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What is Actifed
TriprolidineThe Generic name of this drug
Treatment SummaryPseudoephedrine is a drug related to ephedrine, which is found in the ephedra plant. It has been used for centuries in Eastern medicine and first researched in the West in 1889. In 1927, it was discovered that pseudoephedrine has a decongestant effect, which is a weaker effect than that of ephedrine on the nervous system.
Silafedis the brand name
Actifed Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Silafed
Triprolidine
1988
3
Approved as Treatment by the FDA
Triprolidine, also called Silafed, is approved by the FDA for 9 uses like Vasomotor Rhinitis and Hay Fever .Vasomotor Rhinitis
Hay Fever
upper respiratory discomfort
Used to treat upper respiratory discomfort in combination with Codeine
Urticaria
Allergic Reaction
Allergic Conjunctivitis (AC)
Perennial Allergic Rhinitis (PAR)
Angioedema
Catarrh
Used to treat Common Cold in combination with Codeine
Effectiveness
How Actifed Affects PatientsPseudoephedrine acts as a decongestant by narrowing the blood vessels in the nose and sinuses. Its effects can last for a short time unless it is taken as an extended release product. Taking this drug may cause side effects related to stimulation of the central nervous system, so people should be aware of this risk.
How Actifed works in the bodyPseudoephedrine works by activating certain receptors in the body and by inhibiting certain transporters. This triggers an increase in blood pressure, heart rate and muscle tension. It also affects the body's inflammatory response, making it useful in treating conditions involving inflammation. Pseudoephedrine also helps relieve congestion and treat priapism.
When to interrupt dosage
The suggested measure of Actifed is contingent upon the recognized condition, including Upper Respiratory Tract Infection, Airway secretion clearance therapy and Coughing. The dosage amount is contingent upon the delivery technique (e.g. Tablet, extended release or Oral), which is enumerated in the table beneath.Condition
Dosage
Administration
Angioedema
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Urticaria
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Upper respiratory tract signs and symptoms
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Allergic Conjunctivitis (AC)
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Catarrh
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
upper respiratory discomfort
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Nasal Congestion
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Influenza
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Vasomotor Rhinitis
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Perennial Allergic Rhinitis (PAR)
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Allergic Reaction
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Hay Fever
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Allergy to Tree Pollen
2.5 mg, , 2.5 mg/mL, 0.938 mg/mL, 1.25 mg/mL, 0.625 mg/mL, 1.25 mg, 4.0 mg, 0.313 mg/mL, 30.0 mg/mL, 0.025 mg/mg, 0.66 mg, 0.25 mg/mL, 12.5 mg/mL, 0.125 mg/mL, 2.0 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Suspension - Oral, Solution - Oral, Capsule - Oral, Capsule, Solution
Warnings
Actifed has five counter-indications, and its use should be avoided when encountering any of the circumstances outlined in the following table.There are 20 known major drug interactions with Actifed.Common Actifed Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Triprolidine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Triprolidine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Triprolidine is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Triprolidine is combined with Mobocertinib.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Triprolidine is combined with Oliceridine.
Actifed Toxicity & Overdose RiskThe lowest toxic dose of pseudoephedrine in rats has been found to be 2206mg/kg and 726mg/kg in mice. Symptoms of overdose include dizziness, headaches, nausea, vomiting, increased heart rate, chest pain, difficulty urinating, muscle weakness, anxiety, restlessness, insomnia, mental confusion, irregular heartbeat, fainting, seizures, loss of consciousness, and trouble breathing. Treatments for pseudoephedrine overdose include removing any unabsorbed drug and providing supportive care.
Actifed Novel Uses: Which Conditions Have a Clinical Trial Featuring Actifed?
270 active trials are underway to evaluate the potential of Actifed for alleviating Allergies, Migraines and Ocular ailments.Condition
Clinical Trials
Trial Phases
Influenza
32 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1
Allergic Reaction
3 Actively Recruiting
Not Applicable, Phase 4
Urticaria
0 Actively Recruiting
Allergy to Tree Pollen
0 Actively Recruiting
Perennial Allergic Rhinitis (PAR)
1 Actively Recruiting
Phase 3
Upper respiratory tract signs and symptoms
0 Actively Recruiting
Hay Fever
1 Actively Recruiting
Phase 3
Nasal Congestion
1 Actively Recruiting
Not Applicable
upper respiratory discomfort
0 Actively Recruiting
Catarrh
2 Actively Recruiting
Phase 2, Not Applicable
Vasomotor Rhinitis
0 Actively Recruiting
Angioedema
0 Actively Recruiting
Allergic Conjunctivitis (AC)
1 Actively Recruiting
Phase 2
Actifed Reviews: What are patients saying about Actifed?
5Patient Review
7/15/2012 Walact is an effective sinusitis medication that contains the active ingredient triplodene. You can find it at Walgreens.
5Patient Review
10/4/2014 This treatment is effective and I would recommend it to others.
5Patient Review
2/1/2019 This drug was recommended to me by a pharmacist when I had flu-like symptoms while traveling in France. It worked quickly and effectively.
3.7Patient Review
2/1/2008 I unfortunately had to stop using this medication because it caused me to have severe anxiety attacks.
3.3Patient Review
4/24/2010 I felt terrible the next day after taking this medication. I was extremely sleepy and depressed.
Patient Q&A Section about actifed
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Actifed called now?
"The active ingredients in Wal-Act D are the same as those in the old Actifed formula: Triprolidine HCL and Pseudoehedrine HL. I bought some today at Wallgreens; it's their house brand, and you have to ask the pharmacist for it."
Answered by AI
Does Actifed make you sleep?
"”
Actifed is an effective medication for cold symptoms that cause constant coughing, especially at night. It may cause drowsiness, but this is not a problem for use at night."
Answered by AI
What is the drug Actifed used for?
"Decongestants help to reduce swelling in the nose.
This medication is a combination of an antihistamine and a decongestant and is used to relieve the symptoms of the common cold, flu, allergies, or other breathing illnesses temporarily. The antihistamine component helps relieve watery eyes, itchy eyes, nose, and throat, as well as a runny nose and sneezing. The decongestant component helps to reduce swelling in the nose."
Answered by AI