Estrogel

Amenorrhea, hormonal imbalance, prophylaxis of recurrent spontaneous preterm birth + 9 more

Treatment

20 Active Studies for Estrogel

What is Estrogel

Progesterone

The Generic name of this drug

Treatment Summary

Estradiol is a natural female hormone used in hormone therapy to treat conditions caused by low estrogen, such as hot flashes and vaginal dryness. It is available in several forms, including tablets, injections, patches, gels, and creams. When taken orally or by injection, estradiol is usually combined with an ester side-chain to increase its bioavailability. Ethinyl estradiol is a synthetic form of estradiol commonly used in combination birth control pills because it has a higher bioavailability than estradiol and is less likely to be broken down by the body.

Progesterone

is the brand name

image of different drug pills on a surface

Estrogel Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Progesterone

Progesterone

1978

124

Effectiveness

How Estrogel Affects Patients

Estradiol works on estrogen receptors in the body to help with hot flashes, and vaginal dryness or pain during sex. It can also improve bone density and affect the levels of certain proteins in the body. However, it can increase the risk of cardiovascular disease, blood clotting, stroke, and high blood pressure. Estrogen increases the amount of sodium in the body, which may be responsible for the rise in blood pressure seen in people taking estrogen-based birth control.

How Estrogel works in the body

Estrogen is a hormone found in the body of both men and women. In adult women, the main source of estrogen is the ovarian follicle, which produces 70-500mcg of estradiol per day. After menopause, most estrogen comes from androstenedione, which is produced by the adrenal cortex. Estradiol is more potent than other forms of estrogen, so an excess of it can cause unpleasant symptoms like hot flashes, chills, and mood swings. Estradiol works by binding to two types of estrogen receptors, ERα and ERβ, as well as

When to interrupt dosage

The quantity of Estrogel is contingent upon the diagnosed condition, including Premature Menopause, Pharmaceutical Preparations and Postmenopause. The measure of dosage fluctuates as per the technique of delivery featured in the table beneath.

Condition

Dosage

Administration

recurrent spontaneous preterm birth

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Reproductive Technology

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Endometrial Hyperplasia

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Amenorrhea

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

hormonal imbalance

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Postmenopause

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Hysterectomy

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Amenorrhea

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Uterine hemorrhage

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Vasomotor System

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Hot flashes

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

prophylaxis of recurrent spontaneous preterm birth

50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg

Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal

Warnings

Estrogel Contraindications

Condition

Risk Level

Notes

Liver Diseases

Do Not Combine

Thromboembolism

Do Not Combine

suspected pregnancy

Do Not Combine

Pulmonary Embolism

Do Not Combine

Stroke

Do Not Combine

Cerebrovascular accident

Do Not Combine

Thrombophlebitis

Do Not Combine

Breast

Do Not Combine

Deep Vein Thrombosis

Do Not Combine

Pulmonary Embolism

Do Not Combine

Pulmonary Embolism

Do Not Combine

Breast Cancer

Do Not Combine

Deep Vein Thrombosis

Do Not Combine

Breast

Do Not Combine

Breast

Do Not Combine

undiagnosed abnormal genital bleeding

Do Not Combine

suspected pregnancy

Do Not Combine

Thromboembolism

Do Not Combine

Malignant Neoplasms

Do Not Combine

Stroke

Do Not Combine

undiagnosed vaginal bleeding

Do Not Combine

Abortion, Spontaneous

Do Not Combine

Venous Thrombosis

Do Not Combine

Thrombophlebitis

Do Not Combine

Stroke

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Progesterone may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Progesterone may interact with Pulse Frequency

There are 20 known major drug interactions with Estrogel.

Common Estrogel Drug Interactions

Drug Name

Risk Level

Description

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Progesterone.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Progesterone.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Progesterone.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Progesterone.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Progesterone.

