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What is Amphotec
Amphotericin BThe Generic name of this drug
Treatment SummaryAmphotericin B is an antibiotic used to treat fungal infections caused by a variety of species including Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, and more. It is often effective against Candida albicans, although other species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are usually resistant to the drug. It is not effective against bacteria, rickettsiae, or viruses.
Fungizoneis the brand name
Amphotec Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Fungizone
Amphotericin B
1966
10
Approved as Treatment by the FDA
Amphotericin B, otherwise called Fungizone, is approved by the FDA for 16 uses like Visceral Leishmaniasis and severe Histoplasmosis .Visceral Leishmaniasis
severe Histoplasmosis
Febrile Neutropenia
Mycoses
Gilchrist Disease
Mycoses
Systemic candidiasis
Mucocutaneous Leishmaniasis
Cerebral Cryptococcosis
Invasive Fungal Infections
severe Fungal infection caused by sporotrichosis spp.
severe Mucocutaneous leishmaniasis
Coccidioidomycosis
HIV
failed previous amphotericin B treatment
Used to treat failed previous amphotericin B treatment in combination with DL-dimyristoylphosphatidylcholine
severe Cryptococcosis
Effectiveness
How Amphotec Affects PatientsAmphotericin B is an effective antifungal drug that can be used to treat a wide range of fungi, including Histoplasma capsulatum, Coccidioides immitis, Candida species, and Blastomyces dermatitidis, among others. It does not work on bacteria, rickettsiae, or viruses. The effectiveness of Amphotericin B on Candida albicans is usually good, but it is usually not as effective on other non-albicans species. Pseudallescheria boydii and Fusarium species are usually resistant to this drug.
How Amphotec works in the bodyAmphotericin B is a drug that can kill or stop the growth of certain types of fungi. It works by binding to a part of the cell membrane, called ergosterol, in susceptible fungi. This binding creates a channel in the membrane, which changes how it interacts with other molecules. This change leads to the leakage of important components from inside the cell, eventually leading to the death of the cell.
When to interrupt dosage
The proposed dosage of Amphotec is contingent upon the diagnosed condition, for example Aspergillosis, serious Cryptococcosis and serious Mucocutaneous leishmaniasis. The dosage also varies as per the mode of administration referenced in the table beneath.Condition
Dosage
Administration
Aspergillosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
HIV
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
failed previous amphotericin B treatment
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Cerebral Cryptococcosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Histoplasmosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Mucocutaneous Leishmaniasis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Coccidioidomycosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Mycoses
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Leishmaniasis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Gilchrist Disease
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
severe Histoplasmosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Endophthalmitis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
severe Fungal infection caused by sporotrichosis spp.
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Visceral Leishmaniasis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
disseminated Cryptococcosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Coccidioidomycosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Invasive Aspergillosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Meningitis, Fungal
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Penicillium marneffei infection
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Febrile Neutropenia
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Warnings
There are 20 known major drug interactions with Amphotec.Common Amphotec Drug Interactions
Drug Name
Risk Level
Description
Cyclosporine
Major
Amphotericin B may increase the nephrotoxic activities of Cyclosporine.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Neomycin.
Tenofovir
Major
Amphotericin B may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Amphotericin B may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir disoproxil
Major
Amphotericin B may increase the nephrotoxic activities of Tenofovir disoproxil.
Amphotec Toxicity & Overdose RiskThe toxic dose for rats is more than 5 grams per kilogram. If someone overdoes on amphotericin B, it could lead to cardiopulmonary arrest.
Amphotec Novel Uses: Which Conditions Have a Clinical Trial Featuring Amphotec?
At present, 10 active trials are assessing the utility of Amphotec in addressing Meningeal Fungal Infections, such as Histoplasmosis.Condition
Clinical Trials
Trial Phases
Endophthalmitis
0 Actively Recruiting
Systemic candidiasis
0 Actively Recruiting
Mucocutaneous Leishmaniasis
0 Actively Recruiting
Tuberculosis, Osteoarticular
0 Actively Recruiting
severe Histoplasmosis
0 Actively Recruiting
Aspergillosis
0 Actively Recruiting
Histoplasmosis
1 Actively Recruiting
Phase 1, Phase 2
disseminated Cryptococcosis
0 Actively Recruiting
severe Cryptococcosis
0 Actively Recruiting
Cystitis
0 Actively Recruiting
Invasive Fungal Infections
2 Actively Recruiting
Phase 3, Phase 2
Cerebral Cryptococcosis
0 Actively Recruiting
severe Fungal infection caused by sporotrichosis spp.
0 Actively Recruiting
Invasive Aspergillosis
1 Actively Recruiting
Phase 3
Mycoses
0 Actively Recruiting
Meningitis, Fungal
0 Actively Recruiting
Febrile Neutropenia
2 Actively Recruiting
Phase 2, Phase 4
HIV
146 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
failed previous amphotericin B treatment
0 Actively Recruiting
Penicillium marneffei infection
0 Actively Recruiting
Amphotec Reviews: What are patients saying about Amphotec?
4.3Patient Review
11/30/2009 My husband takes this medication intravenously, and we have found that it works best if he takes two Tylenol, 25mg of Benadryl, and 50mg of hydrocortisone about 30 to 45 minutes before the infusion. If he starts shaking, we give him 12.5mg of Demerol. We've been doing this for three weeks now with good results.
4Patient Review
6/22/2008 I developed tinnitus during my treatment, which was a real bummer.