Study Summary
This trial is looking at using brain scans to predict how well someone with ADHD will respond to treatment with methylphenidate, and to measure the changes in task-related neural activity and brain glutamate levels after treatment.
Video Summary
Treatment Effectiveness
Phase-Based Effectiveness
Study Objectives
2 Primary · 0 Secondary · Reporting Duration: Approximately 90 minutes after dose
Trial Safety
Phase-Based Safety
Side Effects for
Awards & Highlights
Trial Design
2 Treatment Groups
Methylphenidate first
1 of 2
Placebo first
1 of 2
Experimental Treatment
Non-Treatment Group
30 Total Participants · 2 Treatment Groups
Primary Treatment: Methylphenidate · Has Placebo Group · Phase 4
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18 - 40 · All Participants · 1 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Who else is applying?
What state do they live in?
| California | 23.1% |
| Maryland | 15.4% |
| Georgia | 15.4% |
| Other | 46.2% |
How old are they?
| 18 - 65 | 100.0% |
What site did they apply to?
| Johns Hopkins School of Medicine | 100.0% |
What portion of applicants met pre-screening criteria?
| Did not meet criteria | 41.2% |
| Met criteria | 58.8% |
Why did patients apply to this trial?
- "I struggle with my ADHD symptoms. I'm starting law school in the fall, so I really want to figure out a way to manage my symptoms so that I can be successful in school."
- "I do not have insurance and I have been looking for a way to take care of my ADHD for years. My current dr is only $50 a month but does not prescribe controlled substances like my adhd medication. I’ve been with her for almost 10 years and my quality of life has fallen apart and COVID didn’t help. I was enrolled in school and my focus made every day a battle of crying and melt downs trying to study until I had to quit due to stress."
How many prior treatments have patients received?
| 3+ | 100.0% |
How responsive is this trial?
Average response time
- < 2 Days
Most responsive sites:
- Johns Hopkins School of Medicine: < 24 hours
Typically responds via
| 100.0% | |
Frequently Asked Questions
Do I have the required prerequisites to be included in this experiment?
"To qualify for this study, applicants must have an ADHD diagnosis and be between 18 to 40 years old. This trial is accepting up to 30 participants in total." - Anonymous Online Contributor
What is the maximum capacity for enrollees to this research project?
"Indeed, clinicaltrials.gov's data confirms that this medical experiment is presently seeking participants, having been first published on July 27th 2021 and last updated on October 6th 2022. The trial seeks to enrol 30 individuals from one centre." - Anonymous Online Contributor
Are individuals of a younger age able to participate in this experiment?
"Participants of this trial must be between the age brackets of 18 and 40. For those outside these ages, there are 15 trials for minors aged under 18 and 13 studies accommodating patients over 65 years old." - Anonymous Online Contributor
Has there been any other research involving Methylphenidate prior to this current trial?
"At present, there are 29 clinical trials investigating the efficacy of Methylphenidate with two studies in Phase 3. Most research centres for this medication can be found in Lexington, Kentucky; however, 42 different sites across the nation have active trials for it." - Anonymous Online Contributor
Is participation in this research available to the public?
"Affirmative. According to clinicaltrials.gov, this ongoing study is calling for volunteers and was initially posted on the 27th July 2021 with its most recent edit taking place on October 6th 2022. Currently, 30 participants are needed at a single research facility." - Anonymous Online Contributor
Has Methylphenidate been certified by the FDA?
"The safety of Methylphenidate is rated 3, as this drug has already been approved and the current trial is in its fourth phase." - Anonymous Online Contributor