Corzide

Hypertensive disease
Treatment
18 Active Studies for Corzide

What is Corzide

BendroflumethiazideThe Generic name of this drug
Treatment SummaryNadolol is a medication used to treat high blood pressure. It is a type of nonselective beta adrenal receptor blocker, meaning it affects all beta receptors in the body, making it less effective than newer generations of beta blockers that are more selective. It was approved by the FDA in 1979.
Corzideis the brand name
Corzide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Corzide
Bendroflumethiazide
1983
10

Effectiveness

How Corzide Affects PatientsNadolol is a type of medication used to lower blood pressure. It is usually taken once per day, and the amount of medication prescribed can range from 40mg to 240mg daily. When taking nadolol, it is important that you do not suddenly stop taking it as this can worsen a heart condition.
How Corzide works in the bodyNadolol works to reduce blood pressure by blocking beta-1 and beta-2 adrenoceptors in the heart, reducing the strength of contractions and the speed of relaxation and conduction. Nadolol also causes an increase in peripheral vascular resistance, which may contribute to a decrease in insulin sensitivity. In the kidney, nadolol blocks renin and angiotensin II release, reducing water retention. It also inhibits the release of epinephrine, as well as glycogenolysis, bronchodilation, and insulin release in the liver, lungs, and pancreas respectively.

When to interrupt dosage

The endorsed dosage of Corzide is contingent upon the recognized condition, such as Chest Pain, Atrial Fibrillation and Thyrotoxicosis. The quantity of dosage varies, as per the form of administration featured in the table hereunder.
Condition
Dosage
Administration
Hypertensive disease
5.0 mg, , 2.5 mg
, Oral, Tablet, Tablet - Oral

Warnings

There are 20 known major drug interactions with Corzide.
Common Corzide Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Bendroflumethiazide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Bendroflumethiazide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Bendroflumethiazide is combined with Dofetilide.
Lithium carbonate
Major
Bendroflumethiazide may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
Lithium citrate
Major
Bendroflumethiazide may decrease the excretion rate of Lithium citrate which could result in a higher serum level.
Corzide Toxicity & Overdose RiskThe toxic dose of the drug in mice is 4500mg/kg. Those who overdose may experience a slow heartbeat, heart failure, low blood pressure, and spasms in the lungs. Treatment for this includes atropine for the slow heartbeat, digitalis and diuretics for heart failure, medications to raise blood pressure, and drugs that help relax the lungs, as well as cleaning out the stomach and using dialysis.
image of a doctor in a lab doing drug, clinical research

Corzide Novel Uses: Which Conditions Have a Clinical Trial Featuring Corzide?

245 active clinical trials are currently underway to assess the potential of Corzide in providing prophylaxis against Gastroesophageal variceal hemorrhage, treating Thyrotoxicosis and managing Hypertensive diseases.
Condition
Clinical Trials
Trial Phases
Hypertensive disease
18 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3

Corzide Reviews: What are patients saying about Corzide?

5Patient Review
6/27/2011
Corzide for High Blood Pressure
I've been taking this medication for twelve years and it's done wonders for my blood pressure. It's always in the normal range now.
4.3Patient Review
12/9/2009
Corzide for High Blood Pressure
At first I was doubtful, but this treatment really lowered my blood pressure to where it should be.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about corzide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of drug is Corzide?

"Corzide is a combination drug that contains both a beta blocker and a diuretic. It is used to treat high blood pressure, and is available in generic form."

Answered by AI

Is there an alternative to bendroflumethiazide?

"Almost everyone uses bendroflumethiazide (2.5mg) to replace the most commonly prescribed antihypertensive in England. The exception to this is the use of 'thiazide-like' diuretics such as chlortalidone or indapamide."

Answered by AI

What are the long term side effects of bendroflumethiazide?

"Bendroflumethiazide may cause high cholesterol or triglycerides, which could increase the risk of developing some types of gallstones. Around 5% of patients may experience gastrointestinal problems such as lack of appetite, stomach irritation, nausea, vomiting, diarrhea, constipation, or abdominal pain."

Answered by AI

What is the brand name for Bendrofluazide?

"Bendroflumethiazide is a medication used to treat fluid retention and high blood pressure. It is a thiazide diuretic."

Answered by AI

Clinical Trials for Corzide

Have you considered Corzide clinical trials? We made a collection of clinical trials featuring Corzide, we think they might fit your search criteria.
Have you considered Corzide clinical trials? We made a collection of clinical trials featuring Corzide, we think they might fit your search criteria.
Have you considered Corzide clinical trials? We made a collection of clinical trials featuring Corzide, we think they might fit your search criteria.