Exforge

Nephrotic Syndrome, Ascites, Edema + 23 more
Treatment
30 FDA approvals
20 Active Studies for Exforge

What is Exforge

HydrochlorothiazideThe Generic name of this drug
Treatment SummaryAmlodipine is a medication used to treat high blood pressure and chest pain (angina). It belongs to a class of drugs called dihydropyridine calcium channel blockers which are known to have fewer side effects than other types of blood pressure medications. Amlodipine works by widening your blood vessels, reducing the pressure in your blood vessels, and increasing the production of a compound called nitric oxide which helps to lower blood pressure. This medication was first approved by the FDA in 1987 and can be taken once daily.
Esidrixis the brand name
image of different drug pills on a surface
Exforge Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Esidrix
Hydrochlorothiazide
1959
2181

Approved as Treatment by the FDA

Hydrochlorothiazide, also called Esidrix, is approved by the FDA for 30 uses including Stroke and prophylaxis of preeclampsia .
Stroke
Used to treat Cerebrovascular Accident in combination with Losartan
prophylaxis of preeclampsia
Helps manage prophylaxis of preeclampsia
calcium channel blockers
Used to treat calcium channel blockers in combination with Eprosartan
Cirrhosis of the Liver
Used to treat Cirrhosis of the Liver in combination with Spironolactone
Diuretics
Used to treat Hypokalemia caused by diuretics in combination with Amiloride
Hypertension
Used to treat inadequate control of blood pressure with monotherapy in combination with Aliskiren
Congestive Heart Failure
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
Hypertensive disease
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
Antepartum magnesium sulfate prophylaxis
Helps manage prophylaxis of preeclampsia
Hypertrophy, Left Ventricular
Used to treat Left Ventricular Hypertrophy in combination with Losartan
Edema
Used to treat Edema in combination with Triamterene
Left Ventricular Hypertrophy
Used to treat Left Ventricular Hypertrophy in combination with Losartan
inadequate response to other therapeutic measures
Used to treat inadequate response to other therapeutic measures in combination with Spironolactone
Swollen feet or ankles
Used to treat Edema in combination with Triamterene
Congestive Heart Failure (CHF)
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
Hypertension
Used to treat Antihypertensive Treatment in combination with Eprosartan
Nephrotic Syndrome
Used to treat Nephrotic Syndrome in combination with Spironolactone
Hypokalemia
Used to treat hypokalemia with solo treatment in combination with Triamterene
Ascites
Used to treat Ascites in combination with Spironolactone
Premenstrual tension with edema
Helps manage Premenstrual tension with edema
Hypertension, Essential Hypertension
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
Hypertension
Used to treat blood pressure inadequately controlled with monotherapy in combination with Irbesartan
Therapeutic procedure
Used to treat inadequate response to treatment in combination with Spironolactone
Ascites
Used to treat Ascites in combination with Spironolactone
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Losartan
Sodium retention
Used to treat Sodium retention in combination with Spironolactone
Bedrest
Used to treat Bedrest in combination with Spironolactone
Cirrhosis
Used to treat Cirrhosis of the Liver in combination with Spironolactone
restriction of fluid and sodium
Used to treat restriction of fluid and sodium in combination with Spironolactone
Edema
Helps manage Premenstrual tension with edema

Effectiveness

How Exforge Affects PatientsAmlodipine is a drug that attaches to certain cell membranes and slows down the flow of calcium into the cells, resulting in lower blood pressure. Taking amlodipine once a day can maintain the effect for up to 24 hours. It does not usually change heart rate or how electrical signals move through the heart. Amlodipine can help relieve chest pain associated with angina by increasing exercise time, decreasing angina attack frequency, and reducing the need for nitroglycerin tablets.
How Exforge works in the bodyAmlodipine is a drug that helps to lower blood pressure by relaxing blood vessels and allowing blood to flow more easily. It does this by blocking calcium from entering the cells in both the heart and the blood vessels. This blockage leads to a decrease in tension and pressure, allowing for easier circulation and a reduction in blood pressure. In addition, Amlodipine helps to reduce angina symptoms by reducing the amount of energy and oxygen needed by the heart, as well as by widening the main coronary arteries and coronary arterioles. This increases oxygen delivery to the heart, reducing pain and discomfort.

