Doxepin Hydrochloride

Insomnia, Neurotic depression, Depression + 8 more
Treatment
20 Active Studies for Doxepin Hydrochloride

What is Doxepin Hydrochloride

DoxepinThe Generic name of this drug
Treatment SummaryDoxepin is a medication used to treat anxiety and depression. It works by blocking certain receptors in the brain to reduce feelings of anxiety and depression. It is similar to other medications in its class, such as amitriptyline, clomipramine, desipramine, imipramine, nortriptyline, protriptyline, and trimipramine. Doxepin was originally developed by Pfizer and approved by the FDA in 1969 as an antidepressant, but it was later approved in 2010 for the treatment of insomnia.
Sinequanis the brand name
image of different drug pills on a surface
Doxepin Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sinequan
Doxepin
1969
307

Effectiveness

How Doxepin Hydrochloride Affects PatientsDoxepin is a type of antidepressant that is known to cause antidepressant, sedative, and anticholinergic effects. It works by decreasing the electrical activity of the brain and is usually prescribed to treat insomnia or anxiety. The antidepressant effects start to take effect after two weeks, while the sedative effects are felt right away. High doses of doxepin can cause central nervous system depression and limit its effectiveness due to its antiadrenergic and anticholinergic properties.
How Doxepin Hydrochloride works in the bodyDoxepin works by blocking histamine receptors and increasing the amount of certain chemicals in the brain. This helps to reduce anxiety and depression by increasing activity at the nerve cell receptor sites, desensitizing serotonin and beta-adrenergic receptors, and increasing dopamine transmission in the frontal cortex.

When to interrupt dosage

The suggested dosage of Doxepin Hydrochloride is contingent upon the diagnosed condition, such as Depression, Involutional, Mental Disorder, Organic and Insomnia. The amount of dosage likewise deviates as per the approach of delivery (e.g. Oral or Tablet - Oral) outlined in the table beneath.
Condition
Dosage
Administration
Insomnia
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Neurotic depression
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Depression
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Generalized Anxiety Disorder
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Neuropathic Pain
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Itching
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Depressive Disorder, Major
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Behcet Syndrome
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Alcoholism
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Depressive Disorder, Major
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Neurodermatitis
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated

Warnings

Doxepin Hydrochloride Contraindications
Condition
Risk Level
Notes
untreated narrow angle glaucoma
Do Not Combine
Pulse Frequency
Do Not Combine
Urinary Retention
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Doxepin may interact with Pulse Frequency
There are 20 known major drug interactions with Doxepin Hydrochloride.
Common Doxepin Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
Doxepin may increase the vasopressor activities of 4-Methoxyamphetamine.
Acepromazine
Major
Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Doxepin is combined with Aclidinium.
Alfuzosin
Major
Doxepin may increase the hypotensive activities of Alfuzosin.
Aripiprazole
Major
Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole.
Doxepin Hydrochloride Toxicity & Overdose RiskThe highest toxic dose of doxepin in mice and rats has been found to be 180mg/kg and 147mg/kg, respectively. Overdosing on doxepin can cause seizures, irregular heart rhythms, loss of consciousness, low blood pressure, and depression of the central nervous system. Studies have also shown that doxepin can affect fertility, causing an increase in the copulatory interval, decrease in the number of viable embryos, and reduction in sperm motility. There is no evidence suggesting doxepin can cause cancer or mutations.
image of a doctor in a lab doing drug, clinical research

Doxepin Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Doxepin Hydrochloride?

1020 active clinical trials are in progress to analyze the potential of Doxepin Hydrochloride in providing symptom relief for Generalized Anxiety Disorder, Atopic Dermatitis and Bipolar Disorder.
Condition
Clinical Trials
Trial Phases
Generalized Anxiety Disorder
206 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Early Phase 1, Phase 4, Phase 1
Insomnia
1 Actively Recruiting
Not Applicable
Depression
337 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4, Phase 3
Alcoholism
6 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Neurotic depression
0 Actively Recruiting
Depressive Disorder, Major
205 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3
Itching
3 Actively Recruiting
Phase 2, Phase 3, Not Applicable
Behcet Syndrome
1 Actively Recruiting
Not Applicable
Neuropathic Pain
5 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Neurodermatitis
0 Actively Recruiting
Depressive Disorder, Major
0 Actively Recruiting

Doxepin Hydrochloride Reviews: What are patients saying about Doxepin Hydrochloride?

4.7Patient Review
9/4/2020
Doxepin Hydrochloride for Chronic Trouble Sleeping
This medication is older, but it still helps me sleep.
4.3Patient Review
3/10/2020
Doxepin Hydrochloride for Anxiousness associated with Depression
This drug is effective at helping me stay asleep, though it can take a little while to feel the effects. I usually take it two hours before bed. It also helps a bit with anxiety, but if that's your main goal there are probably better options out there.
4.3Patient Review
3/24/2019
Doxepin Hydrochloride for Chronic Trouble Sleeping
I use this medication to help with my depression, anxiety, and fibromyalgia. I find that it works great most nights, but sometimes I'll wake up during the night. Overall, though, I sleep much better with this medication than without it.
4.3Patient Review
10/23/2022
Doxepin Hydrochloride for Anxiousness associated with Depression
This medication has been excellent for my anxiety. I take it twice a day at 50mg each and it makes me feel calmer without the euphoria. Additionally, it's helped curb my more psychopathic tendencies without having to resort to antipsychotics.
4.3Patient Review
8/30/2022
Doxepin Hydrochloride for Chronic Trouble Sleeping
Doxepin has been a lifesaver for me when it comes to insomnia. It's helped me get more restful sleep and I only need to take a break from it every few days or so to prevent tolerance. I haven't experienced many negative side effects, which is great.
View All Reviews
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Patient Q&A Section about doxepin hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Doxepin Hydrochloride used for?

"This medicine is available only with your doctor's prescription

Doxepin can be used to treat anxiety, depression, or insomnia. It is a tricyclic antidepressant (TCA) that works on the central nervous system (CNS) by increasing levels of certain chemicals in the brain. A prescription from a doctor is required in order to purchase this medication."

Answered by AI

Is doxepin a narcotic?

"Doxepin is not classified as a controlled substance by the Drug Enforcement Administration and thus has a low risk for abuse."

Answered by AI

Can doxepin hydrochloride get you high?

"Doxepin can be used to help with symptoms that are linked to anxiety and depression. These symptoms may include fear, guilt, sleep problems, tension, and worry. Doxepin does not have any Euphoric effect and is not associated with dependence or tolerance. However, the most common side effects are drowsiness when starting treatment and weight gain."

Answered by AI

Will doxepin help me sleep?

"Doxepin is a medication used to treat insomnia. It is part of a class of medications called tricyclic antidepressants. These medications work by slowing activity in the brain to allow sleep."

Answered by AI

Clinical Trials for Doxepin Hydrochloride

Have you considered Doxepin Hydrochloride clinical trials? We made a collection of clinical trials featuring Doxepin Hydrochloride, we think they might fit your search criteria.
Have you considered Doxepin Hydrochloride clinical trials? We made a collection of clinical trials featuring Doxepin Hydrochloride, we think they might fit your search criteria.
Have you considered Doxepin Hydrochloride clinical trials? We made a collection of clinical trials featuring Doxepin Hydrochloride, we think they might fit your search criteria.
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