What is Accuretic
HydrochlorothiazideThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a prescription medication used to treat swelling caused by excess fluid and high blood pressure. It is the most commonly prescribed thiazide diuretic, though its popularity has been declining in favor of angiotensin converting enzyme inhibitors. Hydrochlorothiazide is often combined with other medications, such as angiotensin converting enzyme inhibitors and angiotensin II receptor blockers. The drug was approved by the FDA in 1959.
Esidrixis the brand name
Accuretic Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Esidrix
Hydrochlorothiazide
1959
2181
Approved as Treatment by the FDA
Hydrochlorothiazide, also called Esidrix, is approved by the FDA for 22 uses including Stroke and Edema .Stroke
Used to treat Cerebrovascular Accident in combination with Losartan
Edema
Helps manage Premenstrual tension with edema
inadequate response to other therapeutic measures
Used to treat inadequate response to other therapeutic measures in combination with Spironolactone
Therapeutic procedure
Used to treat inadequate response to treatment in combination with Spironolactone
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Losartan
inadequate control of blood pressure with monotherapy
Used to treat inadequate control of blood pressure with monotherapy in combination with Aliskiren
Nephrotic Syndrome
Used to treat Nephrotic Syndrome in combination with Spironolactone
restriction of fluid and sodium
Used to treat restriction of fluid and sodium in combination with Spironolactone
blood pressure inadequately controlled with monotherapy
Used to treat blood pressure inadequately controlled with monotherapy in combination with Irbesartan
Congestive Heart Failure
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
Left Ventricular Hypertrophy
Used to treat Left Ventricular Hypertrophy in combination with Losartan
Antihypertensive Treatment
Used to treat Antihypertensive Treatment in combination with Eprosartan
Cirrhosis
Used to treat Cirrhosis of the Liver in combination with Spironolactone
Hypertensive disease
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
Diuretics
Used to treat Hypokalemia caused by diuretics in combination with Amiloride
Antepartum magnesium sulfate prophylaxis
Helps manage prophylaxis of preeclampsia
calcium channel blockers
Used to treat calcium channel blockers in combination with Eprosartan
Sodium retention
Used to treat Sodium retention in combination with Spironolactone
Swollen feet or ankles
Used to treat Edema in combination with Triamterene
hypokalemia with solo treatment
Used to treat hypokalemia with solo treatment in combination with Triamterene
Ascites
Used to treat Ascites in combination with Spironolactone
Bedrest
Used to treat Bedrest in combination with Spironolactone
Effectiveness
How Accuretic Affects PatientsHydrochlorothiazide helps the body get rid of excess water by blocking the reabsorption of sodium and water in the kidneys. The usual dose is between 25-100mg and may vary depending on the person. It should be used with caution in those with reduced kidney or liver function.
How Accuretic works in the bodyHydrochlorothiazide works by blocking sodium-chloride reabsorption in the distal convoluted tubule. Sodium is normally reabsorbed into cells and pumped into the surrounding tissue, creating a concentration gradient that draws water back into the cells. Hydrochlorothiazide disrupts this process, reducing the concentration gradient and blocking water from being reabsorbed. This results in an increased amount of sodium and water being released from the body.
When to interrupt dosage
The prescribed measure of Accuretic is contingent upon the determined condition, including Antepartum magnesium sulfate prophylaxis, inadequately regulated blood pressure with monotherapy and antihypertensives. The dosage fluctuates, in accordance with the method of delivery (e.g. Tablet, coated - Oral or Oral) noted in the table beneath.Condition
Dosage
Administration
calcium channel blockers
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Therapeutic procedure
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Nephrolithiasis
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Hypertensive disease
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Swollen feet or ankles
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Hypertensive disease
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Bedrest
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
prophylaxis of calcium nephrolithiasis
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Antepartum magnesium sulfate prophylaxis
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Edema
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
hypokalemia with solo treatment
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Diuretics
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
inadequate response to other therapeutic measures
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
blood pressure inadequately controlled with monotherapy
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Therapeutic procedure
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Ascites
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
inadequate control of blood pressure with monotherapy
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
antihypertensives
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Diabetes Insipidus
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Nephrotic Syndrome
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Warnings
Accuretic ContraindicationsCondition
Risk Level
Notes
Toxoplasma Infections
Do Not Combine
Anuria
Do Not Combine
Common Accuretic Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Hydrochlorothiazide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dofetilide.
Fenofibrate
Major
The therapeutic efficacy of Fenofibrate can be decreased when used in combination with Hydrochlorothiazide.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Hydroxyzine.
