Your session is about to expire
What is Aripiprazole
AripiprazoleThe Generic name of this drug
Treatment SummaryAripiprazole lauroxil is an antipsychotic medication used to treat schizophrenia in adults. It works by blocking certain receptors in the brain that are responsible for symptoms like delusions, hallucinations, thought disorders, and social withdrawal. Aripiprazole lauroxil was approved by the FDA in 2015 under the brand name Aristada and can be administered as an intramuscular injection. In July 2020, a new formulation called Aristada Initio was approved which allows for a faster response time of the drug when combined with a single 30 mg oral dose. Aripiprazole lauroxil is generally effective
Abilifyis the brand name
Aripiprazole Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Abilify
Aripiprazole
2002
454
Approved as Treatment by the FDA
Aripiprazole, also known as Abilify, is approved by the FDA for 1 uses such as Schizophrenia .Schizophrenia
Used to treat Schizophrenia in combination with Aripiprazole lauroxil
Effectiveness
How Aripiprazole Affects PatientsAripiprazole is a medication used to reduce symptoms of schizophrenia, such as delusions or hallucinations. It works by modifying the activity of certain chemicals in the brain. Taking aripiprazole lauroxil is not known to affect one's sexual function or levels of prolactin, a hormone produced in the body.
How Aripiprazole works in the bodyAripiprazole works by targeting different receptors in the brain. It acts like a partial stimulator (agonist) at dopamine D2 and serotonin 5-HT1A receptors, and an inhibitor (antagonist) at serotonin 5-HT2A receptors. This combination leads to reduced positive symptoms of schizophrenia, like hallucinations and delusions, while also improving negative symptoms, like lack of motivation and impaired thinking. Aripiprazole also blocks alpha-1 adrenergic receptors, leading to orthostatic hypotension, and histamine H1 receptors, which can cause drowsiness. The drug binds to up to 90% of dopamine
When to interrupt dosage
The suggested measure of Aripiprazole is contingent upon the determined circumstances. The quantity of dosage is subject to the technique of delivery, as delineated in the table below.Condition
Dosage
Administration
Acute Coryza
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Intramuscular, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution, Injection, solution - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
Schizophrenia
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Intramuscular, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution, Injection, solution - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
Autism Spectrum Disorder (ASD)
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Intramuscular, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution, Injection, solution - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
Tourette's Disorder (TD)
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Intramuscular, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution, Injection, solution - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
Irritability
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Intramuscular, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution, Injection, solution - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
Agitation
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Intramuscular, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution, Injection, solution - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
Schizophrenia
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Intramuscular, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution, Injection, solution - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
Bipolar Disorder
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Intramuscular, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution, Injection, solution - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
Bipolar Disorder
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Intramuscular, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution, Injection, solution - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
Psychotic Depression
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Intramuscular, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution, Injection, solution - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
Alzheimer's Disease
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Intramuscular, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution, Injection, solution - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
Depression
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Intramuscular, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution, Injection, solution - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
Bipolar Disorder
, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 15.0 mg, 2.0 mg, 300.0 mg, 400.0 mg, 1.0 mg/mL, 9.75 mg/mL, 400.0 mg/mL, 300.0 mg/mL, 7.5 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Intramuscular, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Solution, Solution - Oral, Injection, solution, Injection, solution - Intramuscular, Injection, powder, lyophilized, for suspension, extended release, Injection, powder, lyophilized, for suspension, extended release - Intramuscular, Injection, Injection - Intramuscular
Warnings
Aripiprazole ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Aripiprazole may interact with Pulse Frequency
Common Aripiprazole Drug Interactions
Drug Name
Risk Level
Description
Acepromazine
Major
Aripiprazole may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Aripiprazole is combined with Aclidinium.
Alfuzosin
Major
Aripiprazole may increase the hypotensive activities of Alfuzosin.
Amisulpride
Major
Aripiprazole may increase the antipsychotic activities of Amisulpride.
Aripiprazole lauroxil
Major
Aripiprazole may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole lauroxil.
Aripiprazole Toxicity & Overdose RiskIn rats, an intramuscular injection of aripiprazole is found to be non-toxic up to 60mg. However, in females, males, and monkeys, the oral LD50 is found to be 705mg/kg, 965mg/kg and greater than 2000mg/kg, respectively. Common side effects of overdosing include vomiting, drowsiness, tremor, and akathisia. In some cases, more serious symptoms such as confusion, seizures, irregular heartbeat, and breathing problems may be seen. Aripiprazole can also cause Neuroleptic Malignant Syndrome (N
Aripiprazole Novel Uses: Which Conditions Have a Clinical Trial Featuring Aripiprazole?
