Exparel

Q: What happens when EXPAREL wears off?

<p>The <a href="https://www.withpower.com/clinical-trials/pain">pain</a> medication, <a href="https://www.withpower.com/clinical-trials/exparel">EXPAREL</a>, slowly wears off after a few days. This may cause patients to start to experience pain at the surgical site.</p>

Stevens-Johnson Syndrome, Ophthalmia, Sympathetic, Berylliosis + 71 more

Treatment

16 FDA approvals

20 Active Studies for Exparel

Treatment for

Stevens-Johnson Syndrome

What is Exparel

Bupivacaine

The Generic name of this drug

Treatment Summary

Bupivacaine is a medication used to numb a specific area of the body, usually for medical procedures.

Bupivacaine Hydrochloride and Epinephrine

is the brand name

image of different drug pills on a surface

Exparel Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Bupivacaine Hydrochloride and Epinephrine

Bupivacaine

1988

197

Approved as Treatment by the FDA

Bupivacaine, also known as Bupivacaine Hydrochloride and Epinephrine, is approved by the FDA for 16 uses including Alopecia Areata and Inflammation .

Alopecia Areata

Used to treat Alopecia Areata (AA) in combination with Lidocaine

Inflammation

Used to treat inflammatory lesions of lichen simplex in combination with Lidocaine

Psoriasis

Used to treat Psoriatic plaque in combination with Lidocaine

Inflammation

Used to treat inflammatory lesions of granuloma annulare in combination with Lidocaine

Nerve Block

Discoid Lupus Erythematosus (DLE)

Used to treat Discoid Lupus Erythematosus (DLE) in combination with Lidocaine

Flatfoot

Used to treat inflammatory lesions of lichen planus in combination with Lidocaine

Tendon structure

Used to treat cystic tumors of tendon in combination with Lidocaine

Alopecia Areata (AA)

Used to treat Alopecia Areata (AA) in combination with Lidocaine

Aponeurosis structure

Used to treat cystic tumors of aponeurosis in combination with Lidocaine

General Anesthesia

Keloids Scars

Used to treat Keloids Scars in combination with Lidocaine

Psoriatic plaque

Used to treat Psoriatic plaque in combination with Lidocaine

Lupus Erythematosus, Discoid

Used to treat Discoid Lupus Erythematosus (DLE) in combination with Lidocaine

Local Anaesthesia therapy

Necrobiosis Lipoidica

Used to treat Necrobiosis lipoidica diabeticorum in combination with Lidocaine

Effectiveness

How Exparel Affects Patients

Bupivacaine is a common anesthetic used to reduce pain before and during surgery. It works for a long time compared to other anesthetics, but it can be dangerous if too much is used. To avoid this, other long-acting anesthetics like ropivacaine and levobupivacaine are often used instead. When an anesthetic is absorbed into the blood, it can affect the heart, leading to problems with the rhythm, contractility, and pressure. It can also affect the central nervous system, causing stimulation, depression, or both.

How Exparel works in the body

Bupivacaine is a type of local anesthetic that numbs nerves in a specific area. It does this by blocking the sodium channels that control the flow of electrical impulses. Once the channels are blocked, the nerve can no longer send signals, resulting in numbness. This effect is stronger for nerves with thicker diameters, more insulation, and faster transmission speeds. Generally, pain is the first sense to be lost when bupivacaine is used, followed by temperature, touch, proprioception, and muscle tone. In addition to blocking sodium channels, bupivacaine may also reduce inflammation, fever, and

When to interrupt dosage

The prescribed dosage of Exparel is contingent upon the determined state, including Idiopathic Nephrotic Syndrome, Lupus and Thyroiditis. The magnitude of dosage is contingent upon the method of delivery as listed in the table beneath.