Estrogel Toxicity & Overdose Risk

The highest safe dose of estradiol for a rat after ninety days is 0.003mg/kg/day, with a toxic dose of 21mg/kg/21D for women. An overdose of estradiol may cause nausea, vomiting, abdominal pain, breast tenderness, blood clots, and vaginal bleeding. It is advised to discontinue estradiol treatment and provide supportive care if an overdose occurs.

image of a doctor in a lab doing drug, clinical research

Estrogel Novel Uses: Which Conditions Have a Clinical Trial Featuring Estrogel?

867 active studies are being conducted to assess Estrogel's potential to treat Osteoporosis, Amenorrhea of 6 Months Duration and Urogenital Atrophy.

Condition

Clinical Trials

Trial Phases

Endometrial Hyperplasia

0 Actively Recruiting

Postmenopause

5 Actively Recruiting

Phase 2, Not Applicable

recurrent spontaneous preterm birth

0 Actively Recruiting

Uterine hemorrhage

0 Actively Recruiting

hormonal imbalance

0 Actively Recruiting

Vasomotor System

0 Actively Recruiting

Amenorrhea

0 Actively Recruiting

Hot flashes

19 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Early Phase 1, Phase 3

Reproductive Technology

2 Actively Recruiting

Not Applicable

Amenorrhea

0 Actively Recruiting

prophylaxis of recurrent spontaneous preterm birth

0 Actively Recruiting

Hysterectomy

3 Actively Recruiting

Phase 3, Not Applicable

Estrogel Reviews: What are patients saying about Estrogel?

5

Patient Review

6/11/2022

Estrogel for Low Estrogen After Operation to Remove Ovaries

I had been using this product for years and it really helped me until my last refill. I received a different looking bottle and the pharmacist said it was the same product, just with a new look. But after using it for two weeks, all of my old symptoms came back. I went back to the older design bottle and my symptoms disappeared. Something has definitely changed with the product or I received a bad batch.

5

Patient Review

6/26/2008

Estrogel for "Change of Life" Signs

I use this product sparingly, about half the recommended dose, and I've found it really effective in preventing vaginal dryness and hot flashes.

5

Patient Review

9/11/2013

Estrogel for "Change of Life" Signs

Estrogel has been working great for me! My hot flashes, vaginal dryness, and general moodiness have all improved a lot. The only downside is that I sometimes feel a slight itch on my arm after applying the gel, but it goes away within an hour.

4.3

Patient Review

3/21/2016

Estrogel for "Change of Life" Signs

This medication definitely controls hot flashes. I was averaging a lot of hot flashes per night, but now only have one. Additionally, I haven't experienced any negative side effects from the treatment.

4

Patient Review

9/21/2007

Estrogel for "Change of Life" Signs

Though this medication did alleviate my menopausal symptoms, I unfortunately developed a deep vein blood clot in my left calf. So while it is effective, the potential risks are too high for me to recommend it.

3

Patient Review

10/12/2015

Estrogel for Wasting of Tissues of the Vulva

I gained 10lbs. in 6 weeks while using this, which is really concerning to me. I didn't change my diet or exercise routine, so the weight gain must be attributed to this treatment. Additionally, it did not help thicken my vaginal walls as much as I'd hoped (my main reason for taking it), so I'll be discontinuing use today.

3

Patient Review

11/11/2021

Estrogel for "Change of Life" Signs

I was getting great sleep with just one pump per day, but the brain fog and agitation were really bad so I stopped.

2.3

Patient Review

10/25/2021

Estrogel for "Change of Life" Signs

After using this treatment, I experienced pins and needles down my arms that went all the way to my hands. My hands also felt numb at night. Additionally, I felt like my heart was racing. So, I stopped using it.

2.3

Patient Review

11/30/2008

Estrogel for Low Estrogen After Operation to Remove Ovaries

I experienced an increased heart rate and higher blood pressure.

1.7

Patient Review

3/5/2015

Estrogel for Low Estrogen After Operation to Remove Ovaries

I found out that I needed more estrogen from this gel, but it doesn't last for 24 hours. This causes a roller coaster effect which is not ideal. I'm glad I don't have to use this on a regular basis.

