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What is Actigall
Ursodeoxycholic acidThe Generic name of this drug
Treatment SummaryUrsodeoxycholic acid is a medication used to treat gallstones. It works by changing the composition of bile in the body, which can help break down gallstones and prevent them from forming. Ursodeoxycholic acid is known as a cholagogue and choleretic, meaning it helps stimulate the production of bile and its secretion into the intestines.
Actigallis the brand name
Actigall Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Actigall
Ursodeoxycholic acid
1987
100
Approved as Treatment by the FDA
Ursodeoxycholic acid, otherwise known as Actigall, is approved by the FDA for 2 uses which include Cholelithiasis and obese experiencing rapid weight loss .Cholelithiasis
obese experiencing rapid weight loss
Effectiveness
How Actigall Affects PatientsUrsodiol is a drug made by bacteria in the intestine. It is a type of bile acid which helps to process fat in food. Ursodiol also controls cholesterol levels by stopping it from being absorbed as quickly, and can break down clumps of cholesterol. It is commonly used to treat gallstones without surgery.
How Actigall works in the bodyUrsodeoxycholic acid helps reduce elevated liver enzyme levels by helping bile flow more easily through the liver and protecting the liver cells. We don't know exactly how it works, but it's thought that the drug binds to cholesterol in bile, reducing the amount of cholesterol in bile. This means that cholesterol-based gallstones dissolve more easily.
When to interrupt dosage
The measure of Actigall is contingent upon the diagnosed condition, such as Primary Biliary Cholangitis, Cholelithiasis and overweight people with accelerated weight loss. The dosage fluctuates in accordance with the technique of delivery featured in the table beneath.Condition
Dosage
Administration
obese experiencing rapid weight loss
, 300.0 mg, 250.0 mg, 500.0 mg, 0.0002 mg/mg, 10.0 mg, 200.0 mg, 400.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Dental, Paste, Paste - Dental
Cholelithiasis
, 300.0 mg, 250.0 mg, 500.0 mg, 0.0002 mg/mg, 10.0 mg, 200.0 mg, 400.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Dental, Paste, Paste - Dental
Primary Biliary Cholangitis
, 300.0 mg, 250.0 mg, 500.0 mg, 0.0002 mg/mg, 10.0 mg, 200.0 mg, 400.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Dental, Paste, Paste - Dental
Warnings
Actigall has nine contraindications, thus its utilization should be avoided for those with any of the conditions in the following table.Actigall ContraindicationsCondition
Risk Level
Notes
Cholangitis
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ursodeoxycholic Acid may interact with Pulse Frequency
Pancreatitis
Do Not Combine
biliary gastrointestinal fistula
Do Not Combine
Calcinosis
Do Not Combine
Bile duct structure
Do Not Combine
radiopaque stones
Do Not Combine
radiolucent bile pigment stones
Do Not Combine
Cholecystitis
Do Not Combine
Common Actigall Drug Interactions
Drug Name
Risk Level
Description
Capmatinib
Major
The serum concentration of Capmatinib can be decreased when it is combined with Ursodeoxycholic acid.
Rimegepant
Major
The metabolism of Rimegepant can be increased when combined with Ursodeoxycholic acid.
Astemizole
Moderate
Ursodeoxycholic acid may decrease the excretion rate of Astemizole which could result in a higher serum level.
Atazanavir
Moderate
Ursodeoxycholic acid may decrease the excretion rate of Atazanavir which could result in a higher serum level.
Atenolol
Moderate
Ursodeoxycholic acid may decrease the excretion rate of Atenolol which could result in a higher serum level.
Actigall Toxicity & Overdose RiskUrsodeoxycholic acid overdoses have not been reported. Tests have shown that doses of 16-20 mg/kg/day can be tolerated for several months without any adverse effects. Animal tests have indicated that the lethal dose of ursodeoxycholic acid in rats is over 5000 mg/kg and over 7500 mg/kg in mice. If someone has a severe overdose, diarrhea is likely to occur, which should be treated as needed.
