63 Participants Needed

Memory Training for Brain Health

EV
Overseen ByErin Venza, MS
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: The University of Texas at Dallas
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) has been suggested as a promising brain imaging tool for identifying biomarkers of brain health.In this pilot study, study investigators will explore the neurophysiological metrics of brain health with a non-invasive brain imaging technique, alongside behavioral and fMRI metrics collected through another study (NCT04869111).

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.

Is the memory training treatment generally safe for humans?

The RehaCom cognitive training program, which is similar to memory training techniques, was used in patients with brain injuries and showed no negative effects like mental fatigue, headache, or eye irritation, suggesting it is generally safe.12345

How is the SMART treatment different from other memory training treatments?

The SMART treatment is unique because it focuses on strategic memory and advanced reasoning training, which has been shown to improve memory and cognitive function in older adults, particularly those with mild cognitive impairment. Unlike other treatments, it emphasizes the use of multiple strategies and metamemory (awareness of one's own memory processes) to enhance cognitive abilities.678910

What data supports the effectiveness of the treatment Strategic Memory Advanced Reasoning Training (SMART)?

Research on similar memory training programs, like the Strategy-based Training to Enhance Memory (STEM) in multiple sclerosis, shows that such treatments can improve daily functioning and memory. Additionally, studies on multi-strategic memory training in older adults suggest that these programs can lead to cognitive improvements, especially in individuals with certain brain characteristics.1371011

Who Is on the Research Team?

SC

Sandra Chapman, PhD

Principal Investigator

University of Texas at Dallas

Are You a Good Fit for This Trial?

This trial is for individuals at least 22 years old who are fluent in English, can interact with computer-based information, and are already participating in The BrainHealth Project. They must pass safety screenings for transcranial magnetic stimulation (TMS) and MRI scans, meaning no non-removable metal on/in the body, severe claustrophobia, pregnancy, significant vision issues without correction, head trauma or central nervous system disease.

Inclusion Criteria

I can read and hear information on a computer.
I am fluent in English.
I am at least 22 years old.
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo two in-person sessions with the Delphi-MD device, aligned with pre-scheduled imaging appointments

2 sessions
2 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

Up to one year

What Are the Treatments Tested in This Trial?

Interventions

  • Strategic Memory Advanced Reasoning Training
Trial Overview The study tests how well a combination of brain imaging techniques (transcranial magnetic stimulation and electroencephalography) works to identify markers of brain health. It's part of a pilot study that includes behavioral assessments and fMRI metrics from another ongoing research project.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Online Strategic Memory Advanced Reasoning Training & Stress SolutionsExperimental Treatment1 Intervention
Strategic Memory Advanced Reasoning Training (SMART) teaches meta-cognitive strategies for individuals to apply to their daily lives for improved performance Stress Solutions provides individuals with opportunities to extend the SMART principles to domains of stress and resilience.

Find a Clinic Near You

Who Is Running the Clinical Trial?

The University of Texas at Dallas

Lead Sponsor

Trials
71
Recruited
108,000+

Published Research Related to This Trial

The modified Story Memory Technique (mSMT) significantly improved memory and learning in individuals with traumatic brain injury (TBI), as shown by changes in cerebral activation in key brain networks after treatment.
In a randomized clinical trial with 18 participants, the treatment group exhibited notable differences in brain activation compared to the placebo group, indicating that behavioral interventions like mSMT can effectively enhance cognitive function in TBI patients.
Examining the Efficacy of the Modified Story Memory Technique (mSMT) in Persons With TBI Using Functional Magnetic Resonance Imaging (fMRI): The TBI-MEM Trial.Chiaravalloti, ND., Dobryakova, E., Wylie, GR., et al.[2019]
In a study of 178 adults with major depressive disorder, using constructive memory support strategies eight times per therapy session was found to optimize treatment outcomes and improve patient recall of treatment content.
The research suggests that the effectiveness of therapy can be enhanced by the frequency of memory support provided by therapists, with implications for long-term patient adherence and recovery.
Optimizing outcomes, mechanisms, and recall of Cognitive Therapy for depression: Dose of constructive memory support strategies.Sarfan, LD., Zieve, G., Gumport, NB., et al.[2023]
In a study of 49 older adults, those with lower education levels were more likely to show cognitive improvement after participating in a multi-strategic memory training program, suggesting that educational background may influence training efficacy.
Brain imaging revealed that specific morphological features, such as thinner cortices in certain brain regions and higher white matter anisotropy, can predict cognitive gains from memory training, highlighting the importance of individual brain characteristics in tailoring cognitive interventions.
Neural predictors of cognitive improvement by multi-strategic memory training based on metamemory in older adults with subjective memory complaints.Park, S., Ryu, SH., Yoo, Y., et al.[2019]

Citations

Examining the Efficacy of the Modified Story Memory Technique (mSMT) in Persons With TBI Using Functional Magnetic Resonance Imaging (fMRI): The TBI-MEM Trial. [2019]
Optimizing outcomes, mechanisms, and recall of Cognitive Therapy for depression: Dose of constructive memory support strategies. [2023]
Neural predictors of cognitive improvement by multi-strategic memory training based on metamemory in older adults with subjective memory complaints. [2019]
The effect of strategic memory training in older adults: who benefits most? [2019]
The application of Strategy-based Training to Enhance Memory (STEM) in multiple sclerosis: A pilot RCT. [2021]
Differential outcomes training facilitates memory in people with Korsakoff and Prader-Willi syndromes. [2019]
Clinical impact of RehaCom software for cognitive rehabilitation of patients with acquired brain injury. [2022]
Treating learning impairments improves memory performance in multiple sclerosis: a randomized clinical trial. [2022]
Mnemonic strategy training of the elderly at risk for dementia enhances integration of information processing via cross-frequency coupling. [2020]
Cognitive Improvement in Older Adults with Mild Cognitive Impairment: Evidence from a Multi-Strategic Metamemory Training. [2020]
The use of commercial computerised cognitive games in older adults: a meta-analysis. [2021]
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