Estrostep Fe

Endometriosis, Low Testosterone, Osteoporosis + 16 more
Treatment
20 Active Studies for Estrostep Fe

What is Estrostep Fe

NorethisteroneThe Generic name of this drug
Treatment SummaryNorethisterone, also known as norethindrone, is a synthetic hormone used to imitate the effects of progesterone in the body. It is classified as a second-generation progestin and is used as contraception, hormone replacement therapy, and to treat irregular menstrual cycles and endometriosis. Norethisterone was first produced in 1951 and was first used as an oral contraceptive in 1962.
Neconis the brand name
image of different drug pills on a surface
Estrostep Fe Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Necon
Norethisterone
1967
347

Effectiveness

How Estrostep Fe Affects PatientsNorethisterone is a medication taken by mouth that is used as a form of birth control or to treat other hormone-related issues such as menopause or endometriosis. It is a strong version of the hormone progesterone and works to change the cervix and uterus, and also blocks other hormones involved in ovulation. Taking norethisterone may slightly increase the risk of getting breast cancer, so patients should be aware of this and perform regular self-examinations for any lumps.
How Estrostep Fe works in the bodyNorethisterone works by binding to progesterone receptors on target cells. This creates a chain reaction that affects genes in the reproductive tract, breast, pituitary, hypothalamus, and central nervous system. As a contraceptive, norethisterone makes the cervical mucus thicker and more difficult for sperm to pass through. It also changes the endometrium, making it less hospitable for implantation. Norethisterone also works on the hypothalamus and anterior pituitary to prevent the release of FSH and LH which stops follicular development, ovulation, and corpus luteum development. When used

When to interrupt dosage

The recommended dosage of Estrostep Fe is reliant upon the diagnosed condition, such as Atrophic, Fracture and Hormone Replacement Therapy. The quantity of dosage is variable, in accordance with the method of delivery (e.g. Oral or Tablet) outlined in the following table.
Condition
Dosage
Administration
Hormone Replacement Therapy
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Atrophic
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Hot flashes
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
female castration
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Low Testosterone
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
hypoestrogenism
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Therapeutic procedure
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Fracture
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Ovarian Failure
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Postmenopausal Osteoporosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Vasomotor System
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Oral Contraceptives
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Hormonal Contraception
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Estrogen Deprivation Symptoms
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Menopause
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Endometriosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Birth Control
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Osteoporosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Endometriosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Warnings

Estrostep Fe has eight counterindications. It should not be taken in combination with any of the conditions given in the subsequent table.Estrostep Fe Contraindications
Condition
Risk Level
Notes
active liver disease
Do Not Combine
Thrombophilia
Do Not Combine
Vaginal Hemorrhage
Do Not Combine
Malignant Neoplasms
Do Not Combine
Benign hepatic neoplasm
Do Not Combine
Breast Cancer
Do Not Combine
Thromboembolism
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Norethisterone may interact with Pulse Frequency
There are 20 known major drug interactions with Estrostep Fe.
Common Estrostep Fe Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Norethisterone.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Norethisterone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Norethisterone.
Clomipramine
Major
The metabolism of Clomipramine can be increased when combined with Norethisterone.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Norethisterone.
Estrostep Fe Toxicity & Overdose RiskThe most toxic dose of oral contraceptives in mice has been found to be 6g/kg and in women is 42mg/kg. There have been no serious reports of effects from taking too many oral contraceptives, even in small children. Symptoms of overdosing may include nausea and vomiting.
image of a doctor in a lab doing drug, clinical research

Estrostep Fe Novel Uses: Which Conditions Have a Clinical Trial Featuring Estrostep Fe?

Currently, 160 active clinical trials are in progress to assess the potential of Estrostep Fe to treat Birth Control, Atrophic Uterine Conditions and Low Testosterone Levels.
Condition
Clinical Trials
Trial Phases
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Menopause
0 Actively Recruiting
Endometriosis
28 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 2, Phase 4, Phase 1
Estrogen Deprivation Symptoms
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Hormone Replacement Therapy
0 Actively Recruiting
Osteoporosis
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4, Phase 3
Postmenopausal Osteoporosis
3 Actively Recruiting
Not Applicable, Phase 4
Birth Control
32 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Early Phase 1
Low Testosterone
14 Actively Recruiting
Phase 1, Phase 4, Phase 2, Not Applicable
Oral Contraceptives
2 Actively Recruiting
Not Applicable
Atrophic
5 Actively Recruiting
Phase 2, Phase 4, Not Applicable
Fracture
0 Actively Recruiting
female castration
0 Actively Recruiting
hypoestrogenism
2 Actively Recruiting
Phase 4
Vasomotor System
0 Actively Recruiting
Endometriosis
1 Actively Recruiting
Phase 4
Ovarian Failure
2 Actively Recruiting
Not Applicable, Phase 1
Hormonal Contraception
0 Actively Recruiting

Estrostep Fe Reviews: What are patients saying about Estrostep Fe?

