Chronulac

Constipation, Hepatic Encephalopathy, Hepatic Encephalopathy

Treatment

6 FDA approvals

17 Active Studies for Chronulac

Treatment for

Constipation

What is Chronulac

Lactulose

The Generic name of this drug

Treatment Summary

Lactulose is a synthetic sugar-based drug used to treat constipation and portal-systemic encephalopathy (PSE). It was first synthesized in 1929, but it wasn't until the 1960s that its use as a laxative was investigated. It was approved by the FDA in 1977 and is now available over-the-counter. While it is an effective and safe option for treating constipation and PSE, its exact effectiveness is not clear. It is typically only used after lifestyle and dietary modifications have failed.

Lactulose

is the brand name

Chronulac Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Lactulose

1966

Approved as Treatment by the FDA

Lactulose, also known as Lactulose, is approved by the FDA for 6 uses which include Hepatic Encephalopathy (HE) and prophylaxis of Hepatic encephalopathy .

Hepatic Encephalopathy (HE)

prophylaxis of Hepatic encephalopathy

Constipation

Hepatic Encephalopathy

Effectiveness

How Chronulac Affects Patients

Lactulose is a laxative commonly taken by mouth or rectally. It stays in the gastrointestinal tract and helps to soften stools and increase their volume, which can cause increased bowel sounds, bloating, burping, gas, and diarrhea.

How Chronulac works in the body

Lactulose is a medication that helps people with constipation and portal-systemic encephalopathy (PSE). It works by breaking down into organic acids in the large intestine and creating gas which increases the water content of the stool, making it softer and easier to pass. It can take 24-48 hours for the laxative effects to be evident. For PSE, Lactulose also creates an acidic environment in the colon which prevents absorbed ammonia from entering the bloodstream by turning it into ammonium ions. This prevents excess ammonia from building up in the body, and also causes urease-producing bacteria to be eliminated

When to interrupt dosage

The measure of Chronulac is reliant upon the diagnosed affliction, including Hepatic Encephalopathy, Chronic Constipation and Hepatic Encephalopathy. The amount of dosage is contingent on the method of delivery (e.g. Oral or Solution) outlined in the table below.

Condition

Dosage

Administration

Constipation

, 1000.0 mg/mL, 2000.0 mg/mL, 1.0 mg/mg, 2.0 mg/mg, 667.0 mg, 667.0 mg/mL, 3300.0 mg/mL, 0.95 mg/mg

, Oral, Solution, Solution - Oral, Solution - Oral; Rectal, Oral; Rectal, Powder, for solution - Oral, Powder, for solution, Liquid, Syrup, Powder, Liquid - Oral; Rectal, Syrup - Oral, Syrup - Oral; Rectal, Powder - Oral, Liquid - Oral

Hepatic Encephalopathy

, 1000.0 mg/mL, 2000.0 mg/mL, 1.0 mg/mg, 2.0 mg/mg, 667.0 mg, 667.0 mg/mL, 3300.0 mg/mL, 0.95 mg/mg

Hepatic Encephalopathy

, 1000.0 mg/mL, 2000.0 mg/mL, 1.0 mg/mg, 2.0 mg/mg, 667.0 mg, 667.0 mg/mL, 3300.0 mg/mL, 0.95 mg/mg

Warnings

Chronulac has two contraindications; therefore, it should not be ingested when encountering the conditions in the following table.

Chronulac Contraindications

Condition

Risk Level

Notes

low galactose diet

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Chronulac.

Common Chronulac Drug Interactions

Drug Name

Risk Level

Description

Alloin

Minor

The risk or severity of adverse effects can be increased when Lactulose is combined with Alloin.

Bisacodyl

Minor

The risk or severity of adverse effects can be increased when Lactulose is combined with Bisacodyl.

Bisoxatin

Minor

The risk or severity of adverse effects can be increased when Lactulose is combined with Bisoxatin.

Calcium polycarbophil

Minor

The risk or severity of adverse effects can be increased when Lactulose is combined with Calcium polycarbophil.

Carboxymethylcellulose

Minor

The risk or severity of adverse effects can be increased when Lactulose is combined with Carboxymethylcellulose.

Chronulac Toxicity & Overdose Risk

The toxic dose of lactulose in mice is 48.8 mL/kg and more than 30 mL/ kg in rats. If someone overdoses on lactulose, they may experience abdominal cramps and diarrhea and should be given fluids and electrolytes as needed. It is not known if lactulose is safe to take during pregnancy or while nursing, so caution should be used. Studies in rats, mice, and rabbits have not shown any effects on fertility. Not enough data exists to say if it is safe to use in children or if it causes long-term mutations or cancer.

Chronulac Novel Uses: Which Conditions Have a Clinical Trial Featuring Chronulac?

25 active studies are examining the potential of Chronulac to manage Hepatic Encephalopathy, Chronic Constipation and Hepatic Encephalopathy related conditions.

Condition

Clinical Trials

Trial Phases

Hepatic Encephalopathy

0 Actively Recruiting

Constipation

17 Actively Recruiting

Phase 2, Not Applicable, Phase 4, Phase 3

Hepatic Encephalopathy

0 Actively Recruiting

Patient Q&A Section about chronulac

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does lactulose do to poop?

"Lactulose can help treat this condition by stopping the absorption of toxins from the bowel into the blood.

Lactulose is a type of laxative called an osmotic laxative. It is broken down by your digestive system into substances that draw water out of your body and into your digestive system to soften feces and make it easier to pass. People with liver disease can sometimes get problems in their brain (hepatic encephalopathy). Lactulose can help treat this condition by stopping the absorption of toxins from the digestive system into the bloodstream."

Answered by AI

Is lactulose a laxative?

"Lactulose is a laxative that comes from lactose. It's used to treat chronic constipation and hepatic encephalopathy or coma, which are brain disorders caused by liver disease."

Answered by AI