170 active clinical trials are examining the utility of Aripiprazole in managing Schizophrenia and other related conditions.Condition
Clinical Trials
Trial Phases
Schizophrenia
34 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4
Bipolar Disorder
1 Actively Recruiting
Phase 4
Bipolar Disorder
0 Actively Recruiting
Agitation
5 Actively Recruiting
Phase 3, Phase 2
Bipolar Disorder
0 Actively Recruiting
Acute Coryza
1 Actively Recruiting
Not Applicable
Autism Spectrum Disorder (ASD)
55 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1, Early Phase 1
Schizophrenia
174 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Alzheimer's Disease
31 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3
Depression
199 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Tourette's Disorder (TD)
2 Actively Recruiting
Not Applicable, Phase 3
Irritability
4 Actively Recruiting
Not Applicable, Phase 4
Psychotic Depression
0 Actively Recruiting
Aripiprazole Reviews: What are patients saying about Aripiprazole?
5Patient Review
1/19/2015 I had been searching for two decades to find a way to combat my depression. I'd tried various types of antidepressants with little-to-no success before finally finding relief in a combination of bupropion, escitalopram, and other mood medications. Once we added Abilify to the mix, it was like a weight had been lifted off my shoulders. I'm able to function now where I wasn't before, and I couldn't be happier with the results.
5Patient Review
3/9/2015 Lexapro and lithium were good, but adding abilify really helped fine-tune my medication regimen.
5Patient Review
3/8/2021 This medication has been a game-changer for me in terms of my depression. I feel so much more clearheaded and energetic without feeling manic.
4.7Patient Review
2/14/20134Patient Review
8/15/2022 I was really hoping this would help me with the anxiety attacks I've been having. So far, it's made them more bearable and given me back some energy. fingers crossed it keeps working!
3.3Patient Review
9/28/2021 I've been taking this medication for over 10 years now. When I first started, it was great! It helped with my anxiety and nightmares. But then, after a while, I started to experience some negative side effects like gambling and increased sexual desire. And now I find that I'm sleeping more than 16 hours a day and have zero motivation.
3.3Patient Review
10/24/2017 Overall this medication does what it's supposed to, but I've gained a lot of weight since starting it which is really frustrating.
3Patient Review
4/16/2021 I've only just started this treatment in place of Prozac, which I was taking for years. I'm also continuing to take cymbalta. I'm feeling a bit nervous about the change, so reviews are helpful. I hope that this will work for my depression and suicidal thoughts.
2.3Patient Review
10/16/2015 Unfortunately, this medication caused me to have manic episodes which resulted in uncontrolled spending. I was also only sleeping 3-4 hours a night, which made the effects even worse.
2.3Patient Review
7/31/2017 I experienced tremors and extreme dizziness after taking just 5mg of this medication. I absolutely need to find a replacement soon.
2Patient Review
10/5/2015 I tried to quit taking Abilify and it gave me Tardive Dyskinesia. It's really painful, my jaw is constantly aching and my mouth is moving involuntarily from side to side. I want to get off of the drug because I've gained 50 pounds, but it's proving difficult.
2Patient Review
7/23/2021 I experienced unexpected drowsiness after taking this medication for a few weeks. One day, I was driving and became so exhausted that I could barely keep my eyes open. As a result, I got into a car accident. Because of this incident (and others like it), I no longer take this medication.
1.7Patient Review
6/20/2014 This medication was a huge disappointment and actually made things worse. I wouldn't wish it on my worst enemy.
1Patient Review
3/7/2021 I've used this for years without any improvement. It's not a good product.
1Patient Review
3/7/2021 I've used this for years without any good results.
Patient Q&A Section about aripiprazole
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does aripiprazole make you high?
"Dopamine agonists drugs such as aripiprazole work by activating dopamine receptors in the brain, which has the effect of opening up those pathways. Some of the potential side effects of this include euphoria, increased orgasmic activity, and developing addictions to activities such as gambling, shopping, binge eating, and sex."
Answered by AI
What is aripiprazole is used for?
"Aripiprazole is a medication used to treat mental conditions such as bipolar disorder, depression, and schizophrenia. It can also be used in children to treat irritability associated with autistic disorder and Tourette syndrome."
Answered by AI
What side effects does aripiprazole have?
"You may experience a headache, nervousness, or restlessness. You may also feel dizzy, unsteady, or have trouble keeping your balance. Additionally, you may have heartburn, constipation, diarrhea, or stomach pain."
Answered by AI
Is aripiprazole the same as Xanax?
"The pill form of Aripiprazole is a prescription drug that comes in four oral dosage forms. Alprazolam is a prescription medication that is available as brand name drugs called Alprazolam Intensol, Xanax, or Xanax XR."
Answered by AI