Clonazepam

Burning Mouth Syndrome, Panic Disorder, Akinetic seizures + 11 more
Treatment
8 FDA approvals
20 Active Studies for Clonazepam

What is Clonazepam

ClonazepamThe Generic name of this drug
Treatment SummaryClonazepam is a type of benzodiazepine that is used to treat different types of seizures and panic disorder. It works by increasing the activity of a neurotransmitter called gamma-aminobutyric acid (GABA). Clonazepam was first developed in 1960 and released for sale in the US by Roche in 1975. It is still widely prescribed today, but it can also be misused recreationally, so it is important that it is taken as prescribed.
Klonopinis the brand name
Clonazepam Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Klonopin
Clonazepam
1975
356

Approved as Treatment by the FDA

Clonazepam, otherwise called Klonopin, is approved by the FDA for 8 uses including Panic Disorder and Lennox Gastaut Syndrome (LGS) .
Panic Disorder
Lennox Gastaut Syndrome (LGS)
Helps manage Lennox Gastaut Syndrome (LGS)
refractory absence Seizures
Helps manage refractory absence Seizures
Lennox Gastaut Syndrome
Helps manage Lennox Gastaut Syndrome (LGS)
Akinetic seizures
Helps manage Akinetic seizures
Seizures
Helps manage refractory absence Seizures
Panic Disorder
myoclonic seizures
Helps manage myoclonic seizures

Effectiveness

How Clonazepam Affects PatientsClonazepam is a type of drug from the benzodiazepine family. It has anti-seizure, calming, muscle relaxing, and anxiety-reducing effects. It helps to reduce the frequency, intensity, duration, and spread of seizures. It is especially effective in treating generalized epileptic seizures, and can also be used to treat focal epileptic seizures.
How Clonazepam works in the bodyGamma-Aminobutyric acid (GABA) is a neurotransmitter that has an inhibitory effect on neurons. When GABA binds to its receptors in neuron synapses, chloride ions are conducted across the neuron cell membrane. This makes it harder for neurons to be excited and helps keep the brain from over-stimulating itself. Clonazepam binds to receptors associated with GABA and further enhances GABA's inhibitory effect. This can help reduce rapid electrical signals in the brain that can cause seizures, as well as reduce the activity of fear circuits in the brain that can lead to anxiety and panic.

When to interrupt dosage

The measure of Clonazepam is contingent upon the recognized condition, including Lennox Gastaut Syndrome (LGS), Tardive Dyskinesia (TD) and myoclonic seizures. The amount likewise fluctuates as per the method of administration (e.g. Tablet or Oral) specified in the table beneath.
Condition
Dosage
Administration
Burning Mouth Syndrome
0.5 mg, , 1.0 mg, 2.0 mg, 0.25 mg, 0.125 mg
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Wafer, Wafer - Oral
Panic Disorder
0.5 mg, , 1.0 mg, 2.0 mg, 0.25 mg, 0.125 mg
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Wafer, Wafer - Oral
Akinetic seizures
0.5 mg, , 1.0 mg, 2.0 mg, 0.25 mg, 0.125 mg
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Wafer, Wafer - Oral
Seizures
0.5 mg, , 1.0 mg, 2.0 mg, 0.25 mg, 0.125 mg
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Wafer, Wafer - Oral
myoclonic seizures
0.5 mg, , 1.0 mg, 2.0 mg, 0.25 mg, 0.125 mg
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Wafer, Wafer - Oral
Acute Coryza
0.5 mg, , 1.0 mg, 2.0 mg, 0.25 mg, 0.125 mg
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Wafer, Wafer - Oral
Bipolar Disorder
0.5 mg, , 1.0 mg, 2.0 mg, 0.25 mg, 0.125 mg
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Wafer, Wafer - Oral
Restless Legs Syndrome
0.5 mg, , 1.0 mg, 2.0 mg, 0.25 mg, 0.125 mg
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Wafer, Wafer - Oral
Eye Movements
0.5 mg, , 1.0 mg, 2.0 mg, 0.25 mg, 0.125 mg
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Wafer, Wafer - Oral
Behcet Syndrome
0.5 mg, , 1.0 mg, 2.0 mg, 0.25 mg, 0.125 mg
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Wafer, Wafer - Oral
Tourette Syndrome
0.5 mg, , 1.0 mg, 2.0 mg, 0.25 mg, 0.125 mg
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Wafer, Wafer - Oral
Tardive Dyskinesia
0.5 mg, , 1.0 mg, 2.0 mg, 0.25 mg, 0.125 mg
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Wafer, Wafer - Oral
Essential Tremor
0.5 mg, , 1.0 mg, 2.0 mg, 0.25 mg, 0.125 mg
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Wafer, Wafer - Oral
Lennox Gastaut Syndrome
0.5 mg, , 1.0 mg, 2.0 mg, 0.25 mg, 0.125 mg
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Wafer, Wafer - Oral

