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What is Ziprasidone Hydrochloride
ZiprasidoneThe Generic name of this drug
Treatment SummaryDisorders like schizophrenia and bipolar disorder can have a big impact on mood, thinking, and behavior. These mental illnesses can also cause depression and substance abuse. Treatment options for these psychotic disorders have been available since 1952, such as first and second generation antipsychotics. Ziprasidone is a second generation antipsychotic used to treat schizophrenia and bipolar disorder. It can help reduce the rate and time of relapses in schizophrenia and treat manic episodes in bipolar disorder. Compared to other second generation antipsychotics, it has a lower chance of causing metabolic side effects.
Geodonis the brand name
Ziprasidone Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Geodon
Ziprasidone
2001
250
Approved as Treatment by the FDA
Ziprasidone, also called Geodon, is approved by the FDA for 2 uses which include Bipolar Disorder and Acute Coryza .Bipolar Disorder
Acute Coryza
Effectiveness
How Ziprasidone Hydrochloride Affects PatientsZiprasidone is a type of antipsychotic medication that works by blocking certain receptors in the brain, including dopamine and serotonin. It also blocks the reuptake of serotonin and norepinephrine, which helps to prevent them from being absorbed back into the brain. Ziprasidone has a very high affinity for serotonin receptors but a low affinity for other types of receptors, such as those for histamine and adrenaline.
How Ziprasidone Hydrochloride works in the bodyZiprasidone works differently than other antipsychotics. It binds to serotonin-2A and dopamine D2 receptors in a similar way, but it has a higher affinity for the serotonin-2A receptor than other drugs. This means it has a better ability to improve mood, reduce negative symptoms, and improve cognition. It also has a lower risk of causing orthostatic hypotension, cognitive disturbance, sedation, weight gain, and disruption in prolactin levels. This is because it binds less strongly to histamine H1, muscarinic M1, and alpha1-adrenoceptors.
When to interrupt dosage
The suggested dosage of Ziprasidone Hydrochloride is contingent upon the diagnosed condition, for example Alzheimer's Disease, Bipolar Disorder and Acute Coryza. The magnitude of dosage fluctuates as per the delivery approach indicated in the table below.Condition
Dosage
Administration
Schizophrenia
20.0 mg, 40.0 mg, 60.0 mg, , 80.0 mg, 20.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular
Acute Agitation
20.0 mg, 40.0 mg, 60.0 mg, , 80.0 mg, 20.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular
acute Mixed manic depressive episode
20.0 mg, 40.0 mg, 60.0 mg, , 80.0 mg, 20.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular
Bipolar Disorder
20.0 mg, 40.0 mg, 60.0 mg, , 80.0 mg, 20.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular
Agitation
20.0 mg, 40.0 mg, 60.0 mg, , 80.0 mg, 20.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular
Alzheimer's Disease
20.0 mg, 40.0 mg, 60.0 mg, , 80.0 mg, 20.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular
Acute Coryza
20.0 mg, 40.0 mg, 60.0 mg, , 80.0 mg, 20.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular
Schizophrenia
20.0 mg, 40.0 mg, 60.0 mg, , 80.0 mg, 20.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular
Unipolar Depression
20.0 mg, 40.0 mg, 60.0 mg, , 80.0 mg, 20.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular
Warnings
Ziprasidone Hydrochloride ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Myocardial Infarction
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Heart Decompensation
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
history of QT prolongation
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ziprasidone may interact with Pulse Frequency
Common Ziprasidone Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Ziprasidone.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Ziprasidone.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Ziprasidone is combined with Aclidinium.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Ziprasidone.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Ziprasidone.
Ziprasidone Hydrochloride Toxicity & Overdose RiskCommon side effects of taking ziprasidone can include sleepiness, respiratory infections, muscle stiffness, dizziness, restlessness, blurry vision, exhaustion, vomiting, headaches, and nausea.
Ziprasidone Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Ziprasidone Hydrochloride?
456 active clinical trials are underway to assess the potential of Ziprasidone Hydrochloride in alleviating Agitation, Alzheimer's Disease and Schizophrenia.Condition
Clinical Trials
Trial Phases
Bipolar Disorder
1 Actively Recruiting
Phase 4
Schizophrenia
175 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Alzheimer's Disease
253 Actively Recruiting
Phase 1, Phase 4, Phase 2, Phase 3, Not Applicable, Early Phase 1
Unipolar Depression
1 Actively Recruiting
Not Applicable
Acute Coryza
1 Actively Recruiting
Not Applicable
Acute Agitation
0 Actively Recruiting
acute Mixed manic depressive episode
0 Actively Recruiting
Agitation
5 Actively Recruiting
Phase 3, Phase 2
Schizophrenia
34 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4
Ziprasidone Hydrochloride Reviews: What are patients saying about Ziprasidone Hydrochloride?
5Patient Review
8/12/20145Patient Review
11/20/2020 I started taking this medication in addition to my depression medication, as it was supposed to help improve my mood. Unfortunately, I began hallucinating soon after starting the medication. It took me a few months to realize that the hallucinations were caused by the ziprasidone. Thankfully, I had a GeneSight test which helped me identify the problem. I start my new medications tomorrow and hopefully will see some improvement.
4.7Patient Review
10/25/2015 I've been on 60 mg for three weeks now. I'm supposed to take one in the morning and one with dinner, but the morning pill makes me so sleepy that I can't function. If I take the dinner pill too late, then I can get up in the morning. The good news is that I haven't had any manic episodes; however, the bad news is that my sex drive has totally disappeared.
2.7Patient Review
1/7/2016 I was on Quetiapine before this Medication and the difference is huge, I'm feeling more energetic and my depression has lifted. Instead of sleeping close to 15 hours most days I'm now happy with 8-9 hours sleep. My thinking is clearer and overall I feel in a better space.
2.7Patient Review
8/24/2014 Unfortunately, this medication caused a lot of weight gain and other problems like tremors, mouth sores, and fatigue.
2.3Patient Review
8/19/2014 I've only been taking this medication for a short while, but it's already helped me. The only downside is that I've developed twitching in my facial muscles.
1.7Patient Review
8/1/2020 I have now tried this treatment four times. I suffer from bi-polar type one with mixed episodes and Geodon has always helped me in the past. I alternate between taking Saphris and Geodon when I build up a tolerance to one or the other. I am currently taking 60mg, but have been as high as 120mg before with no problems.
Patient Q&A Section about ziprasidone hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does ziprasidone help you sleep?
"A sleep study of 12 healthy men showed that those treated with ziprasidone had better sleep continuity and efficiency, less REM sleep, and more stage 2 sleep and slow wave sleep than those who did not receive the treatment."
Answered by AI
What type of medication is ziprasidone hydrochloride?
"Ziprasidone is a type of antipsychotic medication that works by changing the activity of certain natural substances in the brain."
Answered by AI
What is the side effect of ziprasidone hydrochloride?
"The following side effects may occur with this medication: drowsiness, dizziness, lightheadedness, weakness, nausea, vomiting, runny nose, and cough. If you experience any of these side effects, tell your doctor. Dizziness and lightheadedness can increase your risk of falling."
Answered by AI
What is Ziprasidone Hydrochloride used for?
"Ziprasidone is a medication used to treat symptoms associated with mental disorders such as schizophrenia, mania, or bipolar disorder. It is not to be used in elderly patients who suffer from behavioral problems related to dementia. Ziprasidoneadjusts the levels of certain chemicals in the brain in order to alleviate psychotic disorders."
Answered by AI