Bicillin L-A

Gas Gangrene, Botulism, Anthrax + 20 more

Treatment

20 Active Studies for Bicillin L-A

Treatment for

Gas Gangrene

What is Bicillin L-A

BenzylpenicillinThe Generic name of this drug

Treatment SummaryBenzylpenicillin (Penicillin G) is an antibiotic used to treat infections caused by certain types of bacteria. Natural penicillins are the best drugs to treat certain infections caused by susceptible gram positive aerobic organisms like streptococcus and staphylococcus bacteria. It is usually given intravenously or intramuscularly due to poor oral absorption. Benzylpenicillin can also be used as a preventative medication against certain types of bacteria. It may also be used to treat certain gram positive aerobic bacilli such as anthrax and diphtheria, as well as some infections caused by gram

Bicillin L-Ais the brand name

Bicillin L-A Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Bicillin L-A

Benzylpenicillin

1952

Effectiveness

How Bicillin L-A Affects PatientsPenicillin G is an antibiotic used to fight bacterial infections. It is part of a group of antibiotics known as penicillins. It works by stopping the bacteria from forming walls that protect and help them grow, and is effective against both gram-positive and gram-negative bacteria. Penicillin G is resistant to most beta-lactamases, which are enzymes used by bacteria to break down antibiotics.

How Bicillin L-A works in the bodyPenicillin G works by attaching to proteins inside the bacterial cell wall, stopping the cell wall from finishing its growth. This causes the cell to break apart, using enzymes that are naturally found in the cell. Penicillin G may also block an enzyme that helps keep the cell from breaking down.

When to interrupt dosage

The prescribed dosage of Bicillin L-A is contingent upon the diagnosed condition, such as rat bite fever, Haverhill fever and Actinomycosis. The amount of dosage is dependent upon the technique of administration (e.g. Intramuscular; Intravenous or Injection, suspension) as illustrated in the table below.

Condition

Dosage

Administration

Endocarditis

, 5000000.0 [iU], 20000000.0 [iU], 5000000.0 [USP'U], 1200000.0 [iU]/mL, 5000000.0 units, 1000000.0 units, 10000000.0 units, 500000.0 units, 600000.0 [iU]/mL, 2400000.0 [iU]/mL, 100000.0 [iU]/mL, 200000.0 [iU]/mL, 300000.0 [iU]/mL, 1000000.0 [iU], 900000.0 [iU]/mL, 500000.0 units/mL, 1200000.0 units/mL, 250000.0 units/mL, 900000.0 units/mL, 300000.0 units/mL

, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, suspension, Injection, suspension - Intramuscular, Intramuscular, Intramuscular; Intrapleural; Intrathecal; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intrapleural; Intrathecal; Intravenous, Intravenous, Powder, for solution - Intravenous, Powder, for solution - Intramuscular; Intravenous, Intramuscular; Intravenous; Topical, Powder, for solution - Intramuscular; Intravenous; Topical, Oral, Tablet - Oral, Tablet, Suspension - Intramuscular, Suspension, Suspension - Oral, Powder, for solution - Intramuscular, Injection, solution, Injection, solution - Intravenous, Injection, powder, for solution - Intravenous

Communicable Diseases

Bacterial Meningitis

Rat-Bite Fever

Gram-Negative Bacterial Infections

Actinomycosis

Listeriosis

Fusospirochetosis

Rat-Bite Fever

Rheumatic Fever

Sepsis

Endocarditis

Botulism

Anthrax

Lockjaw

Diphtheria

Empyema

Pericarditis

Gonorrhea

Meningitis, Meningococcal

Warnings

Bicillin L-A has one contraindication. It should not be ingested when encountering any of the conditions outlined in the following table.Bicillin L-A Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Benzylpenicillin may interact with Pulse Frequency

There are 20 known major drug interactions with Bicillin L-A.

Common Bicillin L-A Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Benzylpenicillin.

Adefovir dipivoxil

Minor

The excretion of Adefovir dipivoxil can be decreased when combined with Benzylpenicillin.

Chlormadinone

Minor

The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Benzylpenicillin.

Cidofovir

Minor

The excretion of Cidofovir can be decreased when combined with Benzylpenicillin.

Cloprostenol

Minor

The therapeutic efficacy of Cloprostenol can be decreased when used in combination with Benzylpenicillin.

Bicillin L-A Toxicity & Overdose RiskThe lowest toxic dose of penicillin in rats has been found to be 8900mg/kg. High concentrations of the drug in the cerebral spinal fluid can lead to convulsions, and prolonged use of high doses can cause a decrease in white blood cells.