When to interrupt dosage

The preferred dosage of Exforge is contingent upon the diagnosed condition, such as inadequate response to diet, High Cardiovascular Risk and Lifestyle Modification. The measure of dosage can be found in the table below, relative to the method of delivery (e.g. Tablet, film coated or Tablet).
Condition
Dosage
Administration
Edema
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Sodium retention
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Swollen feet or ankles
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antepartum magnesium sulfate prophylaxis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diabetes Insipidus
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Cirrhosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Congestive Heart Failure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Renal tubular acidosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
restriction of fluid and sodium
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertension
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertension
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertrophy, Left Ventricular
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
calcium channel blockers
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Therapeutic procedure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diuretics
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypokalemia
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertension
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
prophylaxis of calcium nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Exforge has one contraindication and should not be incorporated with the conditions presented in the following table.Exforge Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
There are 20 known major drug interactions with Exforge.
Common Exforge Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Hydrochlorothiazide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dofetilide.
Fenofibrate
Major
The therapeutic efficacy of Fenofibrate can be decreased when used in combination with Hydrochlorothiazide.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Hydroxyzine.
Exforge Toxicity & Overdose RiskThe toxic dose of amlodipine in mice is 37mg/kg. An overdose can cause an extreme widening of the blood vessels and a rapid heartbeat. Studies on rats and mice have not found any links to cancer, gene or chromosome damage, or infertility. It is not known if amlodipine is safe for pregnant or breastfeeding women, so use of the drug should be carefully considered. Nursing mothers should stop taking amlodipine before nursing.
image of a doctor in a lab doing drug, clinical research

Exforge Novel Uses: Which Conditions Have a Clinical Trial Featuring Exforge?

46 active clinical trials are currently evaluating the efficacy of Exforge in decreasing High Cardiovascular Risk, alleviating Vasospastic Angina and ameliorating Coronary Artery Disease (CAD).
Condition
Clinical Trials
Trial Phases
Ascites
2 Actively Recruiting
Not Applicable, Phase 2
Antepartum magnesium sulfate prophylaxis
20 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1, Phase 2, Phase 1
Swollen feet or ankles
5 Actively Recruiting
Phase 2, Not Applicable, Phase 4
Congestive Heart Failure
11 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Hypertensive disease
27 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Cirrhosis
52 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4, Early Phase 1
Diuretics
0 Actively Recruiting
restriction of fluid and sodium
0 Actively Recruiting
prophylaxis of calcium nephrolithiasis
0 Actively Recruiting
inadequate response to other therapeutic measures
0 Actively Recruiting
Sodium retention
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Hypertension
0 Actively Recruiting
Hypertrophy, Left Ventricular
0 Actively Recruiting
Nephrotic Syndrome
5 Actively Recruiting
Phase 2, Not Applicable, Phase 3
calcium channel blockers
0 Actively Recruiting
Hypokalemia
0 Actively Recruiting
Hypertension
0 Actively Recruiting
Hypertension
0 Actively Recruiting
Bedrest
0 Actively Recruiting

Exforge Reviews: What are patients saying about Exforge?

