What is Azopt
BrinzolamideThe Generic name of this drug
Treatment SummaryBrinzolamide is a medication used to reduce pressure in the eyes of patients with ocular hypertension or open-angle glaucoma. It works by inhibiting the enzyme carbonic anhydrase, which helps to form bicarbonate ions that are responsible for transporting sodium and fluid in the eye. By reducing the formation of bicarbonate ions, Brinzolamide helps to lower intraocular pressure and relieve symptoms of glaucoma.
Azoptis the brand name
Azopt Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Azopt
Brinzolamide
1998
9
Approved as Treatment by the FDA
Brinzolamide, also known as Azopt, is approved by the FDA for 4 uses which include Open Angle Glaucoma and Ocular Hypertension .Open Angle Glaucoma
Used to treat Open Angle Glaucoma (OAG) in combination with Timolol
Ocular Hypertension
Used to treat Ocular Hypertension in combination with Timolol
inadequate response to monotherapy
Used to treat inadequate response to monotherapy in combination with Timolol
Increased Intra Ocular Pressure (IOP)
Used to treat Increased Intra Ocular Pressure (IOP) in combination with Timolol
Effectiveness
How Azopt Affects PatientsBrinzolamide is a medication used to treat glaucoma. It works by reducing the amount of fluid in the eye, which helps to lower the pressure in the eye that can lead to vision loss. This drug can reduce eye pressure by up to 19% in people with high eye pressure.
How Azopt works in the bodyBrinzolamide is used to reduce the pressure inside the eye. It does this by lowering the amount of sodium and fluid produced in the eye. When it is applied to the eye, brinzolamide is absorbed into the bloodstream and binds to red blood cells, where it reduces the activity of carbonic anhydrase II (CA-II). This slows down aqueous humor secretion, preventing the pressure from building up. Brinzolamide also produces a metabolite called N-desethyl brinzolamide, which binds mainly to carbonic anhydrase I (CA-I).
When to interrupt dosage
The proposed dosage of Azopt is contingent upon the determined ailment, comprising of Open Angle Glaucoma, Ocular Hypertension and Increased Intra Ocular Pressure (IOP). The measure likewise changes as per the technique of delivery (e.g. Suspension - Ophthalmic or Suspension / drops) mentioned in the table beneath.Condition
Dosage
Administration
Open Angle Glaucoma
10.0 mg/mL, , 1.0 %
Suspension - Ophthalmic, Suspension / drops, Suspension, Ophthalmic, , Suspension / drops - Ophthalmic
Ocular Hypertension
10.0 mg/mL, , 1.0 %
Suspension - Ophthalmic, Suspension / drops, Suspension, Ophthalmic, , Suspension / drops - Ophthalmic
Increased Intra Ocular Pressure (IOP)
10.0 mg/mL, , 1.0 %
Suspension - Ophthalmic, Suspension / drops, Suspension, Ophthalmic, , Suspension / drops - Ophthalmic
inadequate response to monotherapy
10.0 mg/mL, , 1.0 %
Suspension - Ophthalmic, Suspension / drops, Suspension, Ophthalmic, , Suspension / drops - Ophthalmic
Warnings
There are 19 known major drug interactions with Azopt.Common Azopt Drug Interactions
Drug Name
Risk Level
Description
Ziconotide
Minor
The risk or severity of CNS depression can be increased when Brinzolamide is combined with Ziconotide.
Avanafil
Moderate
The serum concentration of Avanafil can be increased when it is combined with Brinzolamide.
Benzylpenicillin
Moderate
Brinzolamide may decrease the excretion rate of Benzylpenicillin which could result in a higher serum level.
Haloperidol
Moderate
The serum concentration of Haloperidol can be increased when it is combined with Brinzolamide.
Insulin argine
Moderate
The risk or severity of hypoglycemia can be increased when Brinzolamide is combined with Insulin argine.
Azopt Novel Uses: Which Conditions Have a Clinical Trial Featuring Azopt?
33 active clinical trials are presently examining the potential of Azopt in providing relief for Open Angle Glaucoma, Increased Intra Ocular Pressure (IOP) and inadequate response to monotherapy.Condition
Clinical Trials
Trial Phases
Open Angle Glaucoma
11 Actively Recruiting
Not Applicable, Phase 3, Phase 1, Phase 2
Increased Intra Ocular Pressure (IOP)
0 Actively Recruiting
inadequate response to monotherapy
0 Actively Recruiting
Ocular Hypertension
23 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4
Azopt Reviews: What are patients saying about Azopt?
