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What is Contrave
NaltrexoneThe Generic name of this drug
Treatment SummaryBupropion, also known as Wellbutrin, is a medication used to treat Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and aid smoking cessation. It works by blocking certain enzymes that absorb certain neurotransmitters like norepinephrine and dopamine. This allows these neurotransmitters to stay active in the brain longer and have effects on mood. Bupropion is less likely to cause side effects like sexual dysfunction, sedation, or weight gain compared to other antidepressants. When used to help quit smoking, it has been shown to double abstinence rates compared to placebo. It can also be
Naltrexone Hydrochlorideis the brand name
Contrave Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Naltrexone Hydrochloride
Naltrexone
1998
59
Approved as Treatment by the FDA
Naltrexone, otherwise known as Naltrexone Hydrochloride, is approved by the FDA for 5 uses including Alcoholism and Opioid Dependence .Alcoholism
Helps manage Alcohol Dependency
Opioid Dependence
Helps manage Opioid Dependence
Pain
Used to treat Severe Pain in combination with Morphine
Therapeutic procedure
Used to treat inadequate alternative treatment options in combination with Morphine
Opiate Substitution Treatment
Used to treat requiring long-term opioid treatment in combination with Morphine
Effectiveness
How Contrave Affects PatientsBupropion is a drug not related to other antidepressant medications. It works by increasing the activity of certain chemicals in the brain, like dopamine and norepinephrine, which help improve mood. It also has some stimulant-like effects in animals. However, it has an abuse potential and can lower the seizure threshold, so it should not be taken by people with pre-existing seizure conditions. Taking bupropion can also raise blood pressure, but studies have not found an increase in stroke or heart attack risk in people using it.
How Contrave works in the bodyBupropion is a drug that works by preventing the reabsorption of certain neurotransmitters in the brain. This extends their effects, which can help treat depression, stop smoking, and aid in weight loss. Bupropion is different from other anti-depressants as it does not affect serotonin levels, so it is less likely to cause side effects like weight gain and sedation. When used to help stop smoking, bupropion works by blocking nicotine receptors in the brain and mimicking nicotine's stimulating effects. When taken with naltrexone for weight loss, bupropion boosts certain areas of the brain involved
When to interrupt dosage
The proposed dosage of Contrave is contingent upon the diagnosed state, including Depressive Bipolar Disorder, Depression and Disease. The measure also differs as per the technique of delivery (e.g. Tablet, extended release or Tablet, film coated, extended release) featured in the table under.Condition
Dosage
Administration
Pruritus
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Caloric Restriction
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
BMI >27 kg/m2
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Increased physical activity levels
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Opioid Dependence
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Pain
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Alcoholism
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Opiate Substitution Treatment
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Comorbidity
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Chronic Weight Management therapy
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Therapeutic procedure
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Warnings
Contrave ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Withdrawal syndrome
Do Not Combine
Adrenal gland hypofunction
Do Not Combine
Common Contrave Drug Interactions
Drug Name
Risk Level
Description
Eluxadoline
Major
The risk or severity of constipation can be increased when Naltrexone is combined with Eluxadoline.
Methylene blue
Major
Naltrexone may increase the serotonergic activities of Methylene blue.
Methylnaltrexone
Major
Naltrexone may increase the opioid antagonism activities of Methylnaltrexone.
Mirtazapine
Major
Naltrexone may increase the serotonergic activities of Mirtazapine.
Naloxegol
Major
Naltrexone may increase the opioid antagonism activities of Naloxegol.
Contrave Toxicity & Overdose RiskOverdosing on Prozac can cause seizures, hallucinations, loss of consciousness, rapid heart rate, and even cardiac arrest.
Contrave Novel Uses: Which Conditions Have a Clinical Trial Featuring Contrave?
Currently, 490 active trials are examining the potential of Contrave to reduce symptoms of Attention Deficit Hyperactivity Disorder, Depression and aid Smoking Cessation.Condition
Clinical Trials
Trial Phases
Increased physical activity levels
0 Actively Recruiting
Chronic Weight Management therapy
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Alcoholism
7 Actively Recruiting
Phase 3, Not Applicable, Phase 2
Pruritus
0 Actively Recruiting
Opioid Dependence
14 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1, Early Phase 1
Opiate Substitution Treatment
0 Actively Recruiting
Pain
0 Actively Recruiting
BMI >27 kg/m2
0 Actively Recruiting
Caloric Restriction
0 Actively Recruiting
Comorbidity
0 Actively Recruiting
Contrave Reviews: What are patients saying about Contrave?