Warnings

Clonazepam Contraindications
Condition
Risk Level
Notes
Disease
Do Not Combine
Pulse Frequency
Do Not Combine
Glaucoma
Do Not Combine
There are 20 known major drug interactions with Clonazepam.
Common Clonazepam Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Clonazepam.
Azelastine
Major
Clonazepam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Clonazepam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methadone
Major
Clonazepam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Olanzapine
Major
The risk or severity of adverse effects can be increased when Clonazepam is combined with Olanzapine.
Clonazepam Toxicity & Overdose RiskTaking too much clonazepam can cause drowsiness, lack of coordination, slurred speech, eye twitching, and shallow breathing. In extreme cases, someone may become so unresponsive that they enter a coma, though this usually doesn't last more than a few hours. If taken while pregnant or breastfeeding, clonazepam can cause birth defects or withdrawal symptoms in newborns. Elderly patients should take the lowest possible dose of clonazepam to avoid falls and fractures. The highest toxic dose of clonazepam is greater than 4000 mg/kg for mice, rats, and rabbits.

Clonazepam Novel Uses: Which Conditions Have a Clinical Trial Featuring Clonazepam?

24 active studies are being conducted to assess the potential of Clonazepam to treat Behcet Syndrome, Tremor, Essential and Myoclonic Seizures.
Condition
Clinical Trials
Trial Phases
Tardive Dyskinesia
0 Actively Recruiting
Acute Coryza
1 Actively Recruiting
Not Applicable
Burning Mouth Syndrome
1 Actively Recruiting
Early Phase 1
Akinetic seizures
0 Actively Recruiting
Panic Disorder
13 Actively Recruiting
Not Applicable
Eye Movements
0 Actively Recruiting
Restless Legs Syndrome
3 Actively Recruiting
Not Applicable
Bipolar Disorder
0 Actively Recruiting
myoclonic seizures
0 Actively Recruiting
Seizures
0 Actively Recruiting
Tourette Syndrome
0 Actively Recruiting
Lennox Gastaut Syndrome
2 Actively Recruiting
Phase 1, Phase 2, Phase 4
Essential Tremor
0 Actively Recruiting
Behcet Syndrome
1 Actively Recruiting
Not Applicable

Patient Q&A Section about clonazepam

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the dangers of taking clonazepam?

"- The U.S. Food and Drug Administration (FDA) is warning the public that clonazepam, a seizure medicine and muscle relaxant, may increase the risk of serious or life-threatening breathing problems, sedation, or coma if used along with certain other medications. Clonazepam is sold under the brand names Klonopin, Sprinkle, and Razadyne, and as a generic drug. Clonazepam is used to treat seizures and panic disorder.

If you take clonazepam with certain other drugs, you may have serious or life-threatening side effects. These include breathing problems, sedation, or coma. The FDA is warning people not to take clonazepam with certain other medications."

Answered by AI

Is clonazepam the same thing as a Xanax?

"Both medications are benzodiazepines, which are CNS depressants that can be used to treat anxiety or panic attacks. Both drugs are short acting, but clonazepam stays in the body for longer than Xanax. The half-life of Xanax is 6–25 hours, while for clonazepam, it is 22–54 hours."

Answered by AI

Is clonazepam used as a sleeping pill?

"Clonazepam (Klonopin) is a sedative, so it can help people fall asleep.

Clonazepam (Klonopin) is often used as a sleeping pill even though it is not approved by the FDA for insomnia. This is because clonazepam (Klonopin) is a sedative and can help people fall asleep."

Answered by AI

What is clonazepam prescribed for?

"Clonazepam belongs to a group of medicines called benzodiazepines. It's used to control seizures or fits due to epilepsy, involuntary muscle spasms, panic disorder and sometimes restless legs syndrome. Clonazepam is available by prescription only. It comes as tablets and as a liquid that you swallow."

Answered by AI

Clinical Trials for Clonazepam

Image of Rhode Island Hospital in Providence, United States.

