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What is Estrogel
ProgesteroneThe Generic name of this drug
Treatment SummaryEstradiol is a natural female hormone used in hormone therapy to treat conditions caused by low estrogen, such as hot flashes and vaginal dryness. It is available in several forms, including tablets, injections, patches, gels, and creams. When taken orally or by injection, estradiol is usually combined with an ester side-chain to increase its bioavailability. Ethinyl estradiol is a synthetic form of estradiol commonly used in combination birth control pills because it has a higher bioavailability than estradiol and is less likely to be broken down by the body.
Progesteroneis the brand name
Estrogel Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Progesterone
Progesterone
1978
124
Effectiveness
How Estrogel Affects PatientsEstradiol works on estrogen receptors in the body to help with hot flashes, and vaginal dryness or pain during sex. It can also improve bone density and affect the levels of certain proteins in the body. However, it can increase the risk of cardiovascular disease, blood clotting, stroke, and high blood pressure. Estrogen increases the amount of sodium in the body, which may be responsible for the rise in blood pressure seen in people taking estrogen-based birth control.
How Estrogel works in the bodyEstrogen is a hormone found in the body of both men and women. In adult women, the main source of estrogen is the ovarian follicle, which produces 70-500mcg of estradiol per day. After menopause, most estrogen comes from androstenedione, which is produced by the adrenal cortex. Estradiol is more potent than other forms of estrogen, so an excess of it can cause unpleasant symptoms like hot flashes, chills, and mood swings.
Estradiol works by binding to two types of estrogen receptors, ERα and ERβ, as well as
When to interrupt dosage
The quantity of Estrogel is contingent upon the diagnosed condition, including Premature Menopause, Pharmaceutical Preparations and Postmenopause. The measure of dosage fluctuates as per the technique of delivery featured in the table beneath.Condition
Dosage
Administration
Reproductive Technology
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
Amenorrhea
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
Hysterectomy
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
Hot flashes
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
Secondary Amenorrhea
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
hormonal imbalance
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
Endometrial hyperplasia caused by conjugated estrogen
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
prophylaxis of recurrent spontaneous preterm birth
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
recurrent spontaneous preterm birth
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
Postmenopause
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
Vasomotor System
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
Uterine hemorrhage
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Intramuscular, , Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Oral, Capsule, Capsule - Oral, Gel - Vaginal, Gel, Vaginal, Insert, Insert - Vaginal, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Topical, Cream - Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered, Capsule; Spray, metered - Oral; Transdermal, Solution - Subcutaneous, Subcutaneous, Cream - Transdermal, Transdermal
Warnings
Estrogel ContraindicationsCondition
Risk Level
Notes
liver dysfunction or disease
Do Not Combine
Thromboembolism
Do Not Combine
suspected pregnancy
Do Not Combine
Pulmonary Embolism
Do Not Combine
Stroke
Do Not Combine
Cerebrovascular accident
Do Not Combine
active thrombophlebitis
Do Not Combine
Breast
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Pulmonary Embolism
Do Not Combine
Pulmonary Embolism
Do Not Combine
Breast Cancer
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Breast
Do Not Combine
Breast
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
suspected pregnancy
Do Not Combine
Thromboembolism
Do Not Combine
Malignant Neoplasms
Do Not Combine
Stroke
Do Not Combine
undiagnosed vaginal bleeding
Do Not Combine
Missed Abortion
Do Not Combine
history of deep venous thrombosis
Do Not Combine
Thrombophlebitis
Do Not Combine
cerebral apoplexy
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Progesterone may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Progesterone may interact with Pulse Frequency
Common Estrogel Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Progesterone.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Progesterone.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Progesterone.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Progesterone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Progesterone.
Estrogel Toxicity & Overdose RiskThe highest safe dose of estradiol for a rat after ninety days is 0.003mg/kg/day, with a toxic dose of 21mg/kg/21D for women. An overdose of estradiol may cause nausea, vomiting, abdominal pain, breast tenderness, blood clots, and vaginal bleeding. It is advised to discontinue estradiol treatment and provide supportive care if an overdose occurs.
Estrogel Novel Uses: Which Conditions Have a Clinical Trial Featuring Estrogel?
