This trial is evaluating whether GS-9716 will improve 3 primary outcomes and 10 secondary outcomes in patients with Solid Malignancies. Measurement will happen over the course of First dose date up to 21 days.
This trial requires 205 total participants across 12 different treatment groups
This trial involves 12 different treatments. GS-9716 is the primary treatment being studied. Participants will be divided into 12 treatment groups. There is no placebo group. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.
"Cancer is any abnormality in tissue that, if left untreated, can grow and invade surrounding normal tissue and eventually spread elsewhere in the body. There are many types of cancer, but most have in common the production of growth signals which lead to the uncontrolled division of cells. Most cancers have a combination of two characteristics, an uncontrolled division of cells and the formation of new blood vessels supplying the growing mass with oxygen and nutrients that it needs. These grow into tumor masses, which can eventually metastasise. The development of cancer remains a mystery as to where the cancer develops from, but is believed to arise from a combination of genetic, nutritional, environmental and aging factors." - Anonymous Online Contributor
"Each year, approximately 8 million US adults will be diagnosed with cancer. This makes cancer the leading cause of disease-related deaths for adults in the US. On average, 3.0% (1.2 million) of American adults will die of cancer. Cancer is also a major component of morbidity and mortality for adults, accounting for 20.4% (22.9 million) of hospitalizations, 39% (34.5 million) of outpatient visits requiring treatment, and 20.0% of lifetime earnings lost due to cancer. On average, 1." - Anonymous Online Contributor
"This article discusses signs associated with cancers where it is often not immediately visible. It also provides clues to what may be on the horizon. Although a diagnosis remains possible for some, one sign alone is often not sufficient to exclude a cancer, especially when others might also be present." - Anonymous Online Contributor
"Cancers can be formed when certain genetic abnormalities occur. There are several underlying causes. Most cancers are associated with specific cancers, but some are linked to an accumulation of multiple cancers, or with a type of cancer. In the most common types of cancers which are the subject of this article, some can be prevented by reducing high risk behaviors, eating a healthy diet, and staying physically active.\n" - Anonymous Online Contributor
"The medical oncologists who treat solid tumors have a wide variety of opinions and preferences in their treatment. We think that patients/patients should be involved in this discussion because their treatment decisions can have huge impacts on survival and quality of life as well as on the cost of disease care. Although homeopathy has not shown to have positive results in cancer, it is recommended as it is an effective treatment for many specific diseases such as cough, diarrhea, hepatitis etc. and also it does not worsen the symptom. It is possible that a homeopathic doctor would prescribe a homeopathic remedy to help treat an illness, but we need to know more about that." - Anonymous Online Contributor
"Most common causes of death among cancer patients are cardiovascular diseases and lung cancer. If the disease is left untreated, it does not always lead to immediate death, but it doesn't need to be ignored." - Anonymous Online Contributor
"Although the number of primary factors cannot be narrowed down to a single cause, the majority of cancers seem to have at least one primary factor. Some cancers are multifactorial; for example, colorectal cancer has multiple factors as do many cancers of the bladder and lung. Some of the factors that have been associated are age, smoking, infections through microbes, diet, and genetics. More research is needed to determine whether there is an overall causative agent beyond any single factor as to a single cause of cancer." - Anonymous Online Contributor
"None. The only new treatments for cancer were radiation therapy and cryosurgery. All these treatments had already been known a decade ago and used successfully. All existing treatments for cancer are more or less the same." - Anonymous Online Contributor
"The most common adverse event (and the top reason for discontinuation) was nausea. The most common (and most expensive) side effect (and the top reason for discontinuation) was fatigue. Because of these adverse effects (almost 50% of people discontinued gs-9716), the sponsor expects that further pharmacology studies, studies more tailored to the unique pharmacologic profile of gs-9716, and/or trials of the next generation of drugs will be necessary before the drug continues development." - Anonymous Online Contributor
"While the study was not randomized, and there was no placebo control group there were no known patients who received chemotherapy and survived. It is not safety that should be questioned. Further the results of the study were comparable with those of a number of randomization controlled trials." - Anonymous Online Contributor