

13 active studies are evaluating the potential of Actigall in providing relief from Primary Biliary Cholangitis, Cholelithiasis and helping obese individuals who are undergoing rapid weight loss.

Condition

Clinical Trials

Trial Phases

Liver Cirrhosis, Biliary

5 Actively Recruiting

Phase 3, Phase 2, Not Applicable

Cholelithiasis

0 Actively Recruiting

obese experiencing rapid weight loss

0 Actively Recruiting

Actigall Reviews: What are patients saying about Actigall?

5Patient Review

12/31/2007

Actigall for Rare Progressive Liver Disease - Primary Biliary Cirrhosis

5Patient Review

8/23/2009

Actigall for Rare Progressive Liver Disease - Primary Biliary Cirrhosis

I've been getting hives randomly. They'll show up on different parts of my body, and I'll get one or two at a time.

5Patient Review

10/19/2009

Actigall for Rare Progressive Liver Disease - Primary Biliary Cirrhosis

I didn't experience any negative side effects from this treatment, and it seemed to work well for me.

5Patient Review

12/22/2009

Actigall for Gallstones

I've been taking Actigall for twelve years now to prevent any symptoms of the disease and it's worked perfectly! My gastroenterologist, who specializes in this disease, prescribed it to me.

4.7Patient Review

9/21/2008

Actigall for Treatment to Prevent Gallstones

View All Reviews

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about actigall

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of ursodiol?

"If you experience any of the following symptoms, you may be suffering from a urinary tract infection:

Bladder pain
Bloody or cloudy urine
Difficult, burning, or painful urination
Fast heartbeat
Frequent urge to urinate
Severe nausea
Skin rash or itching over the entire body
Stomach pain"

Answered by AI

How long can you take Actigall?

"You might need to take ursodiol for up to two years to treat gallstones. Once the gallstones have dissolved, your doctor may keep treating you for three to four months to make sure they've completely cleared up."

Answered by AI

What is Actigall used for?

"Ursodiol can help to treat certain types of gallstones and liver disease, as well as prevent gallstones from forming in obese patients who are losing weight rapidly."

Answered by AI

What kind of medication is Actigall?

"The text is discussing the uses of the medication ursodiol. It can be used to dissolve gallstones in people who cannot or do not want to undergo surgery, and it can also be used to treat primary biliary cirrhosis, an autoimmune liver disease."

Answered by AI

Clinical Trials for Actigall

Have you considered Actigall clinical trials? We made a collection of clinical trials featuring Actigall, we think they might fit your search criteria.