5Patient Review
11/16/2017 Azopt is the best medication I've tried in terms of side effects and efficacy.
5Patient Review
10/27/2014 Azopt is the best glaucoma medication I've tried. It lowers eye pressure without any pain or redness, which other drugs have caused for me. I've been using it successfully for four years now.
5Patient Review
5/25/2017 I don't feel groggy after taking this, which is great.
5Patient Review
1/16/2013 Blurred vision and headaches that last for 12 hours or more.
5Patient Review
9/22/2014 I haven't experienced the same negative side effects as many other reviewers. For me, my vision only becomes blurry for a few minutes after using this product and there is also a bad taste in my mouth that goes away. These are much better than Lumigan for me because they have lowered my pressure.
4Patient Review
8/9/2013 I experienced burning, cloudy vision for five minutes or longer. I would advise not driving for at least that period of time. Other side effects I've experienced are occasional dizziness and headaches.
4Patient Review
10/12/2014 I've been using this treatment for over a year now. My doctor had to add combigan to help lower my pressure further. I also use dry eye drops. After using this treatment for six months, I haven't experienced any negative side effects.
4Patient Review
1/27/2015 I took this for over a year and experienced side effects like a stuffy nose and drainage. I didn't realize these were side effects of the medication, since I was also taking two other prescribed eye drops.
3.3Patient Review
7/15/2012 I have been having issues with red eyes and dizziness.
3.3Patient Review
10/29/2012 I have unfortunately developed kidney stones and gout after starting this medication. I would strongly caution others, as it appears the drug has caused both of these issues for me.
3Patient Review
5/20/2022 I developed terrible ringing in my ears after using this product for only six months. Thankfully, I was able to connect the dots and stopped taking it. The tinnitus has since faded away and is barely noticeable most days.
3Patient Review
3/12/2013 This treatment is just okay. It didn't really help me that much.
2.3Patient Review
7/11/20121.7Patient Review
4/11/2014 Unfortunately, this medication caused my eyes a great deal of discomfort. Blurred vision and constant irritation led me to stop using the drug altogether.
1.7Patient Review
4/5/2014 The bottles are so small and difficult to use that my 88 year old wife cannot just get only one drop out by itself. We therefore have to buy extra drops and the insurance does not cover these extra drops.
1.7Patient Review
10/31/2013 The grit in this treatment is really off-putting. It feels like I'm applying sand to my skin, and then it leaves an ashy residue.
1.3Patient Review
11/22/2012 I would suggest that you shake the bottle and look downwards before using, as I found out that this helps the medication work better after using it for a year.
1.3Patient Review
5/1/2013 I feel like this medication stings my eye. I also use another eye drop in right, and since using this one I feel like my eyesight has gotten worse.
Patient Q&A Section about azopt
Is there a generic drug for Azopt?
"There are now two manufacturers of generic Azopt 1% ophthalmic drops, Teva and Sandoz. Azopt is FDA approved to treat elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. The generic is available in a 10ml and 15ml vials." - Anonymous Online Contributor
Unverified Answer
What is Azopt used for?
"Azopt Eye Drops contain brinzolamide, an active ingredient that belongs to a class of medicines known as "carbonic anhydrase inhibitors." Azopt Eye Drops can be used alone or in combination with other eye drops/medicines to lower pressure in the eye and treat glaucoma." - Anonymous Online Contributor
Unverified Answer
What are the side effects of the drug Azopt?
"These effects include temporary blurred vision, a bitter, sour, or unusual taste in your mouth, dry eyes, temporary discomfort or itching or redness of the eye, the feeling that something is in your eye, eye discharge, and headache. If you experience any of these effects, notify your doctor or pharmacist." - Anonymous Online Contributor
Unverified Answer
Is Azopt and brinzolamide the same?
"A class of drugs is a group of medications that work in a similar way.
Azopt and Trusopt are two medications that belong to a class of drugs called carbonic anhydrase inhibitors. Azopt is the brand-name medication, and Trusopt is the generic form of the drug. Both medications work in a similar way." - Anonymous Online Contributor
Unverified Answer