867 active studies are being conducted to assess Estrogel's potential to treat Osteoporosis, Amenorrhea of 6 Months Duration and Urogenital Atrophy.Condition
Clinical Trials
Trial Phases
Amenorrhea
3 Actively Recruiting
Not Applicable, Phase 1
Reproductive Technology
0 Actively Recruiting
prophylaxis of recurrent spontaneous preterm birth
0 Actively Recruiting
Secondary Amenorrhea
0 Actively Recruiting
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
recurrent spontaneous preterm birth
0 Actively Recruiting
Hysterectomy
3 Actively Recruiting
Not Applicable, Phase 4, Phase 3
Endometrial hyperplasia caused by conjugated estrogen
0 Actively Recruiting
hormonal imbalance
0 Actively Recruiting
Vasomotor System
0 Actively Recruiting
Postmenopause
5 Actively Recruiting
Phase 2, Not Applicable
Uterine hemorrhage
3 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Estrogel Reviews: What are patients saying about Estrogel?
5Patient Review
6/11/2022 I had been using this product for years and it really helped me until my last refill. I received a different looking bottle and the pharmacist said it was the same product, just with a new look. But after using it for two weeks, all of my old symptoms came back. I went back to the older design bottle and my symptoms disappeared. Something has definitely changed with the product or I received a bad batch.
5Patient Review
6/26/2008 I use this product sparingly, about half the recommended dose, and I've found it really effective in preventing vaginal dryness and hot flashes.
5Patient Review
9/11/2013 Estrogel has been working great for me! My hot flashes, vaginal dryness, and general moodiness have all improved a lot. The only downside is that I sometimes feel a slight itch on my arm after applying the gel, but it goes away within an hour.
4.3Patient Review
3/21/2016 This medication definitely controls hot flashes. I was averaging a lot of hot flashes per night, but now only have one. Additionally, I haven't experienced any negative side effects from the treatment.
4Patient Review
9/21/2007 Though this medication did alleviate my menopausal symptoms, I unfortunately developed a deep vein blood clot in my left calf. So while it is effective, the potential risks are too high for me to recommend it.
3Patient Review
10/12/2015 I gained 10lbs. in 6 weeks while using this, which is really concerning to me. I didn't change my diet or exercise routine, so the weight gain must be attributed to this treatment. Additionally, it did not help thicken my vaginal walls as much as I'd hoped (my main reason for taking it), so I'll be discontinuing use today.
3Patient Review
11/11/2021 I was getting great sleep with just one pump per day, but the brain fog and agitation were really bad so I stopped.
2.3Patient Review
10/25/2021 After using this treatment, I experienced pins and needles down my arms that went all the way to my hands. My hands also felt numb at night. Additionally, I felt like my heart was racing. So, I stopped using it.
2.3Patient Review
11/30/2008 I experienced an increased heart rate and higher blood pressure.
1.7Patient Review
3/5/2015 I found out that I needed more estrogen from this gel, but it doesn't last for 24 hours. This causes a roller coaster effect which is not ideal. I'm glad I don't have to use this on a regular basis.
1.3Patient Review
11/13/2014 This is a very low dose treatment of bioidentical estrogen. The pump contains 30 pumps per month which gives about 30 pg/ml in the bloodstream if you do 1 pump a day. In the UK the dosage is 2-4 pumps per day. Here in the USA, it is usually written for 1 pump on the arm once a day. Very expensive ($100 a container) and very weak. If you have only mild hot flashes this may be enough for you. I find that it does not last 24 hours.
1Patient Review
9/12/2011 Avoid synthetic estrogens; they're really unhealthy. You should look into plant-derived estrogens instead--they're much better for you.
Patient Q&A Section about estrogel
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Estrogel and estradiol the same?
"The active ingredient in Estrogel is estradiol (as hemihydrate). Estrogel contains 0.6 mg of estradiol per gram of gel (0.06% w/w)."
Answered by AI
How long does Estrogel gel take to work?
"Oestrogel is a medication designed to help relieve the symptoms of menopause caused by an estrogen deficiency. It typically takes up to three months for the medication to take full effect, though most women report noticing a difference sooner than that."
Answered by AI
What are the side effects of Estrogel?
"You may experience the following side effects while taking this medication: nausea, vomiting, stomach cramps, bloating, swelling, weight gain, breast pain or tenderness, headache, vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding, thinning scalp hair, or cold symptoms such as stuffy nose, sneezing, sore throat."
Answered by AI
What is Estrogel used for?
"This medication contains the female hormone estrogen. It is absorbed into the bloodstream through the skin. It is used to help reduce hot flashes, a symptom of menopause. Some brands of the medication may also help reduce vaginal symptoms of menopause, such as vaginal dryness, burning, or itching."
Answered by AI