Bicillin L-A Novel Uses: Which Conditions Have a Clinical Trial Featuring Bicillin L-A?

There are 85 active trials presently assessing the utility of Bicillin L-A in treating Pneumonia, Acute Rheumatic Fever and Gram-Negative Bacterial Infections.

Condition

Clinical Trials

Trial Phases

Pneumonia

19 Actively Recruiting

Not Applicable, Phase 3, Early Phase 1, Phase 2, Phase 1

Lockjaw

1 Actively Recruiting

Phase 4

Botulism

1 Actively Recruiting

Phase 2

Bacterial Meningitis

0 Actively Recruiting

Communicable Diseases

0 Actively Recruiting

Rheumatic Fever

0 Actively Recruiting

Fusospirochetosis

0 Actively Recruiting

Meningitis, Meningococcal

0 Actively Recruiting

Anthrax

1 Actively Recruiting

Phase 2

Gram-Negative Bacterial Infections

0 Actively Recruiting

Gas Gangrene

0 Actively Recruiting

Empyema

0 Actively Recruiting

Listeriosis

0 Actively Recruiting

Actinomycosis

0 Actively Recruiting

Diphtheria

1 Actively Recruiting

Phase 4

Rat-Bite Fever

0 Actively Recruiting

Endocarditis

0 Actively Recruiting

Pericarditis

0 Actively Recruiting

Endocarditis

1 Actively Recruiting

Not Applicable

Sepsis

1 Actively Recruiting

Not Applicable

Bicillin L-A Reviews: What are patients saying about Bicillin L-A?

5Patient Review

12/16/2014

Bicillin L-A for Strep Throat and Tonsillitis

Even though it's expensive, this treatment is definitely worth it. My son felt much better the day after being injected with this antibiotic.

5Patient Review

11/4/2019

Bicillin L-A for Strep Throat

I had strep throat and was given amoxicillin, but it didn't seem to help after four days. So my doctor gave me this bicillin shot instead and I felt SO much better almost immediately! Not only did my sore throat get better, but my body aches went away too. The shot stung a bit, but it wasn't bad at all compared to how I was feeling before.

5Patient Review

4/9/2017

Bicillin L-A for Strep Throat

I found myself in the ER early Saturday morning with swollen glands, difficulty swallowing, and overall neck pain. The doctor diagnosed me with strep throat and gave me the option of an IM antibiotic along with a steroid pill. I felt better hours later, but experienced some stomach pain during the night and following day. The shot hurts, but it's better than having to swallow giant pills for 10 days.

5Patient Review

10/11/2021

Bicillin L-A for Strep Throat

I felt awful going in, but noticed a drastic improvement just four hours later. It was like night and day. The needle hurts a bit, but the pain is manageable and totally worth it when you're feeling better the next day.

5Patient Review

1/26/2011

Bicillin L-A for Strep Throat

I had a really severe strep infection and this medication cleared it up overnight. I woke up feeling great the next morning.

View All Reviews

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about bicillin l-a

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What's the difference between Bicillin CR and LA?

"Bicillin L-A is a recommended treatment for syphilis and upper respiratory tract infections caused by susceptible streptococci. The efficacy of Bicillin C-R for treating syphilis is unknown, but it is indicated for streptococcal infections of the skin and respiratory tract."

Answered by AI

Where is bicillin injection given?

"The recommended site for intramuscular injection in adults is the upper, outer quadrant of the buttock (dorsogluteal). In neonates, infants, and small children, the midlateral aspect of the thigh may be preferable. When doses are repeated, vary the injection site."

Answered by AI

How long does Bicillin L-A stay in your system?

"The blood levels may take up to 10 days to return to normal after 600,000 units have been administered, and up to 14 days after 1,200,000 units have been administered. Blood concentrations of 0.003 units per mL may still be detectable 4 weeks after 1,200,000 units have been administered."

Answered by AI

What is Bicillin L-A used for?

"This drug is used to treat infections caused by bacteria. It is also used to prevent certain infections such as rheumatic fever. This drug will not work against infections caused by viruses such as colds or flu."

Answered by AI

Clinical Trials for Bicillin L-A

Have you considered Bicillin L-A clinical trials? We made a collection of clinical trials featuring Bicillin L-A, we think they might fit your search criteria.

Have you considered Bicillin L-A clinical trials? We made a collection of clinical trials featuring Bicillin L-A, we think they might fit your search criteria.