Azopt

Glaucoma, Open Angle Glaucoma, Ocular Hypertension + 1 more

Treatment

7 FDA approvals

18 Active Studies for Azopt

What is Azopt

Brinzolamide

The Generic name of this drug

Treatment Summary

Brinzolamide is a medication used to reduce pressure in the eyes of patients with ocular hypertension or open-angle glaucoma. It works by inhibiting the enzyme carbonic anhydrase, which helps to form bicarbonate ions that are responsible for transporting sodium and fluid in the eye. By reducing the formation of bicarbonate ions, Brinzolamide helps to lower intraocular pressure and relieve symptoms of glaucoma.

Azopt

is the brand name

image of different drug pills on a surface

Azopt Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Azopt

Brinzolamide

1998

9

Approved as Treatment by the FDA

Brinzolamide, also known as Azopt, is approved by the FDA for 7 uses which include Increased Intra Ocular Pressure (IOP) and Open Angle Glaucoma (OAG) .

Increased Intra Ocular Pressure (IOP)

Used to treat Increased Intra Ocular Pressure (IOP) in combination with Timolol

Open Angle Glaucoma (OAG)

Used to treat Open Angle Glaucoma (OAG) in combination with Timolol

Ocular Hypertension

Used to treat Ocular Hypertension in combination with Timolol

Ocular Hypertension

Used to treat Ocular Hypertension in combination with Timolol

inadequate response to monotherapy

Used to treat inadequate response to monotherapy in combination with Timolol

Glaucoma

Used to treat Increased Intra Ocular Pressure (IOP) in combination with Timolol

Open Angle Glaucoma

Used to treat Open Angle Glaucoma (OAG) in combination with Timolol

Effectiveness

How Azopt Affects Patients

Brinzolamide is a medication used to treat glaucoma. It works by reducing the amount of fluid in the eye, which helps to lower the pressure in the eye that can lead to vision loss. This drug can reduce eye pressure by up to 19% in people with high eye pressure.

How Azopt works in the body

Brinzolamide is used to reduce the pressure inside the eye. It does this by lowering the amount of sodium and fluid produced in the eye. When it is applied to the eye, brinzolamide is absorbed into the bloodstream and binds to red blood cells, where it reduces the activity of carbonic anhydrase II (CA-II). This slows down aqueous humor secretion, preventing the pressure from building up. Brinzolamide also produces a metabolite called N-desethyl brinzolamide, which binds mainly to carbonic anhydrase I (CA-I).

When to interrupt dosage

The proposed dosage of Azopt is contingent upon the determined ailment, comprising of Open Angle Glaucoma, Ocular Hypertension and Increased Intra Ocular Pressure (IOP). The measure likewise changes as per the technique of delivery (e.g. Suspension - Ophthalmic or Suspension / drops) mentioned in the table beneath.

Condition

Dosage

Administration

Glaucoma

, 10.0 mg/mL, 1.0 %

Ophthalmic, Suspension / drops - Ophthalmic, , Suspension / drops, Suspension, Suspension - Ophthalmic

Open Angle Glaucoma

, 10.0 mg/mL, 1.0 %

Ophthalmic, Suspension / drops - Ophthalmic, , Suspension / drops, Suspension, Suspension - Ophthalmic

Ocular Hypertension

, 10.0 mg/mL, 1.0 %

Ophthalmic, Suspension / drops - Ophthalmic, , Suspension / drops, Suspension, Suspension - Ophthalmic

inadequate response to monotherapy

, 10.0 mg/mL, 1.0 %

Ophthalmic, Suspension / drops - Ophthalmic, , Suspension / drops, Suspension, Suspension - Ophthalmic

Warnings

There are 18 known major drug interactions with Azopt.

Common Azopt Drug Interactions

Drug Name

Risk Level

Description

Ziconotide

Minor

The risk or severity of CNS depression can be increased when Brinzolamide is combined with Ziconotide.

Benzylpenicillin

Moderate

Brinzolamide may decrease the excretion rate of Benzylpenicillin which could result in a higher serum level.

