Danocrine

Endometriosis, Thrombocytopenia, Breast + 1 more
Treatment
6 FDA approvals
20 Active Studies for Danocrine

What is Danocrine

DanazolThe Generic name of this drug
Treatment SummaryDanazol is a synthetic steroid that suppresses hormones produced by the pituitary gland. It reduces the production of gonadotropins, and has some androgenic properties. Danazol is used to treat endometriosis and some benign breast conditions.
Danocrineis the brand name
image of different drug pills on a surface
Danocrine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Danocrine
Danazol
1976
22

Approved as Treatment by the FDA

Danazol, also known as Danocrine, is approved by the FDA for 6 uses which include Endometriosis and Fibrocystic Disease of Breast .
Endometriosis
Fibrocystic Disease of Breast
Hereditary Angioedema (HAE)
Helps manage Hereditary Angioedema (HAE)
Angioedemas, Hereditary
Helps manage Hereditary Angioedema (HAE)
Breast
Endometriosis

Effectiveness

How Danocrine Affects PatientsDanazol is a synthetic steroid based on testosterone. It was the first drug approved to treat endometriosis, but its use has been largely replaced by other medications. Danazol reduces the pituitary gland's production of hormones that control the reproductive system and has some androgenic properties.
How Danocrine works in the bodyDanazol works to reduce inflammation by suppressing the body's ovarian function. It does this by preventing the release of hormones from the pituitary gland, as well as blocking the body's ability to produce estrogen. It also lowers concentrations of certain antibodies and decreases ovarian production of estrogen. All of these effects work together to reduce inflammation and stop endometriosis, fibrocystic breast disease, and hereditary angioedema.

When to interrupt dosage

The measure of Danocrine is contingent upon the diagnosed affliction, including Thrombocytopenia, Endometriosis and Angioedemas, Hereditary. The amount of dosage differs, subject to the technique of delivery (e.g. Capsule or Oral) provided in the table underneath.
Condition
Dosage
Administration
Endometriosis
, 100.0 mg, 200.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral
Thrombocytopenia
, 100.0 mg, 200.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral
Breast
, 100.0 mg, 200.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral
Angioedemas, Hereditary
, 100.0 mg, 200.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral

Warnings

Danocrine Contraindications
Condition
Risk Level
Notes
androgen-dependent tumor
Do Not Combine
Thrombosis
Do Not Combine
potential for pregnancy
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Kidney
Do Not Combine
Thromboembolism
Do Not Combine
Porphyrias
Do Not Combine
There are 20 known major drug interactions with Danocrine.
Common Danocrine Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Danazol.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Danazol.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Danazol.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Danazol.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Danazol.

Danocrine Novel Uses: Which Conditions Have a Clinical Trial Featuring Danocrine?

Presently, 43 active studies are assessing the potential of Danocrine to alleviate Thrombocytopenia, Endometriosis and Breast-related conditions.
Condition
Clinical Trials
Trial Phases
Endometriosis
27 Actively Recruiting
Early Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4
Breast
0 Actively Recruiting
Thrombocytopenia
0 Actively Recruiting
Angioedemas, Hereditary
12 Actively Recruiting
Phase 3, Phase 1, Phase 2, Phase 4

Danocrine Reviews: What are patients saying about Danocrine?

5Patient Review
6/10/2016
Danocrine for Endometriosis
Danocrine was great for me. It really helped with the pain I was experiencing. I stopped taking it because I'm post-menopausal, but if it weren't for that, I would still be taking it.
5Patient Review
9/11/2012
Danocrine for Prevention of Angioedema Attacks in Patient with Hereditary Angioedema
I haven't had a single attack since starting this medication 9 years ago. The side effects are manageable and, to me, worth it for the peace of mind of not having any attacks.
1.3Patient Review
4/3/2012
Danocrine for Endometriosis
My sister took this medication for six months to treat endometriosis when she was eighteen. She is now fifty-six and has developed ovarian cancer, as well as breast cancer in the intervening years. I believe that this medication may have contributed to her developing cancer, albeit many years later. Use caution if you are prescribed this medication.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about danocrine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is danocrine used for?

"While Danocrine is most commonly used to treat endometriosis and fibrocystic breast disease, it can also be used to prevent attacks of angioedema in people with an inherited form of the disorder. The brand name Danocrine has been discontinued, but generic versions are likely still available."

Answered by AI

Why would a man take danazol?

"This medication is also used in both men and women to prevent swelling of the abdomen/arms/legs/face/airway due to a certain congenital disease (hereditary angioedema). Danazol is a synthetic hormone similar to testosterone."

Answered by AI

Is danocrine a steroid?

"In the liver, it suppresses cholesterol synthesis.

