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What is Ziprasidone Mesylate
ZiprasidoneThe Generic name of this drug
Treatment SummaryZiprasidone is a medication used to treat mental illnesses such as schizophrenia and bipolar disorder. It is a type of antipsychotic, a class of drugs that was introduced after the discovery of chlorpromazine’s antipsychotic properties in 1952. Ziprasidone is known as an “atypical” antipsychotic, meaning it generally has fewer side effects than “typical” antipsychotics, such as extrapyramidal symptoms and weight gain. Ziprasidone can help reduce the rate and time of relapses in schizophrenia and is used to treat manic episodes in bipolar disorder, although
Geodonis the brand name
Ziprasidone Mesylate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Geodon
Ziprasidone
2001
250
Approved as Treatment by the FDA
Ziprasidone, also called Geodon, is approved by the FDA for 2 uses which include Bipolar Disorder and Acute Coryza .Bipolar Disorder
Acute Coryza
Effectiveness
How Ziprasidone Mesylate Affects PatientsZiprasidone is an "atypical" antipsychotic medication that works by blocking certain receptors in the brain, such as dopamine and serotonin. It also prevents the reabsorption of serotonin and other neurotransmitters. It has a low affinity for receptors related to muscle movement, allergies, and heart rate, making it less likely to cause those types of side effects.
How Ziprasidone Mesylate works in the bodyZiprasidone works differently than other antipsychotics, as it binds to serotonin-2A and dopamine D2 receptors more strongly. This increased binding helps to improve mood and cognitive function, as well as reduce motor dysfunction. Ziprasidone is also less likely to cause side effects like orthostatic hypotension, sedation, and weight gain, because it does not bind as strongly to histamine, muscarinic, and alpha-adrenoceptors.
When to interrupt dosage
The suggested measure of Ziprasidone Mesylate is contingent upon the identified condition, such as Alzheimer's Disease, Bipolar Disorder and Acute Coryza. The amount of dosage fluctuates, as per the technique of administration noted in the table below.Condition
Dosage
Administration
Acute Agitation
20.0 mg, 40.0 mg, 60.0 mg, , 80.0 mg, 20.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular
Schizophrenia
20.0 mg, 40.0 mg, 60.0 mg, , 80.0 mg, 20.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular
acute Mixed manic depressive episode
20.0 mg, 40.0 mg, 60.0 mg, , 80.0 mg, 20.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular
Bipolar Disorder
20.0 mg, 40.0 mg, 60.0 mg, , 80.0 mg, 20.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular
Agitation
20.0 mg, 40.0 mg, 60.0 mg, , 80.0 mg, 20.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular
Alzheimer's Disease
20.0 mg, 40.0 mg, 60.0 mg, , 80.0 mg, 20.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular
Acute Coryza
20.0 mg, 40.0 mg, 60.0 mg, , 80.0 mg, 20.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular
Schizophrenia
20.0 mg, 40.0 mg, 60.0 mg, , 80.0 mg, 20.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular
Unipolar Depression
20.0 mg, 40.0 mg, 60.0 mg, , 80.0 mg, 20.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular
Warnings
Ziprasidone Mesylate has twenty-five contraindications, and so it must not be utilized if any of the conditions in the table below are manifest.Ziprasidone Mesylate ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Myocardial Infarction
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Heart Decompensation
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
history of QT prolongation
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ziprasidone may interact with Pulse Frequency
Common Ziprasidone Mesylate Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Ziprasidone.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Ziprasidone.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Ziprasidone is combined with Aclidinium.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Ziprasidone.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Ziprasidone.
Ziprasidone Mesylate Toxicity & Overdose RiskCommon side effects associated with ziprasidone include drowsiness, infections of the respiratory tract, trembling or jerking movements, dizziness, restlessness, blurred vision, weakness, vomiting, headaches, and nausea.
Ziprasidone Mesylate Novel Uses: Which Conditions Have a Clinical Trial Featuring Ziprasidone Mesylate?
456 active trials are presently examining the potential of Ziprasidone Mesylate to alleviate Agitation, Alzheimer's Disease and Schizophrenia.Condition
Clinical Trials
Trial Phases
Bipolar Disorder
1 Actively Recruiting
Phase 4
Alzheimer's Disease
254 Actively Recruiting
Phase 1, Phase 4, Phase 2, Phase 3, Not Applicable, Early Phase 1
Schizophrenia
174 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Unipolar Depression
1 Actively Recruiting
Not Applicable
Acute Coryza
1 Actively Recruiting
Not Applicable
Acute Agitation
0 Actively Recruiting
acute Mixed manic depressive episode
0 Actively Recruiting
Agitation
5 Actively Recruiting
Phase 3, Phase 2
Schizophrenia
34 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4
Ziprasidone Mesylate Reviews: What are patients saying about Ziprasidone Mesylate?
4.7Patient Review
4/3/2008 I used this medication when I was feeling agitated and it wasn't time for my regular medicine yet. It helped me calm down so that I could deal with the situation more effectively.
Patient Q&A Section about ziprasidone mesylate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is ziprasidone the same as Geodon?
"Ziprasidone is an atypical antipsychotic that treats schizophrenia and bipolar disorder by changing the levels of dopamine and serotonin in the brain."
Answered by AI
What ziprasidone does to the brain?
"Ziprasidone is a medication that treats schizophrenia by working on the brain. It is known as a second generation antipsychotic (SGA) or atypical antipsychotic. Ziprasidone rebalances dopamine and serotonin to improve thinking, mood, and behavior."
Answered by AI
Is ziprasidone a sedating?
"Compared to traditional antipsychotics, atypical antipsychotics like risperidone, olanzapine, quetiapine, and ziprasidone usually cause less drowsiness but are just as effective at managing psychosis and excitement."
Answered by AI
What is ziprasidone mesylate used for?
"Ziprasidone injection is used to quickly treat severe agitation in patients with schizophrenia. It helps to restore the balance of certain neurotransmitters in the brain, which leads to symptom relief."
Answered by AI