Haloperidol

Moderate

The serum concentration of Haloperidol can be increased when it is combined with Brinzolamide.

Insulin argine

Moderate

The risk or severity of hypoglycemia can be increased when Brinzolamide is combined with Insulin argine.

Insulin aspart

Moderate

The risk or severity of hypoglycemia can be increased when Brinzolamide is combined with Insulin aspart.

image of a doctor in a lab doing drug, clinical research

Azopt Novel Uses: Which Conditions Have a Clinical Trial Featuring Azopt?

33 active clinical trials are presently examining the potential of Azopt in providing relief for Open Angle Glaucoma, Increased Intra Ocular Pressure (IOP) and inadequate response to monotherapy.

Condition

Clinical Trials

Trial Phases

Ocular Hypertension

11 Actively Recruiting

Phase 3, Phase 1, Phase 2, Not Applicable, Phase 4

Glaucoma

0 Actively Recruiting

Open Angle Glaucoma

10 Actively Recruiting

Phase 3, Not Applicable, Phase 4

inadequate response to monotherapy

0 Actively Recruiting

Azopt Reviews: What are patients saying about Azopt?

5

Patient Review

11/16/2017

Azopt for Wide-Angle Glaucoma

Azopt is the best medication I've tried in terms of side effects and efficacy.

5

Patient Review

10/27/2014

Azopt for Wide-Angle Glaucoma

Azopt is the best glaucoma medication I've tried. It lowers eye pressure without any pain or redness, which other drugs have caused for me. I've been using it successfully for four years now.

5

Patient Review

5/25/2017

Azopt for Increased Pressure in the Eye

I don't feel groggy after taking this, which is great.

5

Patient Review

1/16/2013

Azopt for Increased Pressure in the Eye

Blurred vision and headaches that last for 12 hours or more.

5

Patient Review

9/22/2014

Azopt for Wide-Angle Glaucoma

I haven't experienced the same negative side effects as many other reviewers. For me, my vision only becomes blurry for a few minutes after using this product and there is also a bad taste in my mouth that goes away. These are much better than Lumigan for me because they have lowered my pressure.

4

Patient Review

8/9/2013

Azopt for Wide-Angle Glaucoma

I experienced burning, cloudy vision for five minutes or longer. I would advise not driving for at least that period of time. Other side effects I've experienced are occasional dizziness and headaches.

4

Patient Review

10/12/2014

Azopt for Increased Pressure in the Eye

I've been using this treatment for over a year now. My doctor had to add combigan to help lower my pressure further. I also use dry eye drops. After using this treatment for six months, I haven't experienced any negative side effects.

4

Patient Review

1/27/2015

Azopt for Increased Pressure in the Eye

I took this for over a year and experienced side effects like a stuffy nose and drainage. I didn't realize these were side effects of the medication, since I was also taking two other prescribed eye drops.

3.3

Patient Review

7/15/2012

Azopt for Wide-Angle Glaucoma

I have been having issues with red eyes and dizziness.

3.3

Patient Review

10/29/2012

Azopt for Increased Pressure in the Eye

I have unfortunately developed kidney stones and gout after starting this medication. I would strongly caution others, as it appears the drug has caused both of these issues for me.

3

Patient Review

5/20/2022

Azopt for Wide-Angle Glaucoma

I developed terrible ringing in my ears after using this product for only six months. Thankfully, I was able to connect the dots and stopped taking it. The tinnitus has since faded away and is barely noticeable most days.

3

Patient Review

3/12/2013

Azopt for Increased Pressure in the Eye

This treatment is just okay. It didn't really help me that much.

2.3

Patient Review

7/11/2012

Azopt for Increased Pressure in the Eye

1.7

Patient Review

4/11/2014

Azopt for Increased Pressure in the Eye

Unfortunately, this medication caused my eyes a great deal of discomfort. Blurred vision and constant irritation led me to stop using the drug altogether.

