Contrave

Pruritus, Caloric Restriction, Obesity + 8 more

Treatment

7 FDA approvals

6 Active Studies for Contrave

Treatment for

Pruritus

What is Contrave

Naltrexone

The Generic name of this drug

Treatment Summary

Bupropion, also known as Wellbutrin, is a medication used to treat Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and aid smoking cessation. It works by blocking certain enzymes that absorb certain neurotransmitters like norepinephrine and dopamine. This allows these neurotransmitters to stay active in the brain longer and have effects on mood. Bupropion is less likely to cause side effects like sexual dysfunction, sedation, or weight gain compared to other antidepressants. When used to help quit smoking, it has been shown to double abstinence rates compared to placebo. It can also be

Naltrexone Hydrochloride

is the brand name

image of different drug pills on a surface

Contrave Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Naltrexone Hydrochloride

Naltrexone

1998

Approved as Treatment by the FDA

Naltrexone, otherwise known as Naltrexone Hydrochloride, is approved by the FDA for 7 uses including Opioid-Related Disorders and Alcohol Dependency .

Opioid-Related Disorders

Helps manage Opioid Dependence

Alcohol Dependency

Helps manage Alcohol Dependency

Opioid Dependence

Helps manage Opioid Dependence

Therapeutic procedure

Used to treat inadequate alternative treatment options in combination with Morphine

Alcoholism

Helps manage Alcohol Dependency

Pain

Used to treat Severe Pain in combination with Morphine

Opiate Substitution Treatment

Used to treat requiring long-term opioid treatment in combination with Morphine

Effectiveness

How Contrave Affects Patients

Bupropion is a drug not related to other antidepressant medications. It works by increasing the activity of certain chemicals in the brain, like dopamine and norepinephrine, which help improve mood. It also has some stimulant-like effects in animals. However, it has an abuse potential and can lower the seizure threshold, so it should not be taken by people with pre-existing seizure conditions. Taking bupropion can also raise blood pressure, but studies have not found an increase in stroke or heart attack risk in people using it.

How Contrave works in the body

Bupropion is a drug that works by preventing the reabsorption of certain neurotransmitters in the brain. This extends their effects, which can help treat depression, stop smoking, and aid in weight loss. Bupropion is different from other anti-depressants as it does not affect serotonin levels, so it is less likely to cause side effects like weight gain and sedation. When used to help stop smoking, bupropion works by blocking nicotine receptors in the brain and mimicking nicotine's stimulating effects. When taken with naltrexone for weight loss, bupropion boosts certain areas of the brain involved

When to interrupt dosage

The proposed dosage of Contrave is contingent upon the diagnosed state, including Depressive Bipolar Disorder, Depression and Disease. The measure also differs as per the technique of delivery (e.g. Tablet, extended release or Tablet, film coated, extended release) featured in the table under.

Condition

Dosage

Administration

Comorbidity