Zestril

Migraine, Heart Attack, prophylaxis of cardiovascular event + 6 more
Treatment
5 FDA approvals
20 Active Studies for Zestril

What is Zestril

LisinoprilThe Generic name of this drug
Treatment SummaryLisinopril is a medication used to treat high blood pressure, heart failure, and heart attack. It is an angiotensin converting enzyme inhibitor (ACEI), and it works by blocking the action of the angiotensin converting enzyme and the renin angiotensin aldosterone system. Lisinopril is usually used together with other medications such as thiazide diuretics or beta blockers for the treatment of hypertension. It was approved by the FDA in 1987.
Prinivilis the brand name
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Zestril Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prinivil
Lisinopril
1987
1222

Approved as Treatment by the FDA

Lisinopril, commonly known as Prinivil, is approved by the FDA for 5 uses which include Congestive Heart Failure (CHF) and Hypertensive disease .
Congestive Heart Failure (CHF)
Used in combination with other therapies
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Acute Myocardial Infarction (AMI)
Helps manage Acute Myocardial Infarction (AMI)
Congestive Heart Failure
Used in combination with other therapies
Heart Attack
Helps manage Acute Myocardial Infarction (AMI)

Effectiveness

How Zestril Affects PatientsLisinopril is a medication used to treat high blood pressure, heart failure, and heart attack. It works by blocking the enzyme and hormone system that control blood pressure and flow. Lisinopril is considered to be a safe drug and produces long lasting effects when taken daily in doses between 10-80mg.
How Zestril works in the bodyLisinopril is a medication that reduces the effects of angiotensin II, a hormone that normally causes constriction of the coronary blood vessels. Without lisinopril, this constriction can lead to myocyte hypertrophy and vascular smooth muscle cell proliferation. Lisinopril works by blocking angiotensin I from converting to angiotensin II, which helps prevent these side effects. It also increases levels of bradykinin, which has a vasodilating effect.

When to interrupt dosage

The measure of Zestril depends on the determined condition, such as Migraine, Congestive Heart Failure and prophylaxis of cardiovascular event. The dosage amount is contingent upon the technique of delivery (e.g. Tablet - Oral or Tablet) presented in the table below.
Condition
Dosage
Administration
Migraine
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Heart Attack
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
prophylaxis of cardiovascular event
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Congestive Heart Failure
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Diabetes
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Diabetic Nephropathies
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Cardiovascular Events
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Migraine Disorders
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Hypertensive disease
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral

Warnings

Zestril has five counter-indications. Its use should be avoided in conditions described in the table below.Zestril Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Type 2 Diabetes
Do Not Combine
Angioedema
Do Not Combine
Pulse Frequency
Do Not Combine
Angioedemas, Hereditary
Do Not Combine
There are 20 known major drug interactions with Zestril.
Common Zestril Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Lisinopril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Lisinopril is combined with Azathioprine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Lisinopril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Lisinopril.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Lisinopril.
Zestril Toxicity & Overdose RiskThe lowest toxic dose of lisinopril in rats has been found to be greater than 8500mg/kg in rats and greater than 9100mg/kg in mice. Those who overdose on lisinopril may experience low blood pressure, which can be reversed by administering saline intravenously. Since lisinopril does not bind to protein, dialysis can be used to remove the drug from the bloodstream.
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Zestril Novel Uses: Which Conditions Have a Clinical Trial Featuring Zestril?

647 active studies are currently being conducted to assess the potential of Zestril to improve Type 2 Diabetes, Diabetic Nephropathy and Hypertensive conditions.
Condition
Clinical Trials
Trial Phases
Diabetes
74 Actively Recruiting
Phase 1, Not Applicable, Phase 4, Phase 2, Phase 3
Migraine Disorders
1 Actively Recruiting
Phase 3
Diabetic Nephropathies
0 Actively Recruiting
prophylaxis of cardiovascular event
0 Actively Recruiting
Congestive Heart Failure
12 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Migraine
53 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1
Cardiovascular Events
4 Actively Recruiting
Not Applicable
Heart Attack
7 Actively Recruiting
Not Applicable, Phase 4, Phase 3

Zestril Reviews: What are patients saying about Zestril?

5Patient Review
1/9/2012
Zestril for High Blood Pressure
I started taking this medication in January and experienced great results; however, in mid-March I began coughing excessively. My doctor initially diagnosed it as acid reflux and prescribed me a different medication. After a month on that treatment with no relief, we realized that the Lisinopril was the root of the problem.
5Patient Review
4/8/2014
Zestril for Heart Attack
This medication worked well for me at first, but I've been noticing some troubling side effects recently. Headaches, shortness of breath, and pain in both shoulders.
5Patient Review
3/15/2011
Zestril for High Blood Pressure
5Patient Review
12/17/2012
Zestril for High Blood Pressure
The only side effect I experienced was some vertigo when waking up in the morning.
4.7Patient Review
6/15/2014
Zestril for High Blood Pressure
I don't have high blood pressure, but rather trouble getting 5 mg tablets from my pharmacy. My dosage is 15mg per day.
View All Reviews
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Patient Q&A Section about zestril

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are Zestril side effects?

"The following are symptoms of the colder: coughing, dizziness, drowsiness, headache, depression, nausea, vomiting, diarrhea."

Answered by AI

What is the difference between Prinivil and lisinopril?

"Are Zestril and Prinivil the same thing?

Zestril and Prinivil are both brand names for the medication lisinopril, which is used to treat different conditions such as high blood pressure and heart failure."

Answered by AI

What is Zestril used for?

"Zestril can be used to improve the following conditions: high blood pressure, heart failure, and a recent heart attack."

Answered by AI

What is the difference between Zestril and lisinopril?

"Zestril contains the active drug lisinopril, which is an exact copy of the active drug in a brand-name medication. The generic is considered to be as safe and effective as the original drug."

Answered by AI

Clinical Trials for Zestril

Have you considered Zestril clinical trials? We made a collection of clinical trials featuring Zestril, we think they might fit your search criteria.
Have you considered Zestril clinical trials? We made a collection of clinical trials featuring Zestril, we think they might fit your search criteria.
Have you considered Zestril clinical trials? We made a collection of clinical trials featuring Zestril, we think they might fit your search criteria.
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