Condition

Dosage

Administration

Berylliosis

, 5.0 mg/mL, 7.5 mg/mL, 2.5 mg/mL, 1.25 mg/mL, 1.0 mg/mL, 2.5 mg, 5.0 mg, 7.5 mg, 13.3 mg/mL, 15.0 mg, 100.0 mg, 50.0 mg, 150.0 mg, 125.0 mg, 250.0 mg, 3.0 mg/mL, 1.0 mg/mg, 3.75 mg/mL, 9.0 mg/mL, 12.5 mg/mL, 25.0 mg/mL, 26.6 mg/mL, 200.0 mg, 60.0 mg, 400.0 mg, 200.0 mg/mL, 30.0 mg/mL, 40.0 mg/mL, 60.0 mg/mL, 10.0 mg/mL, 15.0 mg/mL, 660.0 mg/mL

, Injection, solution, Subcutaneous, Injection, solution - Subcutaneous, Epidural; Retrobulbar, Injection, solution - Epidural; Infiltration; Intracaudal, Injection, solution - Subarachnoid, Subarachnoid, Epidural; Infiltration; Intracaudal, Injection, solution - Epidural; Retrobulbar, Epidural, Injection, solution - Epidural, Perineural, Injection, solution - Perineural, Injection, solution - Epidural; Infiltration, Epidural; Infiltration, Infiltration, Injection, solution - Infiltration, Injection, solution - Epidural; Intracaudal, Epidural; Intracaudal, Kit, Infiltration; Perineural, Injection, solution - Infiltration; Perineural, Epidural; Infiltration; Intracaudal; Perineural, Epidural; Intracaudal; Perineural, Injection, solution - Epidural; Infiltration; Intracaudal; Perineural, Injection, solution - Epidural; Intracaudal; Perineural, Solution, Solution - Epidural; Infiltration, Intraspinal, Solution - Intraspinal, Solution - Epidural; Retrobulbar, Solution - Infiltration, Liquid, Liquid - Epidural; Retrobulbar, Liquid - Epidural; Infiltration, Liquid - Intraspinal, Liquid - Infiltration, Solution - Epidural; Infiltration; Intracaudal, Kit - Topical, Topical, Injection, suspension, liposomal, Injection, suspension, liposomal - Infiltration, Injection, solution - Intraspinal, Kit - Epidural; Infiltration; Intra-articular; Intramuscular; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue, Kit - Epidural; Infiltration, Epidural; Infiltration; Intra-articular; Intramuscular; Topical, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Dental; Infiltration, Dental; Infiltration, Epidural; Infiltration; Intramuscular; Intrasynovial; Soft tissue; Topical, Kit - Epidural; Infiltration; Intramuscular; Intrasynovial; Soft tissue; Topical, Epidural; Infiltration; Intravenous, Kit - Epidural; Infiltration; Intravenous, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular, Epidural; Infiltration; Topical, Kit - Epidural; Infiltration; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Epidural; Infiltration; Intra-articular; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Topical, Epidural; Parenteral, Injection, Injection - Epidural; Parenteral, Injection - Epidural; Parenteral; Retrobulbar, Spray, metered - Topical, Spray, metered, Epidural; Intra-articular; Intramuscular; Topical, Kit - Epidural; Intra-articular; Intramuscular; Topical, Retrobulbar, Injection - Retrobulbar, Epidural; Parenteral; Retrobulbar, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Epidural; Infiltration; Parenteral, Injection - Epidural; Infiltration; Parenteral, Infiltration; Parenteral, Injection - Infiltration; Parenteral, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Parenteral, Injection - Parenteral, Kit - Epidural; Infiltration; Intracaudal; Perineural, Enteral; Epidural; Intracaudal, Injection, solution - Enteral; Epidural; Intracaudal, Injection - Subarachnoid, Injection - Epidural; Intracaudal; Perineural, Intravenous, Injection - Intravenous, Intra-articular; Intramuscular, Implant, Implant - Parenteral, Solution - Intralesional, Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Kit - Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Intralesional

Psoriasis

Psoriatic Arthritis

Red-Cell Aplasia, Pure

Arthritis, Gouty

General Anesthesia

Epidural Block

Anesthesia, Conduction

Idiopathic Nephrotic Syndrome

Inflammation

Analgesics

Multiple Sclerosis

Bullous dermatitis herpetiformis

Arthroscopy

Lupus

Anemia, Hemolytic

Lymphoma, Non-Hodgkin

Inflammation

Interscalene Nerve Block

Lupus erythematosus cell

Warnings

Exparel has seven contraindications that preclude its utilization for the conditions in the following table.

