CMR Imaging Techniques for Heart Disease

(Myomapping Trial)

Overseen By Jacob Rowe, BA

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Medical University of South Carolina

Disqualifiers: Implanted device, Acute psychiatric, Substance abuse, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Approved in 6 Jurisdictions This treatment is already approved in other countries

Compensation: Varies

Number of Visits: 1

240 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests new Cardiac Magnetic Resonance (CMR) imaging techniques to determine if they can better diagnose and treat heart problems such as ischemic heart disease, cardiomyopathies (heart muscle diseases), and myocarditis (heart inflammation). The goal is to make heart scans faster and more useful for doctors and patients. Individuals diagnosed with heart issues or who suspect they have one and are already scheduled for a heart MRI might be suitable candidates for this trial. As an unphased trial, it offers participants the chance to contribute to advancements in heart imaging technology that could enhance future diagnostics and treatments.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that these CMR imaging techniques are safe for heart disease patients?

Research has shown that Cardiac Magnetic Resonance (CMR) imaging is generally safe for most people. It produces detailed images of the heart without harmful radiation, making it a preferred method for examining heart issues.

Studies have found that CMR is safe for individuals without metal devices in their bodies. For those with devices like pacemakers, special safety measures are necessary, but the procedure can still be performed safely.

Overall, CMR is a well-tolerated and safe option for assessing heart health. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about new CMR imaging techniques for heart disease because they could dramatically cut down the time needed for scans. Unlike current imaging options, which often take longer and might require more patient cooperation, these faster MR scans aim to streamline the process without losing accuracy. This advancement could mean quicker diagnoses and more efficient management of heart conditions, benefiting both patients and healthcare providers.

What evidence suggests that CMR imaging techniques are effective for heart disease?

Research has shown that Cardiac Magnetic Resonance (CMR) imaging is a powerful tool for diagnosing heart problems. In one study, CMR influenced treatment decisions for 71% of patients with heart issues. Another study found CMR to be very accurate for individuals suspected of having coronary artery disease. This imaging method is considered the best for assessing heart function. CMR is highly valued for its ability to diagnose and assess heart diseases, even though it isn't used as often as some other methods. Overall, CMR shows strong promise in helping doctors better understand and treat heart diseases. Participants in this trial will undergo an additional 5-minute research MR scan of the heart to evaluate new, faster MR scans. ^{4 6 7 8 9}

Who Is on the Research Team?

Akos Varga-Szemes, MD

Principal Investigator

Medical University of South Carolina

Are You a Good Fit for This Trial?

This trial is for adults aged 18-90 with suspected or diagnosed heart conditions like ischemic heart disease, hypertrophic cardiomyopathy, infiltrative cardiomyopathy, or myocarditis. They must be referred for a CMR scan and can't participate if they have metal implants, acute psychiatric disorders, substance abuse issues, allergies to MRI contrast agents, are in an unstable condition or won't follow the study rules.

Inclusion Criteria

I have or might have a heart condition such as blocked arteries, thickened heart muscle, a disease causing heart tissue buildup, or inflammation of the heart muscle.

You must have been referred for a needed heart imaging test.

Exclusion Criteria

Subject has previously entered this study.

Subject has an allergy against MRI contrast agents.

Subject is in acute unstable condition.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Imaging

Participants undergo fast quantitative myocardial tissue characterization using Cardiac Magnetic Resonance Imaging (CMR) techniques

1 day

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after imaging

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Cardiac Magnetic Resonance (CMR) imaging techniques

Trial Overview

The trial is testing advanced Cardiac Magnetic Resonance Imaging (CMR) techniques to better diagnose and monitor various heart diseases. It aims to see how well these new fast quantitative imaging methods work compared to traditional ones.

How Is the Trial Designed?

Group I: Additional 5 minute research MR scan of heart. Experimental Treatment 1 Intervention

The purpose of this is to evaluate new, faster MR scans

Who Is Running the Clinical Trial?

Medical University of South Carolina

Lead Sponsor

Trials

994

Recruited

7,408,000+

Published Research Related to This Trial

Cardiovascular magnetic resonance (CMR) is a safe, non-invasive imaging technique that provides detailed information about heart function and tissue characteristics without using ionizing radiation.

CMR has become increasingly important in clinical practice, particularly for assessing ischemic cardiomyopathy, highlighting its efficacy in diagnosing and managing heart conditions.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Role of cardiovascular magnetic resonance in acute and chronic ischemic heart disease. Baritussio, A., Scatteia, A., Bucciarelli-Ducci, C.[2018]

Cardiovascular magnetic resonance (CMR) is recognized as a highly accurate diagnostic tool for assessing various cardiac diseases, providing significant additional diagnostic and prognostic information in clinical settings.

