Danocrine

Endometriosis, Thrombocytopenia, Breast + 1 more

Treatment

6 FDA approvals

20 Active Studies for Danocrine

Treatment for

Endometriosis

What is Danocrine

DanazolThe Generic name of this drug

Treatment SummaryDanazol is a synthetic steroid that suppresses hormones produced by the pituitary gland. It reduces the production of gonadotropins, and has some androgenic properties. Danazol is used to treat endometriosis and some benign breast conditions.

Danocrineis the brand name

image of different drug pills on a surface

Danocrine Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Danocrine

Danazol

1976

Approved as Treatment by the FDA

Danazol, also known as Danocrine, is approved by the FDA for 6 uses which include Fibrocystic Disease of Breast and Hereditary Angioedema (HAE) .

Fibrocystic Disease of Breast

Hereditary Angioedema (HAE)

Helps manage Hereditary Angioedema (HAE)

Endometriosis

Angioedemas, Hereditary

Helps manage Hereditary Angioedema (HAE)

Breast

Endometriosis

Effectiveness

How Danocrine Affects PatientsDanazol is a synthetic steroid based on testosterone. It was the first drug approved to treat endometriosis, but its use has been largely replaced by other medications. Danazol reduces the pituitary gland's production of hormones that control the reproductive system and has some androgenic properties.

How Danocrine works in the bodyDanazol works to reduce inflammation by suppressing the body's ovarian function. It does this by preventing the release of hormones from the pituitary gland, as well as blocking the body's ability to produce estrogen. It also lowers concentrations of certain antibodies and decreases ovarian production of estrogen. All of these effects work together to reduce inflammation and stop endometriosis, fibrocystic breast disease, and hereditary angioedema.

When to interrupt dosage

The measure of Danocrine is contingent upon the diagnosed affliction, including Thrombocytopenia, Endometriosis and Angioedemas, Hereditary. The amount of dosage differs, subject to the technique of delivery (e.g. Capsule or Oral) provided in the table underneath.

Condition

Dosage

Administration

Endometriosis

, 100.0 mg, 200.0 mg, 50.0 mg

, Oral, Capsule, Capsule - Oral

Thrombocytopenia

, 100.0 mg, 200.0 mg, 50.0 mg

, Oral, Capsule, Capsule - Oral

Breast

, 100.0 mg, 200.0 mg, 50.0 mg

, Oral, Capsule, Capsule - Oral

Angioedemas, Hereditary

, 100.0 mg, 200.0 mg, 50.0 mg

, Oral, Capsule, Capsule - Oral

Warnings

Danocrine Contraindications

Condition

Risk Level

Notes

androgen-dependent tumor

Do Not Combine

Thrombosis

Do Not Combine

potential for pregnancy

Do Not Combine

undiagnosed abnormal genital bleeding

Do Not Combine

Kidney

Do Not Combine

Thromboembolism

Do Not Combine

Porphyrias

Do Not Combine

There are 20 known major drug interactions with Danocrine.

Common Danocrine Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Major

The metabolism of (R)-warfarin can be decreased when combined with Danazol.

(S)-Warfarin

Major

The metabolism of (S)-Warfarin can be decreased when combined with Danazol.

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be decreased when combined with Danazol.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Danazol.

5-androstenedione

Major

The metabolism of 5-androstenedione can be decreased when combined with Danazol.

Danocrine Novel Uses: Which Conditions Have a Clinical Trial Featuring Danocrine?

Presently, 43 active studies are assessing the potential of Danocrine to alleviate Thrombocytopenia, Endometriosis and Breast-related conditions.

Condition

Clinical Trials

Trial Phases

Endometriosis

29 Actively Recruiting

Early Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4

Breast

0 Actively Recruiting

Thrombocytopenia

0 Actively Recruiting

Angioedemas, Hereditary

13 Actively Recruiting

Phase 3, Phase 2, Phase 1, Phase 4

Danocrine Reviews: What are patients saying about Danocrine?

5Patient Review

6/10/2016

Danocrine for Endometriosis

Danocrine was great for me. It really helped with the pain I was experiencing. I stopped taking it because I'm post-menopausal, but if it weren't for that, I would still be taking it.

5Patient Review

9/11/2012

Danocrine for Prevention of Angioedema Attacks in Patient with Hereditary Angioedema

I haven't had a single attack since starting this medication 9 years ago. The side effects are manageable and, to me, worth it for the peace of mind of not having any attacks.

1.3Patient Review

4/3/2012

Danocrine for Endometriosis

My sister took this medication for six months to treat endometriosis when she was eighteen. She is now fifty-six and has developed ovarian cancer, as well as breast cancer in the intervening years. I believe that this medication may have contributed to her developing cancer, albeit many years later. Use caution if you are prescribed this medication.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about danocrine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is danocrine used for?

"While Danocrine is most commonly used to treat endometriosis and fibrocystic breast disease, it can also be used to prevent attacks of angioedema in people with an inherited form of the disorder. The brand name Danocrine has been discontinued, but generic versions are likely still available."

Answered by AI

Why would a man take danazol?

"This medication is also used in both men and women to prevent swelling of the abdomen/arms/legs/face/airway due to a certain congenital disease (hereditary angioedema). Danazol is a synthetic hormone similar to testosterone."

Answered by AI

Is danocrine a steroid?

"In the liver, it suppresses cholesterol synthesis.

Danocrine is a drug that has many different effects on the body. It works by binding to certain proteins in the body, which affects the production of hormones. It also affects the way cholesterol is made in the liver."

Answered by AI

What is danazol mechanism of action?

"Danazol suppresses the pituitary gland's output of gonadotropins, which in turn reduces hormone levels in the body. Danazol also has some androgenic properties, meaning it can promote male characteristics. The liver breaks down Danazol into two main metabolites: ethisterone and 17-hydroxymethylethisterone."

Answered by AI

Clinical Trials for Danocrine

Have you considered Danocrine clinical trials? We made a collection of clinical trials featuring Danocrine, we think they might fit your search criteria.

Have you considered Danocrine clinical trials? We made a collection of clinical trials featuring Danocrine, we think they might fit your search criteria.