Exparel Contraindications

Condition

Risk Level

Notes

Coronary Artery Bypass Grafting

Do Not Combine

history of NSAID allergy

Do Not Combine

obstetrical paracervical block anesthesia

Do Not Combine

Asthma

Do Not Combine

obstetrical paracervical block anesthesia

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Bupivacaine may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Bupivacaine may interact with Pulse Frequency

There are 20 known major drug interactions with Exparel.

Common Exparel Drug Interactions

Drug Name

Risk Level

Description

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Bupivacaine.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Bupivacaine.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Bupivacaine.

Azelastine

Major

Bupivacaine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Clomipramine

Major

The metabolism of Clomipramine can be decreased when combined with Bupivacaine.

Exparel Toxicity & Overdose Risk

The average lethal dose of bupivacaine in rhesus monkeys is 4.4 mg/kg, with a plasma concentration of 4.5 mcg/mL. In mice, the lowest toxic dose is 6-8 mg/kg intravenously and 38-54 mg/kg subcutaneously. Patients who have seizures due to bupivacaine may quickly develop hypoxia, hypercarbia, and acidosis. It is important to provide immediate oxygen ventilation to avoid cardiac arrest.

image of a doctor in a lab doing drug, clinical research

Exparel Novel Uses: Which Conditions Have a Clinical Trial Featuring Exparel?

Presently, 288 active trials are examining the potential of Exparel to ameliorate Ulcerative Colitis, Systemic Lupus Erythematosus and Rheumatoid Arthritis.

Condition

Clinical Trials

Trial Phases

Lupus

65 Actively Recruiting

Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1

Rheumatoid Arthritis

55 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Labor Pain

0 Actively Recruiting

Osteoarthritis

0 Actively Recruiting

General Anesthesia

1 Actively Recruiting

Phase 4

Regional Analgesia

0 Actively Recruiting

Hypersensitivity

0 Actively Recruiting

Local Analgesia

0 Actively Recruiting

Craniotomy

0 Actively Recruiting

Alopecia Areata

1 Actively Recruiting

Phase 1

Local Anaesthesia therapy

0 Actively Recruiting

Idiopathic Nephrotic Syndrome

0 Actively Recruiting

Ulcerative Colitis

14 Actively Recruiting

Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1

Adrenal Insufficiency

0 Actively Recruiting

induction of Local Anaesthesia

0 Actively Recruiting

Inflammation

0 Actively Recruiting

Open Abdominal Surgery

1 Actively Recruiting

Not Applicable

Multiple Sclerosis

0 Actively Recruiting

Inflammation

0 Actively Recruiting

Tuberculosis, Pulmonary

0 Actively Recruiting

Exparel Reviews: What are patients saying about Exparel?

1.7

Patient Review

10/7/2013

Exparel for Injection to cause Local Loss of Feeling or Numbness

I was very disappointed with this treatment. I had high hopes that it would reduce the pain from my surgery, but it did nothing. Save your money and don't bother with this drug.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about exparel

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long can EXPAREL last?

"The amount of time Exparel provides pain relief varies from 24 to 72 hours, depending on the type of surgery and the dose received."

Answered by AI

Is EXPAREL a nerve block?

"Exparel is a pain reliever that is used as a nerve block for shoulder surgery. It lasts for 48 to 72 hours."

Answered by AI

What happens when EXPAREL wears off?

"The pain medication, EXPAREL, slowly wears off after a few days. This may cause patients to start to experience pain at the surgical site."

Answered by AI

How long does EXPAREL block last?

"Exparel has been shown to provide pain relief for 24 to 72 hours in clinical studies, but this will vary depending on the type of surgery you have and the dose you receive."

Answered by AI

What is the drug EXPAREL used for?

"This means that it takes effect right where you need it and not throughout your body.

Exparel is a medication that is used to control pain after surgery. It is placed into the surgical area by the doctor and works by affecting the area where the surgery was done as opposed to the whole body like opioids would."

Answered by AI