Actigall Novel Uses: Which Conditions Have a Clinical Trial Featuring Actigall?
13 active studies are evaluating the potential of Actigall in providing relief from Primary Biliary Cholangitis, Cholelithiasis and helping obese individuals who are undergoing rapid weight loss.Condition
Clinical Trials
Trial Phases
Primary Biliary Cholangitis
13 Actively Recruiting
Phase 3, Phase 1, Phase 2, Not Applicable
Cholelithiasis
0 Actively Recruiting
obese experiencing rapid weight loss
0 Actively Recruiting
Actigall Reviews: What are patients saying about Actigall?
5Patient Review
12/31/20075Patient Review
8/23/2009 I've been getting hives randomly. They'll show up on different parts of my body, and I'll get one or two at a time.
5Patient Review
10/19/2009 I didn't experience any negative side effects from this treatment, and it seemed to work well for me.
5Patient Review
12/22/2009 I've been taking Actigall for twelve years now to prevent any symptoms of the disease and it's worked perfectly! My gastroenterologist, who specializes in this disease, prescribed it to me.
4.7Patient Review
9/21/20084.7Patient Review
9/2/2009 After only a few days of taking this medication, my nausea has eased up significantly. I'm not sure yet what's happening with the gallstone, but I still get random pain.
4.7Patient Review
12/2/2009 I'm not entirely sure what my diagnosis is, but my doctor recommended this to help with the pain I experience after eating. It's been really effective, though I have experienced some diarrhoea as a side effect.
4.7Patient Review
11/15/2011 After every meal, I have eccessive burbing. It does not matter as to the amount of food or the type of food or how slow I eat. I will have more than 20 minutes of continous burbing which has now caused me to socially isolate when eating with friends and family.
4.3Patient Review
11/13/20074Patient Review
9/4/2013 I have no idea if this is dangerous or not, but I would recommend talking to a doctor before taking it.
3.7Patient Review
10/4/20073.7Patient Review
1/4/20083.7Patient Review
2/21/2015 This treatment is effective, affordable, and easily available.
3.7Patient Review
9/1/2010 I'm glad there's a medication available to address my issue. It started working quickly and has been very effective.
3.7Patient Review
7/25/2010 I was diagnosed in 2001 and started taking Actigall. I'm doing well and still able to work, though I have had to make some adjustments.
2.3Patient Review
3/2/2013 The taste is tough to get down, and I haven't seen any results yet.
2.3Patient Review
9/9/2016 I was just diagnosed with PBC last month. I am currently using this drug. I have been experiencing extreme nausea that lasts for 1 to 3 hours after taking it morning and night. I don't have any results yet so am unsure if it is working but, my experience thus far has been miserable. Hoping I acclimate soon and the nausea will go away.
1Patient Review
11/19/2010 I've been struggling with Alcohol Liver Cirrhosis for over two years now. I quit drinking completely, and while this Ursodiol has been helping, I don't know how long I'll have to keep taking it.
Patient Q&A Section about actigall
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of ursodiol?
"If you experience any of the following symptoms, you may be suffering from a urinary tract infection:
-
Bladder pain
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Bloody or cloudy urine
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Difficult, burning, or painful urination
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Fast heartbeat
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Frequent urge to urinate
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Severe nausea
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Skin rash or itching over the entire body
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Stomach pain"
Answered by AI
How long can you take Actigall?
"You might need to take ursodiol for up to two years to treat gallstones. Once the gallstones have dissolved, your doctor may keep treating you for three to four months to make sure they've completely cleared up."
Answered by AI
What is Actigall used for?
"Ursodiol can help to treat certain types of gallstones and liver disease, as well as prevent gallstones from forming in obese patients who are losing weight rapidly."
Answered by AI
What kind of medication is Actigall?
"The text is discussing the uses of the medication ursodiol. It can be used to dissolve gallstones in people who cannot or do not want to undergo surgery, and it can also be used to treat primary biliary cirrhosis, an autoimmune liver disease."
Answered by AI