Personalized Radiation Therapy for Throat Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
The researchers are doing this study to find out if a personalized approach to chemoradiation therapy (which may include a lower dose of radiation) is as effective as the standard chemoradiation therapy in people with HPV-positive throat cancer. Other purposes of this study include looking at the following:* Whether a lower dose of radiation in combination with standard chemotherapy causes fewer side effects than the standard dose of radiation therapy in combination with standard chemotherapy* How the study approaches (lower dose of radiation therapy + standard chemotherapy and standard dose of radiation therapy + standard chemotherapy) affect participants' quality of life. The researchers will measure quality of life by having participants fill out questionnaires.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is personalized radiation therapy generally safe for humans?
Research on de-escalated or low-dose radiation therapy, which is similar to personalized radiation therapy, has been conducted for head and neck cancers. These studies suggest that while radiation therapy can have side effects, the de-escalated approach is being explored to reduce these effects, indicating a focus on safety.12345
How is Personalized Radiation Therapy different from other treatments for throat cancer?
What data supports the effectiveness of the treatment Personalized Radiation Therapy for Throat Cancer?
Who Is on the Research Team?
Nancy Lee, MD
Principal Investigator
Memorial Sloan Kettering Cancer Center
Are You a Good Fit for This Trial?
This trial is for individuals with HPV-positive throat cancer. Participants should be suitable for chemoradiation therapy and willing to undergo personalized treatment, which may involve a lower radiation dose. Specific eligibility criteria are not provided, but typically include factors like age, health status, and cancer stage.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either standard or personalized chemoradiation therapy based on hypoxia status
Follow-up
Participants are monitored for safety and effectiveness after treatment, including a posttreatment FDG PET/CT scan
Long-term follow-up
Participants' overall survival is monitored over a 2-year period
What Are the Treatments Tested in This Trial?
Interventions
- Personalized Radiation Therapy
Personalized Radiation Therapy is already approved in United States, European Union for the following indications:
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Who Is Running the Clinical Trial?
Memorial Sloan Kettering Cancer Center
Lead Sponsor