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What is Alprostadil
AlprostadilThe Generic name of this drug
Treatment SummaryAlprostadil is a drug naturally produced by the body that causes blood vessels to widen, increasing the amount of blood flowing to certain areas. In infants, it is used to prevent closure of the ductus arteriosus, a blood vessel that helps to provide oxygen and nutrients to the fetus. In adults, it is used to treat erectile dysfunction due to a variety of causes.
Prostin Vr Pediatricis the brand name
Alprostadil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prostin Vr Pediatric
Alprostadil
1981
28
Effectiveness
How Alprostadil Affects PatientsAlprostadil (prostaglandin E1) is a natural substance that can widen the blood vessels and increase blood flow. In adults, this leads to increased blood flow in the penis, causing it to become stiff. In infants, it can help increase the amount of blood going to either the lungs or the rest of the body.
How Alprostadil works in the bodyAlprostadil increases blood flow in infants in multiple ways. It prevents the closure of a blood vessel connecting the pulmonary artery and aorta, allowing blood to flow through it. It also relaxes the smooth muscle of the corpora cavernosa and cavernosal arteries, allowing more blood to enter the penis and causing it to swell and become rigid. These effects create increased pulmonary or systemic blood flow, increased oxygen supply to tissues, improved renal perfusion and increased systemic blood flow to the lower body.
When to interrupt dosage
The suggested dosage of Alprostadil is contingent upon the determined condition, including Impotence, Raynaud's Phenomenon and Aquaporin 2. The amount of dosage is outlined in the following table, based on the method of administration.Condition
Dosage
Administration
Impotence
, 0.125 mg, 0.25 mg, 0.5 mg, 1.0 mg, 0.01 mg/mL, 0.02 mg/mL, 0.04 mg/mL, 0.0232 mg, 0.0119 mg, 0.0105 mg/mL, 0.0054 mg/mL, 0.5 mg/mL, 0.0205 mg/mL, 0.1 mg/mL, 0.0411 mg/mL, 0.2 mg/mL, 0.02 mg, 0.0033 mg/mg, 0.0022 mg/mg
, Urethral, Suppository, Suppository - Urethral, Intracavernous, Injection, powder, lyophilized, for solution - Intracavernous, Injection, powder, lyophilized, for solution, Kit; Liquid; Powder, for solution - Intracavernous, Kit; Liquid; Powder, for solution, Intra-arterial; Intravenous, Solution - Intra-arterial; Intravenous, Solution, Liquid, Liquid - Intra-arterial; Intravenous, Powder, for solution - Intracavernous, Powder, for solution, Topical, Cream - Topical, Cream, Intravascular, Injection, solution, concentrate, Injection, solution, concentrate - Intravascular, Intravascular; Intravenous, Injection, solution, Injection, solution - Intravascular; Intravenous, Solution - Intravascular, Injection, Injection - Intravascular; Intravenous
Aquaporin 2
, 0.125 mg, 0.25 mg, 0.5 mg, 1.0 mg, 0.01 mg/mL, 0.02 mg/mL, 0.04 mg/mL, 0.0232 mg, 0.0119 mg, 0.0105 mg/mL, 0.0054 mg/mL, 0.5 mg/mL, 0.0205 mg/mL, 0.1 mg/mL, 0.0411 mg/mL, 0.2 mg/mL, 0.02 mg, 0.0033 mg/mg, 0.0022 mg/mg
, Urethral, Suppository, Suppository - Urethral, Intracavernous, Injection, powder, lyophilized, for solution - Intracavernous, Injection, powder, lyophilized, for solution, Kit; Liquid; Powder, for solution - Intracavernous, Kit; Liquid; Powder, for solution, Intra-arterial; Intravenous, Solution - Intra-arterial; Intravenous, Solution, Liquid, Liquid - Intra-arterial; Intravenous, Powder, for solution - Intracavernous, Powder, for solution, Topical, Cream - Topical, Cream, Intravascular, Injection, solution, concentrate, Injection, solution, concentrate - Intravascular, Intravascular; Intravenous, Injection, solution, Injection, solution - Intravascular; Intravenous, Solution - Intravascular, Injection, Injection - Intravascular; Intravenous
Raynaud's Phenomenon
, 0.125 mg, 0.25 mg, 0.5 mg, 1.0 mg, 0.01 mg/mL, 0.02 mg/mL, 0.04 mg/mL, 0.0232 mg, 0.0119 mg, 0.0105 mg/mL, 0.0054 mg/mL, 0.5 mg/mL, 0.0205 mg/mL, 0.1 mg/mL, 0.0411 mg/mL, 0.2 mg/mL, 0.02 mg, 0.0033 mg/mg, 0.0022 mg/mg