5Patient Review
8/14/2014
Exforge for High Blood Pressure
Exforge is an excellent medication, but it can be quite expensive.
5Patient Review
12/20/2018
Exforge for High Blood Pressure
I've been taking Exforge for ten years now, and it's never given me any problems. My blood pressure has always stayed at a healthy level since I started taking the medication.
5Patient Review
11/26/2013
Exforge for High Blood Pressure
4.3Patient Review
5/13/2014
Exforge for High Blood Pressure
I've been taking this medication for four years to help with my blood pressure. While it is effective for that, I have found that it also causes me to feel dizzy and experience muscle cramps on a daily basis.
4.3Patient Review
2/18/2014
Exforge for High Blood Pressure
I took this drug for two years to help control my blood pressure, but stopped because the pills were too large and started causing me to lose hair.
4Patient Review
2/6/2022
Exforge for High Blood Pressure
Helped me lower my blood pressure. I have a problem with swelling in my legs and ankles if I sit for too long, but this has alleviated that issue.
3.7Patient Review
5/6/2014
Exforge for High Blood Pressure
Exforge caused some dangerous side effects for me, including but not limited to irregular heartbeats, fast heartbeat, and swollen extremities. I had to stop using it after a month, and even now (over a month later) I'm still dealing with the permanent swelling. This drug needs to be more heavily regulated.
3.7Patient Review
6/30/2015
Exforge for High Blood Pressure
I'm feeling better, though there are some side effects like dizziness and swelling. The wheatgrass powder has been helping a lot too.
3.7Patient Review
5/20/2014
Exforge for High Blood Pressure
While this medication was wonderful in bringing down my blood pressure, the side effects were not worth it. I struggled to breathe normally, and my feet and ankles became so swollen that there was a rash-like redness on both of my legs.
3Patient Review
4/8/2014
Exforge for High Blood Pressure
While this medication has helped to lower my blood pressure, I have noticed some negative side effects, such as increased hair loss and swelling in my ankles.
2.7Patient Review
9/15/2014
Exforge for High Blood Pressure
I generally feel weak and sick to my stomach after taking this medication. Additionally, I often have sudden episodes of energy draining from my body at night when I am just lying in bed. When the daily dose wears off, my blood pressure is even higher than before!
2.7Patient Review
3/28/2014
Exforge for High Blood Pressure
I started having muscular soreness in my upper arms, as well as nausea and vomiting.
2.3Patient Review
1/8/2014
Exforge for High Blood Pressure
Afternoon headaches; expensive medication.
2.3Patient Review
3/3/2014
Exforge for High Blood Pressure
Blurred vision and swollen extremities were some of the side effects I experienced. My blood pressure did improve somewhat, but it was still pretty unstable.
2Patient Review
2/17/2014
Exforge for High Blood Pressure
Though this drug is expensive, I found it didn't help with my cramps at all. In fact, the first night I took it I had such extreme cramps that I couldn't move in bed. Additionally, I experienced daily headaches, dizziness, confusion, and disorientation.
1.7Patient Review
11/20/2013
Exforge for High Blood Pressure
1.7Patient Review
10/14/2014
Exforge for High Blood Pressure
I had to stop taking this medication after only two weeks due to the severe dizziness and swollen feet it caused me. Unfortunately, my feet still have not returned to normal.
1.3Patient Review
11/20/2013
Exforge for High Blood Pressure
1Patient Review
4/3/2014
Exforge for High Blood Pressure
I found that I was actually healthier when I stopped taking FORGE. I experienced side effects like a racing heartbeat, itchiness all over my body, and dizziness/collapse/passing out feelings. My blood pressure is normal without medication now. If my systolic moves up, I will take Metoprolol 12.5mg daily; which is also effective for my lifelong infrequent daily skipping heartbeats.
1Patient Review
1/28/2019
Exforge for High Blood Pressure
I was prescribed this medication yesterday, but after reading all of the reviews online, I'm terrified to take it. The side effects people have experienced sound absolutely awful. Has anyone had any success with this medication? Or do the side effects continue even after taking it for a while?
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about exforge

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Exforge good for kidney?

"Exforge is designed to be gentle on the kidneys, but in some cases it may have the opposite effect. Therefore, regular checkups are important to monitor kidney function before and during treatment."

Answered by AI

What are the side effects of Exforge?

"You may experience dizziness, headaches, or fatigue along with nausea and an upset stomach. A stuffy nose, sinus pain, or sore throat are also common. You may also experience back pain or muscle spasms. Finally, you may notice swelling in your hands, ankles, or feet."

Answered by AI

Is Exforge safe to take?

"Exforge may rarely cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. If you have unexplained muscle pain, tenderness, or weakness, especially if you also have a fever, unusual tiredness, and dark colored urine, call your doctor right away."