Peroneal Nerve Stimulation for Restless Legs Syndrome

18+
Female
Providence, RI
The goal of this study is to evaluate whether peroneal electrical nerve stimulation (PNS) using the TOMAC™ device is a feasible, acceptable, and safe non-pharmacologic intervention for managing Restless Legs Syndrome (RLS) during pregnancy. This pilot study will also collect preliminary information on symptom relief, sleep quality, and maternal-fetal safety associated with device use. The main questions the study aims to answer are: Is TOMAC™ PNS a feasible and acceptable intervention for RLS in pregnant individuals? Are there any maternal, fetal, or neonatal safety concerns with PNS use during pregnancy? What are the patterns of adherence, tolerance, and usability of the TOMAC™ device in this population? Participants will: Use a non-invasive TOMAC™ peroneal nerve stimulator during 30-minute sessions as needed, for 8 weeks. Complete questionnaires assessing feasibility, acceptability, symptom severity, and sleep quality (including AIM, IAM, FIM, IRLS, PGI-I, PSQI, ESS, FOSQ, and MOS-II). Wear an actigraphy monitor to collect objective sleep data at baseline and at 4 weeks. Attend scheduled follow-up visits and phone check-ins for maternal vital signs, uterine contraction and fetal monitoring, and neonatal outcome assessment. This is a prospective, open-label, single-arm pilot study enrolling 15 pregnant participants between 21 and 26 weeks' gestation. Findings will provide the first dataset on the feasibility, acceptability, and safety of TOMAC™ PNS in pregnancy and inform the design of a future randomized controlled trial.
Recruiting
Has No Placebo
Rhode Island Hospital
Image of Baylor College of Medicine in Houston, United States.

Cognitive Behavioral Therapy for Childhood Anxiety and OCD

7 - 17
All Sexes
Houston, TX
Anxiety disorders in children and adolescents are common and confer significant disability. Cognitive behavioral therapy (CBT) is the recommended treatment for youth with anxiety, yet many families cannot access CBT due to cost, practicalities of attending in-person treatment sessions, and a shortage of trained providers, especially in rural areas. To combat these barriers, other treatment methods have been developed. Previous research has shown that family-based, internet-delivered CBT (iCBT) for anxiety and OCD in youth has shown a significant reduction in anxiety symptoms. Parent-coached exposure therapy (PCET) focuses entirely on teaching parents and youth together how to address anxiety through the completion of in-session parent-coached exposures and assigning parent-coached exposure as homework in between sessions. Although both iCBT and PCET show positive results in treating pediatric anxiety in comparison to standard-care CBT, little is known about the comparative efficacy of iCBT and PCET. This research is being done to understand the comparative effectiveness of two different types of cognitive-behavioral therapy (CBT) for treating anxiety or OCD in youth.
Recruiting
Has No Placebo
Baylor College of Medicine
Have you considered Clonazepam clinical trials? We made a collection of clinical trials featuring Clonazepam, we think they might fit your search criteria.Go to Trials
Image of The Hospital for Sick Children in Toronto, Canada.

Epidiolex for Epilepsy

2 - 18
All Sexes
Toronto, Canada
The goal of this clinical trial is to learn the best way to switch children with Lennox-Gastaut Syndrome (LGS) or Dravet Syndrome (DS) taking 'artisanal' (non pharmaceutical-grade) cannabidiol (CBD) to Epidiolex for treatment of seizures. The main questions it aims to answer are: * How well does a gradual switch from 'artisanal' CBD to Epidiolex work? * Does the same dose of Epidiolex as 'artisanal' CBD work best? * What side-effects or medical problems do participants have when switching from 'artisanal' CBD to Epidiolex? Researchers will examine how successful switching from 'artisanal' CBD to Epidiolex is. Participants will: * Gradually increase their dose of Epidiolex and reduce their dose of 'artisanal' CBD until they are taking just Epidiolex * Visit the clinic five times over 20 weeks for checkups and tests * Keep a diary of their seizures, symptoms and the number of times they use a rescue seizure medication
Phase 4
Waitlist Available
The Hospital for Sick ChildrenElizabeth Donner, MDJazz Pharmaceuticals
Image of Sunnybrook Health Sciences Centre in Toronto, Canada.