, Urethral, Suppository, Suppository - Urethral, Intracavernous, Injection, powder, lyophilized, for solution - Intracavernous, Injection, powder, lyophilized, for solution, Kit; Liquid; Powder, for solution - Intracavernous, Kit; Liquid; Powder, for solution, Intra-arterial; Intravenous, Solution - Intra-arterial; Intravenous, Solution, Liquid, Liquid - Intra-arterial; Intravenous, Powder, for solution - Intracavernous, Powder, for solution, Topical, Cream - Topical, Cream, Intravascular, Injection, solution, concentrate, Injection, solution, concentrate - Intravascular, Intravascular; Intravenous, Injection, solution, Injection, solution - Intravascular; Intravenous, Solution - Intravascular, Injection, Injection - Intravascular; Intravenous
Warnings
Alprostadil ContraindicationsCondition
Risk Level
Notes
predisposition to multiple myeloma
Do Not Combine
penis
Do Not Combine
Polycythemia
Do Not Combine
Thrombocythemia
Do Not Combine
predisposition to priapism
Do Not Combine
Disease
Do Not Combine
use for sexual intercourse
Do Not Combine
penile implants
Do Not Combine
leukemia
Do Not Combine
predisposition to sickle cell anemia
Do Not Combine
Pulse Frequency
Do Not Combine
men for whom sexual activity is inadvisable
Do Not Combine
Hyperviscosity syndrome
Do Not Combine
Pulse Frequency
Do Not Combine
Common Alprostadil Drug Interactions
Drug Name
Risk Level
Description
Captopril
Minor
The excretion of Captopril can be decreased when combined with Alprostadil.
Cefdinir
Minor
The excretion of Cefdinir can be decreased when combined with Alprostadil.
Citrulline
Minor
The excretion of Citrulline can be decreased when combined with Alprostadil.
Cyclic adenosine monophosphate
Minor
The excretion of Cyclic adenosine monophosphate can be decreased when combined with Alprostadil.
Didanosine
Minor
The excretion of Didanosine can be decreased when combined with Alprostadil.
Alprostadil Toxicity & Overdose RiskThe lowest toxic dose of the drug in mice has been found to be 186mg/kg, while in rats it is 228mg/kg. Symptoms of overdosing include shortness of breath, slow heart rate, fever, low blood pressure, and redness of the skin.
Alprostadil Novel Uses: Which Conditions Have a Clinical Trial Featuring Alprostadil?
27 active clinical trials are currently underway to investigate the potential of Alprostadil to ameliorate Aquaporin 2 Deficiency, Impotence and Raynaud's Phenomenon.Condition
Clinical Trials
Trial Phases
Aquaporin 2
2 Actively Recruiting
Not Applicable, Phase 3
Impotence
26 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3, Phase 2
Raynaud's Phenomenon
1 Actively Recruiting
Phase 4
Alprostadil Reviews: What are patients saying about Alprostadil?
5Patient Review
10/11/2007 I've unfortunately developed a slight curvature in my penis near the base, but other than that this treatment has been going great! I always get a strong erection that lasts for around 30 minutes.
4.7Patient Review
5/27/2014 No drugs running in your body, no side effects! always works
4.7Patient Review
3/19/2011 If you've tried other treatments like Viagra with no success, this is definitely worth a shot. It's easy to use and not much more trouble than using a condom.
4.3Patient Review
1/1/2009 This treatment is excellent for helping people maintain personal relationships.
3.7Patient Review
1/16/2012 It works decently for me. I take 75 cc at a time.
3Patient Review
12/30/2019 It can be difficult to find a vein to inject, but this treatment is worth it.
Patient Q&A Section about alprostadil
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is alprostadil still available?
"Alprostadil is a medication that is prescribed to men who suffer from erectile dysfunction. It is not available over the counter."
Answered by AI
Where do you inject alprostadil?
"To give the injection, insert the needle into the penis until almost all of the metal part is inside. Do not inject the medicine just under the skin, at the top or head of the penis, or at the base of the penis near the scrotum or testes. Avoid injecting into any blood vessels that you can see."
Answered by AI
What is the side effect of alprostadil?
"Some common side effects of using a penis pump are: mild pain in your penis, urethra, or testicles; redness of the penis; or warmth or burning in your urethra."
Answered by AI
What is the drug alprostadil used for?
"Alprostadil is an injection used to treat erectile dysfunction in males. It is a vasodilator, meaning it increases blood flow by expanding blood vessels. This increased blood flow to the penis causes an erection."
Answered by AI