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Behavioural Intervention

Focused Ultrasound for Memory Loss (LIFUPMEMEMOT Trial)

N/A
Waitlist Available
Led By Taylor P Kuhn, PhD
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
English must be the dominant language
Must be between 35-65 years of age
Timeline
Screening 3 weeks
Treatment Varies
Follow Up pre-lifup and post-lifup at day 1 and day 15
Awards & highlights

LIFUPMEMEMOT Trial Summary

This trial is testing whether a non-invasive brain stimulation technique called low intensity focused ultrasound pulsation (LIFUP) can selectively increase regional activity in the medial temporal lobe (MTL) and improve memory performance.

Who is the study for?
This trial is for right-handed English speakers aged 35-65 with learning disabilities, memory loss, or cognitive issues. It's not suitable for those with MRI contraindications like metal implants, major psychiatric or neurological illnesses, significant head injuries, alcohol/substance abuse history, or cancer.Check my eligibility
What is being tested?
The study tests if Low Intensity Focused Ultrasound Pulsation (LIFUP) can improve memory by stimulating the brain's medial temporal lobe non-invasively. Participants will be randomly assigned to receive either LIFUP or a SHAM ultrasound that mimics treatment without real effects.See study design
What are the potential side effects?
Since this is a non-invasive method using ultrasound waves focused on specific brain areas and does not involve drugs or surgery, side effects are expected to be minimal. However, potential discomfort from the device placement may occur.

LIFUPMEMEMOT Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
English is my primary language.
Select...
I am between 35 and 65 years old.

LIFUPMEMEMOT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~pre-lifup and post-lifup at day 1 and day 15
This trial's timeline: 3 weeks for screening, Varies for treatment, and pre-lifup and post-lifup at day 1 and day 15 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Average Perfusion in Regions Of Interest
Rey Auditory Verbal Learning Task
State Trait Anxiety Inventory - State (STAIS)
Secondary outcome measures
Brief Visuospatial Memory Test
Emotional Reactivity Task

LIFUPMEMEMOT Trial Design

2Treatment groups
Experimental Treatment
Group I: Entorhinal Cortex first, then AmygdalaExperimental Treatment2 Interventions
Low Intensity focused ultrasound pulsation (LIFUP) will be administered to the entorhinal cortex while participants are in the MRI scanner. Then, 2 weeks later, amygdala LIFUP will be administered.
Group II: Amygdala first, then Entorhinal CortexExperimental Treatment2 Interventions
Low Intensity focused ultrasound pulsation (LIFUP) will be administered to the amygdala while participants are in the MRI scanner. Then, 2 weeks later, entorhinal cortex LIFUP will be administered.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Low Intensity Focused Ultrasound Pulsation to Amygdala
2019
N/A
~30
Low Intensity Focused Ultrasound Pulsation to Entorhinal Cortex
2019
N/A
~30

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,529 Previous Clinical Trials
10,277,781 Total Patients Enrolled
Taylor P Kuhn, PhDPrincipal InvestigatorUCLA Longevity Center
3 Previous Clinical Trials
200 Total Patients Enrolled

Media Library

Low Intensity Focused Ultrasound Pulsation (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT03717922 — N/A
Memory Loss Research Study Groups: Entorhinal Cortex first, then Amygdala, Amygdala first, then Entorhinal Cortex
Memory Loss Clinical Trial 2023: Low Intensity Focused Ultrasound Pulsation Highlights & Side Effects. Trial Name: NCT03717922 — N/A
Low Intensity Focused Ultrasound Pulsation (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03717922 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are signed up to take part in this medical experiment?

"Affirmative. Clinicaltrials.gov notes that this research endeavor, initially posted on June 28th 2019, is looking to procure 50 participants from a single medical facility."

Answered by AI

What types of participants are ideal for the research trial?

"This clinical trial requires 50 participants between the ages of 35-65 with a brain disorder. As well, all applicants must be over 18 years of age and below 65 years old."

Answered by AI

Are there any opportunities for participants to enroll in this investigation?

"Affirmative. Per the ClinicalTrials website, this trial is actively recruiting participants. The experiment was first announced on June 28th 2019 and received its most recent update on September 2nd 2022. There are 50 spots open at a single site for interested individuals."

Answered by AI

Does this trial accept applications from individuals younger than 45 years old?

"Prospective participants must be of age (18+) and under the retirement age (65-) for this experiment."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Low Intensity Focused Ultrasound for Learning and Memory and Emotion Regulation
Taylor Kuhn 2019. "Low Intensity Focused Ultrasound for Learning and Memory and Emotion Regulation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03717922.
~4 spots leftby Apr 2025
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