Accuretic Toxicity & Overdose RiskThe amount of hydrochlorothiazide needed to be toxic in mice and rats is more than 10g/kg. Overdosing on hydrochlorothiazide can cause low potassium, chloride, and sodium levels. Treatment for overdose includes giving fluids and electrolytes, vasopressors to treat low blood pressure, and oxygen for breathing difficulties.
Accuretic Novel Uses: Which Conditions Have a Clinical Trial Featuring Accuretic?
158 active trials are currently assessing the potential of Accuretic in relieving Cirrhosis, Edema and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Stroke
14 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Cirrhosis
59 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Swollen feet or ankles
45 Actively Recruiting
Phase 1, Phase 2, Phase 4, Not Applicable, Early Phase 1, Phase 3
Nephrotic Syndrome
13 Actively Recruiting
Phase 2, Not Applicable, Phase 3
inadequate control of blood pressure with monotherapy
0 Actively Recruiting
antihypertensives
0 Actively Recruiting
Bedrest
0 Actively Recruiting
Ascites
12 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1
Hypertensive disease
22 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4
Antepartum magnesium sulfate prophylaxis
13 Actively Recruiting
Phase 1, Not Applicable, Phase 3, Early Phase 1
blood pressure inadequately controlled with monotherapy
0 Actively Recruiting
Hypertensive disease
3 Actively Recruiting
Phase 1, Not Applicable
Left Ventricular Hypertrophy
3 Actively Recruiting
Not Applicable, Phase 4
restriction of fluid and sodium
0 Actively Recruiting
Congestive Heart Failure
24 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Diabetes Insipidus
2 Actively Recruiting
Phase 1, Phase 2
Edema
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Sodium retention
0 Actively Recruiting
Accuretic Reviews: What are patients saying about Accuretic?
5Patient Review
2/19/2008 I experienced some lightheadedness and a decrease in appetite, but nothing that was unmanageable. My mouth felt pretty dry most of the time, and I coughed more than usual.
5Patient Review
10/11/2008 I am thrilled with how this turned out. My blood pressure is now normal and my heart-rate is stable.
5Patient Review
12/7/20074Patient Review
2/2/2009 This has been the most effective medication for my high blood pressure that I've tried in the approximately four years I've had this problem.
3.3Patient Review
1/30/2008 We tried several different blood pressure medications and this one got my blood pressure under control. It's been working great ever since.
3Patient Review
4/1/2011 My husband really doesn't react well to this medication- it causes him a lot of trouble breathing. We're currently looking for an alternative that will be just as effective in treating his high blood pressure without this nasty side effect.
3Patient Review
8/12/2013 I had an itchy throat and was coughing a lot.
2Patient Review
1/6/2012 After being on this drug for 20 years, I experienced some nasty side effects like coughing, dizziness, lightheadedness, and difficulty sleeping. I had to switch drugs four times before my doctors found a replacement that worked better for me. In the meantime, I was off work due to these issues and found it hard to balance my blood pressure.
1Patient Review
9/14/2010 This medication did nothing to help my pulmonary hypertension.
Patient Q&A Section about accuretic
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why did Pfizer recall Accuretic?
"- Health Canada
Pfizer Canada ULC is recalling all lots of Accuretic (quinapril hydrochloride and hydrochlorothiazide) medication due to the presence of a nitrosamine impurity (N-nitroso-quinapril) above the acceptable level."
Answered by AI
Is hydrochlorothiazide being recalled?
", Pfizer Consumer Healthcare, a Division of Pfizer Inc., announced a voluntary recall of lots of ACCURETIC ™ (quinapril HCl/hydrochlorothiazide), quinapril and hydrochlorothiazide tablets, and quinapril HCl/hydrochlorothiazide tablets.
Recall of ACCURETIC™ (quinapril HCl/hydrochlorothiazide), quinapril and hydrochlorothiazide Tablets, and quinapril HCl/hydrochlorothiazide Tablets Due to N-Nitroso- Quinapril Content.
Pfizer Consumer Healthcare is voluntarily recalling lots of ACCURETIC™ (quinapril HCl/hydrochlorothiazide), quinapril and hydrochlorothiazide tablets, and quinapril HCl/hydrochlorothiazide tablets due to N-Nitroso- Quinapril content."
Answered by AI
What is Accuretic used for?
"Your blood pressure may be different at different times of the day. If it stays high over time, it is called high blood pressure. High blood pressure can damage your blood vessels and lead to heart disease and stroke.
Accuretic is a combination of an ACE inhibitor and a diuretic. It is used to lower high blood pressure by helping blood vessels widen and allowing more blood to flow through them easily."
Answered by AI
What is generic name for Accuretic?
"Accuretic is a prescription medication used to treat high blood pressure. The drug is a combination of two drugs, amlodipine and hydrochlorothiazide. It is available as a generic drug, which is sold under the name Quinaretic."
Answered by AI