1.3

Patient Review

11/13/2014

Estrogel for "Change of Life" Signs

This is a very low dose treatment of bioidentical estrogen. The pump contains 30 pumps per month which gives about 30 pg/ml in the bloodstream if you do 1 pump a day. In the UK the dosage is 2-4 pumps per day. Here in the USA, it is usually written for 1 pump on the arm once a day. Very expensive ($100 a container) and very weak. If you have only mild hot flashes this may be enough for you. I find that it does not last 24 hours.

1

Patient Review

9/12/2011

Estrogel for "Change of Life" Signs

Avoid synthetic estrogens; they're really unhealthy. You should look into plant-derived estrogens instead--they're much better for you.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about estrogel

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Estrogel and estradiol the same?

"The active ingredient in Estrogel is estradiol (as hemihydrate). Estrogel contains 0.6 mg of estradiol per gram of gel (0.06% w/w)."

Answered by AI

How long does Estrogel gel take to work?

"Oestrogel is a medication designed to help relieve the symptoms of menopause caused by an estrogen deficiency. It typically takes up to three months for the medication to take full effect, though most women report noticing a difference sooner than that."

Answered by AI

What are the side effects of Estrogel?

"You may experience the following side effects while taking this medication: nausea, vomiting, stomach cramps, bloating, swelling, weight gain, breast pain or tenderness, headache, vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding, thinning scalp hair, or cold symptoms such as stuffy nose, sneezing, sore throat."

Answered by AI

What is Estrogel used for?

"This medication contains the female hormone estrogen. It is absorbed into the bloodstream through the skin. It is used to help reduce hot flashes, a symptom of menopause. Some brands of the medication may also help reduce vaginal symptoms of menopause, such as vaginal dryness, burning, or itching."

Answered by AI

Clinical Trials for Estrogel

Image of VA Greater Los Angeles Healthcare System, West Los Angeles, CA in West Los Angeles, United States.

EBQI Strategies for Women's Health

Any Age
All Sexes
West Los Angeles, CA

Women Veterans are the fastest growing segment of VA users, with most users in midlife. This dramatic growth has created challenges for VA to ensure that appropriate services are available to meet women Veterans' needs, and that they will want and be able to use those services. Furthermore, few VA improvement efforts have focused on women Veterans' health and health care in midlife. The EMPOWER QUERI 3.0 Program is a cluster randomized type 3 hybrid implementation-effectiveness trial testing two strategies designed to support implementation and sustainment of evidence-based practices for women Veterans in at least 18 VA facilities from 4 regions.

Waitlist Available
Has No Placebo

VA Greater Los Angeles Healthcare System, West Los Angeles, CA

Erin P Finley, PhD MPH

Image of Erevna Innovations Inc. in Montreal, Canada.

Sculptra + Restylane for Post-Menopausal Skin Concerns

40 - 65
Female
Montreal, Canada

The post-menopausal state is marked by a sharp decline in estrogen, leading to significant structural and functional changes in the skin, including collagen loss, dryness, thinning, and reduced elasticity. To address these concerns, aesthetic injectables products such as Sculptra® Aesthetic (poly-L-lactic-acid \[PLLA- SCA\]) and Restylane Skinboosters®\[HASBV\] (small-particle hyaluronic acid - SP-HA) can be used. PLLA-SCA stimulates collagen production via cellular activation (biostimulator), gradually improving dermal structure. HASBV enhances hydration, elasticity, and skin texture when injected under the skin. Considering that hydration and laxity represent the primary aesthetic concerns in this patient population. Targeted treatment with SP-HA (HASBV) to improve hydration and PLLA-SCA to address laxity have been shown to produce significant clinical outcomes by directly addressing these key dermal deficiencies. This approach forms the basis of the current study.

Phase 4
Recruiting

Erevna Innovations Inc.

Andreas Nikolis, MD, PhD

Image of Shady Grove Fertility Rockville in Rockville, United States.