1.7

Patient Review

4/5/2014

Azopt for Wide-Angle Glaucoma

The bottles are so small and difficult to use that my 88 year old wife cannot just get only one drop out by itself. We therefore have to buy extra drops and the insurance does not cover these extra drops.

1.7

Patient Review

10/31/2013

Azopt for Increased Pressure in the Eye

The grit in this treatment is really off-putting. It feels like I'm applying sand to my skin, and then it leaves an ashy residue.

1.3

Patient Review

11/22/2012

Azopt for Increased Pressure in the Eye

I would suggest that you shake the bottle and look downwards before using, as I found out that this helps the medication work better after using it for a year.

1.3

Patient Review

5/1/2013

Azopt for Increased Pressure in the Eye

I feel like this medication stings my eye. I also use another eye drop in right, and since using this one I feel like my eyesight has gotten worse.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about azopt

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there a generic drug for Azopt?

"There are now two manufacturers of generic Azopt 1% ophthalmic drops, Teva and Sandoz. Azopt is FDA approved to treat elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. The generic is available in a 10ml and 15ml vials."

Answered by AI

What is Azopt used for?

"Azopt Eye Drops contain brinzolamide, an active ingredient that belongs to a class of medicines known as "carbonic anhydrase inhibitors." Azopt Eye Drops can be used alone or in combination with other eye drops/medicines to lower pressure in the eye and treat glaucoma."

Answered by AI

What are the side effects of the drug Azopt?

"These effects include temporary blurred vision, a bitter, sour, or unusual taste in your mouth, dry eyes, temporary discomfort or itching or redness of the eye, the feeling that something is in your eye, eye discharge, and headache. If you experience any of these effects, notify your doctor or pharmacist."

Answered by AI

Is Azopt and brinzolamide the same?

"A class of drugs is a group of medications that work in a similar way.

Azopt and Trusopt are two medications that belong to a class of drugs called carbonic anhydrase inhibitors. Azopt is the brand-name medication, and Trusopt is the generic form of the drug. Both medications work in a similar way."

Answered by AI

Clinical Trials for Azopt

Have you considered Azopt clinical trials?

We made a collection of clinical trials featuring Azopt, we think they might fit your search criteria.
Go to Trials

Have you considered Azopt clinical trials?

We made a collection of clinical trials featuring Azopt, we think they might fit your search criteria.
Go to Trials
Image of Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham in Birmingham, United States.

AI-Based Screening for Glaucoma

18+
All Sexes
Birmingham, AL

The goal of this clinical trial is to learn if implementation of an eye screening program at Federally Qualified Health Center (FQHC) clinics provides results that participants may have glaucoma, and/or other eye conditions (diabetic retinopathy, cataract, visual acuity impairment). The glaucoma screening will incorporate use of an artificial intelligence (AI)-assisted screening tool. This project is called AI-RONA. The main questions it aims to answer are: * How does this eye screening program compare to the rate of glaucoma and other eye conditions detected at other FQHC clinics where the screening program has not been implemented? * Do particpants who screen positive for these conditions adhere to the physician's recommendation for a follow-up examination by an optometrist or ophthalmologist? * Are referral rates for a follow-up comprehensive eye exam by an optometrist or ophthalmologist similar to those implemented by an ophthalmologist using telemedicine (that is, using the results of the screening to make a diagnosis remotely)? * What is the cost-effectiveness of the AI-assisted screening program in diagnosing glaucoma as compared to a physician-guided program? * Are participants completing the screening satisfied with it? * Are physicians at the FQHC clinics administering the screening satisfied with it? Participants will: * Undergo an ocular screening whose goal is to detect glaucoma, diabetic retinopathy, cataract, and/or impairment in visual acuity. If the screening indicates that participants may have these conditions, participants will be referred for a comprehensive eye examination by an optometrist or ophthalmologist. * Following the screening, participants and physicians will complete a survey on their satisfaction with the program.

Recruiting
Has No Placebo

Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham

Cynthia Owsley, PhD

Have you considered Azopt clinical trials?

We made a collection of clinical trials featuring Azopt, we think they might fit your search criteria.
Go to Trials