Cannabis for Restless Legs Syndrome

18+
All Sexes
Toronto, Canada
Restless Legs Syndrome (RLS) is a disorder that causes painful and uncomfortable sensations in the legs, and its symptoms have a significant impact on sleep and quality of life. Cannabis has been used by some RLS patients as a treatment due to its painkilling and drowsiness effects, however there has never been a clinical research trial investigating cannabis in patients with RLS. A controlled trial is needed to establish how safe and feasible cannabis is as a treatment for RLS. The investigators plan to randomize 30 participants with moderate-to-severe RLS to receive either cannabis or placebo for 8 weeks. The investigators will measure patients sleep quality and quality of life at baseline and 8-week follow-up. The investigators will also monitor patients for any adverse reactions to the study drug.
Recruiting
Drug
Sunnybrook Health Sciences Centre (+1 Sites)
Image of Boston Childrens' Hospital in Boston, United States.

Transdermal CBD for Epilepsy

2 - 55
All Sexes
Boston, MA
This study is a preliminary open-label, single-arm Phase II investigation into the safety and efficacy of transdermal cannabidiol (CBD) delivered using GT4 skin bream technology in individuals diagnosed with Dravet and/or Lennox-Gastatu syndrome (DS and/or LGS). We aim to enroll 25 participants between the ages of 2 and 55 diagnosed with DS and/or LGS. Transdermal delivery of cannabinoids may provide advantages over other traditional routes of administration. Noted advantages include avoidance of first pass metabolism which mitigates potentially dangerous drug-drug interactions due to delayed cannabinoid accumulation, and more stable and constant plasma cannabinoid concentrations. GT4 technology, uses emulsion technology containing penetrating agents, basement membrane disruptors, and vasodilators to overcome hydrophilic and lipophilic structures to open channels and transport cannabinoids deep into the dermis layer of the skin. Once in the dermis, vasodilators dilate the capillary bed to increase fluid dynamic flow into and out of the application site, delivering cannabinoids into the blood stream. The primary objective is to investigate the safety and efficacy of CBD delivery with the A-Synaptic GT4 Transdermal Delivery System in individuals diagnosed with DS and/orLGS. Dr. Rotenberg will apply for and hold the expanded access IND for this study, as the sponsor is running this study as an investigator-initiated study. The study consists of 11 visits over \~160 days, dosing begins at Visit #2.
Phase 1 & 2
Waitlist Available
Boston Childrens' HospitalAlexander Rotenberg, MD, PhD
Image of University of Michigan in Ann Arbor, United States.

Neurofeedback for Anxiety

18 - 24
All Sexes
Ann Arbor, MI
This study seeks to understand emotion regulation in those with young adults with anxiety using real-time functional magnetic resonance imaging neurofeedback, a tool that allows individuals to control brain activity. The goal of this project is to understand how receiving feedback about one's own brain activity relates to emotion regulation ability. This work will help the study team understand the brain areas involved in emotion regulation and could lay the groundwork to test if psychotherapy outcomes can be enhanced using neurofeedback. The study hypotheses include: * Participants receiving veritable-Neurofeedback (NF) will show a greater activation increases in the prefrontal cortex (PFC) compared to sham-NF * Participants receiving veritable-NF will show greater cognitive reappraisal (CR) ability compared to those receiving sham-NF * PFC activation will positively correlate with CR ability
Recruiting
Has No Placebo
University of MichiganStefanie Russman Block, Ph.D
Have you considered Clonazepam clinical trials? We made a collection of clinical trials featuring Clonazepam, we think they might fit your search criteria.Go to Trials
Image of VA San Diego Healthcare System, San Diego, CA in San Diego, United States.

Peer-Delivered Suicide Prevention for Serious Mental Illness

18+
All Sexes
San Diego, CA
Suicide is a major public health concern, particularly among Veterans with serious mental illness (SMI, i.e., psychotic disorders or bipolar disorders). Wellness Recovery Action Plan (WRAP) is a well-established evidence-based practice for those with SMI that centers on identifying warning signs of mental illness, developing wellness tools for functional independence, planning for day-to-day effective living within one's community, and building an action plan to create a valued life worth living. This proposed study will refine and pilot SUicide Prevention by Peers Offering Recovery Tactics (SUPPORT), a novel integrated recovery program that is an adaptation of peer-delivered WRAP for Veterans with SMI. In SUPPORT, a Peer Specialist leads a Veteran at increased risk for suicide through recovery planning that is tailored to the Veteran's suicidal experiences with cognitive learning strategies to enhance safety plan recall and improve functioning.
Recruiting
Has No Placebo
VA San Diego Healthcare System, San Diego, CASamantha A Chalker, PhD
Have you considered Clonazepam clinical trials? We made a collection of clinical trials featuring Clonazepam, we think they might fit your search criteria.Go to Trials
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