Glyset

Physical Activity, Type 2 Diabetes, Diet
Treatment
2 FDA approvals
20 Active Studies for Glyset

What is Glyset

MiglitolThe Generic name of this drug
Treatment SummaryMiglitol is an oral medication used to control blood sugar in people with type 2 diabetes. It works by preventing the digestion of carbohydrates into simple sugars, which can then be absorbed by the body. It should be taken at the start of a meal for the best effect. Unlike other drugs in its class, miglitol is not broken down by the body and is eliminated through the kidneys.
Glysetis the brand name
image of different drug pills on a surface
Glyset Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Glyset
Miglitol
1996
16

Approved as Treatment by the FDA

Miglitol, also known as Glyset, is approved by the FDA for 2 uses including Type 2 Diabetes Mellitus and Type 2 Diabetes .
Type 2 Diabetes Mellitus
Helps manage Type 2 Diabetes Mellitus
Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus

Effectiveness

How Glyset Affects PatientsMiglitol helps to control blood sugar levels in patients with type II diabetes. It works by delaying the digestion of carbohydrates so that the rise of blood sugar after eating is reduced. Miglitol also helps to lower levels of glycosylated hemoglobin, which is a measure of long-term blood sugar control. When taken in combination with sulfonylureas, it has an additive effect in helping to control blood sugar levels without causing weight gain or increasing insulin levels. Miglitol does not usually cause lactose intolerance as it only has minor effects on the enzyme that breaks down lactose.
How Glyset works in the bodyMiglitol works differently than other diabetes medications. It blocks enzymes in the small intestine that break down carbohydrates and sugars. This delays the absorption of glucose, which helps reduce the amount of sugar in the blood after meals.

When to interrupt dosage

The measure of Glyset is contingent upon the ascertained condition, comprising Type 2 Diabetes, Physical Activity and Diet. The extent likewise fluctuates as per the strategy of delivery (e.g. Tablet, coated - Oral or Oral) featured in the table beneath.
Condition
Dosage
Administration
Physical Activity
, 50.0 mg, 100.0 mg, 25.0 mg
Oral, Tablet, coated - Oral, , Tablet, coated, Tablet, film coated - Oral, Tablet, film coated
Type 2 Diabetes
, 50.0 mg, 100.0 mg, 25.0 mg
Oral, Tablet, coated - Oral, , Tablet, coated, Tablet, film coated - Oral, Tablet, film coated
Diet
, 50.0 mg, 100.0 mg, 25.0 mg
Oral, Tablet, coated - Oral, , Tablet, coated, Tablet, film coated - Oral, Tablet, film coated

Warnings

Glyset has nine contraindications and should not be used when suffering from any of the ailments detailed in the following table.Glyset Contraindications
Condition
Risk Level
Notes
Digestive Disorders
Do Not Combine
Pulse Frequency
Do Not Combine
Disease
Do Not Combine
Intestinal Obstruction
Do Not Combine
colonic ulceration
Do Not Combine
Crohn's Disease
Do Not Combine
Intestines
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
Capillaria philippinensis Infection
Do Not Combine
There are 20 known major drug interactions with Glyset.
Common Glyset Drug Interactions
Drug Name
Risk Level
Description
Ketotifen
Minor
The risk or severity of thrombocytopenia can be increased when Miglitol is combined with Ketotifen.
2,4-thiazolidinedione
Moderate
The risk or severity of hypoglycemia can be increased when Miglitol is combined with 2,4-thiazolidinedione.
AICA ribonucleotide
Moderate
The risk or severity of hypoglycemia can be increased when Miglitol is combined with AICA ribonucleotide.
AMG-222
Moderate
The risk or severity of hypoglycemia can be increased when Miglitol is combined with AMG-222.
Acetohexamide
Moderate
The risk or severity of hypoglycemia can be increased when Miglitol is combined with Acetohexamide.
Glyset Toxicity & Overdose RiskIf you take too much miglitol, you are unlikely to experience low blood sugar levels, as with other diabetes treatments. However, you may experience short-term increases in flatulence, diarrhea, or stomach discomfort. Generally, no serious side effects are expected if an overdose occurs.
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Glyset Novel Uses: Which Conditions Have a Clinical Trial Featuring Glyset?

196 active studies are being conducted to evaluate the potential of Glyset to modulate Diet, Type 2 Diabetes and Physical Activity.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
167 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Physical Activity
24 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Diet
5 Actively Recruiting
Not Applicable, Phase 1

Glyset Reviews: What are patients saying about Glyset?

5Patient Review
2/27/2009
Glyset for Type 2 Diabetes Mellitus
This medication is quite effective at controlling glucose spikes. However, it's price tag puts it out of reach for many people who need it.
4Patient Review
2/6/2010
Glyset for Type 2 Diabetes Mellitus
I tried a lot of different treatments before finding this one. So glad it worked for me in the end!
3Patient Review
10/27/2008
Glyset for Type 2 Diabetes Mellitus
1.7Patient Review
10/25/2013
Glyset for Type 2 Diabetes Mellitus
I've been experiencing severe stomach pain for the past three months, and despite multiple tests, doctors haven't been able to find an underlying cause. I've recently stopped taking the medication in hopes that it will provide some relief, but so far there hasn't been any change.
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Patient Q&A Section about glyset

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is miglitol used for?

