Amphotec

Cerebral Cryptococcosis, Histoplasmosis, Coccidioidomycosis + 25 more

Treatment

28 FDA approvals

20 Active Studies for Amphotec

Treatment for

Cerebral Cryptococcosis

What is Amphotec

Amphotericin B

The Generic name of this drug

Treatment Summary

Amphotericin B is an antibiotic used to treat fungal infections caused by a variety of species including Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, and more. It is often effective against Candida albicans, although other species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are usually resistant to the drug. It is not effective against bacteria, rickettsiae, or viruses.

Fungizone

is the brand name

Amphotec Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Fungizone

Amphotericin B

1966

Approved as Treatment by the FDA

Amphotericin B, otherwise called Fungizone, is approved by the FDA for 28 uses like severe Fungal infection caused by Basidiobolus spp. and severe Fungal infection caused by Conidiobolus spp. .

severe Fungal infection caused by Basidiobolus spp.

severe Fungal infection caused by Conidiobolus spp.

severe Mucocutaneous leishmaniasis

severe Fungal infection caused by sporotrichosis spp.

severe North American blastomycosis

Histoplasmosis

Leishmaniasis, Visceral

Sporotrichosis

Mycoses

Cryptococcosis

Febrile Neutropenia

failed previous amphotericin B treatment

Used to treat failed previous amphotericin B treatment in combination with DL-dimyristoylphosphatidylcholine

severe Histoplasmosis

Visceral Leishmaniasis

severe Cryptococcosis

severe Systemic candidiasis

Mucocutaneous Leishmaniasis

Meningitis, Cryptococcal

Febrile Neutropenia

Leishmaniasis, Cutaneous

Gilchrist Disease

Coccidioidomycosis

Systemic candidiasis

Leishmaniasis, Mucocutaneous

Mycoses

Cerebral Cryptococcosis

HIV

Invasive Fungal Infections

Effectiveness

How Amphotec Affects Patients

Amphotericin B is an effective antifungal drug that can be used to treat a wide range of fungi, including Histoplasma capsulatum, Coccidioides immitis, Candida species, and Blastomyces dermatitidis, among others. It does not work on bacteria, rickettsiae, or viruses. The effectiveness of Amphotericin B on Candida albicans is usually good, but it is usually not as effective on other non-albicans species. Pseudallescheria boydii and Fusarium species are usually resistant to this drug.

How Amphotec works in the body

Amphotericin B is a drug that can kill or stop the growth of certain types of fungi. It works by binding to a part of the cell membrane, called ergosterol, in susceptible fungi. This binding creates a channel in the membrane, which changes how it interacts with other molecules. This change leads to the leakage of important components from inside the cell, eventually leading to the death of the cell.

When to interrupt dosage

The proposed dosage of Amphotec is contingent upon the diagnosed condition, for example Aspergillosis, serious Cryptococcosis and serious Mucocutaneous leishmaniasis. The dosage also varies as per the mode of administration referenced in the table beneath.

Condition

Dosage

Administration

Cerebral Cryptococcosis