5Patient Review
7/24/2009
Estrostep Fe for Acne
Out of the five different birth control pills I've tried, this one has been by far the best. Not only did it not give me mood swings or decrease my sex drive, but my breasts were also fuller and perkier while I was on this pill.
5Patient Review
3/5/2015
Estrostep Fe for Birth Control
I've been using this pill for 18 years now and it's really the only one that works for me. I've never had any issues with my cycles, acne, weight gain, mood, or pregnancy scares while on it.
5Patient Review
9/13/2016
Estrostep Fe for Birth Control
I've been taking this medication for about a decade now. I'm very pleased with it; though, like all birth control pills, it does lead to a slight reduction in libido. Additionally, the first month or so after starting the pill is always tough for me emotionally; however, my mood is much more stable once I get acclimated to the medication (and pre-menstrual mood swings are no longer an issue). My periods are also very light and painless now.
5Patient Review
6/18/2011
Estrostep Fe for Birth Control
This treatment has been great for keeping my acne under control and preventing pregnancy; however, I have experienced extreme pain all over my body for the entire time I've been on it. I'm actually considering quitting this birth control because the pain is too much to bear, and it comes on very suddenly. It also brought my period on two weeks before it was supposed to, even though it kept me on a great and organized period schedule.
5Patient Review
12/5/2010
Estrostep Fe for Birth Control
I experienced nausea and weight gain for the first few months, but it was worth it because this treatment has been effective. However, you do have to spend more money on pregnancy tests!
5Patient Review
7/21/2008
Estrostep Fe for Birth Control
This acne treatment has been great for my skin, and I no longer have to deal with cramps or nausea during my period.
5Patient Review
11/25/2007
Estrostep Fe for Birth Control
5Patient Review
12/5/2007
Estrostep Fe for Disease of Ovaries with Cysts
5Patient Review
2/12/2008
Estrostep Fe for Birth Control
5Patient Review
4/9/2008
Estrostep Fe for Birth Control
5Patient Review
7/9/2008
Estrostep Fe for Birth Control
5Patient Review
12/17/2009
Estrostep Fe for Birth Control
I've been on a lot of different birth control pills, and this one was by far the worst. It had a lot of unpleasant side effects and it wasn't very good at regulating my heavy periods.
4.7Patient Review
6/24/2008
Estrostep Fe for Birth Control
4.7Patient Review
10/5/2008
Estrostep Fe for Birth Control
This medication has been great for me. I get a few small pimples before my period, but it's nothing compared to the acne I used to have. My periods are also much lighter now, which is fantastic.
4Patient Review
8/6/2010
Estrostep Fe for Birth Control
I was hesitant to take this medication because I had migraines with previous birth control, but I didn't experience any headaches!
3.3Patient Review
4/24/2013
Estrostep Fe for Birth Control
I'm on the fence about this pill; I love that it didn't affect my sex drive, mood, or weight. However, I started getting more acne from taking this medication-- which is supposed to help with acne! In addition, I had my period for two weeks the first month ( mostly spotting). I don't know if I'll stay on this pill because of the increase in acne.
2.3Patient Review
11/25/2009
Estrostep Fe for Abnormally Long or Heavy Periods
I initially loved this birth control for its ability to regulate my periods and clear up acne. However, after switching to a stronger pill at the recommendation of my doctor, I found that my periods became very painful and difficult to manage. I would much prefer to switch back to this pill.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about estrostep fe

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of Estrostep Fe?

"Nausea, vomiting, headache, bloating, breast tenderness, swelling of the ankles/feet (fluid retention), or weight change may occur. Vaginal bleeding between periods (spotting) or missed/irregular periods may occur, especially during the first few months of use."

Answered by AI

Is estrostep good for acne?

"Estrostep is a medication that contains norethindrone and ethinyl estradiol, which work to lower testosterone levels. It is considered the least effective of the three options for treating acne."

Answered by AI

Is Estrostep Fe discontinued?

"The therapeutic regimen for ESTROSTEP 21 and ESTROSTEP FE is the same, with the exception of the nontherapeutic ferrous fumarate tablets. ESTROSTEP 21 is no longer marketed, while ESTROSTEP FE (now simply known as ESTROSTEP) is still available."

Answered by AI

Does estrostep cause weight gain?

"Does the birth control pill Estrostep Fe cause weight gain? Some women report increased appetite and moderate weight gain (around 10 pounds over the course of a year) while taking Estrostep Fe."

Answered by AI

Clinical Trials for Estrostep Fe

Have you considered Estrostep Fe clinical trials? We made a collection of clinical trials featuring Estrostep Fe, we think they might fit your search criteria.
Have you considered Estrostep Fe clinical trials? We made a collection of clinical trials featuring Estrostep Fe, we think they might fit your search criteria.
Have you considered Estrostep Fe clinical trials? We made a collection of clinical trials featuring Estrostep Fe, we think they might fit your search criteria.