Caplyta

Schizophrenia, Mood Disorders
Treatment
2 FDA approvals
20 Active Studies for Caplyta

What is Caplyta

LumateperoneThe Generic name of this drug
Treatment SummaryLumateperone is a medication recently approved to treat schizophrenia, a mental health disorder that affects about 1% of the population. It is a second-generation antipsychotic, which means it targets specific neurotransmitters in the brain, such as dopamine, serotonin, and glutamate. It has been shown to help reduce both positive and negative symptoms of schizophrenia and is thought to be safer than other antipsychotics due to its selective targeting of dopamine receptors.
Caplytais the brand name
Caplyta Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Caplyta
Lumateperone
2020
4

Approved as Treatment by the FDA

Lumateperone, otherwise known as Caplyta, is approved by the FDA for 2 uses which include Depression, Bipolar and Mood Disorders .
Depression, Bipolar
Used to treat Depression, Bipolar in combination with Lithium carbonate
Mood Disorders
Used to treat Depression, Bipolar in combination with Lithium carbonate

Effectiveness

How Caplyta Affects PatientsLumateperone (also known as ITI-007) is a medication used to treat schizophrenia. It works in a different way than other antipsychotics, targeting schizophrenia symptoms while reducing side effects. It is partly an agonist and partly an antagonist of dopamine receptors in the brain. People with moderate or severe liver problems are more likely to have higher levels of lumateperone in their bloodstream, and should therefore take half the recommended daily dosage.
How Caplyta works in the bodyLumateperone is a second generation antipsychotic drug that works in a unique way to address the pathophysiology of schizophrenia. It works by reducing the amount of dopamine released in the prefrontal and mesolimbic brain regions, which are known to be affected in people with schizophrenia. It also acts on other neurotransmitters like serotonin, glutamate, GABA, and acetylcholine, as well as dopamine (D1) receptors. Lumateperone also increases the activity of N-methyl-D-aspartate (NMDA) GluN2B receptors, which are impaired in people with schizophrenia

When to interrupt dosage

The amount of Caplyta is contingent upon the recognized condition. The quantity of dosage fluctuates as per the technique of administration listed in the table below.
Condition
Dosage
Administration
Schizophrenia
, 42.0 mg
Oral, , Capsule - Oral, Capsule
Mood Disorders
, 42.0 mg
Oral, , Capsule - Oral, Capsule

Warnings

Caplyta Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Lumateperone may interact with Pulse Frequency
There are 20 known major drug interactions with Caplyta.
Common Caplyta Drug Interactions
Drug Name
Risk Level
Description
Amisulpride
Major
Lumateperone may increase the antipsychotic activities of Amisulpride.
Azelastine
Major
Lumateperone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Deutetrabenazine
Major
The risk or severity of adverse effects can be increased when Lumateperone is combined with Deutetrabenazine.
Ethanol
Major
Lumateperone may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Lumateperone is combined with Oliceridine.
Caplyta Toxicity & Overdose RiskSince lumateperone is new, there is no information available yet about what happens when someone overdoses. It is likely that symptoms will be more extreme versions of the normal side effects, such as increased drowsiness.
image of a doctor in a lab doing drug, clinical research

Caplyta Novel Uses: Which Conditions Have a Clinical Trial Featuring Caplyta?

186 active studies are currently underway to explore the potential of Caplyta in alleviating symptoms of Depressive Bipolar Disorder.
Condition
Clinical Trials
Trial Phases
Schizophrenia
108 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 4, Phase 2, Phase 1
Mood Disorders
14 Actively Recruiting
Not Applicable, Early Phase 1, Phase 2, Phase 4, Phase 1, Phase 3

Caplyta Reviews: What are patients saying about Caplyta?

5Patient Review
11/4/2022
Caplyta for Bipolar Depression
I'm grateful to have found this treatment. I feel like it's helped me more than any other medication I've tried for my depression.
4.7Patient Review
8/28/2022
Caplyta for Bipolar Depression
Caplyta does an excellent job of handling my intrusive thoughts. It's almost like they've hired a gang of bouncers to profile negativity and block it from getting into the conscious thought club. Warning: Mid day naps are recommended (for me at least) at the moment. Hopefully once my body adjusts to Caplyta I won't need to nap much longer and should be able to stay up through the day.
4.3Patient Review
10/26/2022
Caplyta for Bipolar Depression
Although the headaches at the beginning are quite literally the worst, after 3 days my mood lifted. 2 weeks in I'm creating again although I'm having a hard time eating and have lost a dramatic amount of weight. So far I am pleased with this medication considering just 2 weeks ago I was suicidal. If the headaches bother you take Excedrin migraine relief at the same time for the first week or so.
4Patient Review
9/21/2022
Caplyta for Bipolar Depression
I've been on the medication for almost a month now. I haven't experienced any negative side effects, which is great. I also feel like it's slowly but surely helping me get better.
2.3Patient Review
7/29/2022
Caplyta for Bipolar Depression
I was doing "ok" before I started taking this medication. It worked well for about a month and a half, but then I was left in crippling depression. Sometimes it's better to be happy with "ok."
View All Reviews
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Patient Q&A Section about caplyta

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the serious side effects of Caplyta?

"Common side effects of antipsychotics include:

  • low blood pressure upon standing up
  • increased blood sugar levels
  • high cholesterol levels
  • seizures
  • difficulty regulating body temperature
  • neuroleptic malignant syndrome (a severe condition that may include muscle rigidity and kidney failure)
  • difficulty swallowing"
Answered by AI

What is Caplyta used for?

"A prescription medication called CAPLYTA is used to treat episodes of depression that are associated with bipolar I or bipolar II disorder. It can be taken alone or with the medicines lithium or valproate, and is effective for bipolar depression. However, it is not yet known if CAPLYTA is safe and effective to use with children."

Answered by AI

Is Caplyta a mood stabilizer?

"The medication Caplyta affects the neurotransmitters dopamine, serotonin, and glutamate in order to improve symptoms of mood, thoughts, and behaviors. It may help with symptoms of schizophrenia, which can in turn improve daily functioning."

Answered by AI

Does Caplyta help anxiety?

"A previous study in patients with generalized anxiety disorder found that a single dose of the drug showed significant anti-anxiety signals in brain imaging and behavioral studies, but without evidence of sedating patients or becoming addictive."

Answered by AI

Clinical Trials for Caplyta

Have you considered Caplyta clinical trials? We made a collection of clinical trials featuring Caplyta, we think they might fit your search criteria.
Have you considered Caplyta clinical trials? We made a collection of clinical trials featuring Caplyta, we think they might fit your search criteria.
Have you considered Caplyta clinical trials? We made a collection of clinical trials featuring Caplyta, we think they might fit your search criteria.
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