Answered by AI

What is the medication Exforge used for?

"This product is used to lower high blood pressure, which can prevent strokes, heart attacks, and kidney problems. It contains two medications, amlodipine and valsartan, which both work by relaxing blood vessels to allow blood to flow more easily."

Answered by AI

Clinical Trials for Exforge

Image of Cedars-Sinai Medical Center in Los Angeles, United States.

AI-Enabled Identification for Fatty Liver Disease

18+
All Sexes
Los Angeles, CA
The goal of this prospective, multicenter, open-label, blinded end-point pragmatic study is to evaluate an artificial intelligence (AI)-augmented echocardiography screening approach for early detection of metabolic dysfunction associated steatotic liver disease (MASLD) and/or cirrhosis, in patients undergoing routine transthoracic echocardiograms (TTEs). The main question it aims to answer is to: 1. Evaluate notification responsiveness and rates of confirmatory testing for patients identified as high risk for having liver disease to determine whether optimized notifications increase timely confirmatory testing and treatment initiation versus standard of care assessment. 2. Compare time to diagnosis, treatment uptake, and clinical outcomes (hospitalizations, incident ASCVD, mortality) between cohorts identified as high risk by the AI algorithm and comparison groups to determine whether AI guided screening shortens time to diagnosis and increases appropriate treatment.
Waitlist Available
Has No Placebo
Cedars-Sinai Medical Center (+3 Sites)
Have you considered Exforge clinical trials? We made a collection of clinical trials featuring Exforge, we think they might fit your search criteria.Go to Trials
Image of University of Alabama at Birmingham in Birmingham, United States.

Dietary Interventions for Hypertension

18+
All Sexes
Birmingham, AL
Natriuretic peptides (NPs) are hormones produced by the heart and play an important role in maintaining cardiovascular health and have favorable metabolic benefits. Low NP levels are associated with an increased likelihood of the development of cardiometabolic diseases like diabetes and hypertension. NP levels are known to be highly heritable, with up to half of the differences in NP levels being explained by genetics. The investigators aim to describe the genetic architecture of NPs by examining the genetic variants associated with NPs, and generate and validate a polygenic score (PGS) for NPs. The investigators will use this NP PGS to examine the association of genetically determined NP levels with cardiometabolic and cardiovascular outcomes. The investigators will conduct a genotype-guided physiological clinical trial that aims to assess the genetic factors affecting NP levels and their impact on blood pressure and NP response to saline infusion, high-salt diet, and low-salt diet. These findings will help support personal medicine approaches to lower the increasing burden of hypertension in the United States.
Waitlist Available
Has No Placebo
University of Alabama at BirminghamPankaj Arora, MD, FAHA
Image of Brooks Rehabilitation Clinical Research Center in Jacksonville, United States.

Q Therapeutic System for Stroke

18 - 80
All Sexes
Jacksonville, FL
This trial tests a promising new intervention to promote post-stroke neural reorganization and functional recovery. The Q Therapeutic (BQ 3.0) is a wearable medical system that produces and delivers non-invasive, extremely-low-intensity and low-frequency, frequency-tuned electromagnetic fields in order to stimulate neuronal networks with the aim of reducing disability and promoting neurorecovery. This trial is a prospective, single-arm, open-label, single center clinical trial designed to evaluate the safety, feasibility, and efficacy of the Q Therapeutic (BQ 3.0) System in the rehabilitation of people with chronic stroke.
Recruiting
Has No Placebo
Brooks Rehabilitation Clinical Research CenterEmily Fox, PT, DPT, MHS, PhDBrainQ Technologies Ltd.
Have you considered Exforge clinical trials? We made a collection of clinical trials featuring Exforge, we think they might fit your search criteria.Go to Trials
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Metabolic Surgery and TIPS for Liver Cirrhosis

