Actifed

Catarrh, Urticaria, Angioedema + 10 more
Treatment
14 FDA approvals
20 Active Studies for Actifed

What is Actifed

TriprolidineThe Generic name of this drug
Treatment SummaryPseudoephedrine is a drug related to ephedrine, which is found in the ephedra plant. It has been used for centuries in Eastern medicine and first researched in the West in 1889. In 1927, it was discovered that pseudoephedrine has a decongestant effect, which is a weaker effect than that of ephedrine on the nervous system.
Silafedis the brand name
image of different drug pills on a surface
Actifed Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Silafed
Triprolidine
1988
3

Approved as Treatment by the FDA

Triprolidine, also called Silafed, is approved by the FDA for 14 uses like Perennial Allergic Rhinitis (PAR) and Vasomotor Rhinitis .
Perennial Allergic Rhinitis (PAR)
Vasomotor Rhinitis
mild Angioedema
mild urticaria
Seasonal Allergic Rhinitis
Hay Fever
Rhinitis, Allergic
Rhinitis, Vasomotor
Catarrh
Used to treat Common Cold in combination with Codeine
upper respiratory discomfort
Used to treat upper respiratory discomfort in combination with Codeine
Urticaria
Allergic Conjunctivitis (AC)
Angioedema
Hypersensitivity

Effectiveness

How Actifed Affects PatientsPseudoephedrine acts as a decongestant by narrowing the blood vessels in the nose and sinuses. Its effects can last for a short time unless it is taken as an extended release product. Taking this drug may cause side effects related to stimulation of the central nervous system, so people should be aware of this risk.
How Actifed works in the bodyPseudoephedrine works by activating certain receptors in the body and by inhibiting certain transporters. This triggers an increase in blood pressure, heart rate and muscle tension. It also affects the body's inflammatory response, making it useful in treating conditions involving inflammation. Pseudoephedrine also helps relieve congestion and treat priapism.

When to interrupt dosage

The suggested measure of Actifed is contingent upon the recognized condition, including Upper Respiratory Tract Infection, Airway secretion clearance therapy and Coughing. The dosage amount is contingent upon the delivery technique (e.g. Tablet, extended release or Oral), which is enumerated in the table beneath.
Condition
Dosage
Administration
Hay Fever
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Urticaria
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Influenza
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Rhinitis, Vasomotor
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Nasal Congestion
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Hypersensitivity
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Catarrh
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Angioedema
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Upper respiratory tract signs and symptoms
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Rhinitis, Allergic
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Allergic Conjunctivitis (AC)
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Allergy to Tree Pollen
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
upper respiratory discomfort
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution

Warnings

Actifed has five counter-indications, and its use should be avoided when encountering any of the circumstances outlined in the following table.There are 20 known major drug interactions with Actifed.
Common Actifed Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Triprolidine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Triprolidine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Triprolidine is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Triprolidine is combined with Mobocertinib.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Triprolidine is combined with Oliceridine.
Actifed Toxicity & Overdose RiskThe lowest toxic dose of pseudoephedrine in rats has been found to be 2206mg/kg and 726mg/kg in mice. Symptoms of overdose include dizziness, headaches, nausea, vomiting, increased heart rate, chest pain, difficulty urinating, muscle weakness, anxiety, restlessness, insomnia, mental confusion, irregular heartbeat, fainting, seizures, loss of consciousness, and trouble breathing. Treatments for pseudoephedrine overdose include removing any unabsorbed drug and providing supportive care.
image of a doctor in a lab doing drug, clinical research

Actifed Novel Uses: Which Conditions Have a Clinical Trial Featuring Actifed?

270 active trials are underway to evaluate the potential of Actifed for alleviating Allergies, Migraines and Ocular ailments.
Condition
Clinical Trials
Trial Phases
Urticaria
0 Actively Recruiting
Angioedema
0 Actively Recruiting
Influenza
38 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Phase 3, Phase 1
Allergic Conjunctivitis (AC)
2 Actively Recruiting
Phase 3
Hay Fever
0 Actively Recruiting
Nasal Congestion
0 Actively Recruiting
Catarrh
0 Actively Recruiting
upper respiratory discomfort
0 Actively Recruiting
Rhinitis, Vasomotor
0 Actively Recruiting
Rhinitis, Allergic
0 Actively Recruiting
Upper respiratory tract signs and symptoms
0 Actively Recruiting
Hypersensitivity
0 Actively Recruiting
Allergy to Tree Pollen
0 Actively Recruiting

Actifed Reviews: What are patients saying about Actifed?

5Patient Review
7/15/2012
Actifed for Inflammation of the Nose due to an Allergy
Walact is an effective sinusitis medication that contains the active ingredient triplodene. You can find it at Walgreens.
5Patient Review
10/4/2014
Actifed for Runny Nose
This treatment is effective and I would recommend it to others.
5Patient Review
2/1/2019
Actifed for Cold Symptoms
This drug was recommended to me by a pharmacist when I had flu-like symptoms while traveling in France. It worked quickly and effectively.
3.7Patient Review
2/1/2008
Actifed for Stuffy Nose
I unfortunately had to stop using this medication because it caused me to have severe anxiety attacks.
3.3Patient Review
4/24/2010
Actifed for Cold Symptoms
I felt terrible the next day after taking this medication. I was extremely sleepy and depressed.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about actifed

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Actifed called now?

"The active ingredients in Wal-Act D are the same as those in the old Actifed formula: Triprolidine HCL and Pseudoehedrine HL. I bought some today at Wallgreens; it's their house brand, and you have to ask the pharmacist for it."

Answered by AI

Does Actifed make you sleep?

"”

Actifed is an effective medication for cold symptoms that cause constant coughing, especially at night. It may cause drowsiness, but this is not a problem for use at night."

Answered by AI

What is the drug Actifed used for?

"Decongestants help to reduce swelling in the nose.

This medication is a combination of an antihistamine and a decongestant and is used to relieve the symptoms of the common cold, flu, allergies, or other breathing illnesses temporarily. The antihistamine component helps relieve watery eyes, itchy eyes, nose, and throat, as well as a runny nose and sneezing. The decongestant component helps to reduce swelling in the nose."

Answered by AI

Clinical Trials for Actifed

Have you considered Actifed clinical trials? We made a collection of clinical trials featuring Actifed, we think they might fit your search criteria.
Have you considered Actifed clinical trials? We made a collection of clinical trials featuring Actifed, we think they might fit your search criteria.
Have you considered Actifed clinical trials? We made a collection of clinical trials featuring Actifed, we think they might fit your search criteria.
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