ICSI vs IVF for Female Infertility

Any Age
Female
Rockville, MD

The goal of this clinical trial is to learn whether two different methods of helping eggs and sperm join-intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)-lead to better embryo development when using frozen donor sperm in people who do not have male fertility problems. The main questions it aims to answer are: Does one method create more usable embryos (blastocysts) than the other? Is there a difference in how often fertilization does not happen at all? Do either of the methods lead to better embryo quality or early pregnancy? Participants will: Have their eggs divided into two groups. One group will be fertilized using ICSI (where a sperm is injected directly into an egg), and the other using conventional IVF (where eggs are mixed with sperm in a dish). The fertilization method for each egg will be randomly assigned, with a random process also used to determine the assignment of any extra egg when an odd number is collected. Continue regular fertility treatment while the study team compares the results of each fertilization method. This study includes people with non-male factor infertility and uses frozen donor sperm. It hopes to learn whether ICSI, which is often used even when it may not be needed, truly helps improve outcomes compared to conventional IVF in these cases.

Recruiting
Has No Placebo

Shady Grove Fertility Rockville

Kate Devine, MD

Have you considered Estrogel clinical trials?

We made a collection of clinical trials featuring Estrogel, we think they might fit your search criteria.
Go to Trials

Have you considered Estrogel clinical trials?

We made a collection of clinical trials featuring Estrogel, we think they might fit your search criteria.
Go to Trials
Image of Don tyson Center for Agricultural Sciencers in Fayetteville, United States.

Protein and Exercise for Postmenopausal Women

Any Age
Female
Fayetteville, AR

The goal of this clinical trial is to learn if consuming a higher protein diet that includes one serving of beef each day, in combination with resistance exercise, improves wellbeing in postmenopausal women. It will also tell us about how higher protein intake changes body composition and blood values related to health. The main questions it aims to answer are: * Does higher protein intake combined with resistance training improve mood and sleep in postmenopausal women? * What other health benefits to postmenopausal women experience when the follow a higher protein diet and participate in resistance exercise? Researchers will compare three groups 1) postmenopausal women living their daily lives as usual, 2) postmenopausal women consuming a higher protein diet, and 2) postmenopausal women consuming a higher protein diet and participating in resistance training. Participants will: * Consume a higher protein diet for 16 weeks * Participate in an at-home resistance training for 16 weeks * Keep a diary of their food intake, sleep habits, and mood * Have health assessments every 4 weeks

Recruiting
Has No Placebo

Don tyson Center for Agricultural Sciencers (+1 Sites)

Jamie Baum

Image of The Buck Institute for Research on Aging in Novato, United States.

GLYLO Supplement for Postmenopausal Aging

45 - 65
Female
Novato, CA

The aim of this study is to assess the effectiveness of GLYLO, a dietary supplement, in postmenopausal women aged 45 to 65 who are overweight or obese and have elevated HbA1c levels. Specifically, the study seeks to evaluate whether GLYLO can reduce advanced glycation end products (AGEs) levels, which are harmful compounds formed when sugar attaches to proteins or fats in the body and can contribute to aging and disease. The primary outcome of the study is to determine if GLYLO reduces AGEs, enhances metabolic and hormonal health, and mitigates age-related functional decline. This study includes one screening visit and three testing visits over a 6-month period. After eligibility is confirmed, participants will be randomly assigned to one of two groups to take either GLYLO (two capsules daily) or a placebo at home for 24 weeks. Participants will provide blood samples at every visit. During the three testing visits, they will complete physical performance and cognitive function tests, provide both blood and urine samples, and fill out quality of life and 24-hour dietary intake questionnaires. The dietary intake questionnaires will be completed only twice i.e. at the baseline visit and again at the final 6-month visit.

Recruiting
Advanced

The Buck Institute for Research on Aging

Image of Noll Laboratory in University Park, United States.

Estradiol and Elagolix for Menopause

42 - 64
Female
University Park, PA

The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men. Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.

Phase 4
Recruiting

Noll Laboratory

W. Larry Kenney, Ph.D.

Have you considered Estrogel clinical trials?

We made a collection of clinical trials featuring Estrogel, we think they might fit your search criteria.
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