Cladribine

Chronic Lymphocytic Leukemia, Non-Hodgkin's Lymphoma, Multiple Sclerosis + 3 more
Treatment
2 FDA approvals
20 Active Studies for Cladribine

What is Cladribine

CladribineThe Generic name of this drug
Treatment SummaryAn antineoplastic agent is a type of medication used to treat lymphoproliferative diseases, such as hairy-cell leukemia.
Leustatinis the brand name
image of different drug pills on a surface
Cladribine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Leustatin
Cladribine
1993
13

Approved as Treatment by the FDA

Cladribine, also called Leustatin, is approved by the FDA for 2 uses which include Hairy Cell Leukemia (HCL) and Hairy Cell Leukemia .
Hairy Cell Leukemia (HCL)
Hairy Cell Leukemia

Effectiveness

How Cladribine Affects PatientsCladribine is a chemical used to treat cancer. It is similar to another chemical, deoxyadenosine, but with an extra chlorine atom that makes it more powerful. Cladribine has a longer lasting effect than deoxyadenosine on resting and growing cells, and is part of a group of drugs called anti-metabolites. These drugs prevent cells from making and repairing their DNA, which stops cancer cells from growing and spreading.
How Cladribine works in the bodyCladribine works differently than other drugs. It is changed by an enzyme into a form that gets absorbed into DNA and stops it from copying. This causes cells, like lymphocytes, to break down and die. Cladribine affects resting and active cells, and it also stops DNA repair. It also binds to a protein called PNP, but we don't know how this affects its action.

When to interrupt dosage

The endorsed measure of Cladribine is subject to the diagnosed condition, for example Non-Hodgkin's Lymphoma, Hairy Cell Leukemia and Chronic Lymphocytic Leukemia. The quantity of dosage can be found in the table below, contingent upon the technique of delivery (e.g. Solution - Intravenous or Injection).
Condition
Dosage
Administration
Chronic Lymphocytic Leukemia
, 1.0 mg/mL, 10.0 mg, 2.0 mg/mL
Intravenous, , Injection, Injection - Intravenous, Solution - Intravenous, Solution, Tablet, Oral, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Injection, solution - Subcutaneous, Subcutaneous
Multiple Sclerosis
, 1.0 mg/mL, 10.0 mg, 2.0 mg/mL
Intravenous, , Injection, Injection - Intravenous, Solution - Intravenous, Solution, Tablet, Oral, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Injection, solution - Subcutaneous, Subcutaneous
Diagnostic Imaging
, 1.0 mg/mL, 10.0 mg, 2.0 mg/mL
Intravenous, , Injection, Injection - Intravenous, Solution - Intravenous, Solution, Tablet, Oral, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Injection, solution - Subcutaneous, Subcutaneous
Non-Hodgkin's Lymphoma
, 1.0 mg/mL, 10.0 mg, 2.0 mg/mL
Intravenous, , Injection, Injection - Intravenous, Solution - Intravenous, Solution, Tablet, Oral, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Injection, solution - Subcutaneous, Subcutaneous
Hairy Cell Leukemia
, 1.0 mg/mL, 10.0 mg, 2.0 mg/mL
Intravenous, , Injection, Injection - Intravenous, Solution - Intravenous, Solution, Tablet, Oral, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Injection, solution - Subcutaneous, Subcutaneous
CTAGE1 protein, human
, 1.0 mg/mL, 10.0 mg, 2.0 mg/mL
Intravenous, , Injection, Injection - Intravenous, Solution - Intravenous, Solution, Tablet, Oral, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Injection, solution - Subcutaneous, Subcutaneous

Warnings

There are 20 known major drug interactions with Cladribine.
Common Cladribine Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Cladribine is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Cladribine is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Cladribine is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Cladribine is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Cladribine is combined with Acteoside.
Cladribine Toxicity & Overdose RiskOverdosing on Cisatracurium may lead to irreversible nerve damage, kidney damage, and decreased numbers of white blood cells, red blood cells, and platelets.
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Cladribine Novel Uses: Which Conditions Have a Clinical Trial Featuring Cladribine?

At present, there are 380 ongoing trials investigating the potential of Cladribine to target CTAGE1 protein, human, Chronic Lymphocytic Leukemia and Non-Hodgkin's Lymphoma.
Condition
Clinical Trials
Trial Phases
Chronic Lymphocytic Leukemia
147 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Early Phase 1, Phase 4
CTAGE1 protein, human
11 Actively Recruiting
Phase 1, Not Applicable, Phase 2, Early Phase 1, Phase 3
Hairy Cell Leukemia
13 Actively Recruiting
Phase 2, Phase 1
Non-Hodgkin's Lymphoma
124 Actively Recruiting
Phase 1, Phase 2, Early Phase 1, Not Applicable, Phase 3, Phase 4
Diagnostic Imaging
0 Actively Recruiting
Multiple Sclerosis
12 Actively Recruiting
Phase 3, Phase 4, Phase 2, Phase 1

Cladribine Reviews: What are patients saying about Cladribine?

5Patient Review
11/14/2007
Cladribine for Type of Leukemia - Hairy Cell Leukemia
I found that I was getting very tired and my appetite decreased during the treatment, but a few days after finishing the fevers started. I had to stay in the hospital for 9 days as a result, which wasn't fun.
5Patient Review
11/26/2009
Cladribine for Type of Leukemia - Hairy Cell Leukemia
After just one week of this treatment, there was zero leukemia cells found in my bone marrow. No other side effects either, which is amazing. I feel great again!
3.3Patient Review
7/23/2020
Cladribine for Multiple Sclerosis Symptoms Return then Become Less Severe
It's not the easiest medication to take, in terms of both the physical act and waiting for it to 'kick in'. I don't find that it lasts as long as I would like, but it is effective while working. However, the symptoms come back relatively quickly after it wears off.
3Patient Review
5/30/2012
Cladribine for Type of Leukemia - Hairy Cell Leukemia
The first treatment was an all-day drip for seven days straight in a hospital setting. The second treatment was five one-hour sessions done consecutively as an outpatient. As side effects, I experienced severe fever, chills, night sweats, fatigue, spleen pain and general discomfort.
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Patient Q&A Section about cladribine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is cladribine used for?

"This medication is used to treat hairy cell leukemia (a cancer of a certain type of white blood cell). It works by slowing or stopping the growth of cancer cells."

Answered by AI

What type of chemo is cladribine?

"How this drug works: Cladribine works by killing cancer cells or by stopping their growth.

Cladribine is an anti-cancer drug that kills cancer cells or prevents their growth."

Answered by AI

How does cladribine work in MS?

"This medication is used to treat relapsing forms of multiple sclerosis. It is not a cure, but it is thought to work by preventing immune system cells from attacking the nerves in the brain and spinal cord. This may help to slow disease progression and reduce the severity of flare-ups."

Answered by AI

Is cladribine a chemotherapy?

"Cladribine is a chemotherapy drug that is mainly used to treat hairy cell leukemia, but it can also be used to treat other types of leukemia."

Answered by AI

Clinical Trials for Cladribine

Have you considered Cladribine clinical trials? We made a collection of clinical trials featuring Cladribine, we think they might fit your search criteria.
Have you considered Cladribine clinical trials? We made a collection of clinical trials featuring Cladribine, we think they might fit your search criteria.
Have you considered Cladribine clinical trials? We made a collection of clinical trials featuring Cladribine, we think they might fit your search criteria.
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