What is Glyset
MiglitolThe Generic name of this drug
Treatment SummaryMiglitol is an oral medication used to control blood sugar in people with type 2 diabetes. It works by preventing the digestion of carbohydrates into simple sugars, which can then be absorbed by the body. It should be taken at the start of a meal for the best effect. Unlike other drugs in its class, miglitol is not broken down by the body and is eliminated through the kidneys.
Glysetis the brand name
Glyset Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Glyset
Miglitol
1996
16
Approved as Treatment by the FDA
Miglitol, also known as Glyset, is approved by the FDA for 1 uses including Type 2 Diabetes .Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus
Effectiveness
How Glyset Affects PatientsMiglitol helps to control blood sugar levels in patients with type II diabetes. It works by delaying the digestion of carbohydrates so that the rise of blood sugar after eating is reduced. Miglitol also helps to lower levels of glycosylated hemoglobin, which is a measure of long-term blood sugar control. When taken in combination with sulfonylureas, it has an additive effect in helping to control blood sugar levels without causing weight gain or increasing insulin levels. Miglitol does not usually cause lactose intolerance as it only has minor effects on the enzyme that breaks down lactose.
How Glyset works in the bodyMiglitol works differently than other diabetes medications. It blocks enzymes in the small intestine that break down carbohydrates and sugars. This delays the absorption of glucose, which helps reduce the amount of sugar in the blood after meals.
When to interrupt dosage
The measure of Glyset is contingent upon the ascertained condition, comprising Type 2 Diabetes, Physical Activity and Diet. The extent likewise fluctuates as per the strategy of delivery (e.g. Tablet, coated - Oral or Oral) featured in the table beneath.Condition
Dosage
Administration
Physical Activity
50.0 mg, 25.0 mg, , 100.0 mg
Tablet, coated - Oral, Oral, , Tablet, film coated, Tablet, coated, Tablet, film coated - Oral
Diet
50.0 mg, 25.0 mg, , 100.0 mg
Tablet, coated - Oral, Oral, , Tablet, film coated, Tablet, coated, Tablet, film coated - Oral
Type 2 Diabetes
50.0 mg, 25.0 mg, , 100.0 mg
Tablet, coated - Oral, Oral, , Tablet, film coated, Tablet, coated, Tablet, film coated - Oral
Warnings
Glyset has nine contraindications and should not be used when suffering from any of the ailments detailed in the following table.Glyset ContraindicationsCondition
Risk Level
Notes
Digestive Disorders
Do Not Combine
Capillaria philippinensis Infection
Do Not Combine
Disease
Do Not Combine
colonic ulceration
Do Not Combine
Intestines
Do Not Combine
partial intestinal obstruction
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
Crohn's Disease
Do Not Combine
Toxoplasma Infections
Do Not Combine
Common Glyset Drug Interactions
Drug Name
Risk Level
Description
Ketotifen
Minor
The risk or severity of thrombocytopenia can be increased when Miglitol is combined with Ketotifen.
2,4-thiazolidinedione
Moderate
The risk or severity of hypoglycemia can be increased when Miglitol is combined with 2,4-thiazolidinedione.
AICA ribonucleotide
Moderate
The risk or severity of hypoglycemia can be increased when Miglitol is combined with AICA ribonucleotide.
AMG-222
Moderate
The risk or severity of hypoglycemia can be increased when Miglitol is combined with AMG-222.
Acetohexamide
Moderate
The risk or severity of hypoglycemia can be increased when Miglitol is combined with Acetohexamide.
Glyset Toxicity & Overdose RiskIf you take too much miglitol, you are unlikely to experience low blood sugar levels, as with other diabetes treatments. However, you may experience short-term increases in flatulence, diarrhea, or stomach discomfort. Generally, no serious side effects are expected if an overdose occurs.
Glyset Novel Uses: Which Conditions Have a Clinical Trial Featuring Glyset?
196 active studies are being conducted to evaluate the potential of Glyset to modulate Diet, Type 2 Diabetes and Physical Activity.Condition
Clinical Trials
Trial Phases
Diet
3 Actively Recruiting
Not Applicable
Physical Activity
34 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1
Type 2 Diabetes
175 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Early Phase 1, Phase 1, Phase 3
Glyset Reviews: What are patients saying about Glyset?
5Patient Review
2/27/2009 This medication is quite effective at controlling glucose spikes. However, it's price tag puts it out of reach for many people who need it.
4Patient Review
2/6/2010 I tried a lot of different treatments before finding this one. So glad it worked for me in the end!
3Patient Review
10/27/20081.7Patient Review
10/25/2013 I've been experiencing severe stomach pain for the past three months, and despite multiple tests, doctors haven't been able to find an underlying cause. I've recently stopped taking the medication in hopes that it will provide some relief, but so far there hasn't been any change.
Patient Q&A Section about glyset
What is miglitol used for?
"Miglitol is used to treat high blood sugar levels that are caused by type 2 diabetes and will expire on July 1, 2022." - Anonymous Online Contributor
Unverified Answer
What is Glyset used for?
"Glyset works by inhibiting alpha-glucosidase, which slows the absorption of carbohydrates. This prevents blood sugar from rising as much after a meal and is used to treat non-insulin-dependent (Type II) diabetes mellitus." - Anonymous Online Contributor
Unverified Answer
Does miglitol cause weightloss?
"Miglitol has been shown in both clinical trials with adult patients and in rodent models of obesity to reduce body weight and ameliorate insulin resistance. The specific mechanism of action of this effect remains unclear, although some mechanisms have been suggested through experimental results." - Anonymous Online Contributor
Unverified Answer
What type of medication is miglitol?
"Miglitol is a medication that helps control blood sugar levels by delaying the digestion of carbohydrates. It does this by inhibiting the breakdown of complex carbohydrates into glucose." - Anonymous Online Contributor
Unverified Answer