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What is Zestril
LisinoprilThe Generic name of this drug
Treatment SummaryLisinopril is a medication used to treat high blood pressure, heart failure, and heart attack. It is an angiotensin converting enzyme inhibitor (ACEI), and it works by blocking the action of the angiotensin converting enzyme and the renin angiotensin aldosterone system. Lisinopril is usually used together with other medications such as thiazide diuretics or beta blockers for the treatment of hypertension. It was approved by the FDA in 1987.
Prinivilis the brand name
Zestril Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prinivil
Lisinopril
1987
1222
Approved as Treatment by the FDA
Lisinopril, commonly known as Prinivil, is approved by the FDA for 3 uses which include Hypertensive disease and Heart Attack .Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Heart Attack
Helps manage Acute Myocardial Infarction (AMI)
Congestive Heart Failure
Used in combination with other therapies
Effectiveness
How Zestril Affects PatientsLisinopril is a medication used to treat high blood pressure, heart failure, and heart attack. It works by blocking the enzyme and hormone system that control blood pressure and flow. Lisinopril is considered to be a safe drug and produces long lasting effects when taken daily in doses between 10-80mg.
How Zestril works in the bodyLisinopril is a medication that reduces the effects of angiotensin II, a hormone that normally causes constriction of the coronary blood vessels. Without lisinopril, this constriction can lead to myocyte hypertrophy and vascular smooth muscle cell proliferation. Lisinopril works by blocking angiotensin I from converting to angiotensin II, which helps prevent these side effects. It also increases levels of bradykinin, which has a vasodilating effect.
When to interrupt dosage
The measure of Zestril depends on the determined condition, such as Migraine, Congestive Heart Failure and prophylaxis of cardiovascular event. The dosage amount is contingent upon the technique of delivery (e.g. Tablet - Oral or Tablet) presented in the table below.Condition
Dosage
Administration
Diabetes
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Heart Attack
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
prophylaxis of cardiovascular event
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
prophylaxis of migraine headaches
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Congestive Heart Failure
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Diabetic Nephropathy
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Hypertensive disease
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Migraine
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Cardiovascular Events
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Warnings
Zestril has five counter-indications. Its use should be avoided in conditions described in the table below.Zestril ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Type 2 Diabetes
Do Not Combine
Angioedema
Do Not Combine
Pulse Frequency
Do Not Combine
Angioedemas, Hereditary
Do Not Combine
Common Zestril Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Lisinopril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Lisinopril is combined with Azathioprine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Lisinopril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Lisinopril.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Lisinopril.
Zestril Toxicity & Overdose RiskThe lowest toxic dose of lisinopril in rats has been found to be greater than 8500mg/kg in rats and greater than 9100mg/kg in mice. Those who overdose on lisinopril may experience low blood pressure, which can be reversed by administering saline intravenously. Since lisinopril does not bind to protein, dialysis can be used to remove the drug from the bloodstream.
Zestril Novel Uses: Which Conditions Have a Clinical Trial Featuring Zestril?
647 active studies are currently being conducted to assess the potential of Zestril to improve Type 2 Diabetes, Diabetic Nephropathy and Hypertensive conditions.Condition
Clinical Trials
Trial Phases
Migraine
52 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Heart Attack
8 Actively Recruiting
Not Applicable, Phase 4, Phase 3
prophylaxis of cardiovascular event
0 Actively Recruiting
Diabetes
541 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable, Phase 4, Early Phase 1
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
prophylaxis of migraine headaches
0 Actively Recruiting
Congestive Heart Failure
22 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Cardiovascular Events
3 Actively Recruiting
Not Applicable
Zestril Reviews: What are patients saying about Zestril?
5Patient Review
1/9/2012 I started taking this medication in January and experienced great results; however, in mid-March I began coughing excessively. My doctor initially diagnosed it as acid reflux and prescribed me a different medication. After a month on that treatment with no relief, we realized that the Lisinopril was the root of the problem.
5Patient Review
4/8/2014 This medication worked well for me at first, but I've been noticing some troubling side effects recently. Headaches, shortness of breath, and pain in both shoulders.
5Patient Review
3/15/20115Patient Review
12/17/2012 The only side effect I experienced was some vertigo when waking up in the morning.
4.7Patient Review
6/15/2014 I don't have high blood pressure, but rather trouble getting 5 mg tablets from my pharmacy. My dosage is 15mg per day.
4.3Patient Review
4/27/2017 I've been on this medication for over a decade, and it's helped me immensely. However, in the last few years I've developed an uncontrollable cough. It's the only side effect I've ever had from the drug, but it's become unbearable. I'm thinking it might be time to switch to a different blood pressure medication.
4.3Patient Review
11/5/2011 I experienced zero negative side effects from this treatment, which is amazing.
4.3Patient Review
11/30/2011 This medication works well for me.
3.7Patient Review
2/15/2017 This medication alleviated my condition; however, after taking it for a prolonged period of time with no issues, I suddenly became allergic to the drug. Consequently, my upper lip swelled and I broke out in hives. My doctor advised me to go to the ER where they administered an IV drip of steroids and antihistamines. To recover, I was required to take steroid pills for 10 days.
3.7Patient Review
10/22/2011 I've been on this medication for a little while now, and I can't stand it anymore. The cough it's supposed to help with is dry, hacking, and incredibly annoying. It's also led to me being sleep deprived, which in turn makes me irritable. I'll be very grateful when my doctor switches me to something else.
3.7Patient Review
4/21/2011 I've been on Lisinopril 2.5 mg and Corgard 20 mg for over a year. It's helped, but lately I've been getting terrible headaches after taking the Lisinpril. Not sure if it's related, but it's worth considering.
3.7Patient Review
1/22/20113.3Patient Review
3/18/2014 I may be taking a higher mg than necessary because I've felt a sinking feeling a few times. Can anyone let me know if halving the pill would provide 1/2 the dosage and prevent this side effect?
3.3Patient Review
10/2/2014 I began taking Zestril in 1988 for high blood pressure. The dosage increased over time, and I eventually switched to another drug in 1998. I never experienced any of the listed side effects. Currently, I am using 100 mg Metoprolol; however, I have experienced too many side effects and am looking for a substitution.
3.3Patient Review
6/12/2012 I've been on this medication for over a year now. The only downside I've noticed is that my hair has been thinning out quite a bit.
2.3Patient Review
4/11/2012 I was disappointed with this treatment for my leg pain.
2.3Patient Review
11/23/20102.3Patient Review
2/16/2011Patient Q&A Section about zestril
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are Zestril side effects?
"The following are symptoms of the colder: coughing, dizziness, drowsiness, headache, depression, nausea, vomiting, diarrhea."
Answered by AI
What is the difference between Prinivil and lisinopril?
"Are Zestril and Prinivil the same thing?
Zestril and Prinivil are both brand names for the medication lisinopril, which is used to treat different conditions such as high blood pressure and heart failure."
Answered by AI
What is Zestril used for?
"Zestril can be used to improve the following conditions: high blood pressure, heart failure, and a recent heart attack."
Answered by AI
What is the difference between Zestril and lisinopril?
"Zestril contains the active drug lisinopril, which is an exact copy of the active drug in a brand-name medication. The generic is considered to be as safe and effective as the original drug."
Answered by AI