18 - 70
All Sexes
Cleveland, OH
Cirrhosis is a form of advanced liver disease that can lead to serious complications, especially when combined with severe obesity. Many patients with cirrhosis also develop a condition called clinically significant portal hypertension (CSPH), which is increased pressure in the veins of the liver. CSPH raises the risk of life-threatening events like internal bleeding and liver failure. Unfortunately, treatment options for people who have both cirrhosis and severe obesity are very limited, especially when portal hypertension is present. This study, called the OPTIMAL Trial, is a randomized clinical trial designed to evaluate whether combining two procedures improves health outcomes in this high-risk population. The first procedure, called TIPS (Transjugular Intrahepatic Portosystemic Shunt), is a minimally invasive treatment that reduces pressure in the liver by creating a pathway for blood to flow more easily. The second procedure is sleeve gastrectomy, a form of metabolic (bariatric) surgery that helps patients lose weight and improve related conditions like diabetes. The study will compare two groups: 1. One group will receive TIPS followed by sleeve gastrectomy (TIPS+SG). 2. The other group will receive medical weight management (standard non-surgical care, including diet, lifestyle changes, and weight loss medications). All participants will have severe obesity and cirrhosis with CSPH but will not have decompensated liver disease (such as large amounts of fluid in the abdomen, a history of variceal bleeding, or recent liver failure). Eligible participants will be randomly assigned to one of the two groups. The main goal of the study is to determine whether the combination of TIPS + SG improves quality of life and leads to greater weight loss compared to medical therapy alone. The study will also monitor for any complications from either the procedures or the medical treatment. Participants will be followed for 6 months after their treatment starts, with periodic assessments of their physical health, liver function, and overall well-being. Some participants may also be followed for a longer period to assess long-term outcomes. This study hopes to provide high-quality evidence for a novel, stepwise treatment strategy that may help people with obesity and liver disease live longer, healthier lives. If successful, it could change how advanced liver disease and obesity are managed together, especially in patients who currently have few safe and effective options. All study care is provided at Cleveland Clinic, Cleveland, Ohio, USA.
Phase 4
Recruiting
Cleveland Clinic Main CampusSobia Laique, MD
Image of NewYork-Presbyterian/Weill Cornell Medical Center in New York, United States.

Melatonin for Liver Cirrhosis

18+
All Sexes
New York, NY
The goal of this clinical trial is to learn the affect of melatonin on sleep, cognitive function, and quality of life (QoL) in patients with cirrhosis and a complication called hepatic encephalopathy (HE). The main questions this study aims to answer are: * Does taking melatonin increase REM sleep, an important part of healthy sleep that is reduced in cirrhosis? * Does taking melatonin improve cognitive function and reported QoL? This is a pilot study, where participants will: * take one month of melatonin, followed by one month of thiamine, which is another supplement but is not suspected to impact sleep significantly. * Undergo cognitive testing and take surveys * Wear a commercial wearable sleep tracker * Have a formal sleep study and salivary melatonin collection at the end of taking each supplement at our sleep center Participants will be blinded, and neither they nor the researchers will know which supplement they are taking first and which they are taking second. They will also be randomized, with half starting with melatonin and the other half starting with thiamine.
Recruiting
Has No Placebo
NewYork-Presbyterian/Weill Cornell Medical CenterAdam Buckholz, MD MS
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Spironolactone for Hypertension

18+
Female
Boston, MA
The hypertensive disorders of pregnancy (preeclampsia and gestational hypertension) are associated with increased long-term maternal risk of developing cardiovascular disease. Recent evidence suggests that activation of the mineralocorticoid receptor promotes ongoing susceptibility to hypertension in women following hypertensive disorders of pregnancy. In addition, women with overweight/obesity are at increased risk for progression to chronic hypertension after experiencing hypertensive disorders of pregnancy. Among women with hypertensive disorders of pregnancy and pre-pregnancy overweight/obesity, the investigators will conduct a randomized trial to test the effect of pharmacologically blocking the mineralocorticoid receptor for three months after delivery on blood pressure and cardiac remodeling at nine months postpartum.
Phase 2
Recruiting
Massachusetts General Hospital (+2 Sites)
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