"Miglitol is used to treat high blood sugar levels that are caused by type 2 diabetes and will expire on July 1, 2022."

Answered by AI

What is Glyset used for?

"Glyset works by inhibiting alpha-glucosidase, which slows the absorption of carbohydrates. This prevents blood sugar from rising as much after a meal and is used to treat non-insulin-dependent (Type II) diabetes mellitus."

Answered by AI

Does miglitol cause weightloss?

"Miglitol has been shown in both clinical trials with adult patients and in rodent models of obesity to reduce body weight and ameliorate insulin resistance. The specific mechanism of action of this effect remains unclear, although some mechanisms have been suggested through experimental results."

Answered by AI

What type of medication is miglitol?

"Miglitol is a medication that helps control blood sugar levels by delaying the digestion of carbohydrates. It does this by inhibiting the breakdown of complex carbohydrates into glucose."

Answered by AI

Clinical Trials for Glyset

Image of University of California, Los Angeles in Los Angeles, United States.

Tailored DPP for Prediabetes

17 - 25
All Sexes
Los Angeles, CA
The goal of this study is to enhance reach and uptake of diabetes prevention among young adults, with a focus on recruiting underserved and high-need students who face additional challenges, including food and financial insecurity. The specific aims are: Aim 1 - Evaluate the efficacy of an AYA-tailored version of the UC DPP for mitigating type 2 diabetes risk (i.e., weight change) in a pre/post pilot trial. The investigators hypothesize that the AYA-tailored intervention will be effective at producing 5% weight loss from baseline to program completion (at 9-months). Aim 2 - Assess the feasibility and acceptability of an AYA-tailored version of the UC DPP program. The investigators hypothesize that it will be feasible to recruit the desired number of participants given proposed innovative outreach strategies, and that the AYA-tailored intervention will be deemed acceptable to participants both qualitatively and in regards to their retention in the program at rates similar to the larger UC DPP. The investigators will recruit 80 UCLA undergraduate students. Participants will be asked to complete a brief screening online form to assess eligibility and to collect contact information. The PI and/or Research Assistants (RAs) will reach out to eligible participants to obtain informed consent and enroll them in the pilot trial. The investigators will randomize participants to the tailored DPP cohort vs control cohort. Control participants will be offered the opportunity to participate in the tailored DPP in the following academic year. The tailored DPP intervention will be online and asynchronously. Participants will be asked to complete the intervention lessons on their own time. Each lesson typically takes on average 15 minutes to complete. Control group will receive each intervention materials via e-mail for participants to review on their own time and will receive acceptability surveys. The interventions for the control group will be remote. A research assistant will meet with control participants via Zoom to explain the intervention materials. Control group will receive access to a study habits intervention, alcohol use intervention, and financial literacy intervention. At the end of each quarter (Fall, Winter, and Spring), both control and intervention participants will receive an email with a unique link to a brief REDCap survey to ascertain acceptability of sessions/lessons. Furthermore, participants will complete baseline and 9-month follow-up assessments. Participants will complete a 30 minute questionnaire and height/weight measurements will be collected by a RA. Participants will be asked to self-report weight and physical activity at the end of the fall and winter quarter; data will be collected via brief REDCap survey.
Recruiting
Has No Placebo
University of California, Los AngelesLauren E Wisk, PhD
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PATAS for Type 2 Diabetes

18 - 55
All Sexes
Cincinnati, OH
The primary objective of Part 1 of this study is to evaluate safety and tolerability of single subcutaneous (SC) doses of PATAS in healthy subjects. The secondary objective of Part 1 of this study is to determine the pharmacokinetics (PK) of single SC doses of PATAS in healthy subjects. The primary objectives of Part 2 of this study are to evaluate the safety and tolerability of 4 weekly SC doses of PATAS in subjects with T2D; and to determine the PK and pharmacodynamics (PD) of 4 weekly SC doses of PATAS in subjects with T2D. The secondary objectives of Part 2 of this study are to evaluate the potential effect of multiple SC doses of PATAS on markers of glycemic control, as measured by glucose levels, insulin levels, and other metabolomic biomarkers; and to characterize the adverse event (AE) profiles of the various dose levels of PATAS.
Phase 1
Waitlist Available
Medpace Clinical Pharmaology UnitVincent Marion, Ph.D.AdipoPharma LLC
Have you considered Glyset clinical trials? We made a collection of clinical trials featuring Glyset, we think they might fit your search criteria.Go to Trials
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Estrogen and Testosterone for Gender Differences in Physiology

