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What is Eplerenone
EplerenoneThe Generic name of this drug
Treatment SummaryEplerenone is a medication that helps regulate the balance of hormones in the body, particularly aldosterone. It works by blocking the receptors that respond to aldosterone, resulting in increased levels of renin and aldosterone in the blood. Eplerenone has a stronger binding to mineralocorticoid receptors than other hormones such as glucocorticoid, progesterone, and androgen.
Insprais the brand name
Eplerenone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Inspra
Eplerenone
2002
36
Approved as Treatment by the FDA
Eplerenone, otherwise known as Inspra, is approved by the FDA for 4 uses like Heart Attack and Hypertensive disease .Heart Attack
Helps manage Myocardial Infarction
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
LVEF <40% Congestive heart failure
Helps manage LVEF <40% Congestive heart failure
Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class II)
Effectiveness
How Eplerenone Affects PatientsEplerenone is a drug that blocks the hormone aldosterone from attaching to receptors in the body. This causes an increase in renin and aldosterone levels, but these increases are not enough to override the effects of the drug. Eplerenone binds to receptors in the body specifically related to mineralocorticoid hormones, and not to those related to other hormones like glucocorticoid, progesterone, or androgen hormones.
How Eplerenone works in the bodyEplerenone helps lower blood pressure by blocking aldosterone, a hormone that helps regulate sodium and water levels in the body. Aldosterone is part of the renin-angiotensin-aldosterone-system (RAAS) and is released by the adrenal gland when stimulated by angiotensin II and other hormones. When aldosterone binds to mineralocorticoid receptors, it causes sodium to be reabsorbed, which then increases blood pressure. Eplerenone works to prevent this from happening, thus lowering blood pressure.
When to interrupt dosage
The measure of Eplerenone is based on the diagnosed disorder, including Hypesthesia, Hypertensive disease and Heart Attack. The amount of dosage relies on the method of delivery (e.g. Tablet, coated or Tablet, film coated - Oral) featured in the table beneath.Condition
Dosage
Administration
Heart Attack
25.0 mg, , 50.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
25.0 mg, , 50.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
LVEF <40% Congestive heart failure
25.0 mg, , 50.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypesthesia
25.0 mg, , 50.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Eplerenone ContraindicationsCondition
Risk Level
Notes
Hypertensive disease
Do Not Combine
Pulse Frequency
Do Not Combine
Hypertensive disease
Do Not Combine
Microalbuminuria
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Hypertensive disease
Do Not Combine
Hypertensive disease
Do Not Combine
Common Eplerenone Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Eplerenone may increase the hypotensive activities of Amifostine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Eplerenone.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Eplerenone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Eplerenone.
Carbamazepine
Major
The metabolism of Carbamazepine can be decreased when combined with Eplerenone.
Eplerenone Toxicity & Overdose RiskTaking too much eplerenone could lead to low blood pressure or high levels of potassium in the blood. So far, there have been no reports of people overdosing on eplerenone.
Eplerenone Novel Uses: Which Conditions Have a Clinical Trial Featuring Eplerenone?
83 active studies are currently investigating the potential of Eplerenone to ameliorate LVEF <40% Congestive Heart Failure, Hypesthesia and Hypertensive Disease.Condition
Clinical Trials
Trial Phases
Hypesthesia
4 Actively Recruiting
Not Applicable
LVEF <40% Congestive heart failure
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Heart Attack
52 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Eplerenone Reviews: What are patients saying about Eplerenone?
5Patient Review
2/13/2014 Eplerenone was a total game-changer for me when it came to my high blood pressure. Within just three days, it had lowered my BP to a normal level and I was able to ditch most of the other meds I'd been taking
4.7Patient Review
8/2/20094Patient Review
3/21/2013 I started taking this medication about two weeks ago and it has helped to normalize my potassium levels. However, today I began experiencing intestinal bleeding and am not sure if it is related to the drug or not.
3.7Patient Review
1/2/2021 I didn't have a great experience with this medication. It made me very dizzy, loss of appetite, and extremely tired. I have no energy whatsoever.
3.3Patient Review
7/7/2012 While this drug may have helped regulate my potassium levels, the side effects were not worth it. I experienced serious jaw pain and confusion, and had to go off of the medication after only two months.
3.3Patient Review
2/22/2014 I was prescribed this for primary hyperaldosteronism by a nephrologist. It worked well at first, lowering my BP significantly. However, after five years of taking it I am now in stage 4 kidney disease, which is irreversible. My nephrologist is pushing me into dialysis and end-of-life care, but there are other options out there. Please be watchful for this dreadful side effect and educate yourself about your treatment options.
2Patient Review
6/10/20111.7Patient Review
2/1/2018 I've experienced a whole range of negative side effects since taking this drug. It's made my menopause symptoms come back, it's given me joint pain, and it doesn't even help with my high blood pressure! I would not recommend this medication to anyone.
Patient Q&A Section about eplerenone
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of the drug eplerenone?
"The following are symptoms of a heart attack: abdominal or stomach pain, arm or jaw pain, chest pain or discomfort, difficulty breathing, fast or irregular heartbeat, large hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs."
Answered by AI
What is the drug eplerenone used for?
"It's used to treat heart failure and reduce the risk of you having other heart problems or a stroke. It also helps to stop heart failure getting worse. It can sometimes be used to treat a condition called hyperaldosteronism."
Answered by AI
What class of drug is eplerenone?
"Eplerenone is a medication used to treat high blood pressure and congestive heart failure. It belongs to a class of medications called antihypertensives. This medicine is taken by mouth, typically once daily."
Answered by AI
Is eplerenone a good diuretic?
"Eplerenone is a potassium-sparing diuretic that is similar to spironolactone. Eplerenone selectively blocks aldosterone, which lowers blood pressure. Eplerenone is a safer option than spironolactone because it has reduced progesterone and androgen-receptor effects."
Answered by AI