Danocrine is a drug that has many different effects on the body. It works by binding to certain proteins in the body, which affects the production of hormones. It also affects the way cholesterol is made in the liver."

Answered by AI

What is danazol mechanism of action?

"Danazol suppresses the pituitary gland's output of gonadotropins, which in turn reduces hormone levels in the body. Danazol also has some androgenic properties, meaning it can promote male characteristics. The liver breaks down Danazol into two main metabolites: ethisterone and 17-hydroxymethylethisterone."

Answered by AI

Clinical Trials for Danocrine

Image of University Hospitals Cleveland Medical Center in Cleveland, United States.

Ketamine for Pelvic Pain

18 - 89
Female
Cleveland, OH
The purpose of this research study is to see if ketamine infusion during surgery can decrease pain after surgery. Ketamine is a medication commonly used as part of anesthesia during surgery and is approved by the US FDA. Patients will be randomized to either receive standard anesthesia with OR without ketamine. The surgical procedure will be the same regardless of which group patients are randomized to. After surgery, patients will be asked to rate their pain in the post-operative observation unit and at their two-week post-operative visit. No additional visits are required for participation in this study. The investigators estimate the surveys will take approximately 10 minutes to complete.
Phase 4
Waitlist Available
University Hospitals Cleveland Medical CenterMorgan Cheeks, MD
Have you considered Danocrine clinical trials? We made a collection of clinical trials featuring Danocrine, we think they might fit your search criteria.Go to Trials
Image of Baylor College of Medicine in Hosuton, United States.

Dronabinol for Endometriosis

18 - 64
Female
Hosuton, TX
This exploratory, proof-of-concept study is a double-blind (participants and investigators will be blinded), placebo-controlled, randomized, two-arm clinical trial of Marinol \[dronabinol, synthetic Δ9-tetrahydrocannabinol (THC)\] for e endometriosis-associated chronic pelvic pain (endo-CPP) with a 2:1 allocation ratio. Up to 75 subjects will be enrolled in this pilot study and randomized to receive doses of THC (up to 30 mg/day), orally, over 8 weeks. This study will be conducted at a single site; it does not include any stratifications, and there is no interim analysis planned. Notably, the goal is to determine whether there is enough evidence of the safety of THC to support the development of later-phase clinical trials. Thus, detailed developmental plans are contingent on the outcomes of this study.
Phase 2
Waitlist Available
Baylor College of Medicine (+1 Sites)Christopher Verrico, PhD in Pharmacology
Have you considered Danocrine clinical trials? We made a collection of clinical trials featuring Danocrine, we think they might fit your search criteria.Go to Trials
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Metformin for Endometriosis

15 - 35
Female
Boston, MA
The goal of this pilot trial is to learn if a novel non-hormonal treatment, metformin hydrochloride, works to treat pelvic pain in young women with endometriosis. The main questions it aims to answer are: * Is metformin superior to placebo in alleviating pain symptoms in young women with endometriosis? * Does metformin alter systemic inflammatory markers over 6 months in young women with endometriosis? Researchers will compare metformin to a placebo (a look-alike substance that contains no drug) to see if metformin works to treat pelvic pain. Participants will: * Take drug metformin or a placebo every day for 6 months * Visit the clinic three times: once at baseline (pre-treatment), once at 3 months, and once at 6 months * Keep a daily symptom diary to track pain, bleeding, and usage of any pain medications
Phase 2
Recruiting
Boston Children's HospitalJessica Shim, MD
Image of WashU Medicine in Saint Louis, United States.

Peer Empowered Endometriosis Pain Support for Endometriosis

18 - 48
Female
Saint Louis, MO
The goal of this clinical trial is to determine if Peer Empowered Endometriosis Pain Support (PEEPS), an 8-week interdisciplinary, integrative group care program, decreases pain interference in participants with endometriosis-associated chronic pelvic pain between the ages 18 and 48. The main question we aim to answer is: Is PEEPS more effective than Education in decreasing pain interference? Researchers will compare people receiving PEEPS plus usual care to those receiving Education plus usual care to see if people participating in PEEPS demonstrate improvements in pain, physical function, and quality of life. Participants will: * Complete baseline quality of life surveys * Participate in an 8-session group care program * Provide feedback on each session and the program globally * Complete follow up quality of life surveys at PEEPS completion, 6- and 12-months post-completion. * A sub-set will complete semi-structured interviews or focus groups about the experience of participating in PEEPS
Recruiting
Has No Placebo
WashU Medicine (+1 Sites)Whitney Ross, MD
Have you considered Danocrine clinical trials? We made a collection of clinical trials featuring Danocrine, we think they might fit your search criteria.Go to Trials
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