18 - 40
All Sexes
Kelowna, Canada
Due to historical exclusion of females from research, there are gaps in the understanding of female physiology, how it differs from males, and how sex-specific hormones contribute. As a result, many diagnoses and treatments are based on male physiology and may not be appropriate or effective for females. Females consistently experience greater risk and report worse neurological outcomes in many diseases, including stroke, cardiac arrest, and dementia. As research in females progresses, differences between sexes and changes throughout the lifespan (e.g., puberty, menopause) highlight the importance of understanding the effects of sex and sex-specific hormones on the body. The brain is arguably the most important organ in the body, consuming 20% of the body's total energy. Previous research supports higher blood flow to the brain in females, and research in animals suggests hormones such as estrogen, progesterone, and testosterone are responsible. However, it is extremely difficult to isolate these hormones in humans, due to natural fluctuations (i.e., menstrual cycle). Therefore, the investigators plan to explore the direct role of these sex-specific hormones in regulating blood flow to the brain by blocking hormone production in healthy males and females and giving back testosterone and estrogen, respectively. The investigators will then conduct a range of tests to look at blood flow to the brain at rest and during various stressors. This research will provide crucial insight into how males and females differ in regulation of brain blood flow and inform new treatments and therapies to a wide range of brain injuries and diseases, improving outcomes and reducing the sex disparity in clinical pathways.
Waitlist Available
Has No Placebo
University of British Columbia - OkanaganPhilip Ainslie, PhD
Have you considered Glyset clinical trials? We made a collection of clinical trials featuring Glyset, we think they might fit your search criteria.Go to Trials
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Aerobic Exercise with Blood Flow Restriction for Type 2 Diabetes

19 - 64
All Sexes
Okanagan, Canada
The goal of this trial is to learn if blood flow restriction training with treadmill walking is possible for individuals living with type 2 diabetes. It will also learn about how the blood flow restriction with treadmill walking could improve health. The main questions it aims to answer are: Is 6 weeks of treadmill walking with blood flow restriction reasonable for people with type 2 diabetes to perform? Does treadmill walking with blood flow restriction training help manage type 2 diabetes better than just treadmill walking? Researchers will compare treadmill walking with blood flow restriction to treadmill walking without blood flow restriction to see if blood flow restriction works to manage type 2 diabetes based on fitness and blood sugar levels. Participants will: Perform treadmill walking with or without blood flow restriction for 96 minutes a week for 6 weeks. Visit the lab before and after the exercise for tests and questionnaires.
Waitlist Available
Has No Placebo
Exercise Metabolism and Inflammation Laboratory (+2 Sites)Martin Senechal, PhD
Image of Jefferson Health New Jersey in Sewell, United States.

Continuous vs Finger-stick Glucose Monitoring for Type 2 Diabetes in Pregnancy

18+
Female
Sewell, NJ
The purpose of this study is to compare patient adherence to blood sugar monitoring during pregnancy using two different measurement methods in pregnancies complicated by pregestational type 2 diabetes (T2DM). Pregnant patients with T2DM are at risk of having larger babies, babies with low sugar levels in the first 24 hours of life, higher rates of cesarean delivery, stillbirth (death of baby inside the womb), and hypertensive or high blood pressure disorders of pregnancy, such as preeclampsia. Prior studies have shown that treating high blood sugars in pregnancy with medications can reduce these risks. To determine the amount of medication needed, recording of blood sugar levels is necessary. This trial aims to determine whether continuous blood sugar monitors have improved patient recording of blood sugar levels over finger stick blood sugar measurements. Patients involved in the study will be assigned to either: 1. Fingerstick glucose monitoring (FSG) 2. Continuous glucose monitoring (CGM) Patients will be randomize in a 1:1 ratio. FSG Group: blood sugar is tested four times daily - once fasting and two hours after every meal (post-prandial). Blood will be tested using a glucometer, and values will be recorded in a blood sugar log from the time of enrollment to the time of delivery. CGM Group: A CGM sensor will be placed on the patient's arm for blood sugar collection every 3-5 minutes. This data is sent to a phone application from the time of enrollment to the time of delivery. These sensors will need to be replaced every 14 days. Percent adherence will be recorded from the time you were randomized to a study group until delivery.
Recruiting
Has No Placebo
Jefferson Health New Jersey (+1 Sites)
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Health Coaching for Type 2 Diabetes and Mental Health

18+
All Sexes
Hamilton, Canada
Managing both type 2 diabetes and mental health challenges can be difficult, and many people do not receive care that supports both. This study looks at how virtual health coaching and support from interdisciplinary care teams can help people better manage their health. The purpose of this study is to test the effectiveness of a virtual health coaching program for adults living with type 2 diabetes and mental health challenges compared to usual care. The Technology-Enabled Collaborative Care for type 2 Diabetes and Mental health (TECC-DM) program includes weekly coaching calls, support from an interdisciplinary care team, and online tools to aid self-management. The findings from this study will be used to help improve services for people who have type 2 diabetes and co-occurring mental health symptoms.
Waitlist Available
Has No Placebo
McMaster UniversityCarly Whitmore, RN PhD
Have you considered Glyset clinical trials? We made a collection of clinical trials featuring Glyset, we think they might fit your search criteria.Go to Trials
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