5Patient Review
9/2/2022 The side effects were tough to get through at first, but luckily they only lasted for a few days. After that, I started feeling really good--happier and more energetic. And now, after being on the medication for eight months, my health is better than it's been in years.
5Patient Review
10/13/2022 I've been on this for two months and it's working great! I've lost 17 pounds, a shirt size, and a pant size. My cravings for alcohol, fast food, and cigarettes are gone. The only downside is headaches but electrolytes help with that. Constipation is another issue but other than that, I'm thrilled with the results.
5Patient Review
10/23/2022 I started this treatment in June of last year and I've already lost 55 pounds. It's easy to take, but you need to be willing to walk if you want it to work well. Personally, I made a goal for myself to walk 10,000 steps every day, and that really seemed to help me lose weight quickly and easily.
5Patient Review
9/29/2022 I've been using Contrave for a little over two years now, and it's helped me lose nearly 30lbs. I highly recommend it to others, especially those who have PCOS like myself. The only side effects I've experienced are nausea and hot flashes, but they haven't been too bad.
5Patient Review
10/14/2022 I've successfully lost 20lbs in two months by eating the same foods, but being more mindful of portion control. I only get headaches if I haven't had enough water to drink that day.
4.3Patient Review
10/26/2022 I want to address the people who gave this a low rating for ease of use - what exactly are you doing that makes taking a tablet so difficult?Contrave, like everything else, works if you're an adult and take the medication as directed. The side effects go after a few days, you just have to get through it. If you're going to be a baby and find it hard to take the tablet, then stay fat and stop complaining. Change takes effort.
4Patient Review
10/22/2022 I've been on Contrave for six weeks and I'm down to 239 pounds. Before starting this medication, I was stuck at 290 despite dieting and exercising regularly. I'm hopeful that I'll continue to see results and reach my goal weight of 225 pounds.
2.3Patient Review
9/27/2022 I took this medication for 3 days as directed. Unfortunately, I started itching and then broke out in red bumps. These white patches now cover my body and I have skin discoloration all over.
2Patient Review
9/21/2022 I was very disappointed with this treatment. I saw no weight loss after using it for three months, despite following the instructions to a T.
2Patient Review
10/27/2022 I only made it one day on this diet before feeling incredibly sick. I would rather be overweight than deal with those side effects.
1.7Patient Review
10/16/2022 The medication helped with food cravings and the urge to snack however once I worked up to more than one pill a day the side effects were unbearable- crippling headaches, to the point where I was unable to work and had to lay down, and horrible nausea. Wish the side effects weren’t so severe.
1.7Patient Review
9/2/2022 This medication had no effect whatsoever on my appetite or making me feel full after eating. Additionally, I experienced hot flashes and a terrible bitter taste in my mouth. It's unfortunately not worth the $250 monthly price tag.
Patient Q&A Section about contrave
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How quickly does Contrave work?
"After about four weeks of taking Contrave (naltrexone / bupropion), you should start to see its effects. To get the most out of the medication, you should also lower your calorie intake and exercise regularly."
Answered by AI
Is CONTRAVE the same as Wellbutrin?
"The same active ingredient as some other antidepressant medications, Contrave includes bupropion. Antidepressants have been shown to increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term trials."
Answered by AI
What does Contrave do to your body?
"This medication is a combination of two drugs that work together to control hunger and cravings, helping you to lose weight and keep it off. The two drugs, bupropion HCl and naltrexone HCl, are both safe, with well-established profiles, and have been prescribed by doctors for other conditions for more than 30 years."
Answered by AI
Is Contrave the same as Wellbutrin?
"These trials did not show an increase in the risk of suicidal thoughts and behavior with bupropion.
The medication Contravente contains bupropion, which is also an active ingredient in some other antidepressants, including, but not limited to, Wellbutrin, Wellbutrin SR, Wellbutrin XL, and Aplenzin. In short-term trials, antidepressants have been shown to increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults. However, these trials did not show an increase in the risk of suicidal thoughts and behavior with bupropion."
Answered by AI
What does CONTRAVE do to your body?
"Contrave is a combination of bupropion and naltrexone. Bupropion is an antidepressant medicine that can also decrease appetite. Naltrexone is usually given to block the effects of opioids or alcohol in people with addiction problems. Naltrexone may also curb hunger and food cravings."
Answered by AI