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What is Danocrine
DanazolThe Generic name of this drug
Treatment SummaryDanazol is a synthetic steroid that suppresses hormones produced by the pituitary gland. It reduces the production of gonadotropins, and has some androgenic properties. Danazol is used to treat endometriosis and some benign breast conditions.
Danocrineis the brand name
Danocrine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Danocrine
Danazol
1976
22
Approved as Treatment by the FDA
Danazol, also known as Danocrine, is approved by the FDA for 3 uses which include Breast and Endometriosis .Breast
Endometriosis
Angioedemas, Hereditary
Helps manage Hereditary Angioedema (HAE)
Effectiveness
How Danocrine Affects PatientsDanazol is a synthetic steroid based on testosterone. It was the first drug approved to treat endometriosis, but its use has been largely replaced by other medications. Danazol reduces the pituitary gland's production of hormones that control the reproductive system and has some androgenic properties.
How Danocrine works in the bodyDanazol works to reduce inflammation by suppressing the body's ovarian function. It does this by preventing the release of hormones from the pituitary gland, as well as blocking the body's ability to produce estrogen. It also lowers concentrations of certain antibodies and decreases ovarian production of estrogen. All of these effects work together to reduce inflammation and stop endometriosis, fibrocystic breast disease, and hereditary angioedema.
When to interrupt dosage
The measure of Danocrine is contingent upon the diagnosed affliction, including Thrombocytopenia, Endometriosis and Angioedemas, Hereditary. The amount of dosage differs, subject to the technique of delivery (e.g. Capsule or Oral) provided in the table underneath.Condition
Dosage
Administration
Endometriosis
, 100.0 mg, 200.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral
Angioedemas, Hereditary
, 100.0 mg, 200.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral
Thrombocytopenia
, 100.0 mg, 200.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral
Breast
, 100.0 mg, 200.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral
Warnings
Danocrine ContraindicationsCondition
Risk Level
Notes
androgen-dependent tumor
Do Not Combine
Thrombosis
Do Not Combine
potential for pregnancy
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Kidney
Do Not Combine
Thromboembolism
Do Not Combine
Porphyria
Do Not Combine
Common Danocrine Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Danazol.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Danazol.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Danazol.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Danazol.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Danazol.
Danocrine Novel Uses: Which Conditions Have a Clinical Trial Featuring Danocrine?
Presently, 43 active studies are assessing the potential of Danocrine to alleviate Thrombocytopenia, Endometriosis and Breast-related conditions.Condition
Clinical Trials
Trial Phases
Breast
0 Actively Recruiting
Thrombocytopenia
0 Actively Recruiting
Angioedemas, Hereditary
13 Actively Recruiting
Phase 2, Phase 3, Phase 1
Endometriosis
32 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 2, Phase 4, Phase 1
Danocrine Reviews: What are patients saying about Danocrine?
5Patient Review
6/10/2016 Danocrine was great for me. It really helped with the pain I was experiencing. I stopped taking it because I'm post-menopausal, but if it weren't for that, I would still be taking it.
5Patient Review
9/11/2012 I haven't had a single attack since starting this medication 9 years ago. The side effects are manageable and, to me, worth it for the peace of mind of not having any attacks.
1.3Patient Review
4/3/2012 My sister took this medication for six months to treat endometriosis when she was eighteen. She is now fifty-six and has developed ovarian cancer, as well as breast cancer in the intervening years. I believe that this medication may have contributed to her developing cancer, albeit many years later. Use caution if you are prescribed this medication.
Patient Q&A Section about danocrine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is danocrine used for?
"While Danocrine is most commonly used to treat endometriosis and fibrocystic breast disease, it can also be used to prevent attacks of angioedema in people with an inherited form of the disorder. The brand name Danocrine has been discontinued, but generic versions are likely still available."
Answered by AI
Why would a man take danazol?
"This medication is also used in both men and women to prevent swelling of the abdomen/arms/legs/face/airway due to a certain congenital disease (hereditary angioedema). Danazol is a synthetic hormone similar to testosterone."
Answered by AI
Is danocrine a steroid?
"In the liver, it suppresses cholesterol synthesis.
Danocrine is a drug that has many different effects on the body. It works by binding to certain proteins in the body, which affects the production of hormones. It also affects the way cholesterol is made in the liver."
Answered by AI
What is danazol mechanism of action?
"Danazol suppresses the pituitary gland's output of gonadotropins, which in turn reduces hormone levels in the body. Danazol also has some androgenic properties, meaning it can promote male characteristics. The liver breaks down Danazol into two main metabolites: ethisterone and 17-hydroxymethylethisterone."
Answered by AI