A collaborative effort by experts from the Italian Society of Cardiology and the Italian Society of Radiology aims to enhance the use of CMR in clinical practice, focusing on conditions like myocarditis, pericardial disease, cardiomyopathies, and valvular heart disease.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Appropriate use criteria for cardiovascular MRI: SIC - SIRM position paper Part 2 (myocarditis, pericardial disease, cardiomyopathies and valvular heart disease). Francone, M., Aquaro, GD., Barison, A., et al.[2023]

Cardiac magnetic resonance (CMR) imaging is a highly effective noninvasive technique that has significantly improved in resolution and speed over the last two decades, making it valuable for diagnosing and monitoring cardiovascular diseases.

CMR can assess various aspects of heart health, including morphology, function, perfusion, and tissue characterization, which supports its use in both diagnosis and follow-up after treatment.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Cardiac MRI: technical basis. Russo, V., Lovato, L., Ligabue, G.[2020]

Cardiac MRI (CMR) is a powerful tool that not only evaluates heart function and structure but also assesses diastolic function, coronary plaque, and myocardial oxygen levels, enhancing its diagnostic capabilities.

Recent technological advancements, including improved imaging systems and techniques like T1 mapping, are expected to broaden the clinical applications of CMR, making it more effective in diagnosing and managing heart conditions.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Cardiac magnetic resonance imaging: current status and future directions. Cannan, C., Friedrich, MG.[2013]

Cardiovascular magnetic resonance (CMR) imaging is a powerful and flexible technique for assessing various cardiovascular diseases, highlighting its growing importance in clinical practice.

CMR provides detailed insights into heart structure and function, aiding in the diagnosis and management of cardiovascular conditions, although specific study details and outcomes were not provided in the abstract.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The Multi-Faceted Utility of Cardiovascular Magnetic Resonance Imaging: Editorial on Special Issue "Advances in Cardiovascular Magnetic Resonance". Lu, M., Sirajuddin, A.[2023]

Cardiac magnetic resonance (CMR) imaging is becoming a key tool for evaluating ischemic heart disease due to its ability to produce high-quality images in various orientations and its advanced techniques for assessing heart structure and function.

Recent advancements in CMR hardware and software have led to improved image quality and the development of quantitative techniques, enhancing the assessment of cardiac function, myocardial perfusion, and tissue characterization.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Current state of the art cardiovascular MR imaging techniques for assessment of ischemic heart disease. François, CJ.[2022]

In a study of 1334 cardiovascular magnetic resonance (CMR) procedures for patients with congenital heart disease, the overall incidence of adverse events (AEs) was low at 1.6%, with most being minor in severity.

The use of general anesthesia and the status of being an inpatient were identified as independent risk factors for experiencing AEs, particularly in the most critically ill patients, highlighting the need for careful monitoring in these cases.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Risk factors for adverse events during cardiovascular magnetic resonance in congenital heart disease. Dorfman, AL., Odegard, KC., Powell, AJ., et al.[2013]

Cardiovascular magnetic resonance (MR) is a safe, non-invasive imaging technique that is the gold standard for assessing heart anatomy and function, but it is important to understand the safety and contraindications of various metal and electronic devices in patients undergoing MR.

The review highlights potential factors affecting image quality and patient comfort, such as arrhythmias and claustrophobia, and discusses the safety and side effects of gadolinium-based contrast agents used in MR imaging.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Cardiovascular magnetic resonance: What clinicians should know about safety and contraindications. Barison, A., Baritussio, A., Cipriani, A., et al.[2021]

The EuroCMR Registry aims to evaluate the clinical utility of cardiovascular magnetic resonance (CMR) imaging, focusing on image quality, safety, and its impact on patient management across multiple European centers.

This registry will also track patients with suspected coronary artery disease and hypertrophic cardiomyopathy over 12 months to gather important prognostic data, enhancing our understanding of CMR's effectiveness in these conditions.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Current variables, definitions and endpoints of the European cardiovascular magnetic resonance registry. Wagner, A., Bruder, O., Schneider, S., et al.[2021]

Cardiovascular magnetic resonance (CMR) is a non-invasive imaging technique that effectively assesses various aspects of heart health, including morphology, function, and blood flow, making it suitable for monitoring treatment effects and disease progression without exposing patients to radiation.

CMR faces unique challenges due to heart and lung movement, requiring advanced techniques like cardiac and respiratory gating to minimize motion artifacts, which is crucial for accurate clinical assessments.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Introduction to Cardiovascular Magnetic Resonance: Technical Principles and Clinical Applications. Tseng, WY., Su, MY., Tseng, YH.[2020]

Cardiac magnetic resonance (CMR) imaging is a valuable tool for assessing various heart conditions, particularly coronary artery disease and heart failure, which are significant health issues globally.

CMR offers unique tissue characterization capabilities that other imaging methods lack, providing critical diagnostic and prognostic insights into different heart diseases.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Advances in Cardiovascular MRI for Diagnostics: Applications in Coronary Artery Disease and Cardiomyopathies. Salerno, M., Kramer, CM.[2021]

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Cardiac Magnetic Resonance Imaging (MRI)

A cardiac MRI is a safe and painless test for most people. People with a metal device inside their body shouldn't have a cardiac MRI unless the ...